{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:03:13Z","timestamp":1791349393467,"version":"4.3.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"27-28","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.vaccine.2003.12.035","type":"journal-article","created":{"date-parts":[[2004,4,28]],"date-time":"2004-04-28T18:23:36Z","timestamp":1083176616000},"page":"3797-3808","source":"Crossref","is-referenced-by-count":73,"title":["Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H\/HeJ mice"],"prefix":"10.1016","volume":"22","author":[{"given":"Lena","family":"Strindelius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Filler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvar","family":"Sj\u00f6holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2003.12.035_BIB1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S1286-4579(01)01498-8","article-title":"Introduction: microbiology and immunology: lessons learned from Salmonella","volume":"3","author":"Kaufmann","year":"2001","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1074-7613(02)00293-5","article-title":"Immune response to Salmonella: location, location location?","volume":"16","author":"Hughes","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0923-2508(94)90031-0","article-title":"Preferential interaction of Salmonella typhimurium with mouse Peyer\u2019s patch M cells","volume":"145","author":"Clark","year":"1994","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.180.1.15","article-title":"Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer\u2019s patches","volume":"180","author":"Jones","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB5","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S1286-4579(01)01488-5","article-title":"The Salmonella pathogenicity island-1 type III secretion system","volume":"3","author":"Lostroh","year":"2001","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB6","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/IAI.70.3.1434-1442.2002","article-title":"Extracellular antigens from Salmonella enteritidis induce effective immune response in mice after oral vaccination","volume":"70","author":"Strindelius","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1615\/CritRevImmunol.v20.i5.30","article-title":"Critical roles of Toll-like receptors in host defense","volume":"20","author":"Kaisho","year":"2000","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1172\/JCI10501","article-title":"Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response","volume":"107","author":"Gewirtz","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1128\/IAI.66.3.1127-1134.1998","article-title":"Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line","volume":"66","author":"Ciacci-Woolwine","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB11","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1128\/IAI.67.7.3619-3624.1999","article-title":"Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes","volume":"67","author":"Wyant","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB12","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1128\/IAI.68.10.5525-5529.2000","article-title":"High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation","volume":"68","author":"McDermott","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB13","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.4049\/jimmunol.166.2.1248","article-title":"Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction","volume":"166","author":"Eaves-Pyles","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB14","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1128\/IAI.69.7.4424-4429.2001","article-title":"Activation of interleukin-1 receptor-associated kinase by Gram-negative flagellin","volume":"69","author":"Moors","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/IAI.70.1.192-198.2002","article-title":"Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide","volume":"70","author":"Liaudet","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB16","doi-asserted-by":"crossref","first-page":"13722","DOI":"10.1073\/pnas.241308598","article-title":"Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells","volume":"98","author":"Sierro","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB17","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.4049\/jimmunol.158.9.4310","article-title":"Identification of a natural T cell epitope presented by Salmonella-infected macrophages and recognized by T cells from orally immunized mice","volume":"158","author":"Cookson","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB18","doi-asserted-by":"crossref","first-page":"986","DOI":"10.4049\/jimmunol.164.2.986","article-title":"Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium","volume":"164","author":"McSorley","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.2468182","article-title":"Immune response to cholera toxin epitope inserted in Salmonella flagellin","volume":"244","author":"Newton","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/08830189409061724","article-title":"Immune responses to epitopes inserted in Salmonella flagellin","volume":"11","author":"Stocker","year":"1994","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0923-2508(97)85242-4","article-title":"Cloning and expression of colonization factor antigen I (CFA\/I) epitopes of enterotoxigenic Escherichia coli (ETEC) in Salmonella flagellin","volume":"148","author":"Luna","year":"1997","journal-title":"Res Microbiol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB22","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/287440a0","article-title":"Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci","volume":"287","author":"O\u2019Brien","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB24","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1128\/IAI.69.9.5716-5725.2001","article-title":"Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells","volume":"69","author":"George-Chandy","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB25","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/jps.2600731103","article-title":"Characterization of polyacryl starch microparticles as carriers for proteins and drugs","volume":"73","author":"Artursson","year":"1984","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB26","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jps.2600751011","article-title":"Biodegradable microspheres. IV. Factors