{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:39:33Z","timestamp":1785577173520,"version":"3.56.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.vaa.2024.12.006","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T07:43:26Z","timestamp":1735544606000},"page":"174-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacodynamics and pharmacokinetics of rocuronium in sevoflurane-anesthetized Thoroughbred horses"],"prefix":"10.1016","volume":"52","author":[{"given":"Kazumichi","family":"Kodaira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kakizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-ichi","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Ode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Mizobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Kurimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Aida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2024.12.006_bib1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1292\/jvms.56.1161","article-title":"Determination of the minimum alveolar concentration (MAC) and physical response to sevoflurane inhalation in horses","volume":"56","author":"Aida","year":"1994","journal-title":"J\u00a0Vet Med Sci"},{"key":"10.1016\/j.vaa.2024.12.006_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2165\/00003088-199936030-00001","article-title":"Clinical pharmacokinetics of the newer neuromuscular blocking drugs","volume":"36","author":"Atherton","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.vaa.2024.12.006_bib3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tvjl.2005.11.014","article-title":"Clinical observations on the use of the muscle relaxant rocuronium bromide in the dog","volume":"173","author":"Auer","year":"2007","journal-title":"Vet J"},{"key":"10.1016\/j.vaa.2024.12.006_bib4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1463-5224.2010.00870.x","article-title":"Neuromuscular blockade with rocuronium bromide for ophthalmic surgery in horses","volume":"14","author":"Auer","year":"2011","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.vaa.2024.12.006_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1467-2995.2005.00262.x","article-title":"A\u00a0clinical study of the effects of rocuronium in isoflurane-anaesthetized cats","volume":"33","author":"Auer","year":"2006","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2024.12.006_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1467-2995.2006.00298.x","article-title":"Observations on the muscle relaxant rocuronium bromide in the horse \u2013 a dose-response study","volume":"34","author":"Auer","year":"2007","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2024.12.006_bib7","first-page":"1019","article-title":"In\u00a0vitro plasma protein binding of neuromuscular blocking agents in different subpopulations of patients","volume":"81","author":"Cameron","year":"1995","journal-title":"Anesth Analg"},{"key":"10.1016\/j.vaa.2024.12.006_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF03017322","article-title":"Rocuronium pharmacokinetic-pharmacodynamic relationship under stable propofol or isoflurane anesthesia","volume":"49","author":"Dragne","year":"2002","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.vaa.2024.12.006_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/bja\/aei005","article-title":"Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values","volume":"94","author":"Ezzine","year":"2005","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2024.12.006_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0021-9673(00)01164-X","article-title":"Quantitative determination of rocuronium in human plasma by liquid chromatography\u2013electrospray ionization mass spectrometry","volume":"910","author":"Farenc","year":"2001","journal-title":"J\u00a0Chromatogr A"},{"key":"10.1016\/j.vaa.2024.12.006_bib11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1399-6576.2007.01352.x","article-title":"Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision","volume":"51","author":"Fuchs-Buder","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.vaa.2024.12.006_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2460\/ajvr.1987.48.02.192","article-title":"Arterial hypotension and the development of postanesthetic myopathy in halothane-anesthetized horses","volume":"48","author":"Grandy","year":"1987","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2024.12.006_bib13","first-page":"R85","article-title":"Allometry of pharmacokinetics and pharmacodynamics of the muscle relaxant metocurine in mammals","volume":"268","author":"Gronert","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.vaa.2024.12.006_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2460\/javma.1989.195.02.212","article-title":"Clinical use of the neuromuscular blocking agents atracurium and pancuronium for equine anesthesia","volume":"15","author":"Hildebrand","year":"1989","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2024.12.006_bib15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.vaa.2024.12.006_bib16","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/00000542-199406000-00011","article-title":"Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis","volume":"80","author":"Khalil","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1016\/j.vaa.2024.12.006_bib17","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00000542-199004000-00016","article-title":"The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat","volume":"72","author":"Khuenl-Brady","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1016\/j.vaa.2024.12.006_bib18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2165\/00003088-199631030-00002","article-title":"Clinical