{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:14:41Z","timestamp":1787606081386,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.vaccine.2005.01.098","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T14:15:45Z","timestamp":1108131345000},"page":"3446-3452","source":"Crossref","is-referenced-by-count":31,"title":["rOv-ASP-1, a recombinant secreted protein of the helminth Onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens"],"prefix":"10.1016","volume":"23","author":[{"given":"Angus J.","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lustigman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.vaccine.2005.01.098_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri1183","article-title":"Immune regulation by helminth parasites: cellular and molecular mechanisms","volume":"3","author":"Maizels","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"10.1016\/j.vaccine.2005.01.098_bib2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0020-7519(01)00213-2","article-title":"Immune evasion genes from filarial nematodes","volume":"31","author":"Maizels","year":"2001","journal-title":"Int J Parasitol"},{"issue":"4","key":"10.1016\/j.vaccine.2005.01.098_bib3","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.171.4.2127","article-title":"A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62","volume":"171","author":"McInnes","year":"2003","journal-title":"J Immunol"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2005.01.098_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.imlet.2004.04.008","article-title":"ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential","volume":"94","author":"Harnett","year":"2004","journal-title":"Immunol Lett"},{"issue":"11","key":"10.1016\/j.vaccine.2005.01.098_bib5","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1128\/IAI.70.11.6058-6067.2002","article-title":"Modulation of a heterologous immune response by the products of Ascaris suum","volume":"70","author":"Paterson","year":"2002","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.vaccine.2005.01.098_bib6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/1521-4141(200007)30:7<1977::AID-IMMU1977>3.0.CO;2-3","article-title":"Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses","volume":"30","author":"Holland","year":"2000","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2005.01.098_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4049\/jimmunol.167.1.442","article-title":"Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response","volume":"167","author":"Okano","year":"2001","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2005.01.098_bib8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1086\/381901","article-title":"Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum","volume":"189","author":"Goud","year":"2004","journal-title":"J Infect Dis"},{"issue":"11","key":"10.1016\/j.vaccine.2005.01.098_bib9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0020-7519(03)00158-9","article-title":"Progress in the development of a recombinant vaccine for human hookworm disease: the human hookworm vaccine initiative","volume":"33","author":"Hotez","year":"2003","journal-title":"Int J Parasitol"},{"issue":"3","key":"10.1016\/j.vaccine.2005.01.098_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0034-5288(02)00125-X","article-title":"A family of activation associated secreted protein (ASP) homologues of Cooperia punctata","volume":"73","author":"Yatsuda","year":"2002","journal-title":"Res Vet Sci"},{"issue":"1","key":"10.1016\/j.vaccine.2005.01.098_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.0141-9838.2004.00685.x","article-title":"Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti-larval immunity","volume":"26","author":"MacDonald","year":"2004","journal-title":"Parasite Immunol"},{"issue":"9413","key":"10.1016\/j.vaccine.2005.01.098_bib12","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(04)15788-7","article-title":"Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors","volume":"363","author":"Liu","year":"2004","journal-title":"Lancet"},{"issue":"24","key":"10.1016\/j.vaccine.2005.01.098_bib13","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1128\/JVI.74.24.11427-11436.2000","article-title":"Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex","volume":"74","author":"Fouts","year":"2000","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2005.01.098_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/aid.1993.9.431","article-title":"Envelope glycoproteins of HIV-1, HIV-2, and SIV purified with Galanthus nivalis agglutinin induce strong immune responses","volume":"9","author":"Gilljam","year":"1993","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"2","key":"10.1016\/j.vaccine.2005.01.098_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0166-6851(00)00231-0","article-title":"Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5","volume":"109","author":"Tawe","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.vaccine.2005.01.098_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.iy.13.040195.001055","article-title":"The regulation of immunity to Leishmania major","volume":"13","author":"Reiner","year":"1995","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"10.1016\/j.vaccine.2005.01.098_bib17","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.4049\/jimmunol.171.12.6723","article-title":"Proinflammatory cytokines dominate the early immune response to filarial parasites","volume":"171","author":"Babu","year":"2003","journal-title":"J Immunol"},{"issue":"27\u201330","key":"10.1016\/j.vaccine.2005.01.098_bib18","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1016\/S0264-410X(03)00451-1","article-title":"Analysis of the immunogenic properties of a single-chain polypeptide analogue of the HIV-1 gp120-CD4 complex in transgenic mice that produce human immunoglobulins","volume":"21","author":"He","year":"2003","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X05001489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X05001489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T18:51:47Z","timestamp":1548701507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X05001489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":18,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0264410X05001489"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2005.01.098","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}