{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:31:37Z","timestamp":1783031497704,"version":"3.54.6"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.vaccine.2007.11.044","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T17:06:25Z","timestamp":1196960785000},"page":"677-685","source":"Crossref","is-referenced-by-count":29,"title":["Immunization with the cysteine proteinase Ldccys1 gene from Leishmania (Leishmania) chagasi and the recombinant Ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis"],"prefix":"10.1016","volume":"26","author":[{"given":"Josie Hayd\u00e9e L.","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Girotto","family":"Gentil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Souza","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo C.","family":"Fedeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara L\u00facia","family":"Barbi\u00e9ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2007.11.044_bib1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0169-4758(00)01637-9","article-title":"The strange case of Leishmania chagasi","volume":"16","author":"Mauricio","year":"2000","journal-title":"Parasitol Today"},{"key":"10.1016\/j.vaccine.2007.11.044_bib2","unstructured":"World Health Organization. Leishmaniasis. Fourteenth Program Report. UNDP\/World Bank\/Special Program for Research and Training in Tropical Diseases (TDR). Tropical Disease Research Progress 1997\u20131998. Geneva: World Health Organization; 1999, p. 1\u20136."},{"key":"10.1016\/j.vaccine.2007.11.044_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3201\/eid0202.960213","article-title":"The reemergence of visceral leishmaniasis in Brazil","volume":"2","author":"Arias","year":"1996","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1198-743x.2001.00262.x","article-title":"HIV-associated visceral leishmaniasis","volume":"7","author":"Pintado","year":"2000","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.vaccine.2007.11.044_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/infdis\/165.3.535","article-title":"Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi","volume":"165","author":"Carvalho","year":"1992","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib6","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4049\/jimmunol.146.8.2763","article-title":"Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis","volume":"146","author":"Kaye","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib7","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/infdis\/161.5.992","article-title":"Effect of continuous administration of interferon-\u03b3 in experimental visceral leishmaniasis","volume":"161","author":"Murray","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib8","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.4049\/jimmunol.138.7.2290","article-title":"Experimental visceral leishmaniasis: production of interleukin 2 and interferon-\u03b3, tissue immune reaction, and response to treatment with interleukin 2 and interferon-\u03b3","volume":"138","author":"Murray","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib9","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.143.12.4244","article-title":"Experimental visceral leishmaniasis: role of endogenous IFN-\u03b3 in host defense and tissue granulomatous response","volume":"143","author":"Squires","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib10","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/IAI.63.5.2062-2069.1995","article-title":"A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice","volume":"63","author":"Wilson","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0264-410X(00)00207-3","article-title":"Immunization with recombinant LD1 antigens protects against experimental leishmaniasis","volume":"19","author":"Dole","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4049\/jimmunol.144.2.699","article-title":"Characterization of two proteins from Leishmania donovani and their use for vaccination against visceral leishmaniasis","volume":"144","author":"Jaffe","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib13","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.4049\/jimmunol.147.10.3538","article-title":"The Leishmania donovani lipophosphoglycan T lymphocyte-reactive component is a tightly associated protein complex","volume":"147","author":"Jardim","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib14","first-page":"547","article-title":"Experimental murine Leishmania donovani infection: immunoprotection by the fucose-mannose ligand (FML)","volume":"27","author":"Palatnik-de-Sousa","year":"1994","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.vaccine.2007.11.044_bib15","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1016\/S0264-410X(01)00031-7","article-title":"Vaccination of BALB\/c mice against experimental visceral leishmaniasis with the GP36 glycoprotein antigen of Leishmania donovani","volume":"19","author":"Paraguai de Souza","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib16","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1016\/S0264-410X(02)00302-X","article-title":"Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL\u00aeadjuvant","volume":"20","author":"Skeiky","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib17","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.4049\/jimmunol.161.11.6171","article-title":"LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile","volume":"161","author":"Skeiky","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib18","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.4049\/jimmunol.165.12.7064","article-title":"Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis","volume":"165","author":"St\u00e4ger","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/expr.1999.4459","article-title":"BCG expressing LCR1 of Leishmania chagasi induces protective immunity in susceptible mice","volume":"94","author":"Streit","year":"2000","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib20","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/4000","article-title":"Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection","volume":"4","author":"Gurunathan","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.vaccine.2007.11.044_bib21","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.186.7.1137","article-title":"Vaccination