{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:40:05Z","timestamp":1792741205692,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.vaccine.2007.02.062","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T10:02:54Z","timestamp":1173780174000},"page":"4029-4037","source":"Crossref","is-referenced-by-count":88,"title":["Immunogenicity of varying dosages of 7-valent pneumococcal polysaccharide\u2013protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine"],"prefix":"10.1016","volume":"25","author":[{"given":"Lisa A.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Neuzil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon H.","family":"Nahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia G.","family":"Whitney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onchee","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat T.","family":"Starkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Dunstan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Carste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Shay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Baggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Carlone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2007.02.062_bib1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00006454-200209000-00005","article-title":"Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia","volume":"21","author":"Black","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2007.02.062_bib2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/00006454-199711000-00010","article-title":"Safety and immunogenicity of tetravalent pneumococcal vaccines containing 6B, 14, 19F and 23F polysaccharides conjugated to either tetanus toxoid or diphtheria toxoid in young infants and their boosterability by native polysaccharide antigens","volume":"16","author":"Dagan","year":"1997","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2007.02.062_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00006454-200003000-00003","article-title":"Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group","volume":"19","author":"Black","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2007.02.062_bib4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJMoa035060","article-title":"A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection","volume":"349","author":"Klugman","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2007.02.062_bib5","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1086\/374785","article-title":"Significant variation in serotype-specific immunogenicity of the seven-valent Streptococcus pneumoniae capsular polysaccharide-CRM197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein","volume":"187","author":"Kamboj","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/infdis\/173.1.256","article-title":"Pneumococcal conjugate vaccine primes for antibody responses to polysaccharide pneumococcal vaccine after treatment of Hodgkin's disease","volume":"173","author":"Chan","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/IAI.65.1.242-247.1997","article-title":"Comparison of pneumococcal polysaccharide and CRM197-conjugated pneumococcal oligosaccharide vaccines in young and elderly adults","volume":"65","author":"Shelly","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.02.062_bib8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/infdis\/173.4.1014","article-title":"Reactogenicity and immunogenicity of a protein-conjugated pneumococcal oligosaccharide vaccine in older adults","volume":"173","author":"Powers","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib9","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1128\/IAI.67.9.4935-4938.1999","article-title":"Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination","volume":"67","author":"Lottenbach","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.02.062_bib10","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1086\/374784","article-title":"Randomized, double-blind, controlled trial of pneumococcal vaccination in renal transplant recipients","volume":"187","author":"Kumar","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/infdis\/173.1.83","article-title":"Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: results from a randomized trial","volume":"173","author":"Ahmed","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0264-410X(01)00347-4","article-title":"Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and\/or 23-valent polysaccharide vaccine among HIV-infected adults","volume":"20","author":"Feikin","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib13","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/S0264-410X(00)00441-2","article-title":"Tolerability and immunogenicity of an 11-valent pneumococcal conjugate vaccine in adults","volume":"19","author":"Wuorimaa","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib14","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.vaccine.2005.09.047","article-title":"Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial","volume":"24","author":"Deloria-Knoll","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib15","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0264-410X(00)00232-2","article-title":"Enhanced antibody response to pneumococcal polysaccharide vaccine after prior immunization with conjugate pneumococcal vaccine in HIV-infected adults","volume":"19","author":"Kroon","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib16","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1001\/jama.1997.03540450065037","article-title":"Determination of deltoid fat pad thickness. Implications for needle length in adult immunization","volume":"277","author":"Poland","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2007.02.062_bib17","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1016\/j.vaccine.2005.02.017","article-title":"Safety of varying dosages of 7-valent pneumococcal protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine","volume":"23","author":"Jackson","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1128\/CDLI.10.4.514-519.2003","article-title":"Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides","volume":"10","author":"Wernette","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2007.02.062_bib19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/CVI.13.3.356-360.2006","article-title":"Critical differences between pneumococcal polysaccharide enzyme-linked