{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:57:31Z","timestamp":1789181851910,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.vaccine.2005.10.025","type":"journal-article","created":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T12:45:31Z","timestamp":1133268331000},"page":"1800-1810","source":"Crossref","is-referenced-by-count":31,"title":["Non PC liposome entrapped promastigote antigens elicit parasite specific CD8+ and CD4+ T-cell immune response and protect hamsters against visceral leishmaniasis"],"prefix":"10.1016","volume":"24","author":[{"given":"Sharad Kumar","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravendra","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owais","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2005.10.025_bib1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0952-7915(96)80040-9","article-title":"Invasion, control and persistence of Leishmania parasites","volume":"8","author":"Bogdan","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(98)10178-2","article-title":"Leishmaniasis","volume":"354","author":"Herwaldt","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2005.10.025_bib3","series-title":"Principles and practice of infectious diseases V","first-page":"2831","article-title":"Leishmania species: visceral (kala-azar), cutaneous, and mucosal leishmaniasis","author":"Pearson","year":"2000"},{"issue":"11","key":"10.1016\/j.vaccine.2005.10.025_bib4","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-3156.2001.00778.x","article-title":"Drug resistance in Indian visceral leishmaniasis","volume":"6","author":"Sundar","year":"2001","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.vaccine.2005.10.025_bib5","first-page":"1205","article-title":"Commentary: some good news for treatment of visceral leishmaniasis in Bihar","volume":"316","author":"Lockwood","year":"1998","journal-title":"Brit Med J"},{"key":"10.1016\/j.vaccine.2005.10.025_bib6","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.vaccine.2004.06.054","article-title":"Isolation of integral membrane proteins of Leishmania promastigotes and evaluation of their prophylactic potential in hamsters against experimental visceral leishmaniasis","volume":"23","author":"Garg","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2005.10.025_bib7","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1016\/S0264-410X(01)00058-5","article-title":"Successful vaccination against Leishmania donvoani infection in Indian langur using alum-precipitated autoclaved Leishmania major with BCG","volume":"19","author":"Mishra","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2005.10.025_bib8","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1128\/IAI.61.12.5205-5213.1993","article-title":"An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells, which protect susceptible BALB\/c mice against infection with virulent L. major","volume":"61","author":"Kimsey","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2005.10.025_bib9","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/S0140-6736(98)09552-X","article-title":"Randomised vaccine trial of single dose of killed Leishmania major plus BCG against anthroponotic cutaneous leishmaniasis in Bam, Iran","volume":"351","author":"Sharifi","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2005.10.025_bib10","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.4049\/jimmunol.157.11.5034","article-title":"Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis","volume":"157","author":"Webb","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.vaccine.2005.10.025_bib11","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0264-410X(01)00469-8","article-title":"Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony stimulating factors","volume":"20","author":"Follador","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2005.10.025_bib12","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1086\/374783","article-title":"Leishmania mexicana and Leishmania major: attenuation of wild type parasites and vaccination with attenuated lines","volume":"187","author":"Daneshvar","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2005.10.025_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/S0074-02761999000100014","article-title":"Vaccination of C57BL\/10 mice against Cutaneous Leishmaniasis: use of purified gp63 encapsulated into niosomes surfactants vesicles: a novel approach","volume":"94","author":"Lezama-D vila","year":"1999","journal-title":"Mem Inst Oswaldo Cruz, Rio de Janeiro"},{"key":"10.1016\/j.vaccine.2005.10.025_bib14","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.4049\/jimmunol.150.6.2322","article-title":"Pure protein from Leishmania donovani protects mice from both cutaneous and visceral leishmaniasis","volume":"150","author":"Rachamim","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib15","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/IAI.69.8.4719-4725.2001","article-title":"Leishmania donovani p36 (LACK) DNA is highly immunogenic but not protective against experimental visceral leishmaniasis","volume":"69","author":"Melby","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2005.10.025_bib16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/intimm\/3.6.587","article-title":"Establishment of resistance to Leishmania major infection in susceptible BALB\/c mice requires parasite specific CD8+ T cells","volume":"3","author":"Muller","year":"1991","journal-title":"Int Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0952-7915(98)80121-0","article-title":"Regulation of protective immunity against Leishmania major in mice","volume":"10","author":"Louis","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib18","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4049\/jimmunol.146.8.2763","article-title":"Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis","volume":"146","author":"Kaye","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib19","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1128\/IAI.62.3.1058-1063.1994","article-title":"Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis","volume":"62","author":"Miralles","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2005.10.025_bib20","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1172\/JCI112209","article-title":"Absence of \u03b3 interferon and interleukin-2 production during active visceral leishmaniasis","volume":"76","author":"Carvalho","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2005.10.025_bib21","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.4049\/jimmunol.148.6.1858","article-title":"Acquired