{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:02:17Z","timestamp":1791378137384,"version":"4.3.2"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010977","name":"Vetcare Oy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.vaa.2021.07.007","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T11:45:55Z","timestamp":1641555955000},"page":"336-343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The impact of vatinoxan on microcirculation after intramuscular co-administration with medetomidine in Beagle dogs: a blinded crossover study"],"prefix":"10.1016","volume":"49","author":[{"given":"Lisa","family":"Niemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette PN","family":"Kutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola B","family":"Joerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela L","family":"Wieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Hartnack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Steblaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2021.07.007_bib1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1164\/rccm.200109-016OC","article-title":"Microvascular blood flow is altered in patients with sepsis","volume":"166","author":"De Backer","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.vaa.2021.07.007_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ahj.2003.07.006","article-title":"Microvascular alterations in patients with acute severe heart failure and cardiogenic shock","volume":"147","author":"De Backer","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.vaa.2021.07.007_bib3","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/cc6118","article-title":"How to evaluate the microcirculation: report of a round table conference","volume":"11","author":"De Backer","year":"2007","journal-title":"Crit Care"},{"key":"10.1016\/j.vaa.2021.07.007_bib4","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1681\/ASN.2008060617","article-title":"Reduced production of creatinine limits its use as marker of kidney injury in sepsis","volume":"20","author":"Doi","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.vaa.2021.07.007_bib5","first-page":"892710","article-title":"From macrohemodynamic to the microcirculation","volume":"2013","author":"Donati","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"10.1016\/j.vaa.2021.07.007_bib6","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2460\/ajvr.69.6.728","article-title":"Effects of a peripheral \u03b12 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs","volume":"69","author":"Enouri","year":"2008","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2021.07.007_bib7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2460\/ajvr.1993.54.02.294","article-title":"Reduction of isoflurane anesthetic requirement by medetomidine and its restoration by atipamezole in dogs","volume":"54","author":"Ewing","year":"1993","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2021.07.007_bib8","doi-asserted-by":"crossref","first-page":"15101","DOI":"10.1364\/OE.15.015101","article-title":"Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation","volume":"15","author":"Goedhart","year":"2007","journal-title":"Opt Express"},{"key":"10.1016\/j.vaa.2021.07.007_bib9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/13529","article-title":"Orthogonal polarization spectral imaging: a new method for study of the microcirculation","volume":"5","author":"Groner","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.vaa.2021.07.007_bib10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2885.2010.01242.x","article-title":"The effects of increasing doses of MK-467, a peripheral \u03b12-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs","volume":"34","author":"Honkavaara","year":"2011","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2021.07.007_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.vaa.2019.07.004","article-title":"Concentrations of medetomidine enantiomers and vatinoxan, an \u03b12-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs","volume":"47","author":"Honkavaara","year":"2020","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.07.007_bib12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.vaa.2017.07.005","article-title":"The relationship between intestinal and oral mucosa microcirculation in anaesthetized horses","volume":"45","author":"Hopster","year":"2018","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.07.007_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00134-018-5070-7","article-title":"Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine","volume":"44","author":"Ince","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.vaa.2021.07.007_bib14","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1152\/jappl.1998.85.6.2360","article-title":"Decreases in organ blood flows associated with increases in sublingual PCO2 during hemorrhagic shock","volume":"85","author":"Jin","year":"1998","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.vaa.2021.07.007_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.vaa.2018.01.008","article-title":"Peripheral \u03b12-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs","volume":"45","author":"Kallio-Kujala","year":"2018","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.07.007_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejcts.2005.04.032","article-title":"In\u00a0vivo effects of hypothermia on the microcirculation during extracorporeal circulation","volume":"28","author":"Kamler","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.vaa.2021.07.007_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/bja\/aen210","article-title":"Effects of propofol on human microcirculation","volume":"101","author":"Koch","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2021.07.007_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13054-016-1213-9","article-title":"A\u00a0guide to human in\u00a0vivo microcirculatory flow image analysis","volume":"20","author":"Massey","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.vaa.2021.07.007_bib19","first-page":"1","article-title":"nlme: Linear and nonlinear mixed effects models","volume":"3","author":"Pinheiro","year":"2013","journal-title":"R\u00a0Package Version"},{"key":"10.1016\/j.vaa.2021.07.007_bib20","first-page":"102483","article-title":"Comparison of different methods for the calculation of the microvascular flow index","volume":"2012","author":"Pozo","year":"2012","journal-title":"Crit Care Res Pract"},{"key":"10.1016\/j.vaa.2021.07.007_bib21","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1532-950X.1998.tb00539.x","article-title":"Hemodynamic effects of medetomidine in the dog: a dose titration study","volume":"27","author":"Pypendop","year":"1998","journal-title":"Vet Surg"},{"key":"10.1016\/j.vaa.2021.07.007_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1467-2995.2000.00003.x","article-title":"Effects of a medetomidine-midazolam-butorphanol combination on renal cortical, intestinal and muscle microvascular blood flow in isoflurane anaesthetized dogs: a laser Doppler study","volume":"27","author":"Pypendop","year":"2000","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.07.007_bib23","series-title":"A\u00a0language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"10.1016\/j.vaa.2021.07.007_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.vaa.2016.04.006","article-title":"Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha(2)-antagonist MK-467 in dogs","volume":"44","author":"Restitutti","year":"2017","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.07.007_bib25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2460\/ajvr.73.5.587","article-title":"Cardiopulmonary and sedative effects of the peripheral \u03b12-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs","volume":"73","author":"Rolfe","year":"2012","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2021.07.007_bib26","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/01.CCM.0000138558.16257.3F","article-title":"Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock","volume":"32","author":"Sakr","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.vaa.2021.07.007_bib27","first-page":"579","article-title":"Measurements of microvascular perfusion in healthy anesthetized dogs using orthogonal polarization spectral imaging","volume":"19","author":"Silverstein","year":"2009","journal-title":"J\u00a0Vet Emerg Crit Care (San Antonio)"},{"key":"10.1016\/j.vaa.2021.07.007_bib28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2460\/ajvr.75.9.809","article-title":"Microcirculatory effects of intravenous fluid administration in anesthetized dogs undergoing elective ovariohysterectomy","volume":"75","author":"Silverstein","year":"2014","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2021.07.007_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.annemergmed.2006.08.021","article-title":"Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival","volume":"49","author":"Trzeciak","year":"2007","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.vaa.2021.07.007_bib30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1467-2995.2012.00768.x","article-title":"Thermographic imaging of superficial temperature in dogs sedated with medetomidine and butorphanol with and without MK-467 (L-659'066)","volume":"40","author":"Vainionp\u00e4\u00e4","year":"2013","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.07.007_bib31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.vaa.2017.08.010","article-title":"Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses","volume":"45","author":"Wittenberg-Voges","year":"2018","journal-title":"Vet Anaesth Analg"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298722000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298722000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:59:50Z","timestamp":1761447590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298722000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1467298722000022"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2021.07.007","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of vatinoxan on microcirculation after intramuscular co-administration with medetomidine in Beagle dogs: a blinded crossover study","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2021.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}