{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:43:26Z","timestamp":1777866206935,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-054697"],"award-info":[{"award-number":["AI-054697"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-040091"],"award-info":[{"award-number":["AI-040091"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.vaccine.2005.07.103","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T07:29:37Z","timestamp":1124954977000},"page":"280-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations"],"prefix":"10.1016","volume":"24","author":[{"given":"Randall J.","family":"Basaraba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo A.","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Orme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.vaccine.2005.07.103_bib1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature","volume":"271","author":"Colditz","year":"1994","journal-title":"JAMA"},{"issue":"1 Pt 1","key":"10.1016\/j.vaccine.2005.07.103_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","article-title":"The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature","volume":"96","author":"Colditz","year":"1995","journal-title":"Pediatrics"},{"issue":"17","key":"10.1016\/j.vaccine.2005.07.103_bib3","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1001\/jama.291.17.2086","article-title":"Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: a 60-year follow-up study","volume":"291","author":"Aronson","year":"2004","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.vaccine.2005.07.103_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/oxfordjournals.aje.a115503","article-title":"The effectiveness of bacillus Calmette-Guerin (BCG) vaccination against tuberculosis. A case-control study in Treaty Indians, Alberta, Canada","volume":"131","author":"Houston","year":"1990","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.vaccine.2005.07.103_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/adc.63.3.277","article-title":"Protective effect of BCG vaccination in infant Asians: a case-control study","volume":"63","author":"Packe","year":"1988","journal-title":"Arch Dis Child"},{"issue":"4","key":"10.1016\/j.vaccine.2005.07.103_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/003655401300077144","article-title":"BCG: the challenge continues","volume":"33","author":"Fine","year":"2001","journal-title":"Scand J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2005.07.103_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1053\/j.spid.2005.01.001","article-title":"Current concepts of childhood tuberculosis","volume":"16","author":"Mandalakas","year":"2005","journal-title":"Semin Pediatr Infect Dis"},{"issue":"10","key":"10.1016\/j.vaccine.2005.07.103_bib8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3928\/0090-4481-20041001-13","article-title":"Childhood turberculosis: reflections from the front line","volume":"33","author":"Marais","year":"2004","journal-title":"Pediatr Ann"},{"issue":"6","key":"10.1016\/j.vaccine.2005.07.103_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1525-1470.1996.tb00723.x","article-title":"Disseminated cutaneous eruption after BCG vaccination","volume":"13","author":"Rositto","year":"1996","journal-title":"Pediatr Dermatol"},{"issue":"17","key":"10.1016\/j.vaccine.2005.07.103_bib10","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1001\/jama.1989.03430170046020","article-title":"Disseminated Mycobacterium bovis infection from BCG vaccination and HIV infection","volume":"262","author":"Boudes","year":"1989","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.vaccine.2005.07.103_bib11","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1136\/adc.63.10.1268","article-title":"Disseminated BCG in HIV infection","volume":"63","author":"Ninane","year":"1988","journal-title":"Arch Dis Child"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2005.07.103_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tube.2004.08.001","article-title":"Mouse and guinea pig models for testing new tuberculosis vaccines","volume":"85","author":"Orme","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"issue":"3","key":"10.1016\/j.vaccine.2005.07.103_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/00365540151060743","article-title":"Determinants of vaccine-induced resistance in animal models of pulmonary tuberculosis","volume":"33","author":"McMurray","year":"2001","journal-title":"Scand J Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2005.07.103_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.70.1.1","article-title":"The search for new vaccines against tuberculosis","volume":"70","author":"Orme","year":"2001","journal-title":"J Leukoc Biol"},{"issue":"3","key":"10.1016\/j.vaccine.2005.07.103_bib15","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/IAI.68.3.1706-1709.2000","article-title":"Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode","volume":"68","author":"Turner","year":"2000","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2005.07.103_bib16","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1128\/IAI.66.6.2951-2959.1998","article-title":"Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis","volume":"66","author":"Baldwin","year":"1998","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2005.07.103_bib17","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI118101","article-title":"Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine","volume":"96","author":"Bernasconi","year":"1995","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.vaccine.2005.07.103_bib18","first-page":"653","article-title":"Cytokine regulation of lung fibroblast proliferation. Pulmonary and systemic changes in asbestos-induced pulmonary fibrosis","volume":"134","author":"Lemaire","year":"1986","journal-title":"Am Rev Respir Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2005.07.103_bib19","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1378\/chest.120.1_suppl.S5","article-title":"Type 