{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:26:45Z","timestamp":1789849605323,"version":"4.0.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.vaccine.2006.10.047","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T12:30:00Z","timestamp":1162989000000},"page":"1513-1525","source":"Crossref","is-referenced-by-count":88,"title":["Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax\u00ae challenge in vaccinia-na\u00efve and vaccinia-immune individuals"],"prefix":"10.1016","volume":"25","author":[{"given":"Janie","family":"Parrino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis H.","family":"McCurdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda D.","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingelise J.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Rucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Enama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Koup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Roederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Bailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Moodie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barney S.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vaccine.2006.10.047_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0733-8627(02)00005-6","article-title":"Threats in bioterrorism. I: CDC category A agents","volume":"20","author":"Darling","year":"2002","journal-title":"Emerg Med Clin North Am"},{"issue":"22","key":"10.1016\/j.vaccine.2006.10.047_bib2","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1001\/jama.281.22.2127","article-title":"Smallpox as a biological weapon: medical and public health management. Working Group on Civilian Biodefense","volume":"281","author":"Henderson","year":"1999","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.vaccine.2006.10.047_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-138-6-200303180-00014","article-title":"Evaluation of 21st-century risks of smallpox vaccination and policy options","volume":"138","author":"Lane","year":"2003","journal-title":"Ann Intern Med"},{"issue":"12","key":"10.1016\/j.vaccine.2006.10.047_bib4","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1086\/421266","article-title":"Modified vaccinia Ankara: potential as an alternative smallpox vaccine","volume":"38","author":"McCurdy","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"47","key":"10.1016\/j.vaccine.2006.10.047_bib5","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1055\/s-0028-1108143","article-title":"MVA vaccination against smallpox: clinical tests with an attenuated live vaccinia virus strain (MVA) (author's transl)","volume":"99","author":"Stickl","year":"1974","journal-title":"Dtsch Med Wochenschr"},{"issue":"Pt 5","key":"10.1016\/j.vaccine.2006.10.047_bib6","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1099\/0022-1317-72-5-1031","article-title":"Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence","volume":"72","author":"Meyer","year":"1991","journal-title":"J Gen Virol"},{"issue":"12","key":"10.1016\/j.vaccine.2006.10.047_bib7","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.vaccine.2005.11.022","article-title":"Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine","volume":"24","author":"Vollmar","year":"2006","journal-title":"Vaccine"},{"issue":"6979","key":"10.1016\/j.vaccine.2006.10.047_bib8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature02331","article-title":"Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox","volume":"428","author":"Earl","year":"2004","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.vaccine.2006.10.047_bib9","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1128\/JVI.79.12.7845-7851.2005","article-title":"Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus","volume":"79","author":"Stittelaar","year":"2005","journal-title":"J Virol"},{"issue":"27","key":"10.1016\/j.vaccine.2006.10.047_bib10","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1016\/S0264-410X(01)00075-5","article-title":"Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques","volume":"19","author":"Stittelaar","year":"2001","journal-title":"Vaccine"},{"issue":"22","key":"10.1016\/j.vaccine.2006.10.047_bib11","doi-asserted-by":"crossref","first-page":"12471","DOI":"10.1128\/JVI.78.22.12471-12479.2004","article-title":"Modified vaccinia virus Ankara immunization protects against lethal challenge with recombinant vaccinia virus expressing murine interleukin-4","volume":"78","author":"McCurdy","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2006.10.047_bib12","unstructured":"CDC, Guide B: Vaccination Guidelines for State and Local Health Agencies, http:\/\/www.bt.cdc.gov\/agent\/smallpox\/response-plan\/#guideb (last updated November 26, 2002, last assessed November 9, 2006)."},{"issue":"2","key":"10.1016\/j.vaccine.2006.10.047_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/infdis\/166.2.244","article-title":"Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160 recombinant vaccinia virus in a blinded, controlled, randomized clinical trial. The AIDS Vaccine Clinical Trials Network","volume":"166","author":"Graham","year":"1992","journal-title":"J Infect Dis"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2006.10.047_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0264-410X(99)00183-8","article-title":"Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children","volume":"18","author":"Boyce","year":"1999","journal-title":"Vaccine"},{"issue":"13","key":"10.1016\/j.vaccine.2006.10.047_bib16","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1073\/pnas.0401165101","article-title":"Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge","volume":"101","author":"Wyatt","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.vaccine.2006.10.047_bib17","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/aje\/kwh269","article-title":"Myopericarditis following smallpox vaccination","volume":"160","author":"Arness","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"9457","key":"10.1016\/j.vaccine.2006.10.047_bib20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0140-6736(05)70234-8","article-title":"Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived vaccine: a blind, single-centre, randomised controlled trial [see comment]","volume":"365","author":"Greenberg","year":"2005","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.vaccine.2006.10.047_bib21","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1086\/378518","article-title":"Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques","volume":"188","author":"Edghill-Smith","year":"2003","journal-title":"J Infect Dis"},{"issue":"16","key":"10.1016\/j.vaccine.2006.10.047_bib22","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1073\/pnas.1233578100","article-title":"Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses","volume":"100","author":"Belyakov","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.vaccine.2006.10.047_bib23","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nm1261","article-title":"Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus","volume":"11","author":"Edghill-Smith","year":"2005","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.vaccine.2006.10.047_bib25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4269\/ajtmh.2005.73.428","article-title":"Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003","volume":"73","author":"Learned","year":"2005","journal-title":"Am J Trop Med Hyg"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X0601173X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X0601173X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T08:30:19Z","timestamp":1555921819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X0601173X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0264410X0601173X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2006.10.047","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}