{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:40:04Z","timestamp":1772952004019,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH"},{"name":"Joint Science and Technology Office\/Defense Threat Reduction Agency"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.vaccine.2010.08.099","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T10:38:37Z","timestamp":1284719917000},"page":"357-362","source":"Crossref","is-referenced-by-count":45,"title":["TNF\u03b1 and IFN\u03b3 contribute to F1\/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague"],"prefix":"10.1016","volume":"29","author":[{"given":"Jr-Shiuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Adamovicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Bliska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Cote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"Smiley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.vaccine.2010.08.099_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis-etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0010","unstructured":"Brubaker RR. Yersinia pestis and bubonic plague. The prokaryotes, an evolving electronic resource for the microbiological community 2000. Available from: http:\/\/141.150.157.117:8080\/prokPUB\/chaprender\/jsp\/showchap.jsp?chapnum=265."},{"key":"10.1016\/j.vaccine.2010.08.099_bib0255","series-title":"Plague","author":"Pollitzer","year":"1954"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0020","series-title":"Plague manual: epidemiology, distribution, surveillance and control WHO\/CDS\/CSR\/EDC\/99.2","author":"Dennis","year":"1999"},{"issue":"April (9568)","key":"10.1016\/j.vaccine.2010.08.099_bib0025","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(07)60566-2","article-title":"Plague","volume":"369","author":"Prentice","year":"2007","journal-title":"Lancet"},{"issue":"May (17)","key":"10.1016\/j.vaccine.2010.08.099_bib0030","first-page":"2281","article-title":"JAMA","volume":"283","author":"Inglesby","year":"2000","journal-title":"Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense"},{"issue":"8","key":"10.1016\/j.vaccine.2010.08.099_bib0035","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1086\/428617","article-title":"Risk of person-to-person transmission of pneumonic plague","volume":"40","author":"Kool","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0040","series-title":"Bioterrorism and infectious agents: a new dilemma for the 21st century","first-page":"37","article-title":"Plague as a biological weapon","author":"Dennis","year":"2005"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2010.08.099_bib0045","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1128\/IAI.73.6.3598-3608.2005","article-title":"Human immune response to a plague vaccine comprising recombinant F1 and V antigens","volume":"73","author":"Williamson","year":"2005","journal-title":"Infect Immun"},{"issue":"April (16)","key":"10.1016\/j.vaccine.2010.08.099_bib0050","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1016\/j.vaccine.2007.01.071","article-title":"Development of a recombinant vaccine against aerosolized plague","volume":"25","author":"Morris","year":"2007","journal-title":"Vaccine"},{"issue":"November (Suppl. 4)","key":"10.1016\/j.vaccine.2010.08.099_bib0055","doi-asserted-by":"crossref","first-page":"D56","DOI":"10.1016\/j.vaccine.2009.07.068","article-title":"Plague","volume":"27","author":"Williamson","year":"2009","journal-title":"Vaccine"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2010.08.099_bib0060","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","article-title":"Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine","volume":"16","author":"Heath","year":"1998","journal-title":"Vaccine"},{"issue":"2\u20133","key":"10.1016\/j.vaccine.2010.08.099_bib0065","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0264-410X(00)00108-0","article-title":"Protection conferred by a fully recombinant sub-unit vaccine against Yersinia pestis in male and female mice of four inbred strains","volume":"19","author":"Jones","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0070","series-title":"Animals models and correlates of protection for plague vaccines workshop","article-title":"Non-human primates as a model for pneumonic plague","author":"Pitt","year":"2004"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2010.08.099_bib0075","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1128\/CVI.00398-06","article-title":"Development of in vitro correlate assays of immunity to infection with Yersinia pestis","volume":"14","author":"Bashaw","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0080","series-title":"5th annual biodefense vaccines & therapeutics policy, funding, and development conference; 2007","article-title":"The \u201cAnimal Rule\u201d","author":"Abdy","year":"2007"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0085","first-page":"37988","article-title":"New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible, final rule","volume":"67","year":"2002","journal-title":"Federal Register"},{"issue":"5","key":"10.1016\/j.vaccine.2010.08.099_bib0090","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1586\/erv.10.22","article-title":"Predictive models and correlates of protection for testing biodefence vaccines","volume":"9","author":"Williamson","year":"2010","journal-title":"Expert Rev Vaccines"},{"issue":"April (4)","key":"10.1016\/j.vaccine.2010.08.099_bib0095","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4269\/ajtmh.1997.56.471","article-title":"Protection