{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:31:18Z","timestamp":1770503478428,"version":"3.49.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.vaccine.2004.08.014","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T21:03:33Z","timestamp":1095195813000},"page":"S31-S38","source":"Crossref","is-referenced-by-count":21,"special_numbering":"S1","title":["Rationale for the development of immunotherapy regimens against enterococcal infections"],"prefix":"10.1016","volume":"22","author":[{"given":"Christian","family":"Theilacker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang A.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kropec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.vaccine.2004.08.014_bib1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2174\/1381612033455189","article-title":"Immune therapy for infectious diseases at the dawn of the 21st century: the past, present and future role of antibody therapy, therapeutic vaccination and biological response modifiers","volume":"9","author":"Buchwald","year":"2003","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1574-695X.2002.tb00589.x","article-title":"Identification of ABC transporters in vancomycin-resistant Enterococcus faecium as potential targets for antibody therapy","volume":"33","author":"Burnie","year":"2002","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"8","key":"10.1016\/j.vaccine.2004.08.014_bib3","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1128\/IAI.68.8.4631-4636.2000","article-title":"Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and resistant enterococci","volume":"68","author":"Huebner","year":"2000","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib4","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/IAI.69.5.3305-3314.2001","article-title":"Antibodies to a surface-exposed, N-terminal domain of aggregation substance are not protective in the rabbit model of Enterococcus faecalis infective endocarditis","volume":"69","author":"McCormick","year":"2001","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.vaccine.2004.08.014_bib5","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJM200003093421007","article-title":"Vancomycin-resistant enterococcal infections","volume":"342","author":"Murray","year":"2000","journal-title":"N Engl J Med"},{"issue":"Suppl 4","key":"10.1016\/j.vaccine.2004.08.014_bib6","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1086\/314078","article-title":"Nosocomial bloodstream infections: organisms, risk factors, and implications","volume":"31","author":"Karchmer","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1086\/520192","article-title":"Nosocomial bloodstream infections in United States hospitals: a three-year analysis","volume":"29","author":"Edmond","year":"1999","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2004.08.014_bib8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/CMR.13.4.513-522.2000","article-title":"Relationships between enterococcal virulence and antimicrobial resistance","volume":"13","author":"Mundy","year":"2000","journal-title":"Clin Microbiol Rev"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/infdis\/171.5.1223","article-title":"Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons","volume":"171","author":"Coque","year":"1995","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib10","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1086\/341977","article-title":"Association between the presence of enterococcal virulence factors gelatinase, hemolysin, and enterococcal surface protein and mortality among patients with bacteremia due to Enterococcus faecalis","volume":"35","author":"Vergis","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0092-8674(93)90153-H","article-title":"Bacterial sex pheromone-induced plasmid transfer","volume":"73","author":"Clewell","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1128\/IAI.60.1.25-30.1992","article-title":"Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells","volume":"60","author":"Kreft","year":"1992","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/infdis\/170.6.1549","article-title":"A plasmid-encoded surface protein on Enterococcus faecalis augments its internalization by cultured intestinal epithelial cells","volume":"170","author":"Olmsted","year":"1994","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/01.CCM.0000109447.04893.48","article-title":"Assessment of the role of antibiotics and enterococcal virulence factors in a mouse model of extra-intestinal translocation","volume":"32","author":"Krueger","year":"2004","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.vaccine.2004.08.014_bib15","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1128\/IAI.68.9.4900-4906.2000","article-title":"Aggregation substance promotes adherence, phagocytosis, and intracellular survival of Enterococcus faecalis within human macrophages and suppresses respiratory burst","volume":"68","author":"Sussmuth","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2004.08.014_bib16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.bi.57.070188.002111","article-title":"Fibronectin and its receptors","volume":"57","author":"Ruoslahti","year":"1988","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/plas.1995.9992","article-title":"Frequency