{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:35:56Z","timestamp":1791304556538,"version":"4.3.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"48","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.vaccine.2007.09.020","type":"journal-article","created":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T18:00:10Z","timestamp":1191261610000},"page":"8190-8197","source":"Crossref","is-referenced-by-count":42,"title":["Immunogenicity of the recombinant leptospiral putative outer membrane proteins as vaccine candidates"],"prefix":"10.1016","volume":"25","author":[{"given":"Yung-Fu","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Sui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavan U.M.","family":"Palaniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve C.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed M.","family":"Faisal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Fu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 6","key":"10.1016\/j.vaccine.2007.09.020_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1099\/jmm.0.46486-0","article-title":"Leptospirosis-induced meningitis and acute renal failure in a 19-month-old male child","volume":"55","author":"de Souza","year":"2006","journal-title":"J Med Microbiol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.09.020_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1590\/S1413-86702007000100029","article-title":"Pathology and pathophysiology of pulmonary manifestations in leptospirosis","volume":"11","author":"Dolhnikoff","year":"2007","journal-title":"Braz J Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2007.09.020_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/MCP.0b013e3280f9df74","article-title":"Leptospiral pneumonias","volume":"13","author":"Dolhnikoff","year":"2007","journal-title":"Curr Opin Pulm Med"},{"issue":"1","key":"10.1016\/j.vaccine.2007.09.020_bib4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1053\/snep.2003.50004","article-title":"Leptospiral nephropathy","volume":"23","author":"Sitprija","year":"2003","journal-title":"Semin Nephrol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.09.020_bib5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1439-0442.2007.00921.x","article-title":"Recurrent uveitis in horses: vitreal examinations with ultrastructural detection of leptospires","volume":"54","author":"Brandes","year":"2007","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"issue":"9","key":"10.1016\/j.vaccine.2007.09.020_bib6","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2460\/javma.1992.201.09.1391","article-title":"Renal dysfunction associated with infection of Leptospira interrogans in a horse","volume":"201","author":"Divers","year":"1992","journal-title":"J Am Vet Med Assoc"},{"issue":"3","key":"10.1016\/j.vaccine.2007.09.020_bib7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0749-0739(17)30088-3","article-title":"Emergent causes of placentitis and abortion","volume":"16","author":"Donahue","year":"2000","journal-title":"Vet Clin North Am Equine Pract"},{"issue":"4","key":"10.1016\/j.vaccine.2007.09.020_bib8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/104063879300500410","article-title":"Equine abortion and stillbirth in central Kentucky during 1988 and 1989 foaling seasons","volume":"5","author":"Hong","year":"1993","journal-title":"J Vet Diagn Invest"},{"issue":"1","key":"10.1016\/j.vaccine.2007.09.020_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1090-0233(97)80011-1","article-title":"Detection of an antigenic protein of Leptospira interrogans which shares epitopes with the equine cornea and lens","volume":"153","author":"Parma","year":"1997","journal-title":"Vet J"},{"issue":"11","key":"10.1016\/j.vaccine.2007.09.020_bib10","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1128\/IAI.73.11.7259-7266.2005","article-title":"LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis","volume":"73","author":"Verma","year":"2005","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2007.09.020_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/vr.153.6.165","article-title":"Comparison of the efficacy of three commercial bacterins in preventing canine leptospirosis","volume":"153","author":"Andre-Fontaine","year":"2003","journal-title":"Vet Rec"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2007.09.020_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.vetmic.2005.03.007","article-title":"Prevention of renal infection and urinary shedding in dogs by a Leptospira vaccination","volume":"108","author":"Schreiber","year":"2005","journal-title":"Vet Microbiol"},{"issue":"1","key":"10.1016\/j.vaccine.2007.09.020_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9394(14)71646-0","article-title":"Uveitis associated with an epidemic outbreak of leptospirosis","volume":"124","author":"Rathinam","year":"1997","journal-title":"Am