{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:16:06Z","timestamp":1774379766244,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.vaccine.2007.03.042","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T11:12:59Z","timestamp":1176376379000},"page":"4368-4375","source":"Crossref","is-referenced-by-count":29,"title":["Complete protection of mice against a lethal dose challenge of western equine encephalitis virus after immunization with an adenovirus-vectored vaccine"],"prefix":"10.1016","volume":"25","author":[{"given":"Josh Q.H.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole D.","family":"Barab\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damon","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Les P.","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.vaccine.2007.03.042_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.7.1.89","article-title":"Medically important arboviruses of the United States and Canada","volume":"7","author":"Calisher","year":"1994","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.vaccine.2007.03.042_bib2","series-title":"Fields virology","first-page":"2265","article-title":"Alphaviruses","author":"Griffin","year":"2001"},{"issue":"7","key":"10.1016\/j.vaccine.2007.03.042_bib3","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1086\/444397","article-title":"Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques","volume":"192","author":"Reed","year":"2005","journal-title":"J Infect Dis"},{"issue":"Pt 8","key":"10.1016\/j.vaccine.2007.03.042_bib4","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1099\/vir.0.81815-0","article-title":"Infectivity variation and genetic diversity among strains of Western equine encephalitis virus","volume":"87","author":"Nagata","year":"2006","journal-title":"J Gen Virol"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib5","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.virol.2006.10.031","article-title":"Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model","volume":"360","author":"Julander","year":"2007","journal-title":"Virology"},{"issue":"806","key":"10.1016\/j.vaccine.2007.03.042_bib6","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.158.3806.1283","article-title":"Arbovirus infections of laboratory workers. Extent of problem emphasizes the need for more effective measures to reduce hazards","volume":"158","author":"Hanson","year":"1967","journal-title":"Science"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2007.03.042_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0166-3542(02)00203-6","article-title":"Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control","volume":"57","author":"Sidwell","year":"2003","journal-title":"Antiviral Res"},{"issue":"Suppl 4","key":"10.1016\/j.vaccine.2007.03.042_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7205\/MILMED.170.4S.92","article-title":"History of U.S. military contributions to the study of viral encephalitis","volume":"170","author":"Hoke","year":"2005","journal-title":"Mil Med"},{"key":"10.1016\/j.vaccine.2007.03.042_bib9","series-title":"Textbook of military medicine part I: warfare, weaponry, and the casualty, medical aspects of chemical and biological warfare","first-page":"561","article-title":"Viral encephalitides","author":"Smith","year":"1997"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4269\/ajtmh.2003.68.218","article-title":"Limited potential for mosquito transmission of genetically engineered, live-attenuated western equine encephalitis virus vaccine candidates","volume":"68","author":"Turell","year":"2003","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/viro.2002.1677","article-title":"Recombinant chimeric western and eastern equine encephalitis viruses as potential vaccine candidates","volume":"302","author":"Schoepp","year":"2002","journal-title":"Virology"},{"issue":"17\u201318","key":"10.1016\/j.vaccine.2007.03.042_bib12","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.vaccine.2005.01.032","article-title":"Efficacy of DNA vaccination against western equine encephalitis virus infection","volume":"23","author":"Nagata","year":"2005","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2007.03.042_bib13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/JVI.71.1.613-623.1997","article-title":"Recombinational history and molecular evolution of western equine encephalomyelitis complex alphaviruses","volume":"71","author":"Weaver","year":"1997","journal-title":"J Virol"},{"issue":"Pt 1","key":"10.1016\/j.vaccine.2007.03.042_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1099\/0022-1317-81-1-151","article-title":"Complete genomic RNA sequence of western equine encephalitis virus and expression of the structural genes","volume":"81","author":"Netolitzky","year":"2000","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2007.03.042_bib15","series-title":"Methods in molecular biology","first-page":"109","article-title":"Manipulation of adenovirus vectors","author":"Graham","year":"1996"},{"key":"10.1016\/j.vaccine.2007.03.042_bib16","series-title":"Virology methods manual","author":"Mahy","year":"1996"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/02724570050031158","article-title":"Construction and characterization of monoclonal antibodies against western equine encephalitis virus","volume":"19","author":"Long","year":"2000","journal-title":"Hybridoma"},{"issue":"7","key":"10.1016\/j.vaccine.2007.03.042_bib18","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1128\/JVI.70.7.4805-4810.1996","article-title":"Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli","volume":"70","author":"Chartier","year":"1996","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.03.042_bib19","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"A simplified system for generating recombinant adenoviruses","volume":"95","author":"He","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0168-1702(03)00116-3","article-title":"Recombinant adenovirus co-expressing capsid proteins of two serotypes of foot-and-mouth disease virus (FMDV): in vitro characterization and induction of neutralizing antibodies against FMDV in swine","volume":"93","author":"Wu","year":"2003","journal-title":"Virus Res"},{"issue":"1","key":"10.1016\/j.vaccine.2007.03.042_bib21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4269\/ajtmh.1971.20.146","article-title":"Inactivated western equine encephalomyelitis vaccine propagated in chick embryo cell culture. Clinical