{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:22:14Z","timestamp":1769739734619,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.vaccine.2007.04.003","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T16:07:33Z","timestamp":1177085253000},"page":"4525-4532","source":"Crossref","is-referenced-by-count":20,"title":["Immunization with Leishmania infantum released proteins confers partial protection against parasite infection with a predominant Th1 specific immune response"],"prefix":"10.1016","volume":"25","author":[{"given":"Ricardo","family":"Rosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia Roos","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela M.","family":"Santos-Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2007.04.003_bib1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1086\/507530","article-title":"Liposomal amphotericin B for the treatment of visceral leishmaniasis","volume":"43","author":"Bern","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2007.04.003_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/00034983.1994.11812879","article-title":"Canine leishmaniasis: clinical, parasitological and entomological follow-up after chemotherapy","volume":"88","author":"Alvar","year":"1994","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.vaccine.2007.04.003_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1939-1676.1999.tb01455.x","article-title":"Combination allopurinol and antimony treatment versus antimony alone and allopurinol alone in the treatment of canine leishmaniasis (96 cases)","volume":"13","author":"Denerolle","year":"1999","journal-title":"J Vet Intern Med"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2007.04.003_bib4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.vetpar.2006.08.019","article-title":"Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate","volume":"143","author":"Ikeda-Garcia","year":"2007","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vaccine.2007.04.003_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2915.1987.tb00364.x","article-title":"Leishmania infantum infection rates in Phlebotomus perniciosus fed on naturally infected dogs under antimonial treatment","volume":"1","author":"Gradoni","year":"1987","journal-title":"Med Vet Entomol"},{"issue":"10","key":"10.1016\/j.vaccine.2007.04.003_bib6","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1439-0442.2006.00869.x","article-title":"Canine leishmaniasis chemotherapy: dog's clinical condition and risk of Leishmania transmission","volume":"53","author":"Jo\u00e3o","year":"2006","journal-title":"J Vet Med Ser A"},{"issue":"11","key":"10.1016\/j.vaccine.2007.04.003_bib7","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1128\/IAI.67.11.5559-5566.1999","article-title":"Control of Leishmania infantum infection is associated with CD8(+) and gamma interferon- and interleukin-5-producing CD4(+) antigen-specific T cells","volume":"67","author":"Mary","year":"1999","journal-title":"Infect Immun"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2007.04.003_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.0141-9838.2004.00672.x","article-title":"CD8(+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis","volume":"25","author":"Tsagozis","year":"2003","journal-title":"Parasite Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.04.003_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.femsim.2004.01.003","article-title":"Hepatic cellular immune responses in mice with \u201ccure\u201d and \u201cnon-cure\u201d phenotype to Leishmania infantum infection: importance of CD8+ T cells and TGF-beta production","volume":"41","author":"Gomes-Pereira","year":"2004","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2007.04.003_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.actatropica.2005.12.003","article-title":"Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells","volume":"97","author":"Rosa","year":"2006","journal-title":"Acta Tropica"},{"key":"10.1016\/j.vaccine.2007.04.003_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.exppara.2004.11.008","article-title":"Leishmania infantum: soluble proteins released by the parasite exert differential effects on host immune response","volume":"109","author":"Rosa","year":"2005","journal-title":"Exp Parasitol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.04.003_bib12","first-page":"7","article-title":"Comparative study of infectivity caused by promastigotes of Leishmania infantum MON-1, L. infantum MON-24 and L. donovani MON-18","volume":"43","author":"Santos-Gomes","year":"1996","journal-title":"Folia Parasitol"},{"issue":"9","key":"10.1016\/j.vaccine.2007.04.003_bib13","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1128\/AAC.39.9.2167","article-title":"Culture microtitration: a sensitive method for quantifying Leishmania infantum in tissues of infected mice","volume":"39","author":"Buffet","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.vaccine.2007.04.003_bib14","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1172\/JCI116878","article-title":"Potential role for interleukin-10 in the immunosuppression associated with kala azar","volume":"92","author":"Holaday","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2007.04.003_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-2427(02)00134-4","article-title":"Cytokine expression during the outcome of canine experimental infection by Leishmania infantum","volume":"88","author":"Santos-Gomes","year":"2002","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2007.04.003_bib16","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1128\/IAI.71.5.2439-2446.2003","article-title":"Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody","volume":"71","author":"Mookerjee","year":"2003","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2007.04.003_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1084\/jem.177.4.1199","article-title":"Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells","volume":"177","author":"Manetti","year":"1993","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.vaccine.2007.04.003_bib18","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.177.6.1797","article-title":"Resolution of cutaneous leishmaniasis: interleukin-12 initiates a protective T helper type 1 immune response","volume":"177","author":"Sypek","year":"1993","journal-title":"J Exp Med"},{"issue":"12","key":"10.1016\/j.vaccine.2007.04.003_bib19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0962-8924(00)01856-0","article-title":"The molecular basis of T helper 1 and T helper 2 cell differentiation","volume":"10","author":"O\u2019Garra","year":"2000","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.vaccine.2007.04.003_bib20","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.vaccine.2005.11.058","article-title":"Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis","volume":"24","author":"Tewary","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.04.003_bib21","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.4049\/jimmunol.145.12.4306","article-title":"Tumor necrosis factor-\u03b1 synergizes with IFN-\u03b3 in mediating killing of Leishmania major through the induction of nitric oxide","volume":"145","author":"Liew","year":"1990","journal-title":"J Immunol"},{"issue":"15","key":"10.1016\/j.vaccine.2007.04.003_bib22","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1073\/pnas.160197797","article-title":"The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory\/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge","volume":"97","author":"Stobie","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.vaccine.2007.04.003_bib23","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.177.5.1505","article-title":"Recombinant interleukin 12 cures mice infected with Leishmania major","volume":"177","author":"Heinzel","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2007.04.003_bib24","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/eji.1830260722","article-title":"Genetically resistant mice lacking interleukin-12 are susceptible to infection with L. major and mount polarized Th2 responses","volume":"26","author":"Mattner","year":"1996","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2007.04.003_bib25","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1046\/j.1365-2567.2002.01394.x","article-title":"Administration of plasmids expressing interleukin-4 and interleukin-10 causes BALB\/c mice to induce a T helper 2-type response despite the expected T helper 1-type response with a low-dose infection of Leishmania major","volume":"105","author":"Yamakami","year":"2002","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.vaccine.2007.04.003_bib26","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/IAI.73.7.3903-3911.2005","article-title":"Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis","volume":"73","author":"Murray","year":"2005","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2007.04.003_bib27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/IAI.66.1.18-27.1998","article-title":"Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani","volume":"66","author":"Melby","year":"1998","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2007.04.003_bib28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.165.2.915","article-title":"Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells","volume":"165","author":"Gurunathan","year":"2000","journal-title":"J Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07004069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07004069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T14:45:49Z","timestamp":1683816349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07004069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":28,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0264410X07004069"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.04.003","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}