of aggregation substance and cytolysin genes among enterococcal endocarditis isolates","volume":"34","author":"Huycke","year":"1995","journal-title":"Plasmid"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s100960050007","article-title":"Virulence factors of Enterococcus faecalis and Enterococcus faecium blood culture isolates","volume":"19","author":"Elsner","year":"2000","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1365-2958.1990.tb00662.x","article-title":"Sequence analysis of Enterococcus faecalis aggregation substance encoded by the sex pheromone plasmid pAD1","volume":"4","author":"Galli","year":"1990","journal-title":"Mol Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib20","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1432-1033.1993.tb17600.x","article-title":"Biochemical, immunological and ultrastructural characterization of aggregation substances encoded by Enterococcus faecalis sex-pheromone plasmids","volume":"211","author":"Hirt","year":"1993","journal-title":"Eur J Biochem"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/jsre.1999.5813","article-title":"Aggregation substance promotes colonic mucosal invasion of Enterococcus faecalis in an ex vivo model","volume":"89","author":"Isenmann","year":"2000","journal-title":"J Surg Res"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib22","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1046\/j.1365-2958.1999.01631.x","article-title":"Cloning and functional analysis of Asa373, a novel adhesin unrelated to the other sex pheromone plasmid-encoded aggregation substances of Enterococcus faecalis","volume":"34","author":"Muscholl-Silberhorn","year":"1999","journal-title":"Mol Microbiol"},{"issue":"11","key":"10.1016\/j.vaccine.2004.08.014_bib23","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1128\/AAC.37.11.2474","article-title":"Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental Enterococcal endocarditis","volume":"37","author":"Chow","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/IAI.66.1.218-223.1998","article-title":"Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditis","volume":"66","author":"Schlievert","year":"1998","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF02768756","article-title":"Does aggregation substance of Enterococcus faecalis contribute to development of endocarditis?","volume":"26","author":"Berti","year":"1998","journal-title":"Infection"},{"issue":"7","key":"10.1016\/j.vaccine.2004.08.014_bib26","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1086\/339604","article-title":"Formation of vegetations during infective endocarditis excludes binding of bacterial-specific host antibodies to Enterococcus faecalis","volume":"185","author":"McCormick","year":"2002","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11908-996-0018-4","article-title":"Immunization for prevention of infective endocarditis","volume":"1","author":"Baddour","year":"1999","journal-title":"Curr Infect Dis Rep"},{"issue":"10","key":"10.1016\/j.vaccine.2004.08.014_bib28","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1128\/IAI.65.10.4146-4151.1997","article-title":"Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats","volume":"65","author":"Lee","year":"1997","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib29","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1161\/01.CIR.84.6.2539","article-title":"Protection against endocarditis due to Staphylococcus epidermidis by immunization with capsular polysaccharide\/adhesin","volume":"84","author":"Takeda","year":"1991","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.vaccine.2004.08.014_bib30","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1128\/IAI.68.9.5218-5224.2000","article-title":"Enterococcus faecalis adhesin, ace, mediates attachment to extracellular matrix proteins collagen type IV and laminin as well as collagen type I","volume":"68","author":"Nallapareddy","year":"2000","journal-title":"Infect Immun"},{"issue":"38","key":"10.1016\/j.vaccine.2004.08.014_bib31","doi-asserted-by":"crossref","first-page":"26939","DOI":"10.1074\/jbc.274.38.26939","article-title":"Ace is a collagen-binding MSCRAMM from Enterococcus faecalis","volume":"274","author":"Rich","year":"1999","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.vaccine.2004.08.014_bib32","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/IAI.69.7.4366-4372.2001","article-title":"Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection","volume":"69","author":"Shankar","year":"2001","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib33","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1128\/IAI.45.2.528-530.1984","article-title":"Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice","volume":"45","author":"Ike","year":"1984","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib34","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1086\/314453","article-title":"Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model","volume":"178","author":"Singh","year":"1998","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/IAI.59.1.415-420.1991","article-title":"Nucleotide sequence of the gelatinase gene (gelE) from Enterococcus faecalis