and serological evaluation in man","volume":"20","author":"Bartelloni","year":"1971","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2007.03.042_bib22","first-page":"191","article-title":"Role of antibodies in controlling alphavirus infection of neurons","volume":"260","author":"Griffin","year":"2001","journal-title":"Curr Top Microbiol Immunol"},{"issue":"5861","key":"10.1016\/j.vaccine.2007.03.042_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/297070a0","article-title":"Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis","volume":"297","author":"Schmaljohn","year":"1982","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.vaccine.2007.03.042_bib24","first-page":"621","article-title":"Efficacy of trivalent inactivated encephalomyelitis virus vaccine in horses","volume":"39","author":"Barber","year":"1978","journal-title":"Am J Vet Res"},{"issue":"4","key":"10.1016\/j.vaccine.2007.03.042_bib25","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ymthe.2004.07.013","article-title":"Adenoviruses as vaccine vectors","volume":"10","author":"Tatsis","year":"2004","journal-title":"Mol Ther"},{"issue":"12","key":"10.1016\/j.vaccine.2007.03.042_bib26","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1086\/509258","article-title":"Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective Recombinant adenovirus vector","volume":"194","author":"Catanzaro","year":"2006","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.vaccine.2007.03.042_bib27","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1371\/journal.pmed.0030177","article-title":"Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs","volume":"3","author":"Sullivan","year":"2006","journal-title":"PLoS Med"},{"issue":"6949","key":"10.1016\/j.vaccine.2007.03.042_bib28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nature01876","article-title":"Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates","volume":"424","author":"Sullivan","year":"2003","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.vaccine.2007.03.042_bib29","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1128\/JVI.80.4.1959-1964.2006","article-title":"Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization","volume":"80","author":"Gao","year":"2006","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2005.04.014","article-title":"Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine","volume":"337","author":"Pacheco","year":"2005","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.vaccine.2007.03.042_bib31","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1086\/507644","article-title":"Protective immunity against respiratory tract challenge with Yersinia pestis in mice immunized with an adenovirus-based vaccine vector expressing V antigen","volume":"194","author":"Chiuchiolo","year":"2006","journal-title":"J Infect Dis"},{"issue":"17","key":"10.1016\/j.vaccine.2007.03.042_bib32","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1089\/104303403322542310","article-title":"Protective immunity evoked against anthrax lethal toxin after a single intramuscular administration of an adenovirus-based vaccine encoding humanized protective antigen","volume":"14","author":"Tan","year":"2003","journal-title":"Hum Gene Ther"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/vim.2005.18.283","article-title":"Adenoviral vectors for mucosal vaccination against infectious diseases","volume":"18","author":"Santosuosso","year":"2005","journal-title":"Viral Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2007.03.042_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/hum.2005.16.157","article-title":"Adenovirus-based genetic vaccines for biodefense","volume":"16","author":"Boyer","year":"2005","journal-title":"Hum Gene Ther"},{"issue":"3","key":"10.1016\/j.vaccine.2007.03.042_bib35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/MMBR.58.3.491-562.1994","article-title":"The alphaviruses: gene expression, replication, and evolution","volume":"58","author":"Strauss","year":"1994","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.vaccine.2007.03.042_bib36","series-title":"Fields virology","first-page":"2265","article-title":"Togaviridae: the viruses and their replication","author":"Schlesinger","year":"2001"},{"issue":"13","key":"10.1016\/j.vaccine.2007.03.042_bib37","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.vaccine.2004.06.056","article-title":"Intranasal immunisation with defective adenovirus serotype 5 expressing the Venezuelan equine encephalitis virus E2 glycoprotein protects against airborne challenge with virulent virus","volume":"23","author":"Phillpotts","year":"2005","journal-title":"Vaccine"},{"issue":"17","key":"10.1016\/j.vaccine.2007.03.042_bib38","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/j.vaccine.2006.02.020","article-title":"Boosting with an adenovirus-based vaccine improves protective efficacy against Venezuelan equine encephalitis virus following DNA vaccination","volume":"24","author":"Perkins","year":"2006","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2007.03.042_bib39","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4049\/jimmunol.129.6.2763","article-title":"Determination of the protective epitopes on the glycoproteins of Venezuelan equine encephalomyelitis virus by passive transfer of monoclonal antibodies","volume":"129","author":"Mathews","year":"1982","journal-title":"J Immunol"},{"issue":"5528","key":"10.1016\/j.vaccine.2007.03.042_bib40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.1059742","article-title":"Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons","volume":"293","author":"Binder","year":"2001","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.vaccine.2007.03.042_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1128\/IAI.4.1.37-43.1971","article-title":"Cross-protection in hamsters immunized with group A arbovirus vaccines","volume":"4","author":"Cole","year":"1971","journal-title":"Infec Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07003684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07003684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T12:18:29Z","timestamp":1683807509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07003684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":41,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0264410X07003684"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.03.042","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}