{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:15:30Z","timestamp":1759637730809,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.vaccine.2006.11.041","type":"journal-article","created":{"date-parts":[[2006,12,9]],"date-time":"2006-12-09T07:15:14Z","timestamp":1165648514000},"page":"2027-2035","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B. microti infection in mice"],"prefix":"10.1016","volume":"25","author":[{"given":"M. Alaa","family":"Terkawi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung-goo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Fujisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuenan","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.vaccine.2006.11.041_bib1","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/IAI.71.4.2002-2008.2003","article-title":"Resistance to acute Babesiosis is associated with interleukin-12 and gamma interferon-mediated responses and requires macrophages and natural killer cells","volume":"71","author":"Aguilar-Delfin","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.041_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1097-2765(00)80411-6","article-title":"The ves multigene family of Babesia bovis encodes components of rapid antigenic variation at the infected erythrocyte surface","volume":"5","author":"Allred","year":"2000","journal-title":"Mol Cells"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.041_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gene.2005.04.007","article-title":"Functional complementation of yeast ribosomal P0 protein with Plasmodium falciparum P0","volume":"357","author":"Aruna","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.vaccine.2006.11.041_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S0031182004005190","article-title":"Babesiosis of cattle","volume":"129","author":"Bock","year":"2004","journal-title":"Parasitology"},{"issue":"33","key":"10.1016\/j.vaccine.2006.11.041_bib5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0195-5616(03)00039-1","article-title":"Canine babesiosi","author":"Boozer","year":"2003","journal-title":"Vet Clin Small Anim"},{"issue":"43","key":"10.1016\/j.vaccine.2006.11.041_bib6","doi-asserted-by":"crossref","first-page":"28057","DOI":"10.1074\/jbc.273.43.28057","article-title":"Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3","volume":"273","author":"Brockstedt","year":"1998","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2006.11.041_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.vetpar.2006.01.041","article-title":"Immune control of Babesia bovis infection","volume":"138","author":"Brown","year":"2006","journal-title":"Vet Parasitol"},{"issue":"2","key":"10.1016\/j.vaccine.2006.11.041_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0166-6851(99)00226-1","article-title":"Characterization of domains of the phosphoriboprotein P0 of Plasmodium falciparum","volume":"107","author":"Chatterjee","year":"2000","journal-title":"Mol Biochem Parasitol"},{"issue":"7","key":"10.1016\/j.vaccine.2006.11.041_bib9","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1128\/IAI.68.7.4312-4318.2000","article-title":"Antibodies against ribosomal phosphoprotein P0 of Plasmodium falciparum protect mice against challenge with Plasmodium yoelii","volume":"68","author":"Chatterjee","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.11.041_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0065-2776(08)60536-2","article-title":"Mechanism and regulation of immunoglobulin isotype switching","volume":"54","author":"Coffman","year":"1993","journal-title":"Adv Immunol"},{"key":"10.1016\/j.vaccine.2006.11.041_bib11","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1128\/jcm.30.5.1210-1215.1992","article-title":"Ribosomal DNA probe for differentiation of Babesia microti and B. gibsoni isolates","volume":"30","author":"Conrad","year":"1992","journal-title":"J Clin Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.041_bib12","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/genetics\/150.4.1487","article-title":"Mutation in P0, a dual function ribosomal protein\/apurinic\/apyrimidinic endonuclease, modifies gene expression and position effect variegation in Drosophila","volume":"150","author":"Frolov","year":"1998","journal-title":"Genetics"},{"issue":"7","key":"10.1016\/j.vaccine.2006.11.041_bib13","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1128\/JCM.39.7.2603-2609.2001","article-title":"Identification and expression of a 50-kilodalton surface antigen of Babesia gibsoni and evaluation of its diagnostic potential in an enzyme-linked immunosorbent assay","volume":"39","author":"Fukumoto","year":"2001","journal-title":"J Clin Microbiol"},{"issue":"18","key":"10.1016\/j.vaccine.2006.11.041_bib14","doi-asserted-by":"crossref","first-page":"12138","DOI":"10.1074\/jbc.272.18.12138","article-title":"Characterization of P0, a ribosomal phosphoprotein of Plasmodium falciparum. Antibody against amino-terminal domain inhibits parasite growth","volume":"272","author":"Goswami","year":"1997","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.vaccine.2006.11.041_bib15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CMR.13.3.451","article-title":"Babesiosis","volume":"13","author":"Homer","year":"2000","journal-title":"Clin Microbiol"},{"issue":"9","key":"10.1016\/j.vaccine.2006.11.041_bib16","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1128\/IAI.73.9.5842-5852.2005","article-title":"Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL\/6 mice but does not prevent progressive disease in BALB\/c mice","volume":"73","author":"Iborra","year":"2005","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2006.11.041_bib17","doi-asserted-by":"crossref","first-page":"6562","DOI":"10.1128\/IAI.71.11.6562-6572.2003","article-title":"The Leishmania infantum acidic ribosomal protein P0 administered as a DNA vaccine confers protective immunity to Leishmania major infection in BALB\/c mice","volume":"71","author":"Iborra","year":"2003","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.041_bib18","first-page":"164","article-title":"Role of CD4+T cells in the control of primary infection with Babesia microti in mice","volume":"4","author":"Igarashi","year":"1994","journal-title":"J Protozool