{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:53:59Z","timestamp":1768092839050,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.vaccine.2008.08.031","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T10:52:57Z","timestamp":1221043977000},"page":"5814-5821","source":"Crossref","is-referenced-by-count":23,"title":["Chimeric hepatitis B virus core particles carrying an epitope of anthrax protective antigen induce protective immunity against Bacillus anthracis"],"prefix":"10.1016","volume":"26","author":[{"given":"Ying","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2008.08.031_bib1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","volume":"55","author":"Mock","year":"2001","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.vaccine.2008.08.031_bib2","first-page":"1","article-title":"Introduction: anthrax history, disease and ecology","volume":"271","author":"Turnbull","year":"2002","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.vaccine.2008.08.031_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10254-004-0028-2","article-title":"Anthrax toxins","volume":"152","author":"Mourez","year":"2004","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.vaccine.2008.08.031_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142728","article-title":"Anthrax toxin: receptor binding, internalization, pore formation, and translocation","volume":"76","author":"Young","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"8","key":"10.1016\/j.vaccine.2008.08.031_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0264-410X(91)90237-Z","article-title":"Anthrax vaccines: past, present and future","volume":"9","author":"Turnbull","year":"1991","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.031_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00001432-200004000-00004","article-title":"Current status of immunization against anthrax: old vaccines may be here to stay for a while","volume":"13","author":"Turnbull","year":"2000","journal-title":"Curr Opin Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.031_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0264-410X(84)90003-3","article-title":"Anthrax: the disease in relation to vaccines","volume":"2","author":"Hambleton","year":"1984","journal-title":"Vaccine"},{"issue":"5\u20136","key":"10.1016\/j.vaccine.2008.08.031_bib8","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0264-410X(01)00387-5","article-title":"Anthrax vaccine: short-term safety experience in humans","volume":"20","author":"Pittman","year":"2001","journal-title":"Vaccine"},{"issue":"18","key":"10.1016\/j.vaccine.2008.08.031_bib9","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1001\/jama.281.18.1735","article-title":"Anthrax as a biological weapon: medical and public health management. Working Group on Civilian Biodefense","volume":"281","author":"Inglesby","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2008.08.031_bib10","unstructured":"Surveillance for adverse events associated with anthrax vaccination\u2014U.S. Department of Defense, 1998\u20132000. MMWR Morb Mortal Wkly Rep 2000;49(16):341\u2013345."},{"issue":"17\u201318","key":"10.1016\/j.vaccine.2008.08.031_bib11","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/S0264-410X(02)00092-0","article-title":"Monitoring anthrax vaccine safety in US military service members on active duty: surveillance of 1998 hospitalizations in temporal association with anthrax immunization","volume":"20","author":"Sato","year":"2002","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2008.08.031_bib12","first-page":"506","article-title":"Development of anthrax DNA vaccines","volume":"6","author":"Ferrari","year":"2004","journal-title":"Curr Opin Mol Ther"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.031_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.virol.2006.05.010","article-title":"Rabies virus glycoprotein as a carrier for anthrax protective antigen","volume":"353","author":"Smith","year":"2006","journal-title":"Virology"},{"issue":"15","key":"10.1016\/j.vaccine.2008.08.031_bib14","doi-asserted-by":"crossref","first-page":"10003","DOI":"10.1128\/JVI.79.15.10003-10012.2005","article-title":"Chimeric influenza virus hemagglutinin proteins containing large domains of the Bacillus anthracis protective antigen: protein characterization, incorporation into infectious influenza viruses, and antigenicity","volume":"79","author":"Li","year":"2005","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.vaccine.2008.08.031_bib15","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/IAI.59.6.1961-1965.1991","article-title":"Protection against anthrax with recombinant virus-expressed protective antigen in experimental animals","volume":"59","author":"Iacono-Connors","year":"1991","journal-title":"Infect Immun"},{"issue":"17","key":"10.1016\/j.vaccine.2008.08.031_bib16","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1089\/104303403322542310","article-title":"Protective immunity evoked against anthrax lethal toxin after a single intramuscular administration of an adenovirus-based vaccine encoding humanized protective antigen","volume":"14","author":"Tan","year":"2003","journal-title":"Hum Gene Ther"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.031_bib17","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1128\/IAI.71.3.1491-1496.2003","article-title":"Venezuelan