{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:28:20Z","timestamp":1790692100950,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.vaccine.2008.11.021","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T08:40:52Z","timestamp":1230108052000},"page":"I9-I14","source":"Crossref","is-referenced-by-count":60,"special_numbering":"S8","title":["Complement factor H related proteins in immune diseases"],"prefix":"10.1016","volume":"26","author":[{"given":"Christine","family":"Skerka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Zipfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2008.11.021_bib1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement. First of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2008.11.021_bib2","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJM200104123441506","article-title":"Complement. Second of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2008.11.021_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s002510050534","article-title":"A radiation hybrid map of complement factor H and factor H-related genes","volume":"49","author":"Diaz-Guillen","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.vaccine.2008.11.021_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0161-5890(00)00024-9","article-title":"Complement factor H: sequence analysis of 221kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes","volume":"37","author":"Male","year":"2000","journal-title":"Mol Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib5","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1371\/journal.pgen.0030041","article-title":"Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome","volume":"3","author":"Zipfel","year":"2007","journal-title":"PLoS Gene"},{"key":"10.1016\/j.vaccine.2008.11.021_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/humu.9408","article-title":"De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome","volume":"27","author":"Heinen","year":"2006","journal-title":"Hum Mutat"},{"issue":"8","key":"10.1016\/j.vaccine.2008.11.021_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.it.2008.04.008","article-title":"Factor H family proteins and human diseases","volume":"29","author":"J\u00f3zsi","year":"2008","journal-title":"Trends Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib8","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1172\/JCI16651","article-title":"Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome","volume":"111","author":"Manuelian","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2008.11.021_bib9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1365-2249.2006.03071.x","article-title":"The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein","volume":"144","author":"Oppermann","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0014-5793(99)01554-9","article-title":"Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin","volume":"462","author":"Hellwage","year":"1999","journal-title":"FEBS Lett"},{"issue":"10","key":"10.1016\/j.vaccine.2008.11.021_bib11","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.4049\/jimmunol.174.10.6250","article-title":"Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein","volume":"174","author":"McRae","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib12","doi-asserted-by":"crossref","first-page":"12015","DOI":"10.1016\/S0021-9258(18)99058-7","article-title":"Molecular cloning of a human serum protein structurally related to complement factor H","volume":"266","author":"Skerka","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2008.11.021_bib13","doi-asserted-by":"crossref","first-page":"18054","DOI":"10.1074\/jbc.271.30.18054","article-title":"Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins","volume":"271","author":"Park","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2008.11.021_bib14","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.4049\/jimmunol.146.4.1265","article-title":"Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions","volume":"146","author":"Timmann","year":"1991","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2008.11.021_bib15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1086\/518509","article-title":"Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins","volume":"196","author":"Haupt","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2008.11.021_bib16","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.4049\/jimmunol.179.5.2979","article-title":"Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein","volume":"179","author":"Kunert","year":"2007","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2008.11.021_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1365-2958.2001.02496.x","article-title":"Group A streptococcal phagocytosis resistance is independent of complement factor H and factor H-like protein 1 binding","volume":"41","author":"Kotarsky","year":"2001","journal-title":"Mol Microbiol"},{"issue":"10","key":"10.1016\/j.vaccine.2008.11.021_bib18","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.4049\/jimmunol.148.10.3313","article-title":"Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes","volume":"148","author":"Skerka","year":"1992","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2008.11.021_bib19","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1016\/S0021-9258(18)53859-X","article-title":"A novel short consensus repeat-containing molecule is related to human complement factor H","volume":"268","author":"Skerka","year":"1993","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.vaccine.2008.11.021_bib20","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.1074\/jbc.272.9.5627","article-title":"The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins","volume":"272","author":"Skerka","year":"1997","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.vaccine.2008.11.021_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/sj.ejhg.5201324","article-title":"FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene","volume":"13","author":"J\u00f3zsi","year":"2005","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"10.1016\/j.vaccine.2008.11.021_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/ajkd.2002.29873","article-title":"Factor H-related protein-5: a novel component of human glomerular immune deposits","volume":"39","author":"Murphy","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"9","key":"10.1016\/j.vaccine.2008.11.021_bib23","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1074\/jbc.M007495200","article-title":"Human factor H-related protein 5 (FHR-5). A new complement-associated protein","volume":"276","author":"McRae","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2008.11.021_bib24","first-page":"905","article-title":"Hemolytic-uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia","volume":"85","author":"Gasser","year":"1955","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1016\/j.vaccine.2008.11.021_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molimm.2005.06.015","article-title":"Complement and diseases: defective alternative pathway control results in kidney and eye diseases","volume":"43","author":"Zipfel","year":"2006","journal-title":"Mol Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib26","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1016\/j.molimm.2007.06.003","article-title":"Where next with atypical hemolytic uremic syndrome?","volume":"44","author":"Jokiranta","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib27","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1182\/blood-2007-09-109876","article-title":"Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1\/CFHR3 deficiency","volume":"111","author":"J\u00f3zsi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2008.11.021_bib28","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1182\/blood-2007-02-071472","article-title":"Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome","volume":"110","author":"J\u00f3zsi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2008.11.021_bib29","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(74)90991-X","article-title":"Haemolytic-uraemic syndrome: evidence for intravascular C3 activation","volume":"2","author":"St\u00fchlinger","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2008.11.021_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/humu.20435","article-title":"The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models","volume":"28","author":"Saunders","year":"2007","journal-title":"Hum Mutat"},{"key":"10.1016\/j.vaccine.2008.11.021_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2007.03552.x","article-title":"Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H","volume":"151","author":"de C\u00f3rdoba","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2008.11.021_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/ki.2008.133","article-title":"Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3)","author":"Koziolek","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.vaccine.2008.11.021_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/humu.9408","article-title":"De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome","volume":"27","author":"Heinen","year":"2006","journal-title":"Hum Mutat"},{"issue":"7","key":"10.1016\/j.vaccine.2008.11.021_bib34","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.molimm.2006.08.004","article-title":"Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome","volume":"44","author":"Monteferrante","year":"2007","journal-title":"Mol Immunol"},{"issue":"7","key":"10.1016\/j.vaccine.2008.11.021_bib35","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/jmg.2005.038315","article-title":"Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)","volume":"43","author":"Abrera-Abeleda","year":"2006","journal-title":"J Med Genet"},{"issue":"3","key":"10.1016\/j.vaccine.2008.11.021_bib36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.vaccine.2008.11.021_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/08820530701745140","article-title":"Review of genetics in age related macular degeneration","volume":"22","author":"Montezuma","year":"2007","journal-title":"Semin Ophthalmol"},{"issue":"21","key":"10.1016\/j.vaccine.2008.11.021_bib38","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/hmg\/ddi353","article-title":"Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk","volume":"14","author":"Rivera","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.vaccine.2008.11.021_bib39","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ng1890","article-title":"A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration","volume":"38","author":"Hughes","year":"2006","journal-title":"Nat Genet"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08015223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08015223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T01:14:08Z","timestamp":1684804448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X08015223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":39,"alternative-id":["S0264410X08015223"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2008.11.021","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}