subsp. liquefaciens","volume":"59","author":"Su","year":"1991","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib36","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1128\/IAI.68.5.2579-2586.2000","article-title":"Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence","volume":"68","author":"Qin","year":"2000","journal-title":"Infect Immun"},{"issue":"14","key":"10.1016\/j.vaccine.2004.08.014_bib37","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJMra011223","article-title":"Vaccines and vaccination","volume":"345","author":"Ada","year":"2001","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.vaccine.2004.08.014_bib38","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1128\/IAI.65.10.4207-4215.1997","article-title":"Enterococcus faecalis antigens in human infections","volume":"65","author":"Xu","year":"1997","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2004.08.014_bib39","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1128\/IAI.70.4.2010-2015.2002","article-title":"Evidence that the enterococcal polysaccharide antigen gene (epa) cluster is widespread in Enterococcus faecalis and influences resistance to phagocytic killing of E. faecalis","volume":"70","author":"Teng","year":"2002","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1128\/IAI.68.2.815-823.2000","article-title":"Analysis of a gene cluster of Enterococcus faecalis involved in polysaccharide biosynthesis","volume":"68","author":"Xu","year":"2000","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.vaccine.2004.08.014_bib41","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1128\/IAI.66.9.4313-4323.1998","article-title":"A cluster of genes involved in polysaccharide biosynthesis from Enterococcus faecalis OG1RF","volume":"66","author":"Xu","year":"1998","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2004.08.014_bib42","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1128\/IAI.62.12.5587-5594.1994","article-title":"Resistance of Enterococcus faecium to neutrophil-mediated phagocytosis","volume":"62","author":"Arduino","year":"1994","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2004.08.014_bib43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1574-695X.2000.tb01489.x","article-title":"Specific antibody promotes opsonization and PMN-mediated killing of phagocytosis-resistant Enterococcus faecium","volume":"28","author":"Rakita","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib44","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1073\/pnas.032448299","article-title":"The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall","volume":"99","author":"Hancock","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib45","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1128\/JCM.42.6.2548-2557.2004","article-title":"Serological and genetic diversity of capsular polysaccharide in Enterococcus faecalis","volume":"42","author":"Hufnagel","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib46","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1128\/IAI.67.3.1213-1219.1999","article-title":"Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium","volume":"67","author":"Huebner","year":"1999","journal-title":"Infect Immun"},{"issue":"1\u20134","key":"10.1016\/j.vaccine.2004.08.014_bib47","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0008-6215(99)00046-4","article-title":"Structure of an antigenic teichoic acid shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium","volume":"316","author":"Wang","year":"1999","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.vaccine.2004.08.014_bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1099\/00221287-36-1-151","article-title":"Serological types of Streptococcus faecalis and its varieties and their cell wall type antigen","volume":"36","author":"Sharpe","year":"1964","journal-title":"J Gen Microbiol"},{"issue":"7","key":"10.1016\/j.vaccine.2004.08.014_bib49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1348-0421.1992.tb02070.x","article-title":"Proposal of a new scheme for the serological typing of Enterococcus faecalis strains","volume":"36","author":"Maekawa","year":"1992","journal-title":"Microbiol Immunol"},{"issue":"18","key":"10.1016\/j.vaccine.2004.08.014_bib50","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1056\/NEJMra010082","article-title":"Infective endocarditis in adults","volume":"345","author":"Mylonakis","year":"2001","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib51","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s11908-003-0016-8","article-title":"Can enterococcal infections initiate sepsis syndrome?","volume":"5","author":"Linden","year":"2003","journal-title":"Curr Infect Dis Rep"},{"issue":"19","key":"10.1016\/j.vaccine.2004.08.014_bib52","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1001\/archinte.162.19.2223","article-title":"Health and economic outcomes of vancomycin-resistant enterococci","volume":"162","author":"Carmeli","year":"2002","journal-title":"Arch Intern Med"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib53","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0002-9610(99)00083-5","article-title":"Vancomycin-resistant Enterococcus in liver transplant patients","volume":"177","author":"Orloff","year":"1999","journal-title":"Am J