1\/type 2 cytokine paradigm and the progression of pulmonary fibrosis","volume":"120","author":"Lukacs","year":"2001","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.vaccine.2005.07.103_bib20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0024-3205(02)02299-3","article-title":"Complex cytokine regulation of tissue fibrosis","volume":"72","author":"Atamas","year":"2002","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.vaccine.2005.07.103_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1172\/JCI22398","article-title":"Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis","volume":"114","author":"Strieter","year":"2004","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.vaccine.2005.07.103_bib22","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1128\/IAI.71.2.864-871.2003","article-title":"Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis","volume":"71","author":"Turner","year":"2003","journal-title":"Infect Immun"},{"issue":"Suppl. 144","key":"10.1016\/j.vaccine.2005.07.103_bib23","first-page":"309","article-title":"Dispersion and viability of intracutaneously injected BCG in the guinea pig","volume":"51","author":"Vogelsang","year":"1961","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1016\/j.vaccine.2005.07.103_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1699-0463.1961.tb01556.x","article-title":"Dispersion and viability of BCG after intradermal injection in the guinea pig. 2. Pathological findings","volume":"52","author":"Vogelsang","year":"1961","journal-title":"Acta Pathol Microbiol Scand"},{"issue":"Suppl. 148","key":"10.1016\/j.vaccine.2005.07.103_bib25","first-page":"207","article-title":"Intradermal BCG infection in the guinea-pig. 2. Dispersion to regional lymph nodes within the first day of infection","author":"Wetteland","year":"1961","journal-title":"Acta Pathol Microbiol Scand"},{"issue":"Suppl. 148","key":"10.1016\/j.vaccine.2005.07.103_bib26","first-page":"197","article-title":"Intradermal BCG infection in the guinea-pig. 1. Dispersion to regional lymph nodes and spleen within the first week of infection","author":"Wetteland","year":"1961","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1016\/j.vaccine.2005.07.103_bib27","unstructured":"Kipnis A, Irwin S, Basaraba RJ, Orme IM. Effector memory T lymphocytes in BCG-vaccinated mice rapidly expand from a reservoir of CD44lo CD62Lhi cells after aerosol challenge with Mycobacterium tuberculosis, submitted for publication."},{"issue":"1","key":"10.1016\/j.vaccine.2005.07.103_bib28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1128\/IAI.72.1.570-575.2004","article-title":"Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis","volume":"72","author":"Junqueira-Kipnis","year":"2004","journal-title":"Infect Immun"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2005.07.103_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tube.2004.09.001","article-title":"The tuberculosis vaccine challenge","volume":"85","author":"Brennan","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"issue":"11","key":"10.1016\/j.vaccine.2005.07.103_bib30","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1128\/IAI.71.11.6411-6419.2003","article-title":"Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination","volume":"71","author":"Buddle","year":"2003","journal-title":"Infect Immun"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2005.07.103_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1054\/tube.2000.0271","article-title":"Optimal models to evaluate the protective efficacy of tuberculosis vaccines","volume":"81","author":"Griffin","year":"2001","journal-title":"Tuberculosis (Edinb)"},{"issue":"4 Pt 1","key":"10.1016\/j.vaccine.2005.07.103_bib32","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1164\/ajrccm.157.4.9706037","article-title":"Bacillus Calmette-Guerin revaccination questionable with low tuberculosis incidence","volume":"157","author":"Tala-Heikkila","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.vaccine.2005.07.103_bib33","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0962-8479(92)90043-J","article-title":"Case-control study of the efficacy of BCG immunization against pulmonary tuberculosis in young adults in Santiago Chile","volume":"73","author":"Sepulveda","year":"1992","journal-title":"Tuber Lung Dis"},{"issue":"10","key":"10.1016\/j.vaccine.2005.07.103_bib34","first-page":"775","article-title":"Effectiveness of BCG vaccination","volume":"58","author":"Kubit","year":"1983","journal-title":"Pediatr Pol"},{"issue":"1","key":"10.1016\/j.vaccine.2005.07.103_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/pmed.2002.1043","article-title":"Is Bacillus Calmette-Guerin revaccination necessary for Japanese children?","volume":"35","author":"Rahman","year":"2002","journal-title":"Prev Med"},{"key":"10.1016\/j.vaccine.2005.07.103_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0140-6736(96)02166-6","article-title":"Randomized controlled trial of single BCG, repeated BCG or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi","volume":"348","author":"Group","year":"1996","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.vaccine.2005.07.103_bib37","first-page":"1110","article-title":"Adverse effects of BCG revaccination: a report on 13 cases from Rio de Janeiro","volume":"6","author":"Cunha","year":"2002","journal-title":"Brazil Int J Tuberc Lung Dis"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X05007590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X05007590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:12:42Z","timestamp":1777536762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X05007590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0264410X05007590"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2005.07.103","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2005.07.103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}