with DNA encoding the immunodominat LACK parasite antigen confers protective immunity to mice infected with Leishmania major","volume":"186","author":"Gurunathan","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2007.11.044_bib22","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/S0264-410X(98)00075-9","article-title":"Vaccination with recombinant parasitic surface antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection","volume":"16","author":"Sjolander","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib23","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1089\/hum.1998.9.13-1899","article-title":"Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis","volume":"9","author":"Walker","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.vaccine.2007.11.044_bib24","first-page":"173","article-title":"Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major","volume":"84","author":"Xu","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.vaccine.2007.11.044_bib25","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0264-410X(01)00427-3","article-title":"A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36\/LACK antigen protects BALB\/c mice from cutaneous leishmaniasis","volume":"20","author":"Gonzalo","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib26","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1128\/IAI.72.8.4924-4928.2004","article-title":"DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination biases towards T helper 1 responses and enhances protection against Leishmania major infection in mice","volume":"72","author":"Lange","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib27","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1086\/430348","article-title":"A heterologous prime-boost vaccination regimen using ORFF DNA and recombinant ORFF protein confers protective immunity against experimental visceral leishmaniasis","volume":"191","author":"Tewary","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib28","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1128\/IAI.65.6.2052-2059.1997","article-title":"Characterization of an antigen from Leishmania amazonensis amastigotes able to elicit protective responses in a murine model","volume":"65","author":"Beyrodt","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0020-7519(00)00037-0","article-title":"Identification of a 30kDa antigen from Leishmania (L.) chagasi amastigotes implicated in protective cellular responses in a murine model","volume":"30","author":"Pinto","year":"2000","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib30","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/S0264-410X(01)00081-0","article-title":"A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major","volume":"19","author":"Rafati","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib31","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.vaccine.2005.11.011","article-title":"Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis","volume":"24","author":"Rafati","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib32","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1016\/j.vaccine.2005.02.009","article-title":"Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinase type I and II of L. infantum","volume":"23","author":"Rafati","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib33","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1128\/IAI.73.6.3787-3789.2005","article-title":"Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses","volume":"73","author":"Pinheiro","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.2005.72.126","article-title":"A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis","volume":"72","author":"Dias","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2007.11.044_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0014-4894(90)90024-7","article-title":"Lysosomal depletion in macrophages from spleen and foot lesions of Leishmania-infected hamster","volume":"71","author":"Barbi\u00e9ri","year":"1990","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib36","series-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.vaccine.2007.11.044_bib37","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1128\/AAC.39.9.2167","article-title":"Culture microtitration: a sensitive method for quantifying Leishmania infantum in tissues of infected mice","volume":"39","author":"Buffet","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.vaccine.2007.11.044_bib38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0264-410X(01)00322-X","article-title":"Immunization with A2 protein results in a mixed Th1\/Th2 and a humoral response which protects mice against Leishmania donovani infections","volume":"20","author":"Ghosh","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-2427(02)00315-X","article-title":"A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum","volume":"92","author":"Molano","year":"2003","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0264-410X(02)00444-9","article-title":"Saponins, IL-12 and BCG adjuvant in the FML-vaccine formulation against murine visceral leishmaniasis","volume":"21","author":"Santos","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib41","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1128\/IAI.62.3.1058-1063.1994","article-title":"Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis","volume":"62","author":"Miralles","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-3083.1993.tb01751.x","article-title":"Immunobiological studies on experimental visceral leishmaniasis. III. Cytokine-mediated regulation of parasite replication","volume":"37","author":"Saha","year":"1993","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.exppara.2006.09.013","article-title":"Leishmania infantum: mixed T-helper-1\/T-helper-2 immune response in experimentally infected BALB\/c mice","volume":"115","author":"Rol\u00e3o","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib44","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.4049\/jimmunol.156.6.2231","article-title":"Local suppression of IFN-gamma in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi","volume":"156","author":"Wilson","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1172\/JCI116570","article-title":"Interleukin 