{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:54:28Z","timestamp":1792637668899,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.vaccine.2010.04.072","type":"journal-article","created":{"date-parts":[[2010,5,8]],"date-time":"2010-05-08T10:00:29Z","timestamp":1273312829000},"page":"4335-4339","source":"Crossref","is-referenced-by-count":106,"title":["Overview of the development and current use of CRM197 conjugate vaccines for pediatric use"],"prefix":"10.1016","volume":"28","author":[{"given":"Henry R.","family":"Shinefield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2010.04.072_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1084\/jem.152.2.361","article-title":"Preparation, characterization and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates","volume":"152","author":"Schneerson","year":"1980","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.vaccine.2010.04.072_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0163-4453(83)93645-9","article-title":"Vaccine potential of meningococcal group C polysaccharide-tetanus toxoid conjugate","volume":"6","author":"Beuvery","year":"1983","journal-title":"J Infect"},{"issue":"3","key":"10.1016\/j.vaccine.2010.04.072_bib3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/AEM.46.3.560-564.1983","article-title":"Isolation and characterization of Corynebacterium diphtheriae nontandem double lysogens hyperproducing CRM197","volume":"46","author":"Rappuoli","year":"1983","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"10.1016\/j.vaccine.2010.04.072_bib4","first-page":"610","volume":"11","author":"Black","year":"1992","journal-title":"Pediatr Infect Dis"},{"issue":"11","key":"10.1016\/j.vaccine.2010.04.072_bib5","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/00006454-199511000-00011","article-title":"Postlicensure surveillance for Haemophilus influenzae type b invasive disease after use of Haemophilus influenzae type b oligosaccharide CRM197 conjugate vaccine in a large defined United States population: a four-year eight-month follow-up","volume":"14","author":"Shinefield","year":"1995","journal-title":"Pediatr Infect Dis J"},{"issue":"2 Pt 1","key":"10.1016\/j.vaccine.2010.04.072_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0022-3476(05)80424-X","article-title":"Comparative trial in infants of four conjugate Haemophilus influenzae type b vaccines","volume":"120","author":"Decker","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.vaccine.2010.04.072_bib7","series-title":"Prevnar 13 [package insert]","year":"2010"},{"issue":"3","key":"10.1016\/j.vaccine.2010.04.072_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00006454-200003000-00003","article-title":"Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group","volume":"19","author":"Black","year":"2000","journal-title":"Pediatr Infect Dis J"},{"issue":"9","key":"10.1016\/j.vaccine.2010.04.072_bib9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/INF.0b013e318124a494","article-title":"Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine","volume":"26","author":"Black","year":"2007","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.vaccine.2010.04.072_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1086\/599827","article-title":"Changing epidemiology of invasive pneumococcal disease in Canada, 1998\u20132007: update from the Calgary-area Streptococcus pneumoniae research (CASPER) study","volume":"49","author":"Kellner","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2010.04.072_bib11","first-page":"893","article-title":"Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease\u2014United States, 1998\u20132003","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.vaccine.2010.04.072_bib12","first-page":"144","article-title":"Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction\u2014eight states, 1998\u20132005","volume":"57","author":"Centers for Disease Control and Prevention","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"9431","key":"10.1016\/j.vaccine.2010.04.072_bib13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0140-6736(04)16725-1","article-title":"Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction","volume":"364","author":"Trotter","year":"2004","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.vaccine.2010.04.072_bib14","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1086\/314753","article-title":"Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory","volume":"179","author":"Richmond","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2010.04.072_bib15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1086\/527401","article-title":"Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity","volume":"197","author":"Maiden","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2010.04.072_bib16","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(02)08679-8","article-title":"Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination","volume":"359","author":"Maiden","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.vaccine.2010.04.072_bib17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/INF.0b013e31818e037d","article-title":"Immunogenicity and immune memory of a nonadjuvanted quadrivalent meningococcal glycoconjugate vaccine in infants","volume":"28","author":"Perrett","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.vaccine.2010.04.072_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/jama.2007.29-c","article-title":"Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial","volume":"299","author":"Snape","year":"2008","journal-title":"JAMA"},{"issue":"RR-7","key":"10.1016\/j.vaccine.2010.04.072_bib19","first-page":"1","article-title":"Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2010.04.072_bib20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1542\/peds.2004-2514","article-title":"Cost-effectiveness