J Ophthalmol"},{"issue":"5645","key":"10.1016\/j.vaccine.2007.09.020_bib14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1126\/science.1092329","article-title":"Reverse vaccinology and genomics","volume":"302","author":"Rappuoli","year":"2003","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.vaccine.2007.09.020_bib15","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1128\/IAI.70.11.5924-5930.2002","article-title":"Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogans","volume":"70","author":"Palaniappan","year":"2002","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.vaccine.2007.09.020_bib16","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1128\/IAI.73.7.4062-4069.2005","article-title":"Protection against Leptospira interrogans sensu lato challenge by DNA immunization with the gene encoding hemolysin-associated protein 1","volume":"73","author":"Branger","year":"2005","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2007.09.020_bib17","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1128\/IAI.69.11.6831-6838.2001","article-title":"Identification of the hemolysis-associated protein 1 as a cross-protective immunogen of Leptospira interrogans by adenovirus-mediated vaccination","volume":"69","author":"Branger","year":"2001","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2007.09.020_bib18","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1128\/IAI.70.5.2311-2318.2002","article-title":"Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai","volume":"70","author":"Cullen","year":"2002","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2007.09.020_bib19","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1128\/IAI.67.12.6572-6582.1999","article-title":"Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection","volume":"67","author":"Haake","year":"1999","journal-title":"Infect Immun"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2007.09.020_bib20","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.vaccine.2003.10.007","article-title":"Leptospiral immunoglobulin-like proteins elicit protective immunity","volume":"22","author":"Koizumi","year":"2004","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2007.09.020_bib21","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1128\/IAI.74.3.1745-1750.2006","article-title":"Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infection","volume":"74","author":"Palaniappan","year":"2006","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2007.09.020_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1348-0421.2003.tb03400.x","article-title":"Probable laboratory contamination of clinical specimens with Leptospira meyeri","volume":"47","author":"Koizumi","year":"2003","journal-title":"Microbiol Immunol"},{"issue":"33","key":"10.1016\/j.vaccine.2007.09.020_bib23","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1016\/j.vaccine.2007.05.053","article-title":"The terminal portion of leptospiral immunoglobulin-like protien A confers protective immunity against lethal infection in the hamster model of leptospirosis","volume":"25","author":"Silva","year":"2007","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2007.09.020_bib24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1139\/w06-138","article-title":"Evaluation of different ways of presenting LipL32 to the immune system with the aim of developing a recombinant vaccine against leptospirosis","volume":"53","author":"Seixas","year":"2007","journal-title":"Can J Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2007.09.020_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"issue":"Pt 10","key":"10.1016\/j.vaccine.2007.09.020_bib26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1099\/jmm.0.45568-0","article-title":"Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISA","volume":"53","author":"Palaniappan","year":"2004","journal-title":"J Med Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2007.09.020_bib27","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1128\/IAI.61.5.2089-2095.1993","article-title":"Molecular characterization of a leukotoxin gene from a Pasteurella haemolytica-like organism, encoding a new member of the RTX toxin family","volume":"61","author":"Chang","year":"1993","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.vaccine.2007.09.020_bib28","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1128\/IAI.63.9.3543-3549.1995","article-title":"Recombinant OspA protects dogs against infection and disease caused by Borrelia burgdorferi","volume":"63","author":"Chang","year":"1995","journal-title":"Infect Immun"},{"issue":"5\u20136","key":"10.1016\/j.vaccine.2007.09.020_bib29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0264-410X(99)00187-5","article-title":"Vaccination against lyme disease with recombinant Borrelia burgdorferi outer-surface