{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:36:57Z","timestamp":1757777817198},"reference-count":46,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.vaccine.2008.08.028","type":"journal-article","created":{"date-parts":[[2008,9,27]],"date-time":"2008-09-27T05:38:30Z","timestamp":1222493910000},"page":"5791-5797","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of different formulations of oral Mycobacterium bovis Bacille Calmette-Gu\u00e9rin (BCG) vaccine in rodent models for immunogenicity and protection against aerosol challenge with M. bovis"],"prefix":"10.1016","volume":"26","author":[{"given":"Simon","family":"Clark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin L.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Court","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Vipond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Nadian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Glyn","family":"Hewinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah K.","family":"Batchelor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Perrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E.","family":"Aldwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2008.08.028_bib1","unstructured":"Anon. Animal Health 2006. The report of the Chief Veterinary Officer. London: Department for Environment, Food and Rural Affairs; 2007."},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2008.08.028_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1054\/tube.2000.0256","article-title":"Cattle-to-cattle transmission of Mycobacterium bovis","volume":"81","author":"Goodchild","year":"2001","journal-title":"Tuberculosis (Edinb)"},{"issue":"6968","key":"10.1016\/j.vaccine.2008.08.028_bib3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature02192","article-title":"Impact of localized badger culling on tuberculosis incidence in British cattle","volume":"426","author":"Donnelly","year":"2003","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.vaccine.2008.08.028_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.prevetmed.2004.10.009","article-title":"The impact of badger removal on the control of tuberculosis in cattle herds in Ireland","volume":"67","author":"Griffin","year":"2005","journal-title":"Prev Vet Med"},{"issue":"7078","key":"10.1016\/j.vaccine.2008.08.028_bib5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature04454","article-title":"Positive and negative effects of widespread badger culling on tuberculosis in cattle","volume":"439","author":"Donnelly","year":"2006","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.vaccine.2008.08.028_bib6","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/vr.160.12.416-b","article-title":"Attitudes to badger culling","volume":"160","author":"Coles","year":"2007","journal-title":"Vet Rec"},{"issue":"4","key":"10.1016\/j.vaccine.2008.08.028_bib7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijid.2007.04.001","article-title":"Impacts of widespread badger culling on cattle tuberculosis: concluding analyses from a large-scale field trial","volume":"11","author":"Donnelly","year":"2007","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.vaccine.2008.08.028_bib8","unstructured":"Anon. Development of vaccines for bovine tuberculosis. Towards a sustainable policy to control TB in cattle. London: Department for Environment, Food and Rural Affairs; 2003."},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.028_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1586\/14760584.6.3.323","article-title":"Oral vaccination against bovine tuberculosis with Mycobacterium bovis BCG","volume":"6","author":"Cross","year":"2007","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2008.08.028_bib10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.tvjl.2006.10.005","article-title":"The potential of oral vaccines for disease control in wildlife species","volume":"174","author":"Cross","year":"2006","journal-title":"Vet J"},{"key":"10.1016\/j.vaccine.2008.08.028_bib11","first-page":"228","article-title":"Viability and multiplication of vaccines in immunization against tuberculosis","volume":"71","author":"Bloch","year":"1955","journal-title":"Am Rev Tuberc Pulm Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.028_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.rvsc.2004.07.007","article-title":"Improving protective efficacy of BCG vaccination for wildlife against bovine tuberculosis","volume":"78","author":"Skinner","year":"2005","journal-title":"Res Vet Sci"},{"issue":"4","key":"10.1016\/j.vaccine.2008.08.028_bib13","first-page":"377","article-title":"Intraduodenal vaccination of brushtail possums with bacille Calmette-Guerin enhances immune responses and protection against Mycobacterium bovis infection","volume":"1","author":"Buddle","year":"1997","journal-title":"Int J Tuberc Lung Dis"},{"issue":"7","key":"10.1016\/j.vaccine.2008.08.028_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/00480169.