{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:31:12Z","timestamp":1792715472244,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.vaccine.2003.08.041","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T15:49:31Z","timestamp":1066232971000},"page":"1007-1015","source":"Crossref","is-referenced-by-count":24,"title":["Trypanosome microtubule-associated protein p15 as a vaccine for the prevention of African sleeping sickness"],"prefix":"10.1016","volume":"22","author":[{"given":"Reuven","family":"Rasooly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Balaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2003.08.041_BIB1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0020-7519(98)00067-8","article-title":"Vector-borne parasitic diseases\u2014an overview of recent changes","volume":"28","author":"Molyneux","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1473-3099(03)00488-2","article-title":"Lessons learned from the emergence of a new Trypanosoma brucei rhodesiense sleeping sickness focus in Uganda","volume":"3","author":"Hutchinson","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB3","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nm0902-908b","article-title":"Resurrecting the resurrection drug","volume":"8","author":"Wickware","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1472-8206.2003.00167.x","article-title":"Treatment perspectives for human African trypanosomiasis","volume":"17","author":"Bouteille","year":"2003","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S1473-3099(03)00501-2","article-title":"Tsetse eradication program under fire","volume":"3","author":"Ahmad","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1471-4922(02)02419-4","article-title":"Tsetse control: the next 100 years","volume":"18","author":"Sones","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB7","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1126\/science.7516579","article-title":"Antigenic variation in African trypanosomes","volume":"264","author":"Borst","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2003.08.041_BIB8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0020-7519(97)00154-9","article-title":"Immune responses of cattle to African trypanosomes: protective or pathogenic?","volume":"18","author":"Taylor","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0264-410X(95)93128-V","article-title":"Partial protection against natural trypanosomiasis after vaccination with a flagellar pocket antigen from Trypanosoma brucei rhodesiense","volume":"13","author":"Mkunza","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.041_BIB10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/infdis\/172.3.845","article-title":"Intracellular antigens (microtubule-associated protein copurified with glycosomal enzymes)\u2014possible vaccines against trypanosomiasis","volume":"172","author":"Balaban","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(98)00014-0","article-title":"Molecular architecture of the trypanosome cytoskeleton","volume":"93","author":"Kohl","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/cm.970140309","article-title":"Isolation of a subpellicular microtubule protein from Trypanosoma brucei that mediates crosslinking of microtubules","volume":"14","author":"Balaban","year":"1989","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.vaccine.2003.08.041_BIB13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/jsbi.1994.1024","article-title":"The repetitive microtubule-associated proteins MARP-1 and MARP-2 of Trypanosoma brucei","volume":"112","author":"Affolter","year":"1994","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB14","first-page":"378","article-title":"The Trypanosoma brucei autoantigen I\/6 is an internally repetitive cytoskeletal protein","volume":"72","author":"Detmer","year":"1997","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/cm.970210207","article-title":"Isolation and characterization of a unique 15 kilodalton trypanosome subpellicular microtubule-associated protein","volume":"21","author":"Balaban","year":"1992","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.vaccine.2003.08.041_BIB16","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s00436-002-0704-6","article-title":"Structure of p15 trypanosome microtubule associated protein","volume":"88","author":"Rasooly","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-4894(02)00140-6","article-title":"Immunization with a tubulin-rich preparation from Trypanosoma brucei confers broad protection against African trypanosomosis","volume":"102","author":"Lubega","year":"2002","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0014-4894(70)90120-7","article-title":"Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose","volume":"28","author":"Lanham","year":"1970","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB19","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1016\/S0264-410X(03)00108-7","article-title":"Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection","volume":"21","author":"Luhrs","year":"2003","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2003.08.041_BIB20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0014-4894(03)00035-3","article-title":"Trypanosoma brucei: tubulin antibodies specifically inhibit trypanosome growth in culture","volume":"102","author":"Lubega","year":"2002","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB21","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0264-410X(99)00380-1","article-title":"Paraflagellar rod proteins administered with alum and IL-12 or recombinant adenovirus expressing IL-12 generates antigen-specific responses and protective immunity in mice against Trypanosoma cruzi","volume":"18","author":"Wrightsman","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.08.041_BIB22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-3024.1998.00125.x","article-title":"Induction of CD4+CD8+ double positive T cells and increase in CD5+ B cells in efferent lymph in sheep infected with Trypanosoma evansi","volume":"20","author":"Onah","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-2478(98)00063-7","article-title":"Activation of CD4+ and CD8+ parasite-specific T cells by macrophages infected with live T. cruzi amastigotes","volume":"63","author":"Caulada-Benedetti","year":"1998","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0092-8674(93)90400-K","article-title":"CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule","volume":"72","author":"Olsson","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2003.08.041_BIB25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-2478(96)02521-7","article-title":"Different trypanozoan species possess CD8 dependent lymphocyte triggering factor-like activity","volume":"50","author":"Bakhiet","year":"1996","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB26","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1128\/IAI.64.10.4115-4122.1996","article-title":"Nitric oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression","volume":"64","author":"Taylor","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB27","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1128\/IAI.68.8.4653-4657.2000","article-title":"l-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis","volume":"68","author":"Gobert","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.08.041_BIB28","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1073\/pnas.91.19.8802","article-title":"An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3","volume":"19","author":"Bett","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X03006649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X03006649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T03:33:26Z","timestamp":1585193606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X03006649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0264410X03006649"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2003.08.041","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}