{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:54:56Z","timestamp":1791179696861,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.vaccine.2008.05.075","type":"journal-article","created":{"date-parts":[[2008,6,14]],"date-time":"2008-06-14T08:57:30Z","timestamp":1213433850000},"page":"4150-4159","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of St. Louis encephalitis virus\/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys"],"prefix":"10.1016","volume":"26","author":[{"suffix":"Jr.","given":"Joseph E.","family":"Blaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Speicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj S.","family":"Sathe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Pletnev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2008.05.075_bib1","series-title":"Fields virology","first-page":"1043","article-title":"Flaviviridae: the viruses and their replication","author":"Lindenbach","year":"2001"},{"key":"10.1016\/j.vaccine.2008.05.075_bib2","series-title":"St. Louis encephalitis","author":"Monath","year":"1980"},{"issue":"August (1)","key":"10.1016\/j.vaccine.2008.05.075_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1017\/S0950268899004227","article-title":"Epidemiological features of and public health response to a St. Louis encephalitis epidemic in Florida, 1990\u20131","volume":"125","author":"Meehan","year":"2000","journal-title":"Epidemiol Infect"},{"issue":"11","key":"10.1016\/j.vaccine.2008.05.075_bib4","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3201\/eid1211.060486","article-title":"Genotype III Saint Louis encephalitis virus outbreak, Argentina, 2005","volume":"12","author":"Diaz","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2008.05.075_bib5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3201\/eid1301.060905","article-title":"Saint Louis encephalitis virus, Brazil","volume":"13","author":"Mondini","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2008.05.075_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-3527(03)61004-3","article-title":"Epidemiology of St. Louis encephalitis virus","volume":"61","author":"Reisen","year":"2003","journal-title":"Adv Virus Res"},{"key":"10.1016\/j.vaccine.2008.05.075_bib7","series-title":"Fields virology","first-page":"1043","article-title":"Flaviviruses","author":"Burke","year":"2001"},{"issue":"5","key":"10.1016\/j.vaccine.2008.05.075_bib8","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1073\/pnas.022652799","article-title":"West Nile virus\/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy","volume":"99","author":"Pletnev","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"September (1)","key":"10.1016\/j.vaccine.2008.05.075_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0042-6822(03)00450-1","article-title":"Molecularly engineered live-attenuated chimeric West Nile\/dengue virus vaccines protect rhesus monkeys from West Nile virus","volume":"314","author":"Pletnev","year":"2003","journal-title":"Virology"},{"issue":"September (40\u201341)","key":"10.1016\/j.vaccine.2008.05.075_bib10","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1016\/j.vaccine.2006.06.008","article-title":"Chimeric West Nile\/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity","volume":"24","author":"Pletnev","year":"2006","journal-title":"Vaccine"},{"issue":"Springs (1)","key":"10.1016\/j.vaccine.2008.05.075_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/vbz.2005.5.1","article-title":"Infectivity of West Nile\/dengue chimeric viruses for West Nile and dengue mosquito vectors","volume":"5","author":"Hanley","year":"2005","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2008.05.075_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3201\/eid0803.010238","article-title":"Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis","volume":"8","author":"Tesh","year":"2002","journal-title":"Emerg Inf Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2008.05.075_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4269\/ajtmh.2006.75.480","article-title":"Previous infection with West Nile or St. Louis encephalitis viruses provides cross protection during reinfection in house finches","volume":"75","author":"Fang","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2008.05.075_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1128\/JVI.76.2.525-531.2002","article-title":"Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes","volume":"76","author":"Hanley","year":"2002","journal-title":"J Virol"},{"issue":"November (21)","key":"10.1016\/j.vaccine.2008.05.075_bib15","doi-asserted-by":"crossref","first-page":"10532","DOI":"10.1073\/pnas.89.21.10532","article-title":"Construction and characterization of chimeric tick-borne encephalitis\/dengue type 4 viruses","volume":"89","author":"Pletnev","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.vaccine.2008.05.075_bib16","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1073\/pnas.95.4.1746","article-title":"Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4","volume":"95","author":"Pletnev","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"October (27\u201328)","key":"10.1016\/j.vaccine.2008.05.075_bib17","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1016\/S0264-410X(03)00487-0","article-title":"Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2\/4 vaccine candidate in Vero cells","volume":"21","author":"Blaney","year":"2003","journal-title":"Vaccine"},{"issue":"April (15\u201316)","key":"10.1016\/j.vaccine.2008.05.075_bib18","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0264-410X(98)00487-3","volume":"17","author":"Monath","year":"1999","journal-title":"Vaccine"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2008.05.075_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vaccine.2005.07.067","article-title":"Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys","volume":"24","author":"Rumyantsev","year":"2006","journal-title":"Vaccine"},{"issue":"October (27\u201328)","key":"10.1016\/j.vaccine.2008.05.075_bib20","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1016\/S0264-410X(03)00488-2","article-title":"Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys","volume":"21","author":"Whitehead","year":"2003","journal-title":"Vaccine"},{"issue":"September (17)","key":"10.1016\/j.vaccine.2008.05.075_bib21","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1128\/JVI.75.17.8259-8267.2001","article-title":"Tick-borne Langat\/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: evaluation in rhesus monkeys and in mosquitoes","volume":"75","author":"Pletnev","year":"2001","journal-title":"J Virol"},{"issue":"22","key":"10.1016\/j.vaccine.2008.05.075_bib22","doi-asserted-by":"crossref","first-page":"10342","DOI":"10.1073\/pnas.88.22.10342","article-title":"Construction