{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:11:24Z","timestamp":1788228684962,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"31-32","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.vaccine.2006.04.002","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T17:42:46Z","timestamp":1145468566000},"page":"5904-5911","source":"Crossref","is-referenced-by-count":59,"title":["Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein"],"prefix":"10.1016","volume":"24","author":[{"given":"Lisa F.","family":"Shubitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieh-Juen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Yu","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo N.","family":"Kirkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Perrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry T.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Galgiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"September (5)","key":"10.1016\/j.vaccine.2006.04.002_bib1","first-page":"1039","article-title":"In vitro whole-blood analysis of cellular immunity in patients with active coccidioidomycosis by using the antigen preparation T27K","volume":"9","author":"Ampel","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"issue":"April (4)","key":"10.1016\/j.vaccine.2006.04.002_bib2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1086\/313747","article-title":"Practice guideline for the treatment of coccidioidomycosis. Infectious Diseases Society of America","volume":"30","author":"Galgiani","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2006.04.002_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/infdis\/174.2.440","article-title":"Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis","volume":"174","author":"Corry","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2006.04.002_bib4","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1001\/jama.1956.02960420026008","article-title":"Pattern of 39,500 serologic tests in coccidioidomycosis","volume":"160","author":"Smith","year":"1956","journal-title":"JAMA"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2006.04.002_bib5","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1128\/IAI.70.7.3330-3335.2002","article-title":"Localization within a proline-rich antigen (Ag2\/PRA) of protective antigenicity against infection with Coccidioides immitis in mice","volume":"70","author":"Peng","year":"2002","journal-title":"Infect Immun"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2006.04.002_bib6","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1128\/IAI.70.6.3287-3289.2002","article-title":"Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2\/PRA","volume":"70","author":"Shubitz","year":"2002","journal-title":"Infect Immun"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2006.04.002_bib7","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1128\/IAI.69.5.2878-2887.2001","article-title":"Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice","volume":"69","author":"Li","year":"2001","journal-title":"Infect Immun"},{"issue":"February (1)","key":"10.1016\/j.vaccine.2006.04.002_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/fgbi.2000.1243","article-title":"Seeking a vaccine against Coccidioides immitis and serologic studies: expectations and realities","volume":"32","author":"Pappagianis","year":"2001","journal-title":"Fungal Genet Biol"},{"issue":"6","key":"10.1016\/j.vaccine.2006.04.002_bib9","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1128\/IAI.67.6.2935-2940.1999","article-title":"Resistance to Coccidioides immitis in mice after immunization with recombinant protein or DNA vaccine of a proline-rich antigen","volume":"67","author":"Abuodeh","year":"1999","journal-title":"Infect Immun"},{"issue":"November (11)","key":"10.1016\/j.vaccine.2006.04.002_bib10","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1128\/IAI.67.11.5848-5853.1999","article-title":"Coadministration of interleukin 12 expression vector with antigen 2 cDNA enhances induction of protective immunity against Coccidioides immitis","volume":"67","author":"Jiang","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2006.04.002_bib11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1128\/IAI.66.2.424-431.1998","article-title":"Immunogenicity of a 48-kilodalton recombinant T-cell-reactive protein of Coccidioides immitis","volume":"66","author":"Kirkland","year":"1998","journal-title":"Infect Immun"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2006.04.002_bib12","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1128\/IAI.66.5.2342-2345.1998","article-title":"Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules","volume":"66","author":"Zimmermann","year":"1998","journal-title":"Infect Immun"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2006.04.002_bib13","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1128\/IAI.71.6.3010-3019.2003","article-title":"A recombinant beta-1,3-glucanosyltransferase homolog of Coccidioides posadasii protects mice against coccidioidomycosis","volume":"71","author":"Delgado","year":"2003","journal-title":"Infect Immun"},{"issue":"May (27)","key":"10.1016\/j.vaccine.2006.04.002_bib14","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1016\/j.vaccine.2005.01.147","article-title":"Immune