{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:45:36Z","timestamp":1776689136035,"version":"3.51.2"},"reference-count":31,"publisher":"Elsevier BV","issue":"11-12","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.vaccine.2003.10.022","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T13:24:17Z","timestamp":1070371457000},"page":"1486-1493","source":"Crossref","is-referenced-by-count":23,"title":["Mouse neurotoxicity test for vaccinia-based smallpox vaccines"],"prefix":"10.1016","volume":"22","author":[{"given":"Zhongqi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf E","family":"Taffs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Merchlinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.vaccine.2003.10.022_BIB1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/MMBR.55.1.80-122.1991","article-title":"Poxvirus pathogenesis","volume":"55","author":"Buller","year":"1991","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB2","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.2047875","article-title":"Vaccinia virus: a tool for research and vaccine development","volume":"252","author":"Moss","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2003.10.022_BIB3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0065-3527(08)60515-1","article-title":"Vaccinia: virus, vector, vaccine","volume":"34","author":"Piccini","year":"1988","journal-title":"Adv. Virus Res."},{"issue":"3","key":"10.1016\/j.vaccine.2003.10.022_BIB4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1542\/peds.55.3.342","article-title":"Smallpox vaccination reactions, prophylaxis, and therapy of complications","volume":"55","author":"Goldstein","year":"1975","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2003.10.022_BIB5","first-page":"154","article-title":"Vaccinia virus in postvaccinial encephalitis","volume":"27","author":"Gurvich","year":"1983","journal-title":"Acta Virol."},{"issue":"1","key":"10.1016\/j.vaccine.2003.10.022_BIB6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ana.410050116","article-title":"Postvaccinial encephalomyelitis without cutaneous vaccination reaction","volume":"5","author":"Rockoff","year":"1979","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB7","unstructured":"Henderson DA, Moss B, Smallpox and vaccinia. In: Plotkin SA, Orenstein WA, editors. Vaccines. Philadelphia: W.B. Saunders Company; 1999. p. 74\u201397."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB8","first-page":"66","volume":"6","author":"Romanov","year":"1975","journal-title":"Zh. Mikrobiol. Epidemiol. Immunobiol."},{"issue":"5","key":"10.1016\/j.vaccine.2003.10.022_BIB9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0882-4010(88)90060-5","article-title":"Poxvirus deletion mutants: virulence and immunogenicity","volume":"4","author":"Edwards","year":"1988","journal-title":"Microb. Pathogen."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB10","unstructured":"World Health Organization. Requirements for biological substances: requirements for smallpox vaccine. WHO Tech. Rep. 1966;Ser. 323:56\u201371."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3201\/eid0706.010602","article-title":"Developing new smallpox vaccines","volume":"7","author":"Rosenthal","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB12","unstructured":"World Health Organization. Advisory Committee on Variola Virus Research: Report of a WHO meeting. WHO\/CDS\/CSR\/2000; 2000. p. 1:1\u201318."},{"issue":"Pt 10","key":"10.1016\/j.vaccine.2003.10.022_BIB13","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1099\/0022-1317-80-10-2751","article-title":"A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnae","volume":"80","author":"Tscharke","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/biol.1994.1025","article-title":"Evaluation of various virulence test with low virulence vaccinia virus in mice","volume":"22","author":"Ludvikova","year":"1994","journal-title":"Biologicals"},{"key":"10.1016\/j.vaccine.2003.10.022_BIB15","first-page":"398","article-title":"Results of a study of the pathogenesis of postvaccinal encephalitis","volume":"4","author":"Dzagurov","year":"1981","journal-title":"Vopr. Virusol."