equine encephalitis virus-vectored vaccines protect mice against anthrax spore challenge","volume":"71","author":"Lee","year":"2003","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2008.08.031_bib18","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1128\/IAI.72.12.7096-7106.2004","article-title":"Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA","volume":"72","author":"Galen","year":"2004","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.vaccine.2008.08.031_bib19","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.addr.2005.01.028","article-title":"Molecular basis for improved anthrax vaccines","volume":"57","author":"Brey","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"issue":"6619","key":"10.1016\/j.vaccine.2008.08.031_bib20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/385833a0","article-title":"Crystal structure of the anthrax toxin protective antigen","volume":"385","author":"Petosa","year":"1997","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.031_bib21","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1128\/IAI.70.3.1653-1656.2002","article-title":"A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection","volume":"70","author":"Flick-Smith","year":"2002","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.031_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ymthe.2004.10.018","article-title":"Passive immunotherapy for anthrax toxin mediated by an adenovirus expressing an anti-protective antigen single-chain antibody","volume":"11","author":"Kasuya","year":"2005","journal-title":"Mol Ther"},{"issue":"6","key":"10.1016\/j.vaccine.2008.08.031_bib23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nbt0602-597","article-title":"Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity","volume":"20","author":"Maynard","year":"2002","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.vaccine.2008.08.031_bib24","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.bbrc.2006.01.080","article-title":"The 2\u03b22\u20132\u03b23 loop of anthrax protective antigen contains a dominant neutralizing epitope","volume":"341","author":"Zhang","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"10.1016\/j.vaccine.2008.08.031_bib25","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1128\/IAI.72.11.6313-6317.2004","article-title":"Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies","volume":"72","author":"Brossier","year":"2004","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.vaccine.2008.08.031_bib26","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1128\/IAI.00150-06","article-title":"A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1","volume":"74","author":"Rivera","year":"2006","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2008.08.031_bib27","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1574-695X.2006.00114.x","article-title":"Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen","volume":"47","author":"Gubbins","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2008.08.031_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s007260070072","article-title":"Insertion of foreign epitopes in HBcAg: how to make the chimeric particle assemble","volume":"18","author":"Karpenko","year":"2000","journal-title":"Amino Acids"},{"key":"10.1016\/j.vaccine.2008.08.031_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-3527(08)60808-8","article-title":"Core particles of hepatitis B virus as carrier for foreign epitopes","volume":"50","author":"Ulrich","year":"1998","journal-title":"Adv Virus Res"},{"issue":"4782","key":"10.1016\/j.vaccine.2008.08.031_bib30","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1126\/science.3491425","article-title":"The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen","volume":"234","author":"Milich","year":"1986","journal-title":"Science"},{"issue":"6146","key":"10.1016\/j.vaccine.2008.08.031_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/330381a0","article-title":"Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein","volume":"330","author":"Clarke","year":"1987","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.vaccine.2008.08.031_bib32","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1128\/JVI.64.7.3319-3330.1990","article-title":"B virus nucleocapsid assembly: primary structure requirements in the core protein","volume":"64","author":"Birnbaum","year":"1990","journal-title":"J Virol"},{"issue":"23","key":"10.1016\/j.vaccine.2008.08.031_bib33","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1021\/bi9604800","article-title":"Dimorphism of hepatitis B virus capsids is strongly influenced by the C-terminus of the capsid protein","volume":"35","author":"Zlotnick","year":"1996","journal-title":"Biochemistry"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2008.08.031_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000150415","article-title":"Hepatitis B virus core particles as epitope carriers","volume":"38","author":"Pumpens","year":"1995","journal-title":"Intervirology"},{"key":"10.1016\/j.vaccine.2008.08.031_bib35","unstructured":"Schodel F, Will H, Milich D. Hybrid hepatitis B virus core\/pre-S particles expressed in live attenuated Salmonella for oral immunization. In: Chanock RM, Ginsberg HS, Brown F, Lerner RA, editors. Vaccines. New York: Cold Spring Harbor Laboratory Press; 1991. p. 319\u201325."