immunosorbent assays with and without 22F inhibition at low antibody concentrations in pediatric sera","volume":"13","author":"Henckaerts","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2007.02.062_bib20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/CDLI.10.4.616-621.2003","article-title":"Efficiency of a pneumococcal opsonophagocytic killing assay improved by multiplexing and by coloring colonies","volume":"10","author":"Kim","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2007.02.062_bib21","doi-asserted-by":"crossref","first-page":"828","DOI":"10.7326\/0003-4819-123-11-199512010-00003","article-title":"Antibody responses to polysaccharide and polysaccharide-conjugate vaccines after treatment of Hodgkin disease","volume":"123","author":"Molrine","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.vaccine.2007.02.062_bib22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1086\/516965","article-title":"IgG response to pneumococcal polysaccharide-protein conjugate appears similar to IgG response to polysaccharide in bone marrow transplant recipients and healthy adults","volume":"25","author":"Storek","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0264-410X(97)00162-X","article-title":"Circulating antibody secreting cell response to parenteral pneumococcal vaccines as an indicator of a salivary IgA antibody response","volume":"16","author":"Nieminen","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib24","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1183\/09031936.02.00289702","article-title":"Vaccination of COPD patients with a pneumococcus type 6B tetanus toxoid conjugate vaccine","volume":"20","author":"Jonsson","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.vaccine.2007.02.062_bib25","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1086\/515346","article-title":"Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination","volume":"178","author":"Granoff","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1128\/CVI.00123-06","article-title":"Priming for immunologic memory in adults by meningococcal group C conjugate vaccination","volume":"13","author":"Vu","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2007.02.062_bib27","first-page":"2726","article-title":"Dose dependency of antibody response in infants and children to pneumococcal polysaccharides conjugated to tetanus toxoid","volume":"17","author":"Ahman","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00006454-199803000-00008","article-title":"Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory","volume":"17","author":"Ahman","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2007.02.062_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00006454-200002000-00013","article-title":"Safety and immunogenicity of three doses of a Neisseria meningitidis A+C diphtheria conjugate vaccine in infants from Niger","volume":"19","author":"Campagne","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2007.02.062_bib30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/infdis\/175.1.200","article-title":"Induction of immunologic memory in Gambian children by vaccination in infancy with a group A plus group C meningococcal polysaccharide-protein conjugate vaccine","volume":"175","author":"Leach","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib31","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1001\/jama.280.19.1685","article-title":"Induction of immunologic memory by conjugated vs plain meningococcal C polysaccharide vaccine in toddlers: a randomized controlled trial","volume":"280","author":"MacDonald","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2007.02.062_bib32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/infdis\/128.6.769","article-title":"Immunogenicity of group A and group C meningococcal polysaccharides in human infants","volume":"128","author":"Goldschneider","year":"1973","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib33","first-page":"201","article-title":"Meningococcal polysaccharide vaccines","volume":"12","author":"Gold","year":"1977","journal-title":"Hosp Pharm"},{"key":"10.1016\/j.vaccine.2007.02.062_bib34","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archpedi.159.10.907","article-title":"Safety, immunogenicity, and immune memory of a novel meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine (MCV-4) in healthy adolescents","volume":"159","author":"Keyserling","year":"2005","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"2","key":"10.1016\/j.vaccine.2007.02.062_bib35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1086\/315284","article-title":"Meningococcal C polysaccharide vaccine induces immunologic hyporesponsiveness in adults that is overcome by meningococcal C conjugate vaccine","volume":"181","author":"Richmond","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.02.062_bib36","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/S0264-410X(01)00050-0","article-title":"Comparison of antibody kinetics following meningococcal serogroup C conjugate vaccine between healthy adults previously vaccinated with meningococcal A\/C polysaccharide vaccine and vaccine-naive controls","volume":"19","author":"Borrow","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.02.062_bib37","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/CDLI.11.6.1100-1104.2004","article-title":"Effects of prior polysaccharide vaccination on magnitude, duration, and quality of immune responses to and safety profile of a meningococcal serogroup C tetanus toxoid conjugate vaccination in adults","volume":"11","author":"Southern","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2007.02.062_bib38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0264-410X(03)00521-8","article-title":"Revaccination with the 23-valent pneumococcal polysaccharide vaccine in middle-aged and elderly persons previously treated for pneumonia","volume":"22","author":"Torling","year":"2003","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07002319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07002319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T21:02:17Z","timestamp":1587416537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07002319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":38,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0264410X07002319"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.02.062","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}