response of vaccinated and non-vaccinated mice to Coccidioides posadasii infection","volume":"23","author":"Xue","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2006.04.002_bib15","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/IAI.67.2.630-635.1999","article-title":"Genetic Vaccination against Coccidioides immitis: comparison of vaccine efficacy of recombinant antigen 2 and antigen 2 cDNA","volume":"67","author":"Jiang","year":"1999","journal-title":"Infect Immun"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2006.04.002_bib16","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1128\/IAI.66.8.3519-3522.1998","article-title":"Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice","volume":"66","author":"Kirkland","year":"1998","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2006.04.002_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.1996.0086","article-title":"Cloning and sequence analysis of the cDNA for a protein from Coccidioides immitis with immunogenic potential","volume":"218","author":"Dugger","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.vaccine.2006.04.002_bib18","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/IAI.63.10.3994-4002.1995","article-title":"Molecular and biochemical characterization of a Coccidioides immitis-specific antigen","volume":"63","author":"Pan","year":"1995","journal-title":"Infect Immun"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2006.04.002_bib19","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1128\/IAI.70.7.3539-3545.2002","article-title":"Role of signal sequence in vaccine-induced protection against experimental coccidioidomycosis","volume":"70","author":"Jiang","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.04.002_bib20","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1128\/jcm.8.3.346-348.1978","article-title":"Specificity of exoantigens for identifying cultures of Coccidioides immitis","volume":"8","author":"Huppert","year":"1978","journal-title":"J Clin Microbiol"},{"issue":"August (2)","key":"10.1016\/j.vaccine.2006.04.002_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/ajcp\/82.2.206","article-title":"Evaluation of commercial reagents to identify the exoantigens of Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma species cultures","volume":"82","author":"Sekhon","year":"1984","journal-title":"Am J Clin Pathol"},{"issue":"March (3)","key":"10.1016\/j.vaccine.2006.04.002_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/ajcp\/79.3.379","article-title":"Evaluation of a commercial exoantigen test system for the rapid identification of systemic fungal pathogens","volume":"79","author":"Denys","year":"1983","journal-title":"Am J Clin Pathol"},{"issue":"March (3)","key":"10.1016\/j.vaccine.2006.04.002_bib23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1128\/JCM.11.3.238-241.1980","article-title":"Evaluation of the exoantigen test for identification of Histoplasma species and Coccidioides immitis cultures","volume":"11","author":"DiSalvo","year":"1980","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2006.04.002_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/jcm.8.1.42-45.1978","article-title":"Improved version of the exoantigen test for identification of Coccidioides immitis and Histoplasma capsulatum cultures","volume":"8","author":"Kaufman","year":"1978","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2006.04.002_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1128\/CMR.3.3.247","article-title":"Serology of coccidioidomycosis","volume":"3","author":"Pappagianis","year":"1990","journal-title":"Clin Microbiol Rev"},{"issue":"September (3)","key":"10.1016\/j.vaccine.2006.04.002_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biologicals.2005.04.002","article-title":"Comparison of the rabbit pyrogen test and Limulus amoebocyte lysate (LAL) assay for endotoxin in hepatitis B vaccines and the effect of aluminum hydroxide","volume":"33","author":"Park","year":"2005","journal-title":"Biologicals"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2006.04.002_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2307\/3761847","article-title":"Molecular and phenotypic description of Coccidioides Posadasii sp nov., previously recognized as the non-California population of Coccidioides immitis","volume":"94","author":"Fisher","year":"2002","journal-title":"Mycologia"},{"key":"10.1016\/j.vaccine.2006.04.002_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-1119(96)00486-6","article-title":"Coccidioides immitis antigen 2: analysis for gene and protein","volume":"181","author":"Zhu","year":"1996","journal-title":"Gene"},{"issue":"April (4)","key":"10.1016\/j.vaccine.2006.04.002_bib29","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1128\/IAI.69.4.2211-2222.2001","article-title":"Cloning and expression of the gene which encodes a tube precipitin antigen and wall-associated beta-glucosidase of Coccidioides immitis","volume":"69","author":"Hung","year":"2001","journal-title":"Infect Immun"},{"issue":"January (1\u20132)","key":"10.1016\/j.vaccine.2006.04.002_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0378-1119(99)00496-5","article-title":"expression