{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:25:06Z","timestamp":1791095106266,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.vaccine.2008.12.021","type":"journal-article","created":{"date-parts":[[2009,1,10]],"date-time":"2009-01-10T09:34:30Z","timestamp":1231580070000},"page":"1184-1191","source":"Crossref","is-referenced-by-count":36,"title":["Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: Results of a Phase 2, randomized, double-blind placebo-controlled trial"],"prefix":"10.1016","volume":"27","author":[{"given":"Odile","family":"Launay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sadorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Poirier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"B\u00e9chet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"van der Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Seffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Fenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaela","family":"Giemza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ndiaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Vray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sansonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Morand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Poyart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Lise","family":"Gougeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.vaccine.2008.12.021_bib1","first-page":"651","article-title":"Global burden of Shigella infections: implications for vaccine development and implementation of control strategies","volume":"77","author":"Kotloff","year":"1999","journal-title":"Bull World Health Org"},{"issue":"5668","key":"10.1016\/j.vaccine.2008.12.021_bib2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","article-title":"Bacterial invasions: the paradigms of enteroinvasive pathogens","volume":"304","author":"Cossart","year":"2004","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.vaccine.2008.12.021_bib3","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/IAI.58.6.2002-2004.1990","article-title":"Specific immunoglobulin A-secreting cells in peripheral blood of humans following oral immunization with a bivalent Salmonella typhi-Shigella sonnei vaccine or infection by pathogenic S. sonnei","volume":"58","author":"Van de Verg","year":"1990","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2008.12.021_bib4","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/infdis\/157.5.1068","article-title":"Serum antibodies to lipopolysaccharide and natural immunity to shigellosis in an Israeli military population","volume":"157","author":"Cohen","year":"1988","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2008.12.021_bib5","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.4049\/jimmunol.164.4.2221","article-title":"Production of IFN-gamma and IL-10 to Shigella invasins by mononuclear cells from volunteers orally inoculated with a Shiga toxin-deleted Shigella dysenteriae type 1 strain","volume":"164","author":"Samandari","year":"2000","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.vaccine.2008.12.021_bib6","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/IAI.59.7.2341-2350.1991","article-title":"Prospective study of systemic and mucosal immune responses in dysenteric patients to specific Shigella invasion plasmid antigens and lipopolysaccharides","volume":"59","author":"Oberhelman","year":"1991","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2008.12.021_bib7","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1128\/CDLI.3.6.701-705.1996","article-title":"Lipopolysaccharide-specific antibodies in plasma and stools of children with Shigella-associated leukemoid reaction and hemolytic-uremic syndrome","volume":"3","author":"Azim","year":"1996","journal-title":"Clin Diagn Lab Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2008.12.021_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/infdis\/164.3.533","article-title":"Effect of prior infection with virulent Shigella flexneri 2a on the resistance of monkeys to subsequent infection with Shigella sonnei","volume":"164","author":"Formal","year":"1991","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2008.12.021_bib9","first-page":"457","article-title":"Studies on vaccination against bacillary dysentery. Protection of children by oral immunization with streptomycin-dependent Shigella strains","volume":"45","author":"Mel","year":"1971","journal-title":"Bull World Health Org"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2008.12.021_bib10","first-page":"109","article-title":"Live oral Shigella vaccine: vaccination schedule and the effect of booster dose","volume":"21","author":"Mel","year":"1974","journal-title":"Acta Microbiol Acad Sci Hung"},{"issue":"2","key":"10.1016\/j.vaccine.2008.12.021_bib11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/JCM.29.2.386-389.1991","article-title":"Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis","volume":"29","author":"Cohen","year":"1991","journal-title":"J Clin Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2008.12.021_bib12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1586\/14760584.5.5.669","article-title":"Live-attenuated Shigella vaccines","volume":"5","author":"Venkatesan","year":"2006","journal-title":"Expert Rev Vaccines"},{"issue":"7","key":"10.1016\/j.vaccine.2008.12.021_bib13","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.vaccine.2007.11.024","article-title":"Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 \u0394icsA \u0394ent \u0394fep \u0394stxA:HgR oral vaccine SC599 in healthy human adult volunteers","volume":"26","author":"Sadorge","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2008.12.021_bib14","first-page":"83","article-title":"Bacterial lipopolysaccharides: extraction with phenol-water and further application of the procedures","volume":"5","author":"Westphal","year":"1965","journal-title":"Meth Carbohydrate Chem"},{"issue":"4","key":"10.1016\/j.vaccine.2008.12.021_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0264-410X(90)90088-4","article-title":"Antibody secreting cells in the evaluation of the immunogenicity of an oral vaccine","volume":"8","author":"Kantele","year":"1990","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2008.12.021_bib16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/infdis\/165.4.785","article-title":"Natural immunity to shigellosis in two groups with different previous risks of exposure to Shigella is only partly expressed by serum antibodies to lipopolysaccharide","volume":"165","author":"Cohen","year":"1992","journal-title":"J Infect Dis"},{"issue":"9046","key":"10.1016\/j.vaccine.2008.12.021_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(96)06255-1","article-title":"Double-blind vaccine-controlled randomized efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults","volume":"349","author":"Cohen","year":"1997","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.vaccine.2008.12.021_bib18","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/IAI.67.7.3437-3443.1999","article-title":"Vaccination against Shigellosis with Attenuated Shigella flexneri 2a Strain SC602","volume":"67","author":"Coster","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2008.12.021_bib19","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1128\/IAI.72.2.923-930.2004","article-title":"Two studies evaluating the safety and immunogenicity of a live, attenuated Shigellaflexneri 2a vaccine [SC602] and excretion of vaccine organisms in North American volunteers","volume":"72","author":"Katz","year":"2004","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.vaccine.2008.12.021_bib20","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1128\/JCM.30.7.1636-1641.1992","article-title":"Antibodies to shiga holotoxin and to two synthetic peptides of the B subunit in sera of patients with Shigelladysenteriae 1 dysentery","volume":"30","author":"Levine","year":"1992","journal-title":"J Clin Microbiol"},{"issue":"7","key":"10.1016\/j.vaccine.2008.12.021_bib21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrmicro1662","article-title":"Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road","volume":"5","author":"Levine","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2008.12.021_bib22","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/j.vaccine.2008.03.079","article-title":"Safety and immunogenicity of WRSd1, a live attenuated Shigella dysenteriae type 1 vaccine candidate","volume":"26","author":"McKenzie","year":"2008","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08017490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X08017490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T14:52:29Z","timestamp":1589467949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X08017490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0264410X08017490"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2008.12.021","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}