Surg"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib54","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1086\/501624","article-title":"Enterococcal bacteremia: risk factors for vancomycin resistance and predictors of mortality","volume":"20","author":"Lautenbach","year":"1999","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"4","key":"10.1016\/j.vaccine.2004.08.014_bib55","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/infdis\/172.4.993","article-title":"Epidemiology and mortality risk of vancomycin-resistant enterococcal bloodstream infections","volume":"172","author":"Shay","year":"1995","journal-title":"J Infect Dis"},{"issue":"13","key":"10.1016\/j.vaccine.2004.08.014_bib56","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/archinte.156.13.1458","article-title":"Bloodstream infections with vancomycin-resistant enterococci","volume":"156","author":"Montecalvo","year":"1996","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.11.1.1","article-title":"Use of licensed vaccines for active immunization of the immunocompromised host","volume":"11","author":"Pirofski","year":"1998","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"10.1016\/j.vaccine.2004.08.014_bib58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1086\/315245","article-title":"Pneumococcal vaccine response in cirrhosis and liver transplantation","volume":"181","author":"McCashland","year":"2000","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib59","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/00007890-199403150-00009","article-title":"Polysaccharide conjugate vaccine responses in bone marrow transplant patients","volume":"57","author":"Guinan","year":"1994","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib60","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1086\/375782","article-title":"Effectiveness of the 23-valent polysaccharide vaccine against invasive pneumococcal disease in Navajo adults","volume":"188","author":"Benin","year":"2003","journal-title":"J Infect Dis"},{"issue":"Suppl","key":"10.1016\/j.vaccine.2004.08.014_bib61","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1093\/clinids\/3.Supplement_1.S168","article-title":"Serum antibody responses of high-risk children and adults to vaccination with capsular polysaccharides of Streptococcus pneumoniae","volume":"3","author":"Giebink","year":"1981","journal-title":"Rev Infect Dis"},{"issue":"10","key":"10.1016\/j.vaccine.2004.08.014_bib62","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1086\/374784","article-title":"Randomized, double-blind, controlled trial of pneumococcal vaccination in renal transplant recipients","volume":"187","author":"Kumar","year":"2003","journal-title":"J Infect Dis"},{"issue":"8","key":"10.1016\/j.vaccine.2004.08.014_bib63","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/sj.bmt.1701424","article-title":"Comparison of multiple immunization schedules for Haemophilus influenzae type b-conjugate and tetanus toxoid vaccines following bone marrow transplantation","volume":"22","author":"Vance","year":"1998","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib64","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1182\/blood-2002-03-0832","article-title":"Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation","volume":"101","author":"Molrine","year":"2003","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.vaccine.2004.08.014_bib65","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1182\/blood.V87.7.3012.bloodjournal8773012","article-title":"Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation","volume":"87","author":"Molrine","year":"1996","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000045246","article-title":"Immune response to Haemophilus influenzae type B vaccination in renal transplant recipients with well-functioning allografts","volume":"81","author":"Sever","year":"1999","journal-title":"Nephron"},{"issue":"7","key":"10.1016\/j.vaccine.2004.08.014_bib67","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJMoa011297","article-title":"Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis","volume":"346","author":"Shinefield","year":"2002","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.vaccine.2004.08.014_bib68","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJMoa035060","article-title":"A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection","volume":"349","author":"Klugman","year":"2003","journal-title":"N Engl J Med"},{"issue":"9221","key":"10.1016\/j.vaccine.2004.08.014_bib69","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(00)02377-1","article-title":"23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial","volume":"355","author":"French","year":"2000","journal-title":"Lancet"},{"issue":"3-4","key":"10.1016\/j.vaccine.2004.08.014_bib70","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0264-410X(01)00347-4","article-title":"Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and\/or 23-valent polysaccharide vaccine among HIV-infected adults","volume":"20","author":"Feikin","year":"2001","journal-title":"Vaccine"},{"issue":"26","key":"10.1016\/j.vaccine.2004.08.014_bib71","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1056\/NEJM199112263252603","article-title":"Antibody responses to Haemophilus influenzae type B vaccines in men