{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T03:00:12Z","timestamp":1771383612883,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"21-22","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.vaccine.2003.12.024","type":"journal-article","created":{"date-parts":[[2004,2,3]],"date-time":"2004-02-03T05:09:03Z","timestamp":1075784943000},"page":"2887-2893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection"],"prefix":"10.1016","volume":"22","author":[{"given":"Shigefumi","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetada","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Fujitaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Uehira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2003.12.024_BIB1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/BF03027968","article-title":"Severe group A streptococcal infection and streptococcal toxic shock syndrome","volume":"47","author":"Baxter","year":"2000","journal-title":"Can. J. Anesth."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB2","doi-asserted-by":"crossref","unstructured":"Kaul R, McGeer A, Low DE, Green K, Schwartz B, Ontario Group A Streptococcal Study, et al. Population-based surveillance for group A streptococcal necrotizing fasciitis: clinical features, prognostic indications, and microbiologic analysis of seventy-seven cases. Ontario Group A Streptococcal Study. Am J Med 1997 103:18-24.","DOI":"10.1016\/S0002-9343(97)00160-5"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1086\/514543","article-title":"A clinical and bacteriologic investigation of invasive streptococcal infections in Japan on the basis of serotypes, toxin production and genomic DNA fingerprints","volume":"25","author":"Nakashima","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB4","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1128\/JVI.77.7.4104-4112.2003","article-title":"Influenza A virus-infected hosts boost invasive type of Streptococcus pyogenes infection in mice","volume":"77","author":"Okamoto","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB5","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/clind\/16.6.792","article-title":"Severe invasive group A streptococcal infections in Ontario, Canada: 1987\u20131991","volume":"16","author":"Demers","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB6","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1001\/archinte.158.16.1769","article-title":"Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens","volume":"158","author":"Nichol","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB7","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0264-410X(03)00070-7","article-title":"The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccines","volume":"21","author":"Nichol","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/mr.44.2.303-330.1980","article-title":"Pathogenicity of influenza virus","volume":"44","author":"Sweet","year":"1998","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1128\/jcm.28.6.1308-1313.1990","article-title":"Rapid focus reduction neutralization test of influenza A and B viruses in microtiter system","volume":"28","author":"Okuno","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB10","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1128\/IAI.69.11.6633-6642.2001","article-title":"Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells","volume":"69","author":"Okamoto","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/mpat.1999.0283","article-title":"Capsular hyaluronic acid of group A streptococci hampers their invasion into human pharyngeal epithelial cells","volume":"27","author":"Kawabata","year":"1999","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1086\/322021","article-title":"Microbiological and inflammatory factors associated with the development of pneumococcal pneumonia","volume":"184","author":"Dallaire","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB13","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/S0264-410X(02)00187-1","article-title":"Intranasal immunization with synthetic recombinant vaccine containing multiple epitopes of influenza virus","volume":"20","author":"Jeon","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB14","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1128\/IAI.69.2.924-930.2001","article-title":"Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice","volume":"69","author":"Kawabata","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB15","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1128\/iai.58.9.2809-2814.1990","article-title":"Pulmonary antibacterial defenses during mild and severe influenza virus infection","volume":"58","author":"Nickerson","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0171-2985(11)80292-5","article-title":"Programmed cell death (apoptosis) in human monocytes infected with influenza A virus","volume":"190","author":"Fesq","year":"1994","journal-title":"Immunobiology"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB17","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1182\/blood.V93.7.2395","article-title":"Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria","volume":"93","author":"Colamussi","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0264-410X(01)00268-7","article-title":"Nasal immunization with subunit proteosome influenza vaccines induces serum HAI, mucosal IgA and protection against influenza challenge","volume":"20","author":"Plante","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0264-410X(90)90053-O","article-title":"Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination","volume":"8","author":"Hirabayashi","year":"1990","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB20","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/S0264-410X(00)00556-9","article-title":"Nasal or intramuscular immunization of mice with influenza subunit antigen and the B subunit of Escherichia coli heat-labile toxin induces IgA- or IgG-mediated protective mucosal immunity","volume":"19","author":"Haan","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/(SICI)1096-9071(200005)61:1<100::AID-JMV16>3.0.CO;2-5","article-title":"Local and systemic immune response in community-dwelling elderly after intranasal or intramuscular immunization with inactivated influenza vaccine","volume":"61","author":"Muszkat","year":"2000","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB22","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1016\/S0264-410X(03)00234-2","article-title":"Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice","volume":"21","author":"Takada","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0264-410X(89)90192-8","article-title":"Protection against influenza virus infection by a two-dose regimen of nasal vaccination using vaccines combined with cholera toxin B subunit","volume":"7","author":"Tamura","year":"1989","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB24","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/S0264-410X(03)00078-1","article-title":"Roles of anti-hemagglutinin IgA and IgG antibodies in different sites of the respiratory tract of vaccinated mice in preventing lethal influenza pneumonia","volume":"21","author":"Ito","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB25","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.4049\/jimmunol.158.3.1222","article-title":"Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell depleted, \u03b23-microglobulin-deficient, and J chain-deficient mice","volume":"158","author":"Epstein","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB26","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1086\/318084","article-title":"Heterosubtypic immunity to influenza A virus infection requires B cells but not CD8+ cytotoxic T lymphocytes","volume":"183","author":"Nguyen","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB27","first-page":"56","article-title":"Bacterial pneumonia. Managing a deadly complication of influenza in older adults with comorbid diseases","volume":"57","author":"Sethi","year":"2002","journal-title":"Geriatrics"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/infdis\/137.2.176","article-title":"Bacterial adherence to virus-infected cells: a cell culture model of bacterial superinfection","volume":"137","author":"Sanford","year":"1978","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.7326\/0003-4819-130-5-199903020-00003","article-title":"Relation between influenza vaccination and outpatient visits, hospitalization, and mortality in elderly persons with chronic lung diseases","volume":"130","author":"Nichol","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/PL00012155","article-title":"Influenza vaccine, anti-influenza drugs, and rapid diagnosis in Japan","volume":"6","author":"Sugaya","year":"2000","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB31","first-page":"13","article-title":"Surveillance for influenza, United States, 1994\u20131995, 1995\u20131996, and 1996\u20131997 seasons","volume":"49","author":"Brammer","year":"2000","journal-title":"Morb. Mortal. Wkly. Rep. CDC Surveill. Summ."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/viro.2000.0495","article-title":"The 1918 influenza virus: a killer comes into view","volume":"274","author":"Taubenberger","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2003.12.024_BIB33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/archsurg.1924.01120080083007","article-title":"Hemolytic Streptococcus gangrene","volume":"9","author":"Meleney","year":"1924","journal-title":"Arch. Surg."},{"key":"10.1016\/j.vaccine.2003.12.024_BIB34","first-page":"18","article-title":"Group A Streptococcus invasive infections: a review","volume":"40","author":"Weiss","year":"1997","journal-title":"Can. J. Surg."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X04000246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X04000246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:14:27Z","timestamp":1759400067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X04000246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":34,"journal-issue":{"issue":"21-22","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0264410X04000246"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2003.12.024","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2003.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}