of conjugate meningococcal vaccination strategies in the United States","volume":"115","author":"Shepard","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2010.04.072_bib21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/649209","article-title":"Changes in Neisseria meningitidis disease epidemiology in the United States, 1998\u20132007: implications for prevention of meningococcal disease","volume":"50","author":"Cohn","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2010.04.072_bib22","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1128\/IAI.66.5.2093-2098.1998","article-title":"Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants","volume":"66","author":"Dagan","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2010.04.072_bib23","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1016\/j.vaccine.2008.05.087","article-title":"A clinical trial examining the effect of increased total CRM197 carrier protein dose on the antibody response to Haemophilus influenzae type b CRM197 conjugate vaccine","volume":"26","author":"Usonis","year":"2008","journal-title":"Vaccine"},{"issue":"14","key":"10.1016\/j.vaccine.2010.04.072_bib24","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1001\/jama.293.14.1751","article-title":"Immunogenicity and safety of a combination pneumococcal\u2013meningococcal vaccine in infants: a randomized controlled trial","volume":"298","author":"Buttery","year":"2005","journal-title":"JAMA"},{"issue":"3 Pt 1","key":"10.1016\/j.vaccine.2010.04.072_bib25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.113.3.443","article-title":"Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine","volume":"113","author":"Kaplan","year":"2004","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.vaccine.2010.04.072_bib26","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.1542\/peds.2004-2338","article-title":"Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004","volume":"116","author":"Huang","year":"2005","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.vaccine.2010.04.072_bib27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/INF.0b013e31805cdbeb","article-title":"Impact of the pneumococcal conjugate vaccine on serotype distribution and antimicrobial resistance of invasive Streptococcus pneumoniae isolates in Dallas, TX, children from 1999 through 2005","volume":"26","author":"Messina","year":"2007","journal-title":"Pediatr Infect Dis J"},{"issue":"9","key":"10.1016\/j.vaccine.2010.04.072_bib28","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.1097\/INF.0b013e3181a74b22","article-title":"Laboratory-based surveillance of Streptococcus pneumoniae invasive disease in children in 10 Latin American countries: a SIREVA II project, 2000\u20132005","volume":"28","author":"Caste\u00f1ada","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"11","key":"10.1016\/j.vaccine.2010.04.072_bib29","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/01.inf.0000143645.58215.f0","article-title":"Seven valent pneumococcal conjugate vaccine immunization in two Boston communities; changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates","volume":"23","author":"Pelton","year":"2004","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl. 3","key":"10.1016\/j.vaccine.2010.04.072_bib30","doi-asserted-by":"crossref","first-page":"C22","DOI":"10.1016\/j.vaccine.2009.06.004","article-title":"Serotype replacement in perspective","volume":"27","author":"Dagan","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2010.04.072_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/INF.0b013e3181c391fb","article-title":"The volatile nature of pneumococcal serotype epidemiology: potential for misinterpretation","volume":"29","author":"Black","year":"2010","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"10.1016\/j.vaccine.2010.04.072_bib32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/INF.0b013e31818e0e2e","article-title":"Serotype coverage of invasive and mucosal pneumococcal disease in Israeli children younger than 3 years by various pneumococcal conjugate vaccines","volume":"28","author":"Shouval","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl","key":"10.1016\/j.vaccine.2010.04.072_bib33","first-page":"S2","article-title":"Vaccine preventable diseases and vaccination coverage in Aboriginal and Torres Strait Islander people, Australia 2003 to 2006","volume":"32","author":"Menzies","year":"2008","journal-title":"Commun Dis Intell"},{"issue":"17\u201318","key":"10.1016\/j.vaccine.2010.04.072_bib34","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.vaccine.2005.01.063","article-title":"MeNZB: a safe and highly immunogenic tailor-made vaccine against the New Zealand Neisseria meningitidis serogroup B disease epidemic strain","volume":"23","author":"Oster","year":"2005","journal-title":"Vaccine"},{"issue":"1010","key":"10.1016\/j.vaccine.2010.04.072_bib35","first-page":"437","article-title":"Meningococcal disease epidemiology and control in New Zealand","volume":"108","author":"Wilson","year":"1995","journal-title":"N Z Med J"},{"issue":"2","key":"10.1016\/j.vaccine.2010.04.072_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1086\/517385","article-title":"New Zealand epidemic of meningococcal disease identified by a strain with