affecting the distribution and degradation of polyacryl starch microparticles","volume":"75","author":"Laakso","year":"1986","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB27","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1128\/JCM.22.6.1040-1044.1985","article-title":"Method for the isolation of highly purified Salmonella flagellins","volume":"22","author":"Ibrahim","year":"1985","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB28","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/S0021-9258(17)30106-0","article-title":"A novel method of activation of cross-linked agaroses with 1,1\u2032-carbonyldiimidazole which gives a matrix for affinity chromatography devoid of additional charged groups","volume":"254","author":"Bethell","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1074-7613(02)00289-3","article-title":"Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection","volume":"16","author":"McSorley","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB31","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.4049\/jimmunol.169.7.3914","article-title":"Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo","volume":"169","author":"McSorley","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jlb.67.4.457","article-title":"Immune response to infection with Salmonella typhimurium in mice","volume":"67","author":"Mittrucker","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1365-3083.2001.00894.x","article-title":"Induction in mucosa of IgG and IgA antibodies against parenterally administered soluble immunogens","volume":"53","author":"Decroix","year":"2001","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-3083.2002.01113.x","article-title":"Mucosal immunity induced by intramuscular administration of free peptides in-line with PADRE: IgA antibodies to the ELDKWA epitope of HIV gp41","volume":"56","author":"Decroix","year":"2002","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB35","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4049\/jimmunol.133.4.1818","article-title":"Cholera toxin B subunit as a carrier protein to stimulate a mucosal immune response","volume":"133","author":"McKenzie","year":"1984","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB36","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/IAI.57.4.1072-1077.1989","article-title":"Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues","volume":"57","author":"Czerkinsky","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB37","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1365-2958.1991.tb00785.x","article-title":"Intranasal immunization using the B subunit of the Escherichia coli heat-labile toxin fused to an epitope of the Bordetella pertussis P.69 antigen","volume":"5","author":"Lipscombe","year":"1991","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB38","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S0264-410X(00)00226-7","article-title":"Preparation and preclinical evaluation of experimental group B streptococcus type III polysaccharide-cholera toxin B subunit conjugate vaccine for intranasal immunization","volume":"19","author":"Shen","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/IAI.69.1.297-306.2001","article-title":"Group B Streptococcus capsular polysaccharide-cholera toxin B subunit conjugate vaccines prepared by different methods for intranasal immunization","volume":"69","author":"Shen","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB40","doi-asserted-by":"crossref","unstructured":"Holmgren J, Czerkinsky J, Sun B, Svennerholm, A-M. Oral vaccination, mucosal immunity and oral tolerance with special reference to cholera toxin. In: Kaufmann SHE, editor. Concepts in vaccine development. Berlin, Germany: Walter de Gruyter; 1996. p. 437\u201358.","DOI":"10.1515\/9783110906660.437"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1073\/pnas.93.1.226","article-title":"Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets","volume":"93","author":"Nashar","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB42","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0022-2836(02)00139-0","article-title":"Interactions between bacterial flagellar axial proteins in their monomeric state in solution","volume":"318","author":"Furukawa","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB43","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1073\/pnas.96.17.9469","article-title":"Cross-linked protein crystals for vaccine delivery","volume":"96","author":"St. Clair","year":"1999","journal-title":"Proc Natl Acad Sci U. S. A."},{"key":"10.1016\/j.vaccine.2003.12.035_BIB44","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/icb.1996.75","article-title":"Immune deviation: a historical perspective","volume":"74","author":"Parish","year":"1996","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB45","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.167.4.1882","article-title":"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression","volume":"167","author":"Gewirtz","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB46","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","article-title":"Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria","volume":"2","author":"Rescigno","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB47","doi-asserted-by":"crossref","first-page":"22414","DOI":"10.1074\/jbc.M201762200","article-title":"Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5","volume":"277","author":"Mizel","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2003.12.035_BIB48","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4049\/jimmunol.133.2.950","article-title":"Monoclonal antibodies to Salmonella lipopolysaccharide: Anti-O-polysaccharide antibodies protect C3H mice against challenge with virulent Salmonella typhimurium","volume":"133","author":"Colwell","year":"1984","journal-title":"J Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X04002889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X04002889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T07:28:10Z","timestamp":1705130890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X04002889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":48,"journal-issue":{"issue":"27-28","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0264410X04002889"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2003.12.035","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}