{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:43:13Z","timestamp":1770990193010,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.vaccine.2006.11.067","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T12:24:43Z","timestamp":1166703883000},"page":"2269-2278","source":"Crossref","is-referenced-by-count":20,"title":["Immunogenicity and characterization of WRSF2G11: A second generation live attenuated Shigella flexneri 2a vaccine strain"],"prefix":"10.1016","volume":"25","author":[{"given":"Ryan T.","family":"Ranallo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sejal","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malabi M.","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vaccine.2006.11.067_bib1","first-page":"133","article-title":"Shigellosis","volume":"43","author":"Niyogi","year":"2005","journal-title":"J Microbiol"},{"issue":"9","key":"10.1016\/j.vaccine.2006.11.067_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030353","article-title":"A Multicentre Study of Shigella Diarrhoea in Six Asian Countries: disease burden, clinical manifestations, and microbiology","volume":"3","author":"von Seidlein","year":"2006","journal-title":"PLoS Med"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.femsle.2005.08.046","article-title":"Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors","volume":"252","author":"Parsot","year":"2005","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.femsre.2003.07.002","article-title":"Shigella flexneri infection: pathogenesis and vaccine development","volume":"28","author":"Jennison","year":"2004","journal-title":"FEMS Microbiol Rev"},{"issue":"5668","key":"10.1016\/j.vaccine.2006.11.067_bib5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","article-title":"Bacterial invasion: the paradigms of enteroinvasive pathogens","volume":"304","author":"Cossart","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/jb.171.1.353-359.1989","article-title":"virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence","volume":"171","author":"Lett","year":"1989","journal-title":"J Bacteriol"},{"issue":"10","key":"10.1016\/j.vaccine.2006.11.067_bib7","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1073\/pnas.86.10.3867","article-title":"Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin","volume":"86","author":"Bernardini","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"issue":"52","key":"10.1016\/j.vaccine.2006.11.067_bib8","doi-asserted-by":"crossref","first-page":"30874","DOI":"10.1074\/jbc.270.52.30874","article-title":"Extracellular transport of VirG protein in Shigella","volume":"270","author":"Suzuki","year":"1995","journal-title":"J Biol Chem"},{"issue":"36","key":"10.1016\/j.vaccine.2006.11.067_bib9","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1074\/jbc.271.36.21878","article-title":"Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility","volume":"271","author":"Suzuki","year":"1996","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib10","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.180.4.1307","article-title":"Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis","volume":"180","author":"Perdomo","year":"1994","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/IAI.65.1.110-115.1997","article-title":"Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed","volume":"65","author":"Mandic-Mulec","year":"1997","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib12","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.4049\/jimmunol.164.4.2221","article-title":"Production of IFN-gamma and IL-10 to Shigella invasins by mononuclear cells from volunteers orally inoculated with a Shiga toxin-deleted Shigella dysenteriae type 1 strain","volume":"164","author":"Samandari","year":"2000","journal-title":"J Immunol"},{"issue":"16","key":"10.1016\/j.vaccine.2006.11.067_bib13","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/0264-410X(95)00102-7","article-title":"A modified Shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for Shigella infectivity","volume":"13","author":"Kotloff","year":"1995","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4269\/ajtmh.1995.53.47","article-title":"Characteristics of Shigella sonnei infection of volunteers: signs, symptoms, immune responses, changes in selected cytokines and acute-phase substances","volume":"53","author":"Munoz","year":"1995","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.067_bib15","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1128\/IAI.63.5.2054-2061.1995","article-title":"Immunoglobulin subclass distribution and dynamics of Shigella-specific antibody responses in serum and stool samples in shigellosis","volume":"63","author":"Islam","year":"1995","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2006.11.067_bib16","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1128\/IAI.68.12.6624-6632.2000","article-title":"Isolation and characterization of a Shigella flexneri invasin complex subunit vaccine","volume":"68","author":"Turbyfill","year":"2000","journal-title":"Infect Immun"},{"issue":"13","key":"10.1016\/j.vaccine.2006.11.067_bib17","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.vaccine.2005.11.040","article-title":"Development and evaluation of a Shigella flexneri 2a and S. sonnei bivalent invasin complex (Invaplex) vaccine","volume":"24","author":"Oaks","year":"2006","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2006.11.067_bib18","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1128\/IAI.61.9.3678-3687.1993","article-title":"Synthesis, characterization, and clinical evaluation of conjugate vaccines composed of the O-specific polysaccharides of Shigella dysenteriae type 1, Shigella flexneri type 2a, and Shigella sonnei (Plesiomonas shigelloides) bound to bacterial toxoids","volume":"61","author":"Taylor","year":"1993","journal-title":"Infect Immun"},{"issue":"9046","key":"10.1016\/j.vaccine.2006.11.067_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(96)06255-1","article-title":"Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults","volume":"349","author":"Cohen","year":"1997","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.vaccine.2006.11.067_bib20","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/IAI.63.7.2762-2765.1995","article-title":"Protection against local Shigella sonnei infection in mice by parenteral immunization with a nucleoprotein subcellular vaccine","volume":"63","author":"Levenson","year":"1995","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2006.11.067_bib21","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1128\/IAI.73.12.8027-8032.2005","article-title":"Community-based