{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:32:49Z","timestamp":1783362769908,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.vaccine.2007.05.020","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T07:11:49Z","timestamp":1181027509000},"page":"5263-5271","source":"Crossref","is-referenced-by-count":70,"title":["Gantrez\u00ae AN nanoparticles as an adjuvant for oral immunotherapy with allergens"],"prefix":"10.1016","volume":"25","author":[{"given":"Sara","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gamazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz San","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Irache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.vaccine.2007.05.020_bib1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00130832-200212000-00013","article-title":"Preventive capacity of subcutaneous immunotherapy","volume":"2","author":"Valovirta","year":"2002","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"4 Pt 1","key":"10.1016\/j.vaccine.2007.05.020_bib2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0091-6749(92)90129-P","article-title":"Systemic reactions from allergen immunotherapy","volume":"90","author":"Stewart","year":"1992","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2007.05.020_bib3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1067\/mai.2003.129","article-title":"Noninjection routes for immunotherapy","volume":"111","author":"Canonica","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.vaccine.2007.05.020_bib4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1034\/j.1398-9995.1999.00267.x","article-title":"Post-marketing surveillance study on the safety of sublingual immunotherapy in pediatric patients","volume":"54","author":"Di Rienzo","year":"1999","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1081-1206(10)62844-X","article-title":"WHO position paper on oral (sublingual) immunotherapy","volume":"83","author":"Morris","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2007.05.020_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijpharm.2005.04.008","article-title":"Evaluation of Eudragit-coated chitosan microparticles as an oral immune delivery system","volume":"297","author":"Hori","year":"2005","journal-title":"Int J Pharm"},{"issue":"6","key":"10.1016\/j.vaccine.2007.05.020_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2222.1984.tb02242.x","article-title":"A controlled trial of oral hyposensitization in pollen asthma and rhinitis in children","volume":"14","author":"Cooper","year":"1984","journal-title":"Clin Allergy"},{"issue":"1","key":"10.1016\/j.vaccine.2007.05.020_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2222.1994.tb00917.x","article-title":"A three-year double-blind placebo-controlled study with specific oral immunotherapy to Dermatophagoides: evidence of safety and efficacy in paediatric patients","volume":"24","author":"Giovane","year":"1994","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.vaccine.2007.05.020_bib9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0091-6749(97)70191-X","article-title":"Oral immunotherapy with short ragweed extract in a novel encapsulated preparation: a double-blind study","volume":"100","author":"Litwin","year":"1997","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2007.05.020_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1398-9995.1986.tb02028.x","article-title":"Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy. A double blind study","volume":"41","author":"Moller","year":"1986","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.vaccine.2007.05.020_bib11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1398-9995.1987.tb00362.x","article-title":"High dose grass pollen tablets used for hyposensitization in hay fever patients. A one-year double blind placebo-controlled study","volume":"42","author":"Mosbech","year":"1987","journal-title":"Allergy"},{"issue":"1 Pt 1","key":"10.1016\/j.vaccine.2007.05.020_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0091-6749(94)90233-X","article-title":"Safety and efficacy of oral immunotherapy with standardized cat extract","volume":"93","author":"Oppenheimer","year":"1994","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1398-9995.1985.tb00243.x","article-title":"Oral administration of grass pollen to hay fever patients. An efficacy study in oral hyposensitization","volume":"40","author":"Taudorf","year":"1985","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.vaccine.2007.05.020_bib14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0091-6749(87)90124-2","article-title":"Oral immunotherapy in birch pollen hay fever","volume":"80","author":"Taudorf","year":"1987","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.vaccine.2007.05.020_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1081-1206(10)63218-8","article-title":"Efficacy and safety of oral immunotherapy with short ragweed extract","volume":"78","author":"Van Deusen","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.0818-9641.2004.01272.x","article-title":"Vaccine adjuvants: current state and future trends","volume":"82","author":"Petrovsky","year":"2004","journal-title":"Immunol Cell Biol"},{"issue":"23","key":"10.1016\/j.vaccine.2007.05.020_bib17","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1007\/s00018-005-5290-1","article-title":"Generation of improved mucosal vaccines by induction of innate immunity","volume":"62","author":"Lavelle","year":"2005","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"10.1016\/j.vaccine.2007.05.020_bib18","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1128\/IAI.68.10.5509-5516.2000","article-title":"Adjuvant activity of monophosphoryl lipid A for nasal and oral immunization with soluble or liposome-associated antigen","volume":"68","author":"Childers","year":"2000","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2007.05.020_bib19","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1128\/IAI.70.6.3111-3121.2002","article-title":"Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis","volume":"70","author":"Doherty","year":"2002","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2007.05.020_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1440-1711.2005.01319.x","article-title":"ISCOM-based vaccines: the second decade","volume":"83","author":"Sanders","year":"2005","journal-title":"Immunol Cell Biol"},{"issue":"2","key":"10.1016\/j.vaccine.2007.05.020_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-0987(97)10007-0","article-title":"Binding and uptake of biodegradable poly-dl-lactide micro- and nanoparticles in intestinal epithelia","volume":"6","author":"McClean","year":"1998","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10.1016\/j.vaccine.2007.05.020_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10611860108995631","article-title":"In vivo uptake of chitosan microparticles by murine Peyer's patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry","volume":"9","author":"Van Der Lubben","year":"2001","journal-title":"J Drug Target"},{"issue":"2","key":"10.1016\/j.vaccine.2007.05.020_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1586\/14760584.2.2.269","article-title":"Microparticles as vaccine adjuvants and delivery systems","volume":"2","author":"O\u2019Hagan","year":"2003","journal-title":"Expert Rev Vaccines"},{"issue":"1","key":"10.1016\/j.vaccine.2007.05.020_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2004.01.006","article-title":"Nanoparticles with specific bioadhesive properties to circumvent the pre-systemic degradation of fluorinated pyrimidines","volume":"96","author":"Arbos","year":"2004","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.vaccine.2007.05.020_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-3659(03)00066-X","article-title":"Influence of the surface characteristics of PVM\/MA nanoparticles on their bioadhesive properties","volume":"89","author":"Arbos","year":"2003","journal-title":"J Control Release"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2007.05.020_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2005.03.033","article-title":"Salmonella-like bioadhesive nanoparticles","volume":"106","author":"Salman","year":"2005","journal-title":"J Control Release"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib27","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1128\/IAI.57.5.1419-1426.1989","article-title":"Comparative analyses of proteins extracted by hot saline or released spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis","volume":"57","author":"Gamazo","year":"1989","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2007.05.020_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1432-1033.1969.tb00601.x","article-title":"A new method for the extraction of R lipopolysaccharides","volume":"9","author":"Galanos","year":"1969","journal-title":"Eur J Biochem"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2007.05.020_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-5173(02)00182-5","article-title":"Quantification of the bioadhesive properties of protein-coated PVM\/MA nanoparticles","volume":"242","author":"Arbos","year":"2002","journal-title":"Int J Pharm"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2007.05.020_bib30","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1166\/jnn.2006.471","article-title":"Development of a novel vaccine delivery system based on Gantrez nanoparticles","volume":"6","author":"G\u00f3mez","year":"2006","journal-title":"J Nanosci Nanotechnol"},{"issue":"8","key":"10.1016\/j.vaccine.2007.05.020_bib31","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/S0021-9258(18)69851-5","article-title":"The thiobarbituric acid assay of sialic acids","volume":"234","author":"Warren","year":"1959","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.vaccine.2007.05.020_bib32","first-page":"149","article-title":"Variations in antigen-specific histamine release related with immunotherapeutic treatment","volume":"17","author":"Castillo","year":"1989","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"3","key":"10.1016\/j.vaccine.2007.05.020_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.intimp.2003.10.009","article-title":"The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis","volume":"4","author":"Watanabe","year":"2004","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1165\/ajrcmb.21.5.3755","article-title":"Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice","volume":"21","author":"Stampfli","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib35","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2222.1987.tb02039.x","article-title":"Effect of homogenization and pasteurization on the allergenicity of bovine milk analysed by a murine anaphylactic shock model","volume":"17","author":"Poulsen","year":"1987","journal-title":"Clin Allergy"},{"issue":"8","key":"10.1016\/j.vaccine.2007.05.020_bib36","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1128\/IAI.73.8.5137-5143.2005","article-title":"MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus","volume":"73","author":"Weiss","year":"2005","journal-title":"Infect Immun"},{"issue":"1\u20133","key":"10.1016\/j.vaccine.2007.05.020_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0168-3659(02)00276-6","article-title":"Modulation of the cellular immune response after oral or subcutaneous immunization with microparticles containing Brucella ovis antigens","volume":"85","author":"Murillo","year":"2002","journal-title":"J Control Release"},{"issue":"Suppl. 4","key":"10.1016\/j.vaccine.2007.05.020_bib38","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1038\/sj.ejcn.1601661","article-title":"Analysis of the intestinal microflora using molecular methods","volume":"56","author":"Tannock","year":"2002","journal-title":"Eur J Clin Nutr"},{"issue":"4","key":"10.1016\/j.vaccine.2007.05.020_bib39","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1053\/j.gastro.2004.01.007","article-title":"Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells","volume":"126","author":"Otte","year":"2004","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib40","doi-asserted-by":"crossref","first-page":"L987","DOI":"10.1152\/ajplung.00440.2005","article-title":"TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway","volume":"290","author":"Moisan","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"10.1016\/j.vaccine.2007.05.020_bib41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000091162","article-title":"Prophylactic intranasal treatment with fragments of 1,3-beta-glucanase olive pollen allergen prevents airway inflammation in a murine model of type I allergy","volume":"139","author":"Palomares","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.05.020_bib42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2249.2004.02519.x","article-title":"Influence of the route of sensitization on local and systemic immune responses in a murine model of type I allergy","volume":"137","author":"Repa","year":"2004","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.05.020_bib43","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.4049\/jimmunol.164.5.2701","article-title":"IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma","volume":"164","author":"Wild","year":"2000","journal-title":"J Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07005853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07005853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T12:22:20Z","timestamp":1628943740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07005853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":43,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0264410X07005853"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.05.020","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}