and functional analysis of the Coccidioides immitis ODC (ornithine decarboxylase) gene","volume":"242","author":"Guevara-Olvera","year":"2000","journal-title":"Gene"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2006.04.002_bib31","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1128\/IAI.70.7.3443-3456.2002","article-title":"A parasitic phase-specific adhesin of Coccidioides immitis contributes to the virulence of this respiratory fungal pathogen","volume":"70","author":"Hung","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.04.002_bib32","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/(SICI)1522-2683(19990101)20:4\/5<860::AID-ELPS860>3.0.CO;2-I","article-title":"Identification of proteins in a human pleural exudate using two-dimensional preparative liquid-phase electrophoresis and matrix-assisted laser desorption\/ionization mass spectrometry","volume":"20","author":"Nilsson","year":"1999","journal-title":"Electrophoresis"},{"key":"10.1016\/j.vaccine.2006.04.002_bib33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0378-1119(97)00342-9","article-title":"Isolation and characterization of the urease gene (URE) from the pathogenic fungus Coccidioides immitis","volume":"198","author":"Yu","year":"1997","journal-title":"Gene"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2006.04.002_bib34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/jhep.2003.50000","article-title":"Hepatitis C virus-like particles combined with novel adjuvant systems enhance virus-specific immune responses","volume":"37","author":"Qiao","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.vaccine.2006.04.002_bib35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2307\/2281868","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2006.04.002_bib36","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1345\/aph.1A410","article-title":"Clinical implications of endotoxin concentrations in vaccines","volume":"36","author":"Geier","year":"2002","journal-title":"Ann Pharmacother"},{"issue":"April (2)","key":"10.1016\/j.vaccine.2006.04.002_bib37","first-page":"58","article-title":"Endotoxin content in Haemophilus influenzae type b vaccine","volume":"57","author":"Ochiai","year":"2004","journal-title":"Jpn J Infect Dis"},{"issue":"December (6)","key":"10.1016\/j.vaccine.2006.04.002_bib38","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1086\/515044","article-title":"Coccidioidomycosis in Arizona: increase in incidence from 1990 to 1995","volume":"27","author":"Ampel","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2006.04.002_bib39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4049\/jimmunol.94.1.132","article-title":"Immunization of mice to Coccidioides immitis: dose, regimen and spherulation stage of killed spherule vaccines","volume":"94","author":"Levine","year":"1965","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2006.04.002_bib40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/oxfordjournals.aje.a113776","article-title":"Immunologic responsiveness and safety associated with the Coccidioides immitis spherule vaccine in volunteers of White, Black, and Filipino ancestry","volume":"119","author":"Williams","year":"1984","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2006.04.002_bib41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1164\/ajrccm\/148.3.656","article-title":"Valley Fever Vaccine Study Group. Evaluation of the protective efficacy of the killed Coccidioides immitis spherule vaccine in humans","volume":"148","author":"Pappagianis","year":"1993","journal-title":"Am Rev Respir Dis"},{"issue":"November (16)","key":"10.1016\/j.vaccine.2006.04.002_bib42","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/0264-410X(95)00103-8","article-title":"Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV-induced papilloma formation","volume":"13","author":"Jansen","year":"1995","journal-title":"Vaccine"},{"issue":"November (5)","key":"10.1016\/j.vaccine.2006.04.002_bib43","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1086\/514105","article-title":"Human papillomavirus type 11 (HPV-11) neutralizing antibodies in the serum and genital mucosal secretions of African green monkeys immunized with HPV-11 virus-like particles expressed in yeast","volume":"176","author":"Lowe","year":"1997","journal-title":"J Infect Dis"},{"issue":"10","key":"10.1016\/j.vaccine.2006.04.002_bib44","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2165\/00003495-200363100-00006","article-title":"Recombinant hepatitis B vaccine (Engerix-B): a review of its immunogenicity and protective efficacy against hepatitis B","volume":"63","author":"Keating","year":"2003","journal-title":"Drugs"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X06004233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X06004233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T04:11:48Z","timestamp":1683432708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X06004233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":44,"journal-issue":{"issue":"31-32","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0264410X06004233"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2006.04.002","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}