pharmacokinetics of rocuronium bromide","volume":"31","author":"Khuenl-Brady","year":"1996","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.vaa.2024.12.006_bib19","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1213\/00000539-199810000-00036","article-title":"Neuromuscular effects of rocuronium during sevoflurane, isoflurane, and intravenous anesthesia","volume":"87","author":"Lowry","year":"1998","journal-title":"Anaesth Analg"},{"key":"10.1016\/j.vaa.2024.12.006_bib20","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1213\/00000539-199312000-00019","article-title":"Pharmacokinetics and pharmacodynamics of rocuronium (Org 9426) in elderly surgical patients","volume":"77","author":"Matteo","year":"1993","journal-title":"Anesth Analg"},{"key":"10.1016\/j.vaa.2024.12.006_bib21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/bja\/aeq172","article-title":"Reversal of profound rocuronium block monitored in three muscle groups with sugammadex in ponies","volume":"105","author":"Mosing","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2024.12.006_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-3565(24)35364-9","article-title":"Structure-pharmacokinetics relationship of series of aminosteroidal neuromuscular blocking agents in the cat","volume":"292","author":"Proost","year":"2000","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.vaa.2024.12.006_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00003643-199908000-00002","article-title":"Pharmacokinetics of rocuronium bromide in obese female patients","volume":"16","author":"P\u00fchringer","year":"1999","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.vaa.2024.12.006_bib24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00003643-200501000-00002","article-title":"Pharmacokinetics and pharmacodynamics of rocuronium in patients with and without renal failure","volume":"22","author":"Robertson","year":"2005","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.vaa.2024.12.006_bib25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1292\/jvms.18-0479","article-title":"Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs","volume":"81","author":"Sakata","year":"2019","journal-title":"J\u00a0Vet Med Sci"},{"key":"10.1016\/j.vaa.2024.12.006_bib26","first-page":"419","article-title":"Neuromuscular blocking effects, pharmacokinetics and safety of Org 9426 (rocuronium bromide) in Japanese patients","volume":"55","author":"Suzuki","year":"2006","journal-title":"Masui"},{"key":"10.1016\/j.vaa.2024.12.006_bib27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0952-8180(94)90075-2","article-title":"Clinical pharmacology of rocuronium (Org 9426): study of the time course of action, dose requirement, reversibility, and pharmacokinetics","volume":"6","author":"van den Broek","year":"1994","journal-title":"J\u00a0Clin Anesth"},{"key":"10.1016\/j.vaa.2024.12.006_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1365-2125.1997.00653.x","article-title":"The pharmacokinetics and pharmacodynamics of rocuronium in patients with hepatic cirrhosis","volume":"44","author":"van Miert","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.vaa.2024.12.006_bib29","first-page":"45","article-title":"Structure-pharmacodynamic-pharmacokinetic relationships of steroidal neuromuscular blocking agents","volume":"11","author":"Wierda","year":"1995","journal-title":"Eur J Anaesthesiol Suppl"},{"key":"10.1016\/j.vaa.2024.12.006_bib30","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/BF03012303","article-title":"Comparison of neuromuscular effects, efficacy and safety of rocuronium and atracurium in ambulatory anaesthesia","volume":"45","author":"Whalley","year":"1998","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.vaa.2024.12.006_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1399-6576.2001.450112.x","article-title":"The\u00a0influence of halothane, isoflurane and sevoflurane on rocuronium infusion in children","volume":"45","author":"Woloszczuk-Gebicka","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.vaa.2024.12.006_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01117450","article-title":"Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations","volume":"6","author":"Yamaoka","year":"1978","journal-title":"J\u00a0Pharmacokinet Biopharm"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298724004185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298724004185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T09:45:08Z","timestamp":1740995108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298724004185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1467298724004185"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2024.12.006","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacodynamics and pharmacokinetics of rocuronium in sevoflurane-anesthetized Thoroughbred horses","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2024.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}