{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:49:21Z","timestamp":1790383761793,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5-6","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.vaccine.2003.08.027","type":"journal-article","created":{"date-parts":[[2003,10,16]],"date-time":"2003-10-16T11:12:33Z","timestamp":1066302753000},"page":"629-642","source":"Crossref","is-referenced-by-count":68,"title":["Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines"],"prefix":"10.1016","volume":"22","author":[{"given":"Carmen","family":"Arigita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Jiskoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janny","family":"Westdijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cor","family":"van Ingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim E.","family":"Hennink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan J.A.","family":"Crommelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon F.A.","family":"Kersten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2003.08.027_BIB1","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0140-6736(02)08416-7","article-title":"Development of vaccines against meningococcal disease","volume":"359","author":"Jodar","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB2","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.4049\/jimmunol.138.12.4402","article-title":"An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues","volume":"138","author":"Finne","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/0140-6736(91)91961-S","article-title":"Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway","volume":"338","author":"Bjune","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB4","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/0140-6736(92)93086-3","article-title":"Protective efficacy of serogroup B meningococcal vaccine in Sao Paulo, Brazil","volume":"340","author":"De Moraes","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB5","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0264-410X(99)00423-5","article-title":"Immunogenicity and safety of a hexavalent meningococcal outer-membrane-vesicle vaccine in children of 2\u20133 and 7\u20138 years of age","volume":"18","author":"de Kleijn","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB6","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0264-410X(00)00320-0","article-title":"Immunogenicity and safety of monovalent P1.7b,4 meningococcal outer membrane vesicle vaccine in toddlers: comparison of two vaccination schedules and two vaccine formulations","volume":"19","author":"De Kleijn","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB7","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0264-410X(02)00546-7","article-title":"Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes","volume":"21","author":"Arigita","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB8","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0264-410X(02)00591-1","article-title":"Serum bactericidal activity correlated with the vaccine efficacy of outer membrane vesicle vaccines against Neisseria meningitidis serogroup B disease","volume":"21","author":"Holst","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB9","unstructured":"Netherlands Reference Laboratory for Bacterial Meningitis (AMC\/RIVM). Bacterial meningitis in the Netherlands. Annual report 1998. Amsterdam: University of Amsterdam, 1999."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-2697(77)90043-4","article-title":"A simplification of the protein assay of Lowry et al. which is more generally applicable","volume":"83","author":"Peterson","year":"1977","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB11","unstructured":"Sambrook S, Fritsch EF, Maniatis T. Ethidium bromide fluorescent quantitation of the amount of double-stranded DNA. In: Nolan E, editor. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Laboratory Press; 1989. p. E-5."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0264-410X(96)00020-5","article-title":"Production, characterization and control of a Neisseria meningitidis class 1 outer membrane protein containing vesicle vaccine","volume":"14","author":"Claasen","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB13","doi-asserted-by":"crossref","unstructured":"Lakowicz, JR. Principles of fluorescence spectroscopy. 2nd ed. New York: Kluwer Academic Publishers\/Plenum Press; 1999.","DOI":"10.1007\/978-1-4757-3061-6"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB14","doi-asserted-by":"crossref","first-page":"12299","DOI":"10.1021\/bi00097a005","article-title":"Characterization of a folding intermediate of apoplatocyanin trapped by proline isomerization","volume":"32","author":"Koide","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0005-2736(00)00155-3","article-title":"Biochemical and biophysical characterization of in vitro folded outer membrane porin PorA of Neisseria meningitidis","volume":"1464","author":"Jansen","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0014-5793(75)80272-9","article-title":"Electrophoretic resolution of the \u2018major outer membrane protein\u2019 of Escherichia coli K-12 into four bands","volume":"58","author":"Lugtenberg","year":"1975","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0264-410X(90)90184-N","article-title":"Outer membrane PhoE protein of Escherichia coli as a carrier for foreign antigenic determinants: immunogenicity of epitopes of foot-and-mouth disease virus","volume":"8","author":"Agterberg","year":"1990","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1574-6968.1987.tb02626.x","article-title":"Whole cell ELISA for typing Neisseria meningitidis with monoclonal antibodies","volume":"48","author":"Abdillahi","year":"1987","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB19","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1128\/IAI.63.9.3473-3478.1995","article-title":"Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis","volume":"63","author":"Hoogerhout","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0304-4157(94)00161-6","article-title":"Forces and factors that contribute to structural stability of membrane proteins","volume":"1241","author":"Hatia","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB21","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0264-410X(96)00032-1","article-title":"Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro","volume":"14","author":"Xing","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0304-4165(98)00097-X","article-title":"Physico-chemical and antigenic properties of tetanus and diphteria toxoids and steps towards improvement","volume":"1425","author":"Johansen","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB23","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/bit.260480511","article-title":"Chemical instability of proteins: mechanisms of oxidation and strategies for stabilization","volume":"48","author":"Li","year":"1995","journal-title":"Biotechn. Bioeng."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1023\/A:1015929109894","article-title":"Stability of protein pharmaceuticals","volume":"6","author":"Manning","year":"1989","journal-title":"Pharm. Res."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1021\/js980374e","article-title":"Solid-state stability of proteins and peptides","volume":"88","author":"Lai","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB26","unstructured":"van den Dobbelsteen G, Kuipers B, van Dijken H, van Alphen L. Comparison of immunogenicity of individual PorA in trivalent and monovalent OMVs. In: Proceedings of the Twelfth Pathogenic Neisseria Conference, Galveston, Texas, 2002. Abstract #140."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0264-410X(01)00371-1","article-title":"Serum bactericidal activity and isotope distribution of antibodies in toddlers and schoolchildren after vaccination with RIVM hexavalent PorA vesicle vaccine","volume":"20","author":"de Kleijn","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.027_BIB28","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1128\/IAI.59.9.2963-2971.1991","article-title":"Topology of outer membrane porins in Neisseria spp","volume":"59","author":"van der Ley","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.08.027_BIB29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1046\/j.1462-5822.2002.00214.x","article-title":"Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity","volume":"4","author":"Steeghs","year":"2002","journal-title":"Cell Microbiol."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X03006364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X03006364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T01:27:15Z","timestamp":1682558835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X03006364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":29,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0264410X03006364"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2003.08.027","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}