{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:14:28Z","timestamp":1776258868186,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.vaccine.2009.11.080","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T04:32:01Z","timestamp":1260851521000},"page":"1847-1853","source":"Crossref","is-referenced-by-count":7,"title":["Screening and identification of dominant functional fragments of human epididymal protease inhibitor"],"prefix":"10.1016","volume":"28","author":[{"given":"Li-Li","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Zhang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Long","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Qing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.vaccine.2009.11.080_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1471-4906(02)02182-8","article-title":"Antifertility vaccines","volume":"23","author":"Delves","year":"2002","journal-title":"Trends Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2009.11.080_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/14712598.5.3.381","article-title":"Contraceptive vaccines targeting sperm","volume":"5","author":"Suri","year":"2005","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"10.1016\/j.vaccine.2009.11.080_bib3","first-page":"83","article-title":"Peptide vaccines in immunocontraception","volume":"6","author":"Ferro","year":"2004","journal-title":"Curr Opin Mol Ther"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2009.11.080_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mce.2005.12.039","article-title":"Eppin: an effective target for male contraception","volume":"250","author":"O\u2019Rand","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.vaccine.2009.11.080_bib5","first-page":"535","article-title":"Eppin: a molecular strategy for male contraception","volume":"65","author":"Wang","year":"2007","journal-title":"Soc Reprod Fertil Suppl"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2009.11.080_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-1119(01)00462-0","article-title":"Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis","volume":"270","author":"Richardson","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.vaccine.2009.11.080_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-1119(03)00608-5","article-title":"Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2","volume":"312","author":"Sivashanmugam","year":"2003","journal-title":"Gene"},{"issue":"5699","key":"10.1016\/j.vaccine.2009.11.080_bib8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1126\/science.1099743","article-title":"Reversible immunocontraception in male monkeys immunized with Eppin","volume":"306","author":"O\u2019Rand","year":"2004","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.vaccine.2009.11.080_bib9","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1016\/j.vaccine.2007.03.033","article-title":"Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive","volume":"25","author":"Curtis","year":"2007","journal-title":"Vaccine"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2009.11.080_bib10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0264-410X(02)00438-3","article-title":"Evaluation of the immunocontraceptive potential of Escherichia coli expressed recombinant non-human primate zona pellucida glycoproteins in homologous animal model","volume":"21","author":"Govind","year":"2002","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2009.11.080_bib11","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1111\/j.1742-4658.2008.06333.x","article-title":"Functional domains of the human epididymal protease inhibitor, eppin","volume":"275","author":"McCrudden","year":"2008","journal-title":"FEBS J"},{"issue":"4","key":"10.1016\/j.vaccine.2009.11.080_bib12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1586\/14760584.6.4.591","article-title":"Design and development of synthetic peptide vaccines: past, present and future","volume":"6","author":"Bijker","year":"2007","journal-title":"Expert Rev Vac"},{"issue":"10","key":"10.1016\/j.vaccine.2009.11.080_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0161-5890(99)00080-2","article-title":"Hypervariable epitope construct: a synthetic immunogen that overcomes MHC restriction of antigen presentation","volume":"36","author":"Meyer","year":"1999","journal-title":"Mol Immunol"},{"issue":"22","key":"10.1016\/j.vaccine.2009.11.080_bib14","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1021\/jm010021j","article-title":"Toward the quantitative prediction of T-cell epitopes: coMFA and coMSIA studies of peptides with affinity for the class I MHC molecule HLA-A*0201","volume":"44","author":"Doytchinova","year":"2001","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.vaccine.2009.11.080_bib15","first-page":"365","article-title":"Studies on the immunological properties of phage peptides recognized by McAb 9E10","volume":"13","author":"Li","year":"1997","journal-title":"Chin J Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2009.11.080_bib16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1095\/biolreprod57.4.879","article-title":"Examination of the immunocontraceptive potential of recombinant rabbit fertilin subunits in rabbit","volume":"57","author":"Hardy","year":"1997","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1016\/j.vaccine.2009.11.080_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2164\/jandrol.05192","article-title":"Antisperm immunity for contraception","volume":"27","author":"Naz","year":"2006","journal-title":"J Androl"},{"issue":"5","key":"10.1016\/j.vaccine.2009.11.080_bib18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.vaccine.2008.11.025","article-title":"Protein prime-peptide boost as a new strategy induced an Eppin dominant B-cell epitope specific immune response and suppressed fertility","volume":"27","author":"Chen","year":"2009","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X09018878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X09018878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T12:51:08Z","timestamp":1544791868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X09018878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0264410X09018878"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2009.11.080","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}