10 production correlates with pathology in human Leishmania donovani infections","volume":"92","author":"Ghalib","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2007.11.044_bib46","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1172\/JCI116372","article-title":"In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma","volume":"91","author":"Karp","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2007.11.044_bib47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/IAI.66.1.18-27.1998","article-title":"Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani","volume":"66","author":"Melby","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib48","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1002\/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T","article-title":"IL-10 mediates susceptibility to Leishmania donovani infection","volume":"31","author":"Murphy","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib49","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1086\/376510","article-title":"Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis","volume":"188","author":"Murray","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib50","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1128\/IAI.70.11.6284-6293.2002","article-title":"Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy","volume":"70","author":"Murray","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00436-005-0008-8","article-title":"Intramuscular immunization with p36(LACK) DNA vaccine induces IFN-\u03b3 production but does not protect BALB\/c mice against Leishmania chagasi intravenous challenge","volume":"98","author":"Marques-da-Silva","year":"2005","journal-title":"Parasitol Res"},{"key":"10.1016\/j.vaccine.2007.11.044_bib52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-4017(00)00312-5","article-title":"Infection of a canine macrophage cell line with Leishmania infantum: determination of nitric oxide production and anti-leishmanial activity","volume":"2","author":"Pinelli","year":"2000","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0147-9571(00)00026-6","article-title":"Nitric oxide production by macrophages of dogs vaccinated with killed Leishmania infantum promastigotes","volume":"24","author":"Panaro","year":"2001","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s005990050076","article-title":"Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide","volume":"29","author":"Panaro","year":"1999","journal-title":"Int J Clin Lab Res"},{"key":"10.1016\/j.vaccine.2007.11.044_bib55","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4049\/jimmunol.167.2.893","article-title":"Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi","volume":"167","author":"Gantt","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0264-410X(96)00101-6","article-title":"Characterization of humoral immune responses induced by an influenza hemagglutinin DNA vaccine","volume":"15","author":"Deck","year":"1997","journal-title":"Vaccine"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2007.11.044_bib57","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1086\/514176","article-title":"DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs","volume":"176","author":"Robinson","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2007.11.044_bib58","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1128\/IAI.73.8.5286-5289.2005","article-title":"Heterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis","volume":"73","author":"Dondji","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2007.11.044_bib59","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1084\/jem.184.4.1555","article-title":"Gene vaccination with naked plasmid DNA: mechanism of CTL priming","volume":"184","author":"Corr","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2007.11.044_bib60","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.140.11.3971","article-title":"Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis","volume":"140","author":"Stern","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib61","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.0141-9838.2004.00672.x","article-title":"CD8 (+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis","volume":"25","author":"Tsagozis","year":"2003","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.vaccine.2007.11.044_bib62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.parint.2005.02.005","article-title":"Function of CD8+ T lymphocytes in a self-curing mouse model of visceral leishmaniasis","volume":"54","author":"Tsagozis","year":"2005","journal-title":"Parasitol Int"},{"key":"10.1016\/j.vaccine.2007.11.044_bib63","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/S0264-410X(03)00032-X","article-title":"Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK","volume":"21","author":"Ramiro","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2007.11.044_bib64","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1084\/jem.20020147","article-title":"Vaccination with heat-killed Leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-trem memory CD4+ and CD8+ T cell responses and protection against Leishmania major infection","volume":"195","author":"Rhee","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2007.11.044_bib65","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1590\/S0100-879X2004000400020","article-title":"Immunity and immunosupression in experimental visceral leishmaniasis","volume":"37","author":"Goto","year":"2004","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.vaccine.2007.11.044_bib66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.micpath.2004.11.002","article-title":"Immunopathogenesis of infection with the visceralizing Leishmania species","volume":"38","author":"Wilson","year":"2005","journal-title":"Microb Pathog"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07013473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X07013473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T04:56:15Z","timestamp":1684126575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X07013473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0264410X07013473"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2007.11.044","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}