safety, immunogenicity, and transmissibility study of the Shigella sonnei WRSS1 vaccine in Israeli volunteers","volume":"73","author":"Orr","year":"2005","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2006.11.067_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0264-410X(92)90070-Z","article-title":"Safety and immunogenicity of the live oral auxotrophic Shigella flexneri SFL124 in volunteers","volume":"10","author":"Li","year":"1992","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2006.11.067_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0264-410X(93)90015-P","article-title":"Safety and immunogenicity of the live oral auxotrophic Shigella flexneri SFL124 in adult Vietnamese volunteers","volume":"11","author":"Li","year":"1993","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0163-4453(94)94006-1","article-title":"Immune responses in Vietnamese children after a single dose of the auxotrophic, live Shigella flexneri Y vaccine strain SFL124","volume":"28","author":"Li","year":"1994","journal-title":"J Infect"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib25","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1128\/IAI.70.4.2016-2021.2002","article-title":"Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults","volume":"70","author":"Kotloff","year":"2002","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.vaccine.2006.11.067_bib26","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1086\/424680","article-title":"Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208","volume":"190","author":"Kotloff","year":"2004","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2006.11.067_bib27","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1128\/IAI.68.3.1034-1039.2000","article-title":"Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans","volume":"68","author":"Kotloff","year":"2000","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2006.11.067_bib28","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1128\/IAI.64.11.4542-4548.1996","article-title":"Safety, immunogenicity and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG","volume":"64","author":"Kotloff","year":"1996","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.067_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0264-410X(94)00011-B","article-title":"Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2","volume":"13","author":"Kotloff","year":"1995","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2006.11.067_bib30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1128\/IAI.72.2.923-930.2004","article-title":"Two studies evaluating the safety and immunogenicity of a live, attenuated Shigella flexneri 2a vaccine (SC602) and excretion of vaccine organisms in North American volunteers","volume":"72","author":"Katz","year":"2004","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0264-410X(95)80017-8","article-title":"Safety and immunogenicity study of the auxotrophic Shigella flexneri 2a vaccine SFL1070 with a deleted aroD gene in adult Swedish volunteers","volume":"13","author":"Karnell","year":"1995","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.vaccine.2006.11.067_bib32","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/IAI.67.7.3437-3443.1999","article-title":"Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602","volume":"67","author":"Coster","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.11.067_bib33","article-title":"Safety and immunogenicity of an oral, inactivated, whole-cell vaccine for Shigella sonnei: preclinical studies and a Phase I trial","author":"McKenzie","year":"2005","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/infdis\/125.1.12","article-title":"Immunity in shigellosis. II. Protection induced by oral live vaccine or primary infection","volume":"125","author":"DuPont","year":"1972","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0264-410X(90)90094-3","article-title":"Studies in volunteers to evaluate candidate Shigella vaccines: further experience with a bivalent Salmonella typhi-Shigella sonnei vaccine and protection conferred by previous Shigella sonnei disease","volume":"8","author":"Herrington","year":"1990","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2006.11.067_bib36","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/oxfordjournals.aje.a116134","article-title":"Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, Chile","volume":"134","author":"Ferreccio","year":"1991","journal-title":"Am J Epidemiol"},{"issue":"2","key":"10.1016\/j.vaccine.2006.11.067_bib37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/JCM.29.2.386-389.1991","article-title":"Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis","volume":"29","author":"Cohen","year":"1991","journal-title":"J Clin Microbiol"},{"issue":"6","key":"10.1016\/j.vaccine.2006.11.067_bib38","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/infdis\/153.6.1132","article-title":"The role of Shigella spp., enteroinvasive Escherichia coli, and other enteropathogens as causes of childhood dysentery in Thailand","volume":"153","author":"Taylor","year":"1986","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.vaccine.2006.11.067_bib39","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.4049\/jimmunol.120.6.1892","article-title":"The role of Peyer's patches in the local immune response of rabbit ileum to live bacteria","volume":"120","author":"Keren","year":"1978","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.067_bib40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1586\/14760584.5.5.669","article-title":"Live attenuate Shigella vaccines","volume":"5","author":"Venkatesan","year":"2006","journal-title":"Expert Rev Vaccines"},{"issue":"12","key":"10.1016\/j.vaccine.2006.11.067_bib41","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1128\/IAI.63.12.4721-4728.1995","article-title":"Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains","volume":"63","author":"Nataro","year":"1995","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2006.11.067_bib42","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1172\/JCI117991","article-title":"Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro","volume":"95","author":"Fasano","year":"1995","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib43","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/gut.40.4.505","article-title":"Effect of shigella enterotoxin 1 (ShET1) on rabbit intestine in vitro and in vivo","volume":"40","author":"Fasano","year":"1997","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.vaccine.2006.11.067_bib44","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1128\/JCM.37.11.3608-3611.1999","article-title":"Prevalence