{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:02:40Z","timestamp":1790218960258,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"37-38","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.vaccine.2007.07.002","type":"journal-article","created":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T11:10:45Z","timestamp":1185275445000},"page":"6721-6729","source":"Crossref","is-referenced-by-count":83,"title":["Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB\/c mice"],"prefix":"10.1016","volume":"25","author":[{"given":"Maria Victoria","family":"Delpino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Marcela","family":"Estein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo C\u00e9sar","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Cassataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vaccine.2007.07.002_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","article-title":"An overview of human brucellosis","volume":"21","author":"Young","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2007.07.002_bib2","first-page":"147","article-title":"Vaccination against Brucella","volume":"13","author":"Nicoletti","year":"1990","journal-title":"Adv Biotechnol Processes"},{"issue":"4","key":"10.1016\/j.vaccine.2007.07.002_bib3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1128\/CDLI.3.4.472-476.1996","article-title":"Humoral immune response against lipopolysaccharide and cytoplasmic proteins of Brucella abortus in cattle vaccinated with B. abortus S19 or experimentally infected with Yersinia enterocolitica serotype 0:9","volume":"3","author":"Baldi","year":"1996","journal-title":"Clin Diagn Lab Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.07.002_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/vetres:2003037","article-title":"Rough vaccines in animal brucellosis: structural and genetic basis and present status","volume":"35","author":"Moriyon","year":"2004","journal-title":"Vet Res"},{"issue":"25\u201326","key":"10.1016\/j.vaccine.2007.07.002_bib5","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1016\/j.vaccine.2004.02.041","article-title":"Adverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51","volume":"22","author":"Ashford","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.07.002_bib6","volume":"740","author":"Joint FAO\/WHO Expert Committee on Brucellosis","year":"1986"},{"issue":"10","key":"10.1016\/j.vaccine.2007.07.002_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0264-410X(96)00018-7","article-title":"Immunization of mice with recombinant L7\/L12 ribosomal protein confers protection against Brucella abortus infection","volume":"14","author":"Oliveira","year":"1996","journal-title":"Vaccine"},{"issue":"10","key":"10.1016\/j.vaccine.2007.07.002_bib8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0264-410X(94)90035-3","article-title":"Modulation of immune responses in Balb\/c mice vaccinated with Brucella abortus Cu\u2013Zn superoxide dismutase synthetic peptide vaccine","volume":"12","author":"Tabatabai","year":"1994","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2007.07.002_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1099\/0022-1317-49-2-165","article-title":"Identification and partial characterisation of a new protective antigen of Brucella abortus","volume":"49","author":"Cespedes","year":"2000","journal-title":"J Med Microbiol"},{"issue":"8","key":"10.1016\/j.vaccine.2007.07.002_bib10","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1128\/IAI.69.8.4816-4822.2001","article-title":"Protection of BALB\/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant","volume":"69","author":"Al-Mariri","year":"2001","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.vaccine.2007.07.002_bib11","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1128\/IAI.71.10.5750-5755.2003","article-title":"Brucella lumazine synthase elicits a mixed Th1\u2013Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used","volume":"71","author":"Velikovsky","year":"2003","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2007.07.002_bib12","doi-asserted-by":"crossref","first-page":"8079","DOI":"10.1128\/IAI.73.12.8079-8088.2005","article-title":"Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection","volume":"73","author":"Cassataro","year":"2005","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2007.07.002_bib13","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1128\/IAI.73.11.7297-7303.2005","article-title":"Selection of protective epitopes for Brucella melitensis by DNA vaccination","volume":"73","author":"Yang","year":"2005","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2007.07.002_bib14","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1128\/IAI.74.5.2734-2741.2006","article-title":"Protective immunity elicited by a divalent DNA vaccine encoding both the L7\/L12 and Omp16 genes of Brucella abortus in BALB\/c mice","volume":"74","author":"Luo","year":"2006","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2007.07.002_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.vaccine.2006.07.046","article-title":"The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16 M genes","volume":"25","author":"Commander","year":"2007","journal-title":"Vaccine"},{"issue":"22","key":"10.1016\/j.vaccine.2007.07.002_bib16","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1016\/j.vaccine.2007.03.028","article-title":"A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination","volume":"25","author":"Cassataro","year":"2007","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2007.07.002_bib17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1365-2958.1996.tb02510.x","article-title":"Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes","volume":"20","author":"Kohler","year":"1996","journal-title":"Mol Microbiol"},{"issue":"2","key":"10.1016\/j.vaccine.2007.07.002_bib18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2958.2005.04674.x","article-title":"Interactions between folding factors and bacterial outer membrane proteins","volume":"57","author":"Mogensen","year":"2005","journal-title":"Mol Microbiol"},{"issue":"6","key":"10.1016\/j.vaccine.2007.07.002_bib19","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/jb.178.6.1770-1773.1996","article-title":"SurA assists the folding of Escherichia coli outer membrane proteins","volume":"178","author":"Lazar","year":"1996","journal-title":"J Bacteriol"},{"issue":"22","key":"10.1016\/j.vaccine.2007.07.002_bib20","doi-asserted-by":"crossref","first-page":"7680","DOI":"10.1128\/JB.187.22.7680-7686.2005","article-title":"Periplasmic peptidyl prolyl cis\u2013trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli","volume":"187","author":"Justice","year":"2005","journal-title":"J Bacteriol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.07.002_bib21","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1371\/journal.pbio.0040002","article-title":"Conserved and variable functions of the sigmaE stress response in related genomes","volume":"4","author":"Rhodius","year":"2006","journal-title":"PLoS