{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:47:04Z","timestamp":1777538824572,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.vaccine.2008.10.090","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T16:50:42Z","timestamp":1227199842000},"page":"573-580","source":"Crossref","is-referenced-by-count":14,"title":["The temperature-sensitive mutants of Toxoplasma gondii and ocular toxoplasmosis"],"prefix":"10.1016","volume":"27","author":[{"given":"Fangli","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd H.","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2008.10.090_bib1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.vaccine.2008.10.090_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0169-4758(98)01377-5","article-title":"Pathogenesis of toxoplasmic retinochoroiditis","volume":"15","author":"Roberts","year":"1999","journal-title":"Parasitol Today"},{"key":"10.1016\/j.vaccine.2008.10.090_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0950268899002800","article-title":"Incidence of symptomatic toxoplasma eye disease: etiology and public health implications","volume":"123","author":"Gilbert","year":"1999","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.vaccine.2008.10.090_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s10384-003-0069-0","article-title":"Clinical features and prognosis in ocular toxoplasmosis","volume":"48","author":"Atmaca","year":"2004","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/sj.icb.7100038","article-title":"Cytokine regulation of immunopathology in toxoplasmosis","volume":"85","author":"Gaddi","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0169-4758(94)90251-8","article-title":"Immunization against Toxoplasma gondii","volume":"10","author":"Araujo","year":"1994","journal-title":"Parasitol Today"},{"key":"10.1016\/j.vaccine.2008.10.090_bib7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.146.1.286","article-title":"Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-\u03b3 production and protective immunity induced by an attenuated Toxoplasma gondii vaccine","volume":"146","author":"Gazzinelli","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1076\/ocii.7.1.17.8109","article-title":"Experimental OT induced in naive and preinfected mice by intracameral inoculation","volume":"7","author":"Hu","year":"1999","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.vaccine.2008.10.090_bib9","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1128\/IAI.72.9.4966-4972.2004","article-title":"CD4+ T cells in the pathogenesis of murine ocular toxoplasmosis","volume":"72","author":"Lu","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2307\/3281293","article-title":"Temperature sensitive mutants of Toxoplasma gondii: pathogenicity and persistence in mice","volume":"69","author":"Waldeland","year":"1983","journal-title":"J Parasitol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib11","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1128\/IAI.64.8.3088-3092.1996","article-title":"Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii","volume":"64","author":"Sayles","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2307\/3284022","article-title":"Further characterization of the TS-4 temperature-sensitive mutant of Toxoplasma gondii in mice","volume":"81","author":"Pinckney","year":"1995","journal-title":"J Parasitol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2307\/3283280","article-title":"Safety and results of challenge of weaned pigs given a temperature-sensitive mutant of Toxoplasma gondii","volume":"79","author":"Lindsay","year":"1993","journal-title":"J Parasitol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib14","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1128\/IAI.73.8.5160-5165.2005","article-title":"Experimental ocular toxoplasmosis in genetically susceptible and resistant mice","volume":"73","author":"Lu","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2307\/3283415","article-title":"Evaluation of the safety and efficacy of vaccination of nursing pigs with living tachyzoites of two strains of Toxoplasma gondii","volume":"80","author":"Pinckney","year":"1994","journal-title":"J Parasitol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib16","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1128\/IAI.71.12.7159-7163.2003","article-title":"Interleukin-10 and pathogenesis of murine OT","volume":"71","author":"Lu","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib17","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4049\/jimmunol.147.7.2310","article-title":"CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells","volume":"147","author":"Hakim","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-3024.1995.tb01017.x","article-title":"Induction of CD4+ and CD8+ T cell responses in efferent lymph responding to Toxoplasma gondii infection: analysis of phenotype and function","volume":"17","author":"Innes","year":"1995","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib19","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.4049\/jimmunol.141.10.3600","article-title":"Induction of antigen specific parasiticidal cytotoxic T-cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii","volume":"141","author":"Khan","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2307\/3282598","article-title":"Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CD8+ cytotoxic cells","volume":"75","author":"Yano","year":"1989","journal-title":"J Parasitol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib21","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1348-0421.1994.tb01858.x","article-title":"CD8+ T lymphocytes are the major cell population involved in the early gamma interferon response and resistance to acute primary Toxoplasma gondii infection in mice","volume":"38","author":"Shirahata","year":"1994","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib22","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.4049\/jimmunol.140.11.3943","article-title":"Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice","volume":"140","author":"Suzuki","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/IAI.70.1.185-191.2002","article-title":"Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice","volume":"70","author":"Johnson","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/IAI.71.1.309-316.2003","article-title":"A GRA1 DNA vaccine primes cytolytic CD8+ T cells to control acute Toxoplasma gondii infection","volume":"71","author":"Scorza","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/expr.1994.1022","article-title":"Toxoplasma gondii: acquired OT in the murine model, protective role of TNF-\u03b1 and IFN-\u03b3","volume":"78","author":"Gazzinelli","year":"1994","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.184.2.597","article-title":"Association of CD4 T-cell dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii","volume":"184","author":"Liesenfeld","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2008.10.090_bib27","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1007\/s00417-006-0274-x","article-title":"The antibody response in experimental ocular toxoplasmosis","volume":"244","author":"Garweg","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib28","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/IAI.68.3.1026-1033.2000","article-title":"B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii","volume":"68","author":"Sayles","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib29","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.4049\/jimmunol.164.5.2629","article-title":"Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-\u03b3, TNF-\u03b1, and inducible nitric oxide synthase","volume":"164","author":"Kang","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib30","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1128\/IAI.73.12.8060-8068.2005","article-title":"Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion","volume":"73","author":"Couper","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2008.10.090_bib31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/82717","article-title":"Reciprocal regulation of polarized cytokine production by effector B and T cells","volume":"1","author":"Harris","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vaccine.2008.10.090_bib32","doi-asserted-by":"crossref","unstructured":"Menard LC, Minns LA, Darche S, Mielcarz DW, Foureau DM, Roos D, Dzierszinski F, Kasper LH, Buzoni-Gatel D. B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism. J Immunol 2007; 179(7):4857\u201366.","DOI":"10.4049\/jimmunol.179.7.4857"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08015028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08015028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T06:38:11Z","timestamp":1684651091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X08015028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0264410X08015028"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2008.10.090","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}