},{"key":"10.1016\/j.vaccine.2008.08.031_bib36","first-page":"652","article-title":"Expression, purification and characterization of the recombinant anthrax protective antigen","volume":"20","author":"Xu","year":"2004","journal-title":"Chin J Biotechnol"},{"key":"10.1016\/j.vaccine.2008.08.031_bib37","first-page":"749","article-title":"Expression and characterization of the recombinant anthrax lethal factor","volume":"44","author":"Guo","year":"2004","journal-title":"Acta Microbiol Sinica"},{"issue":"2\u20133","key":"10.1016\/j.vaccine.2008.08.031_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0168-1656(99)00117-0","article-title":"New chimaeric hepatitis B virus core particles carrying hantavirus (serotype Puumala) epitopes: immunogenicity and protection against virus challenge","volume":"73","author":"Ulrich","year":"1999","journal-title":"J Biotechnol"},{"issue":"5","key":"10.1016\/j.vaccine.2008.08.031_bib39","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1073\/pnas.96.5.1915","article-title":"Native display of complete foreign protein domains on the surface of hepatitis B virus capsids","volume":"96","author":"Kratz","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"20","key":"10.1016\/j.vaccine.2008.08.031_bib40","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1016\/j.vaccine.2006.02.051","article-title":"Recombinant virus-like particles as a carrier of B- and T-cell epitopes of hepatitis C virus (HCV)","volume":"24","author":"Mihailova","year":"2006","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.031_bib41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.virol.2004.02.022","article-title":"An amino-terminal segment of hantavirus nucleocapsid protein presented on hepatitis B virus core particles induces a strong and highly cross-reactive antibody response in mice","volume":"323","author":"Geldmacher","year":"2004","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.vaccine.2008.08.031_bib42","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/0264-410X(94)90027-2","article-title":"Efficacy of a standard human anthrax vaccine against Bacillus anthracis spore challenge in guinea-pigs","volume":"12","author":"Ivins","year":"1994","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2008.08.031_bib43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/IAI.52.2.509-512.1986","article-title":"Comparative efficacy of Bacillus anthracis live spore vaccine and protective antigen vaccine against anthrax in the guinea pig","volume":"52","author":"Little","year":"1986","journal-title":"Infect Immun"},{"issue":"23\u201324","key":"10.1016\/j.vaccine.2008.08.031_bib44","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1016\/S0264-410X(01)00021-4","article-title":"Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin","volume":"19","author":"Fellows","year":"2001","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2008.08.031_bib45","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/IAI.69.5.2888-2893.2001","article-title":"Search for correlates of protective immunity conferred by anthrax vaccine","volume":"69","author":"Reuveny","year":"2001","journal-title":"Infect Immun"},{"issue":"2\u20133","key":"10.1016\/j.vaccine.2008.08.031_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000050037","article-title":"HBV core particles as a carrier for B cell\/T cell epitopes","volume":"44","author":"Pumpens","year":"2001","journal-title":"Intervirology"},{"issue":"7","key":"10.1016\/j.vaccine.2008.08.031_bib47","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1073\/pnas.87.7.2545","article-title":"Immunological properties of hepatitis B core antigen fusion proteins","volume":"87","author":"Francis","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.vaccine.2008.08.031_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(98)01599-3","article-title":"Hepatitis B core particles as a universal display model: a structure-function basis for development","volume":"442","author":"Pumpens","year":"1999","journal-title":"FEBS Lett"},{"issue":"9","key":"10.1016\/j.vaccine.2008.08.031_bib49","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1128\/JVI.66.9.5232-5241.1992","article-title":"RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication","volume":"66","author":"Hatton","year":"1992","journal-title":"J Virol"},{"issue":"10","key":"10.1016\/j.vaccine.2008.08.031_bib50","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1371\/journal.ppat.0030142","article-title":"A viral nanoparticle with dual function as an anthrax antitoxin and vaccine","volume":"3","author":"Manayani","year":"2007","journal-title":"PLoS Pathog"},{"issue":"8","key":"10.1016\/j.vaccine.2008.08.031_bib51","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1128\/IAI.00070-07","article-title":"Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge","volume":"75","author":"Bielinska","year":"2007","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08011377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08011377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:35:11Z","timestamp":1588916111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X08011377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":51,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0264410X08011377"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2008.08.031","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}