Biol"},{"issue":"23","key":"10.1016\/j.vaccine.2007.07.002_bib22","doi-asserted-by":"crossref","first-page":"8739","DOI":"10.1073\/pnas.0401283101","article-title":"Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen","volume":"101","author":"Rollenhagen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 5","key":"10.1016\/j.vaccine.2007.07.002_bib23","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1099\/mic.0.28744-0","article-title":"Identification of the sigmaE regulon of Salmonella enterica serovar Typhimurium","volume":"152","author":"Skovierova","year":"2006","journal-title":"Microbiology"},{"issue":"12","key":"10.1016\/j.vaccine.2007.07.002_bib24","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1073\/pnas.85.12.4267","article-title":"Stress proteins are immune targets in leprosy and tuberculosis","volume":"85","author":"Young","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.vaccine.2007.07.002_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/1529-0131(199802)41:2<315::AID-ART16>3.0.CO;2-#","article-title":"Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis. Heat-shock protein 60 drives a major immune response","volume":"41","author":"Mertz","year":"1998","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.vaccine.2007.07.002_bib26","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.4049\/jimmunol.174.6.3306","article-title":"Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells","volume":"174","author":"Wang","year":"2005","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.vaccine.2007.07.002_bib27","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.4049\/jimmunol.168.6.2997","article-title":"Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs","volume":"168","author":"Panjwani","year":"2002","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.vaccine.2007.07.002_bib28","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1128\/IAI.64.8.2955-2961.1996","article-title":"Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12","volume":"64","author":"Noll","year":"1996","journal-title":"Infect Immun"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2007.07.002_bib29","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0264-410X(00)00237-1","article-title":"Immunity to Chlamydia pneumoniae induced by vaccination with DNA vectors expressing a cytoplasmic protein (Hsp60) or outer membrane proteins (MOMP and Omp2)","volume":"19","author":"Penttila","year":"2000","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2007.07.002_bib30","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nm0896-888","article-title":"Vaccination against tuberculosis by DNA injection","volume":"2","author":"Tascon","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.vaccine.2007.07.002_bib31","first-page":"451","article-title":"Heat shock proteins as immunological carriers and vaccines","volume":"77","author":"Suzue","year":"1996","journal-title":"Exs"},{"issue":"2","key":"10.1016\/j.vaccine.2007.07.002_bib32","first-page":"163","article-title":"A laboratory reference vaccine to titrate immunogenic activity of antibrucella vaccines in mice","volume":"14","author":"Bosseray","year":"1983","journal-title":"Ann Rech Vet"},{"issue":"1","key":"10.1016\/j.vaccine.2007.07.002_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CDLI.11.1.111-114.2004","article-title":"Antibody reactivity to Omp31 from Brucella melitensis in human and animal infections by smooth and rough Brucellae","volume":"11","author":"Cassataro","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"issue":"10","key":"10.1016\/j.vaccine.2007.07.002_bib34","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/IAI.73.10.6537-6546.2005","article-title":"A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response","volume":"73","author":"Cassataro","year":"2005","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2007.07.002_bib35","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1128\/IAI.61.11.4899-4901.1993","article-title":"Endogenous gamma interferon mediates resistance to Brucella abortus infection","volume":"61","author":"Zhan","year":"1993","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2007.07.002_bib36","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1128\/IAI.68.5.2954-2961.2000","article-title":"Characterization of heat, oxidative, and acid stress responses in Brucella melitensis","volume":"68","author":"Teixeira-Gomes","year":"2000","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2007.07.002_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mib.2003.11.001","article-title":"Organelle robbery: Brucella interactions with the endoplasmic reticulum","volume":"7","author":"Celli","year":"2004","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2007.07.002_bib38","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1073\/pnas.81.3.848","article-title":"Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous","volume":"81","author":"Bardwell","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.vaccine.2007.07.002_bib39","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.4049\/jimmunol.169.10.5622","article-title":"The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo","volume":"169","author":"Harmala","year":"2002","journal-title":"J Immunol"},{"issue":"32","key":"10.1016\/j.vaccine.2007.07.002_bib40","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1016\/j.vaccine.2007.05.049","article-title":"A DNA vaccine coding for the chimera BLSOmp31 induced a better degree of protection against B. ovis and a similar degree of protection against B. melitensis than Rev.1 vaccination","volume":"25","author":"Cassataro","year":"2007","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2007.07.002_bib41","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1128\/IAI.66.5.2093-2098.1998","article-title":"Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants","volume":"66","author":"Dagan","year":"1998","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2007.07.002_bib42","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.4049\/jimmunol.169.12.6779","article-title":"The role of T cell antagonism and original antigenic sin in genetic immunization","volume":"169","author":"Singh","year":"2002","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.07.002_bib43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1586\/14760584.2.1.129","article-title":"Contemporary approaches to designing and evaluating vaccines against Chlamydia","volume":"2","author":"Igietseme","year":"2003","journal-title":"Expert Rev Vaccines"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07007785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07007785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T09:32:27Z","timestamp":1587807147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07007785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":43,"journal-issue":{"issue":"37-38","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0264410X07007785"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.07.002","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}