},{"issue":"6","key":"10.1016\/j.vaccine.2003.10.022_BIB16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1046\/j.1365-2605.1998.00141.x","article-title":"Immunohistochemical detection of testicular macrophages during the period of postnatal maturation in the mouse","volume":"21","author":"Li","year":"1998","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB17","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1128\/IAI.13.4.1221-1227.1976","article-title":"Vaccinia virus meningitis in mice after intracerebral inoculation","volume":"13","author":"Ginsberg","year":"1976","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.vaccine.2003.10.022_BIB18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF00687701","article-title":"Changes in vascular permeability of the central nervous system by experimental herpes simplex and vaccinia virus infections","volume":"14","author":"Kristensson","year":"1969","journal-title":"Acta Neuropathol. (Berl.)"},{"issue":"7","key":"10.1016\/j.vaccine.2003.10.022_BIB19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1348-0421.1977.tb00306.x","article-title":"A comparison of neurovirulence of vaccinia virus by intrathalamic and\/or intracisternal inoculations into cynomolgus monkeys","volume":"21","author":"Morita","year":"1977","journal-title":"Microbiol. Immunol."},{"issue":"3","key":"10.1016\/j.vaccine.2003.10.022_BIB20","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1128\/IAI.25.3.1035-1042.1979","article-title":"Vaccinia virus infection of the central nervous system in X-irradiated mice","volume":"25","author":"Simon","year":"1979","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0165-3806(98)00180-1","article-title":"Viral teratogenesis: brain developmental damage associated with maturation state at the time of infection","volume":"112","author":"Rubin","year":"1999","journal-title":"Dev. Brain Res."},{"issue":"4","key":"10.1016\/j.vaccine.2003.10.022_BIB22","first-page":"434","article-title":"Neurovirulence of vaccinia viruses for mice","volume":"226","author":"Soekawa","year":"1974","journal-title":"Zentralbl. Bakteriol. [Orig A]"},{"issue":"3","key":"10.1016\/j.vaccine.2003.10.022_BIB23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00691954","article-title":"Experimental vaccinia virus meningoencephalitis in adult albino mice: virological, light microscopic and ultrastructural studies","volume":"40","author":"Blinzinger","year":"1977","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.vaccine.2003.10.022_BIB24","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3171\/jns.1981.54.6.0767","article-title":"Communicating hydrocephalus in newborn hamsters and cats following vaccinia virus infection","volume":"54","author":"Davis","year":"1981","journal-title":"J. Neurosurg."},{"issue":"3","key":"10.1016\/j.vaccine.2003.10.022_BIB25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1128\/IAI.20.3.752-759.1978","article-title":"Meningeal exudate cells in vaccinia meningitis of mice: role of local T cells","volume":"20","author":"Morishima","year":"1978","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF01322704","article-title":"Studies on poxvirus infections in irradiated animals","volume":"64","author":"Werner","year":"1980","journal-title":"Arch. Virol."},{"issue":"6","key":"10.1016\/j.vaccine.2003.10.022_BIB27","first-page":"652","article-title":"St. Louis encephalitis virus infection in mice. Electron microscopic studies of central nervous system","volume":"19","author":"Murphy","year":"1968","journal-title":"Lab. Invest."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02298200","article-title":"Viral tropisms in mouse brain cell cultures","volume":"170","author":"Beranek","year":"1982","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1099\/0022-1317-6-1-41","article-title":"Observation on cultures of rabbit infected with vaccinia and herpes simplex virus","volume":"6","author":"Kristensson","year":"1970","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vaccine.2003.10.022_BIB30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-642-81553-9_44","article-title":"Vaccinia infection of the nervous system in animals with normal and altered immune reaction","volume":"7","author":"Simon","year":"1981","journal-title":"Acta Neuropathol. Suppl. (Berl.)"},{"key":"10.1016\/j.vaccine.2003.10.022_BIB31","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1128\/JVI.66.5.2617-2630.1992","article-title":"Molecular attenuation of vaccinia virus: mutant generation and animal characterization","volume":"66","author":"Lee","year":"1992","journal-title":"J. Virol."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X03007667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X03007667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:12:38Z","timestamp":1682608358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X03007667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":31,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0264410X03007667"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2003.10.022","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}