\/1995.35920","article-title":"Route of BCG administration in possums affects protection against bovine tuberculosis","volume":"43","author":"Aldwell","year":"1995","journal-title":"N Z Vet J"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.028_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1128\/IAI.71.1.101-108.2003","article-title":"Oral delivery of Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in mice","volume":"71","author":"Aldwell","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.028_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0264-410X(03)00539-5","article-title":"Oral vaccination with Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in brushtail possums","volume":"22","author":"Aldwell","year":"2003","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.028_bib17","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1128\/IAI.73.3.1903-1905.2005","article-title":"Mice fed lipid-encapsulated Mycobacterium bovis BCG are protected against aerosol challenge with Mycobacterium tuberculosis","volume":"73","author":"Aldwell","year":"2005","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2008.08.028_bib18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1440-1711.2005.01369.x","article-title":"Oral vaccination of mice with lipid-encapsulated Mycobacterium bovis BCG: anatomical sites of bacterial replication and immune activity","volume":"83","author":"Aldwell","year":"2005","journal-title":"Immunol Cell Biol"},{"issue":"5","key":"10.1016\/j.vaccine.2008.08.028_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/00480169.2005.36564","article-title":"Oral vaccination of brushtail possums (Trichosurus vulpecula) with BCG: immune responses, persistence of BCG in lymphoid organs and excretion in faeces","volume":"53","author":"Wedlock","year":"2005","journal-title":"N Z Vet J"},{"issue":"12","key":"10.1016\/j.vaccine.2008.08.028_bib20","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.vaccine.2005.11.017","article-title":"Oral delivery of lipid-encapsulated Mycobacterium bovis BCG extends survival of the bacillus in vivo and induces a long-term protective immune response against tuberculosis","volume":"24","author":"Aldwell","year":"2006","journal-title":"Vaccine"},{"issue":"27","key":"10.1016\/j.vaccine.2008.08.028_bib21","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1016\/j.vaccine.2005.01.150","article-title":"Effect of oral vaccination of cattle with lipid-formulated BCG on immune responses and protection against bovine tuberculosis","volume":"23","author":"Buddle","year":"2005","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2008.08.028_bib22","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1128\/IAI.00052-08","article-title":"Oral vaccination of guinea pigs with Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine in a lipid matrix protects against aerosol infection with virulent M. bovis","volume":"76","author":"Clark","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.08.028_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0144-8617(88)90001-X","volume":"8","author":"Gacesa","year":"1988","journal-title":"Alginates Carbohydr Polym"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.028_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/ABAB:128:1:001","article-title":"Toward a new generation of therapeutics: artificial cell targeted delivery of live cells for therapy","volume":"128","author":"Prakash","year":"2006","journal-title":"Appl Biochem Biotechnol"},{"issue":"23","key":"10.1016\/j.vaccine.2008.08.028_bib25","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1016\/j.vaccine.2007.03.039","article-title":"Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB\/c mice","volume":"25","author":"Ajdary","year":"2007","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2008.08.028_bib26","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1080\/02652040601034013","article-title":"Stabilizing effects of calcium alginate microspheres on Mycobacterium bovis BCG intended for oral vaccination","volume":"23","author":"Dobakhti","year":"2006","journal-title":"J Microencapsul"},{"issue":"7","key":"10.1016\/j.vaccine.2008.08.028_bib27","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.vaccine.2006.09.088","article-title":"Oral vaccination of mice with lipid-encapsulated Mycobacterium bovis BCG: effect of reducing or eliminating BCG load on cell-mediated immunity","volume":"25","author":"Cross","year":"2007","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.028_bib28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1462-5822.2006.00810.x","article-title":"Lymphatic tracing and T cell responses following oral vaccination with live Mycobacterium bovis (BCG)","volume":"9","author":"Dorer","year":"2007","journal-title":"Cell Microbiol"},{"issue":"13","key":"10.1016\/j.vaccine.2008.08.028_bib29","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.1130426100","article-title":"The complete genome sequence of Mycobacterium bovis","volume":"100","author":"Garnier","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.028_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.femsim.2004.04.001","article-title":"Patterns of cytokine induction by gram-positive and gram-negative probiotic bacteria","volume":"42","author":"Cross","year":"2004","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.028_bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.icb.7100126","article-title":"Murine cytokine responses following multiple oral immunizations using lipid-formulated mycobacterial antigens","volume":"86","author":"Cross","year":"2008","journal-title":"Immunol Cell Biol"},{"issue":"Suppl. 