protein A (rOspA) in horses","volume":"18","author":"Chang","year":"1999","journal-title":"Vaccine"},{"issue":"5127","key":"10.1016\/j.vaccine.2007.09.020_bib30","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1126\/science.8367727","article-title":"Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells","volume":"261","author":"Arruda","year":"1993","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.vaccine.2007.09.020_bib31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.femsle.2005.02.004","article-title":"Whole-genome analysis of Leptospira interrogans to identify potential vaccine candidates against leptospirosis","volume":"244","author":"Gamberini","year":"2005","journal-title":"FEMS Microbiol Lett"},{"issue":"4","key":"10.1016\/j.vaccine.2007.09.020_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1462-5822.2001.00110.x","article-title":"Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry","volume":"3","author":"Chitale","year":"2001","journal-title":"Cell Microbiol"},{"issue":"2","key":"10.1016\/j.vaccine.2007.09.020_bib33","first-page":"165","article-title":"Pathologic-clinical characterization of leptospirosis in a golden Syrian hamster model","volume":"25","author":"Oliva","year":"1994","journal-title":"Arch Med Res"},{"issue":"1","key":"10.1016\/j.vaccine.2007.09.020_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/00480169.1995.35833","article-title":"The epidemiology of Leptospira interrogans serovar Pomona in grower pig herds","volume":"43","author":"Bolt","year":"1995","journal-title":"N Z Vet J"},{"issue":"3","key":"10.1016\/j.vaccine.2007.09.020_bib35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3201\/eid1203.050809","article-title":"Canine leptospirosis, United States, 2002\u20132004","volume":"12","author":"Moore","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2007.09.020_bib36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0165-2427(00)00247-6","article-title":"Antibody isotypes in sera of equine fetuses aborted due to Leptospira interrogans serovar Pomona-type kennewicki infection","volume":"77","author":"Sheoran","year":"2000","journal-title":"Vet Immunol Immunopathol"},{"issue":"3","key":"10.1016\/j.vaccine.2007.09.020_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/153036603768395843","article-title":"Prevalence of leptospiral infection in Texas cattle: implications for transmission to humans","volume":"3","author":"Talpada","year":"2003","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"712","key":"10.1016\/j.vaccine.2007.09.020_bib38","first-page":"494","article-title":"The occupational hazards of leptospirosis in the meat industry","volume":"95","author":"Blackmore","year":"1982","journal-title":"N Z Med J"},{"issue":"10","key":"10.1016\/j.vaccine.2007.09.020_bib39","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00063-002-1202-4","article-title":"Leptospirosis as a differential diagnosis of acute renal failure","volume":"97","author":"Brueck","year":"2002","journal-title":"Med Klin (Munich)"},{"issue":"5","key":"10.1016\/j.vaccine.2007.09.020_bib40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2460\/javma.2000.216.676","article-title":"Analysis of the 1998 outbreak of leptospirosis in Missouri in humans exposed to infected swine","volume":"216","author":"Campagnolo","year":"2000","journal-title":"J Am Vet Med Assoc"},{"issue":"707","key":"10.1016\/j.vaccine.2007.09.020_bib41","first-page":"299","article-title":"Leptospirosis of pig farmers: the results of a serological survey","volume":"95","author":"Schollum","year":"1982","journal-title":"N Z Med J"},{"issue":"11","key":"10.1016\/j.vaccine.2007.09.020_bib42","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1128\/IAI.70.11.6147-6157.2002","article-title":"Evaluation of type 1 immune response in naive and vaccinated animals following challenge with Leptospira borgpetersenii serovar Hardjo: involvement of WC1(+) gammadelta and CD4 T cells","volume":"70","author":"Naiman","year":"2002","journal-title":"Infect Immun"},{"issue":"15","key":"10.1016\/j.vaccine.2007.09.020_bib43","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.vaccine.2006.12.023","article-title":"Predicted epitopes of Lig A of Leptospira interrogans by bioinformatics method: a clue for further vaccine development","volume":"25","author":"Wiwanitkit","year":"2007","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07010420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07010420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T08:12:05Z","timestamp":1708243925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07010420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":43,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0264410X07010420"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.09.020","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}