with human immunodeficiency virus infection","volume":"325","author":"Steinhoff","year":"1991","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib72","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0264-410X(95)00195-7","article-title":"Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological reagents","volume":"14","author":"Lees","year":"1996","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2004.08.014_bib73","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1128\/IAI.71.9.5115-5120.2003","article-title":"Preparation and characterization of group A meningococcal capsular polysaccharide conjugates and evaluation of their immunogenicity in mice","volume":"71","author":"Jin","year":"2003","journal-title":"Infect Immun"},{"issue":"13","key":"10.1016\/j.vaccine.2004.08.014_bib74","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0264-410X(99)00370-9","article-title":"Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for use in protein\u2013polysaccharide conjugate vaccines and immunological reagents, II. Selective crosslinking of proteins to CDAP-activated polysaccharides","volume":"18","author":"Shafer","year":"2000","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2004.08.014_bib75","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/IAI.68.3.1529-1534.2000","article-title":"Phase 1 and phase 2 studies of Salmonella enterica serovar paratyphi A O-specific polysaccharide-tetanus toxoid conjugates in adults, teenagers, and 2- to 4-year-old children in Vietnam","volume":"68","author":"Konadu","year":"2000","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib76","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1128\/IAI.67.5.2491-2496.1999","article-title":"Alpha C protein as a carrier for type III capsular polysaccharide and as a protective protein in group B streptococcal vaccines","volume":"67","author":"Gravekamp","year":"1999","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib77","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1128\/AAC.38.6.1363","article-title":"Outbreak of vancomycin-, ampicillin-, and aminoglycoside-resistant Enterococcus faecium bacteremia in an adult oncology unit","volume":"38","author":"Montecalvo","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib78","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/clinids\/20.5.1126","article-title":"Vancomycin-resistant Enterococcus faecium bacteremia: risk factors for infection","volume":"20","author":"Edmond","year":"1995","journal-title":"Clin Infect Dis"},{"issue":"12","key":"10.1016\/j.vaccine.2004.08.014_bib79","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1128\/AAC.32.12.1769","article-title":"Effects of clindamycin and metronidazole on the intestinal colonization and translocation of enterococci in mice","volume":"32","author":"Wells","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.vaccine.2004.08.014_bib80","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/infdis\/162.1.82","article-title":"Evidence for the translocation of Enterococcus faecalis across the mouse intestinal tract","volume":"162","author":"Wells","year":"1990","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2004.08.014_bib81","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/infdis\/164.5.982","article-title":"Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine","volume":"164","author":"Takala","year":"1991","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib82","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/infdis\/174.6.1271","article-title":"Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine","volume":"174","author":"Dagan","year":"1996","journal-title":"J Infect Dis"},{"issue":"9320","key":"10.1016\/j.vaccine.2004.08.014_bib83","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(02)08679-8","article-title":"Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination","volume":"359","author":"Maiden","year":"2002","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM200102083440602","article-title":"Efficacy of a pneumococcal conjugate vaccine against acute otitis media","volume":"344","author":"Eskola","year":"2001","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.vaccine.2004.08.014_bib85","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/infdis\/171.6.1387","article-title":"Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum","volume":"171","author":"Robbins","year":"1995","journal-title":"J Infect Dis"},{"issue":"8","key":"10.1016\/j.vaccine.2004.08.014_bib86","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/IAI.63.8.2818-2825.1995","article-title":"Clearance of Pseudomonas aeruginosa from the murine gastrointestinal tract is effectively mediated by O-antigen-specific circulating antibodies","volume":"63","author":"Pier","year":"1995","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X04006164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X04006164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T04:29:40Z","timestamp":1585888180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X04006164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":86,"alternative-id":["S0264410X04006164"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2004.08.014","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}