Res"},{"key":"10.1016\/j.vaccine.2006.11.041_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2149\/tmh1973.6.15","article-title":"Pathophysiological findings on blood of beagles experimentally infected with B. gibsoni","volume":"6","author":"Ishimine","year":"1978","journal-title":"Jpn J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2006.11.041_bib20","first-page":"361","article-title":"Babesiosis","volume":"86","author":"Krause","year":"2002","journal-title":"Med Clin"},{"key":"10.1016\/j.vaccine.2006.11.041_bib21","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1182\/blood.V92.9.3394","article-title":"Identification of four genes in endothelial cells whose expression is affected by tumour cells and host immune status\u2014a study in ex vivoisolated endothelial cells","volume":"92","author":"Liliensiek","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2006.11.041_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2460\/javma.2002.220.325","article-title":"Babesia gibsoni infection among dogs in the southeastern United States","volume":"220","author":"Macintire","year":"2002","journal-title":"J Am Vet Med"},{"key":"10.1016\/j.vaccine.2006.11.041_bib23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1751-0813.2002.tb10961.x","article-title":"Babesia gibsoni infection in three dogs in Victoria","volume":"8","author":"Muhlnickel","year":"2002","journal-title":"Aust Vet J"},{"key":"10.1016\/j.vaccine.2006.11.041_bib24","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0020-7519(01)00278-8","article-title":"Characterization of the gene encoding a protective antigen from Babesia microti identified it as the eta subunit of chaperonin-containing T-complex protein 1","volume":"31","author":"Nishisaka","year":"2001","journal-title":"Int J Parasitol"},{"issue":"9","key":"10.1016\/j.vaccine.2006.11.041_bib25","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1128\/IAI.72.9.5515-5521.2004","article-title":"The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites","volume":"72","author":"Rajeshwari","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.11.041_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0167-4781(90)90140-W","article-title":"The acidic ribosomal proteins as regulators of the eukaryotic ribosomal activity","volume":"1050","author":"Saenz-Robles","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.vaccine.2006.11.041_bib27","doi-asserted-by":"crossref","first-page":"15689","DOI":"10.1016\/S0021-9258(17)40736-8","article-title":"Ribosomal protein P0, contrary to phosphoproteins P1 and P2, is required for ribosome activity and Saccharomyces cereisiae viability","volume":"269","author":"Santos","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2006.11.041_bib28","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0020-7519(03)00267-4","article-title":"Translocation of ribosomal protein P0 on Toxoplasma gondii tachyzoite surface","volume":"33","author":"Sehgal","year":"2003","journal-title":"Int J Parasitol"},{"issue":"9","key":"10.1016\/j.vaccine.2006.11.041_bib29","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1128\/IAI.68.9.5139-5145.2000","article-title":"Babesia bovis-stimulated macrophages express interleukin-1\u03b2, interleukin-12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitro","volume":"68","author":"Shoda","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.11.041_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0166-6851(01)00394-2","article-title":"Surface expression of the conserved ribosomal protein P0 on parasite and other cells","volume":"119","author":"Singh","year":"2002","journal-title":"Mol Biochem Parasitol"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.041_bib31","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1128\/iai.62.5.1643-1651.1994","article-title":"Antigens shared by Leishmania species and Trypanosoma cruzi: immunological comparison of the acidic ribosomal P0 proteins","volume":"62","author":"Skeiky","year":"1994","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.041_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.176.1.201","article-title":"Cloning and expression of Trypanosoma cruzi ribosomal protein P0 and epitope analysis of anti-P0 autoantibodies in Chagas\u2019 disease patients","volume":"176","author":"Skeiky","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2006.11.041_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0165-2478(95)02436-0","article-title":"Identification of the Leishmania infantum P0 ribosomal protein epitope in canine visceral leishmaniasis","volume":"48","author":"Soto","year":"1995","journal-title":"Immunol Lett"},{"key":"10.1016\/j.vaccine.2006.11.041_bib34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/JCM.39.2.705-709.2001","article-title":"Expression of Babesia equi merozoite antigen 1 in insect cells by a recombinant baculovirus and evaluation of its diagnostic potential in an enzyme-linked immunosorbent assay","volume":"39","author":"Xuan","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2006.11.041_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0168-1702(96)01374-3","article-title":"Characterization of canine herpesvirus glycoprotein C expressed in insect cells","volume":"46","author":"Xuan","year":"1996","journal-title":"Virus Res"},{"issue":"2","key":"10.1016\/j.vaccine.2006.11.041_bib36","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.molbiopara.2006.03.015","article-title":"Characterization of the Babesia gibsoni P18 as a homologue of thrombospondin related adhesive protein","volume":"148","author":"Zhou","year":"2006","journal-title":"Mol Biochem Parasitol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X06012503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X06012503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:15:05Z","timestamp":1759400105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X06012503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0264410X06012503"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2006.11.041","relation":{},"ISSN":["0264-410X"],"issn-type":[{"type":"print","value":"0264-410X"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B. microti infection in mice","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2006.11.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}