resistance and granuloma formation in experimental visceral leishmaniasis. Differential T cell and lymphokine roles in initial versus established immunity","volume":"148","author":"Murray","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib22","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1016\/S0021-9258(19)69590-6","article-title":"Influence of changes in polar head group composition on the lipid phase transition and characterization of a mutant containing only saturated phospholipid acyl-chains","volume":"268","author":"Pluschke","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2005.10.025_bib23","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1046\/j.0014-2956.2001.02507.x","article-title":"Fusogenic potential of prokaryotic membrane lipids: implication in vaccine development","volume":"268","author":"Ahmad","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.vaccine.2005.10.025_bib24","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0264-410X(03)00106-3","article-title":"Antigen entrapped in the escheriosomes leads to the generation of CD4+ helper and CD8+ cytotoxic T-cell response","volume":"21","author":"Faisal","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2005.10.025_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02558256","article-title":"method for adsorbent fractionation of cottonseed oil for experimental intravenous fat emulsions","volume":"42","author":"Singleton","year":"1965","journal-title":"J Am Oil Chem Soc"},{"key":"10.1016\/j.vaccine.2005.10.025_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0035-9203(90)90319-A","article-title":"Enzyme linked immunosorbant assay in diagnosis of kala-azar in Bhadohi (Varanasi) India","volume":"84","author":"Choudhury","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2005.10.025_bib27","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1046\/j.1432-1327.2000.01447.x","article-title":"Liposome mediated cytosolic delivery of macromolecules and its possible use in vaccine development","volume":"267","author":"Owais","year":"2000","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.vaccine.2005.10.025_bib28","series-title":"Selected methods in cellular immunology","author":"Mishell","year":"1980"},{"key":"10.1016\/j.vaccine.2005.10.025_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0022-1759(89)90198-1","article-title":"Specific assays for cytokine production by T-cells","volume":"116","author":"Mosmann","year":"1989","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.vaccine.2005.10.025_bib30","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","article-title":"Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production","volume":"141","author":"Ding","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib31","series-title":"The enzyme linked immunosorbant assay (ELISA): a guide with abstracts of microplate application","author":"Voller","year":"1979"},{"key":"10.1016\/j.vaccine.2005.10.025_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/IAI.42.2.702-707.1983","article-title":"Cell mediated immune response in Indian kala-azar and post kala-azar dermal leishmaniasis","volume":"42","author":"Haldar","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2005.10.025_bib33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/IAI.66.1.18-27.1998","article-title":"Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani","volume":"66","author":"Melby","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2005.10.025_bib34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.iy.07.040189.002305","article-title":"Clonal expansion versus clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy","volume":"7","author":"Mueller","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0092-8674(94)90335-2","article-title":"Signals and signs for lymphocyte responses","volume":"76","author":"Janeway","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2005.10.025_bib36","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.143.12.4244","article-title":"Experimental visceral leishmaniasis: role of endogenous IFN-\u03b3 in host defense and tissue granulomatous response","volume":"143","author":"Squires","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib37","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.vaccine.2003.09.030","article-title":"A mixed Th1\/Th2 response elicited by a liposomal formulation of Leishmania vaccine instructs Th1 responses and resistance to Leishmania donovani in susceptible BALB\/c mice","volume":"22","author":"Tuhina","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2005.10.025_bib38","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.189.4.741","article-title":"Macrophage microbicidal mechanisims in vivo: reactive nitrogen versus oxygen intermediates in killing of intracellular visceral Leishmania donovani","volume":"189","author":"Murray","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2005.10.025_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-3083.2001.00944.x","article-title":"Use of liposomes as an immunopotentiating delivery system: in perspective of vaccine development","volume":"54","author":"Owais","year":"2001","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/cimm.2001.1805","article-title":"liposome mediated antigen delivery leads to induction of CD8+ T lymphocyte and antibody responses against the V3 loop region of HIV gp120","volume":"210","author":"Ahmad","year":"2001","journal-title":"Cell Immunol"},{"key":"10.1016\/j.vaccine.2005.10.025_bib41","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.vaccine.2003.11.054","article-title":"Liposome adjuvants prepare from the total polar lipids of Haloferax volcanii, Planococcus spp. And Bacillus firmus differ in their ability to elicit and sustain immune responses","volume":"22","author":"Sprott","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2005.10.025_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1128\/IAI.68.1.54-63.2000","article-title":"Archeosome vaccine adjuvants induce strong humoral, cell mediated and memory responses: comparison to conventional liposome and alum","volume":"68","author":"Krishnan","year":"2000","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X05010625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X05010625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:13:59Z","timestamp":1706764439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X05010625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0264410X05010625"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2005.10.025","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}