of intertypic chimeric dengue viruses by substitution of structural protein genes","volume":"88","author":"Bray","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"10.1016\/j.vaccine.2008.05.075_bib23","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1128\/JVI.74.12.5477-5485.2000","article-title":"Recombinant chimeric yellow fever-dengue type 2 virus is immunogenic and protective in nonhuman primates","volume":"74","author":"Guirakhoo","year":"2000","journal-title":"J Virol"},{"issue":"November (21)","key":"10.1016\/j.vaccine.2008.05.075_bib24","doi-asserted-by":"crossref","first-page":"11436","DOI":"10.1128\/JVI.77.21.11436-11447.2003","article-title":"Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development","volume":"77","author":"Huang","year":"2003","journal-title":"J Virol"},{"issue":"November (Pt 11)","key":"10.1016\/j.vaccine.2008.05.075_bib25","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1099\/vir.0.81909-0","article-title":"Chimeric Japanese encephalitis virus\/dengue 2 virus infectious clone: biological properties, immunogenicity and protection against dengue encephalitis in mice","volume":"87","author":"Chambers","year":"2006","journal-title":"J Gen Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2008.05.075_bib26","doi-asserted-by":"crossref","first-page":"639","DOI":"10.4269\/ajtmh.2004.71.639","article-title":"Construction of yellow fever\/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool","volume":"71","author":"Pugachev","year":"2004","journal-title":"Am J Trop Med Hyg"},{"issue":"9","key":"10.1016\/j.vaccine.2008.05.075_bib27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1086\/378356","article-title":"Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen","volume":"188","author":"Monath","year":"2003","journal-title":"J Infect Dis"},{"issue":"November (6)","key":"10.1016\/j.vaccine.2008.05.075_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/hv.2.6.3494","article-title":"Whitehead SS. rDEN2\/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naive adults","volume":"2","author":"Durbin","year":"2006","journal-title":"Hum Vaccines"},{"issue":"March\u2013April (2)","key":"10.1016\/j.vaccine.2008.05.075_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4161\/hv.2.2.2555","article-title":"Live attenuated chimeric yellow fever dengue type 2 (ChimeriVax-DEN2) vaccine: phase I clinical trial for safety and immunogenicity: effect of yellow fever pre-immunity in induction of cross neutralizing antibody responses to all 4 dengue serotypes","volume":"2","author":"Guirakhoo","year":"2006","journal-title":"Hum. Vaccines"},{"issue":"April (17)","key":"10.1016\/j.vaccine.2008.05.075_bib30","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1073\/pnas.0601932103","article-title":"A live, attenuated recombinant West Nile virus vaccine","volume":"103","author":"Monath","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.vaccine.2008.05.075_bib31","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.vaccine.2007.12.015","article-title":"Evaluation of the Langat\/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers","volume":"26","author":"Wright","year":"2008","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2008.05.075_bib32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.4269\/ajtmh.2004.71.811","article-title":"Genetically modified, live attenuated dengue virus type 3 vaccine candidates","volume":"71","author":"Blaney","year":"2004","journal-title":"Am J Trop Med Hyg"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2008.05.075_bib33","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1128\/JVI.67.8.4956-4963.1993","article-title":"Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice","volume":"67","author":"Pletnev","year":"1993","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2008.05.075_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1743-422X-4-23","article-title":"Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1","volume":"4","author":"Blaney","year":"2007","journal-title":"Virol J"},{"issue":"4","key":"10.1016\/j.vaccine.2008.05.075_bib35","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1128\/JVI.73.4.3095-3101.1999","article-title":"Yellow fever\/Japanese encephalitis chimeric viruses: construction and biological properties","volume":"73","author":"Chambers","year":"1999","journal-title":"J Virol"},{"issue":"7","key":"10.1016\/j.vaccine.2008.05.075_bib36","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1128\/JVI.74.7.3020-3028.2000","article-title":"Chimeric dengue type 2 (vaccine strain PDK-53)\/dengue type 1 virus as a potential candidate dengue type 1 virus vaccine","volume":"74","author":"Huang","year":"2000","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2008.05.075_bib37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4269\/ajtmh.2001.65.405","article-title":"Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3\u2032-untranslated region","volume":"65","author":"Durbin","year":"2001","journal-title":"Am J Trop Med Hyg"},{"issue":"Spring (1)","key":"10.1016\/j.vaccine.2008.05.075_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/vim.2006.19.10","article-title":"Development of a live attenuated dengue virus vaccine using reverse genetics","volume":"19","author":"Blaney","year":"2006","journal-title":"Viral Immunol"},{"issue":"11","key":"10.1016\/j.vaccine.2008.05.075_bib39","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1128\/JVI.00172-08","article-title":"Comparative neuropathogenesis and neurovirulence of attenuated flaviviruses in non-human primates","volume":"82","author":"Maximova","year":"2008","journal-title":"J Virol"},{"issue":"Pt 12","key":"10.1016\/j.vaccine.2008.05.075_bib40","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1099\/0022-1317-74-12-2653","article-title":"Molecular and biological characterization of a non-glycosylated isolate of St. Louis encephalitis virus","volume":"74","author":"Vorndam","year":"1993","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2008.05.075_bib41","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1099\/0022-1317-79-10-2375","article-title":"West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neurovirulence","volume":"79","author":"Chambers","year":"1998","journal-title":"J Gen Virol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08006907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08006907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T09:58:08Z","timestamp":1588759088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X08006907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":41,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0264410X08006907"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2008.05.075","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}