of Shigella enterotoxins 1 and 2 among Shigella strains isolated from patients with traveler's diarrhea","volume":"37","author":"Vargas","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2006.11.067_bib45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1017\/S0950268802006866","article-title":"Prevalence of the genes for shigella enterotoxins 1 and 2 among clinical isolates of shigella in Israel","volume":"128","author":"Yavzori","year":"2002","journal-title":"Epidemiol Infect"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mpat.2000.0404","article-title":"Genetic organization of the she pathogenicity island in Shigella flexneri 2a","volume":"30","author":"Al-Hasani","year":"2001","journal-title":"Microb Pathog"},{"issue":"3","key":"10.1016\/j.vaccine.2006.11.067_bib47","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/infdis\/119.3.296","article-title":"The response of man to virulent Shigella flexneri 2a","volume":"119","author":"DuPont","year":"1969","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib48","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1128\/IAI.64.4.1190-1196.1996","article-title":"Induction of a local anti-IpaC antibody response in mice by use of a Shigella flexneri 2a vaccine candidate: implications for use of IpaC as a protein carrier","volume":"64","author":"Barzu","year":"1996","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2006.11.067_bib49","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1574-695X.2006.00118.x","article-title":"Developing live Shigella vaccines using lambda Red recombineering","volume":"47","author":"Ranallo","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0378-1119(95)00193-A","article-title":"Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant","volume":"158","author":"Cherepanov","year":"1995","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.vaccine.2006.11.067_bib51","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1128\/IAI.73.1.258-267.2005","article-title":"Construction and characterization of bivalent Shigella flexneri 2a vaccine strains SC608(pCFAI) and SC608(pCFAI\/LTB) that express antigens from enterotoxigenic Escherichia coli","volume":"73","author":"Ranallo","year":"2005","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2006.11.067_bib52","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1128\/IAI.56.11.2933-2941.1988","article-title":"Shigella flexneri invasion plasmid antigens B and C: epitope location and characterization with monoclonal antibodies","volume":"56","author":"Mills","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2006.11.067_bib53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0076-6879(94)36030-8","article-title":"Measurement of invasion by gentamicin resistance","volume":"236","author":"Elsinghorst","year":"1994","journal-title":"Methods Enzymol"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib54","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/IAI.65.4.1486-1496.1997","article-title":"Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis","volume":"65","author":"Fernandez-Prada","year":"1997","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2006.11.067_bib55","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1128\/IAI.68.6.3608-3619.2000","article-title":"Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages","volume":"68","author":"Fernandez-Prada","year":"2000","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2006.11.067_bib56","first-page":"293","article-title":"Experimental shigella keratoconjunctivitis; a preliminary report","volume":"2","author":"Sereny","year":"1955","journal-title":"Acta Microbiol Acad Sci Hung"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.067_bib57","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0264-410X(89)90160-6","article-title":"Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis","volume":"7","author":"Sansonetti","year":"1989","journal-title":"Vaccine"},{"issue":"2\u20133","key":"10.1016\/j.vaccine.2006.11.067_bib58","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0928-8244(03)00063-4","article-title":"Immune responses dependent on antigen location in recombinant attenuated Salmonella typhimurium vaccines following oral immunization","volume":"37","author":"Kang","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"11","key":"10.1016\/j.vaccine.2006.11.067_bib59","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1128\/IAI.59.11.4075-4083.1991","article-title":"Small-animal model to measure efficacy and immunogenicity of Shigella vaccine strains","volume":"59","author":"Hartman","year":"1991","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2006.11.067_bib60","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/IAI.69.2.1072-1083.2001","article-title":"Parameters underlying successful protection with live attenuated mutants in experimental shigellosis","volume":"69","author":"Bernardini","year":"2001","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2006.11.067_bib61","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1046\/j.1365-2958.2000.02179.x","article-title":"The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri","volume":"38","author":"Buchrieser","year":"2000","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.067_bib62","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1128\/IAI.69.5.3271-3285.2001","article-title":"Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri","volume":"69","author":"Venkatesan","year":"2001","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2006.11.067_bib63","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1128\/IAI.68.5.2457-2463.2000","article-title":"The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation","volume":"68","author":"Al-Hasani","year":"2000","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.vaccine.2006.11.067_bib64","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.4049\/jimmunol.168.10.5240","article-title":"Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium","volume":"168","author":"D\u2019Hauteville","year":"2002","journal-title":"J Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X06013065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X06013065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T05:59:22Z","timestamp":1683698362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X06013065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0264410X06013065"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2006.11.067","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}