3","key":"10.1016\/j.vaccine.2008.08.028_bib32","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.1086\/313878","article-title":"Comparison of the protective efficacy of bacille Calmette-Guerin vaccination against aerosol challenge with Mycobacterium tuberculosis and Mycobacterium bovis","volume":"30","author":"Williams","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"12","key":"10.1016\/j.vaccine.2008.08.028_bib33","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1128\/IAI.68.12.7094-7099.2000","article-title":"Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin","volume":"68","author":"Chambers","year":"2000","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.028_bib34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1046\/j.1365-2672.2000.00807.x","article-title":"Survival of mycobacterial species in aerosols generated from artificial saliva","volume":"31","author":"Lever","year":"2000","journal-title":"Lett Appl Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.028_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-1135(00)00378-3","article-title":"A guinea pig model of low-dose Mycobacterium bovis aerogenic infection","volume":"80","author":"Chambers","year":"2001","journal-title":"Vet Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2008.08.028_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/abbs\/36.4.269","article-title":"Protection of mice with a divalent tuberculosis DNA vaccine encoding antigens Ag85B and MPT64","volume":"36","author":"Tian","year":"2004","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.028_bib37","first-page":"119","article-title":"Immunobiological studies with mycobacterial ribonucleic acid-protein complex: Part I\u2014Immune responses and protective role against experimental tuberculosis","volume":"28","author":"Pancholi","year":"1990","journal-title":"Indian J Exp Biol"},{"issue":"5","key":"10.1016\/j.vaccine.2008.08.028_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00189412","article-title":"Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria","volume":"177","author":"Mehta","year":"1988","journal-title":"Med Microbiol Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.028_bib39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/02652040601058525","article-title":"Preparation of microcapsules with self-microemulsifying core by a vibrating nozzle method","volume":"24","author":"Homar","year":"2007","journal-title":"J Microencapsul"},{"key":"10.1016\/j.vaccine.2008.08.028_bib40","series-title":"Physiology of the gastrointestinal tract","first-page":"1867","article-title":"Intestinal lipid absorption","author":"Tso","year":"1994"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.028_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1017\/S0950268800056624","article-title":"Mycobacterium bovis in the European badger (Meles meles): epidemiological findings in tuberculous badgers from a naturally infected population","volume":"111","author":"Clifton-Hadley","year":"1993","journal-title":"Epidemiol Infect"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.028_bib42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0005-2760(88)90147-6","article-title":"Lingual and gastric lipases: species differences in the origin of prepancreatic digestive lipases and in the localization of gastric lipase","volume":"959","author":"DeNigris","year":"1988","journal-title":"Biochim Biophys Acta"},{"issue":"1\u20133","key":"10.1016\/j.vaccine.2008.08.028_bib43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0168-3659(02)00281-X","article-title":"Effects of cellulose derivatives and poly(ethylene oxide)-poly(propylene oxide) tri-block copolymers (Pluronic)surfactants on the properties of alginate based microspheres and their interactions with phagocytic cells","volume":"85","author":"Kidane","year":"2002","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2008.08.028_bib44","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/(SICI)1097-4628(19970314)63:11<1481::AID-APP10>3.0.CO;2-5","article-title":"Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin","volume":"63","author":"Norris","year":"1997","journal-title":"J Appl Polym Sci"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.028_bib45","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/AEM.66.2.869-873.2000","article-title":"Survival of Bifidobacterium longum immobilized in calcium alginate beads in simulated gastric juices and bile salt solution","volume":"66","author":"Lee","year":"2000","journal-title":"Appl Environ Microbiol"},{"issue":"30","key":"10.1016\/j.vaccine.2008.08.028_bib46","doi-asserted-by":"crossref","first-page":"12434","DOI":"10.1073\/pnas.0703510104","article-title":"Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis","volume":"104","author":"Mittrucker","year":"2007","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08011432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08011432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T06:30:27Z","timestamp":1545719427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X08011432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":46,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0264410X08011432"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2008.08.028","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}