phenotype B:4:P1.4","volume":"177","author":"Martin","year":"1998","journal-title":"J Infect Dis"},{"issue":"1272","key":"10.1016\/j.vaccine.2010.04.072_bib37","first-page":"38","article-title":"Surveillance of vaccine breakthrough cases following MeNZB vaccination","volume":"121","author":"McNicholas","year":"2008","journal-title":"N Z Med J"},{"issue":"4","key":"10.1016\/j.vaccine.2010.04.072_bib38","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1086\/590001","article-title":"Changing epidemiology of invasive pneumococcal disease among White Mountain Apache persons in the era of the pneumococcal conjugate vaccine","volume":"47","author":"Lacapa","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.vaccine.2010.04.072_bib39","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1001\/archinte.168.7.749","article-title":"Invasive pneumococcal disease among White Mountain Apache adults, 1991\u20132005","volume":"168","author":"Bliss","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.vaccine.2010.04.072_bib40","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.2105\/AJPH.90.10.1550","article-title":"Toward elimination of Haemophilus influenzae type B carriage and disease among high-risk American Indian children","volume":"90","author":"Millar","year":"2000","journal-title":"Am J Public Health"},{"issue":"2","key":"10.1016\/j.vaccine.2010.04.072_bib41","doi-asserted-by":"crossref","first-page":"e421","DOI":"10.1542\/peds.2006-0287","article-title":"The Alaska Haemophilus influenzae type b experience: lessons in controlling a vaccine-preventable disease","volume":"118","author":"Singleton","year":"2006","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.vaccine.2010.04.072_bib42","first-page":"466","article-title":"Invasive pneumococcal disease in Australia, 2002. Invasive pneumococcal disease in Australia, 2002","volume":"27","author":"Roche","year":"2003","journal-title":"Commun Dis Intell"},{"issue":"9381","key":"10.1016\/j.vaccine.2010.04.072_bib43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(03)14022-6","article-title":"Efficacy and safety of seven-valent conjugate pneumococcal vaccine in American Indian children: group randomized trial","volume":"362","author":"O\u2019Brien","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.vaccine.2010.04.072_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1086\/504802","article-title":"Effect of community-wide conjugate pneumococcal vaccine use in infancy on nasopharyngeal carriage through 3 years of age: a cross-sectional study in a high-risk population","volume":"43","author":"Millar","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"48\u201349","key":"10.1016\/j.vaccine.2010.04.072_bib45","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1016\/j.vaccine.2005.07.038","article-title":"Immunogenicity and effectiveness of Haemophilus influenzae type b conjugate vaccine in HIV infected and uninfected African children","volume":"23","author":"Madhi","year":"2005","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2010.04.072_bib46","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1086\/597388","article-title":"Quantitative and qualitative anamnestic immune responses to pneumococcal conjugate vaccine in HIV-infected and HIV-uninfected children 5 years after vaccination","volume":"199","author":"Madhi","year":"2009","journal-title":"J Infect Dis"},{"issue":"8","key":"10.1016\/j.vaccine.2010.04.072_bib47","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/INF.0b013e31819d97be","article-title":"Seven-valent pneumococcal conjugate vaccine in pediatric solid organ transplant recipients: a prospective study of safety and immunogenicity","volume":"28","author":"Barton","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"35","key":"10.1016\/j.vaccine.2010.04.072_bib48","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1016\/j.vaccine.2008.05.083","article-title":"Neonatal immune response and serum bactericidal activity induced by a meningococcal conjugate vaccine is enhanced by LT-K63 and CpG2006","volume":"26","author":"Brynjolfsson","year":"2008","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2010.04.072_bib49","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1086\/381708","article-title":"Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system","volume":"189","author":"Baudner","year":"2004","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2010.04.072_bib50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/intimm\/12.3.295","article-title":"Synthetic oligodeoxynucleotide containing CpG motif induces an anti-polysaccharide type 1-like immune response after immunization of mice with Haemophilus influenzae type b conjugate vaccine","volume":"12","author":"von Hunolstein","year":"2000","journal-title":"Int Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2010.04.072_bib51","first-page":"163","article-title":"Safety of immunization injections in Africa: not simply a problem of logistics","volume":"78","author":"Dicko","year":"2000","journal-title":"Bull World Health Org"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X10006080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X10006080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T12:42:27Z","timestamp":1635338547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X10006080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":51,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0264410X10006080"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2010.04.072","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}