of mice from fatal bubonic and pneumonic plague by passive immunization with monoclonal antibodies against the F1 protein of Yersinia pestis","volume":"56","author":"Anderson","year":"1997","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.vaccine.2010.08.099_bib0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1574-695X.1999.tb01229.x","article-title":"The SCID\/Beige mouse as a model to investigate protection against Yersinia pestis","volume":"23","author":"Green","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"April (4)","key":"10.1016\/j.vaccine.2010.08.099_bib0105","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1128\/IAI.71.4.2234-2238.2003","article-title":"Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis","volume":"71","author":"Hill","year":"2003","journal-title":"Infect Immun"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2010.08.099_bib0110","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1128\/IAI.74.5.3068-3070.2006","article-title":"Administration of antibody to the lung protects mice against pneumonic plague","volume":"74","author":"Hill","year":"2006","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2010.08.099_bib0115","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1586\/14760584.7.2.209","article-title":"Current challenges in the development of vaccines for pneumonic plague","volume":"7","author":"Smiley","year":"2008","journal-title":"Expert Rev Vaccines"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2010.08.099_bib0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.micpath.2006.09.003","article-title":"Immunogenicity of the rF1+rV vaccine for plague with identification of potential immune correlates","volume":"42","author":"Williamson","year":"2007","journal-title":"Microb Pathog"},{"issue":"21\u201322","key":"10.1016\/j.vaccine.2010.08.099_bib0125","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1016\/S0264-410X(03)00112-9","article-title":"Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague","volume":"21","author":"Garmory","year":"2003","journal-title":"Vaccine"},{"issue":"September (9)","key":"10.1016\/j.vaccine.2010.08.099_bib0130","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1128\/IAI.73.9.6127-6137.2005","article-title":"Anti-LcrV antibody inhibits delivery of Yops by Yersinia pestis KIM5 by directly promoting phagocytosis","volume":"73","author":"Cowan","year":"2005","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2010.08.099_bib0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/mpat.2002.0498","article-title":"Anti-V antigen antibody protects macrophages from Yersinia pestis-induced cell death and promotes phagocytosis","volume":"32","author":"Weeks","year":"2002","journal-title":"Microb Pathog"},{"issue":"March (13)","key":"10.1016\/j.vaccine.2010.08.099_bib0140","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.vaccine.2008.01.033","article-title":"Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague","volume":"26","author":"Zauberman","year":"2008","journal-title":"Vaccine"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2010.08.099_bib0145","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1128\/CVI.00091-08","article-title":"Modified caspase-3 assay indicates correlation of caspase-3 activity with immunity of nonhuman primates to Yersinia pestis infection","volume":"15","author":"Welkos","year":"2008","journal-title":"Clin Vaccine Immunol"},{"issue":"December (12)","key":"10.1016\/j.vaccine.2010.08.099_bib0150","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/CVI.00333-09","article-title":"Dual-function antibodies to Yersinia pestis LcrV required for pulmonary clearance of plague","volume":"16","author":"Eisele","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1600-065X.2008.00674.x","article-title":"Immune defense against pneumonic plague","volume":"225","author":"Smiley","year":"2008","journal-title":"Immunol Rev"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2010.08.099_bib0160","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1128\/IAI.00185-06","article-title":"Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection","volume":"74","author":"Parent","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0165","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1016\/j.vaccine.2008.09.063","article-title":"Antibodies and cytokines independently protect against pneumonic plague","volume":"26","author":"Kummer","year":"2008","journal-title":"Vaccine"},{"issue":"November (50)","key":"10.1016\/j.vaccine.2010.08.099_bib0170","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1016\/j.vaccine.2008.09.031","article-title":"Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4+ cells are required at the time of challenge for optimal protection","volume":"26","author":"Chattopadhyay","year":"2008","journal-title":"Vaccine"},{"issue":"April (16)","key":"10.1016\/j.vaccine.2010.08.099_bib0175","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1016\/j.vaccine.2009.02.016","article-title":"CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague","volume":"27","author":"Amemiya","year":"2009","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2010.08.099_bib0180","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1128\/IAI.65.11.4476-4482.1997","article-title":"Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization","volume":"65","author":"Hill","year":"1997","journal-title":"Infect Immun"},{"issue":"November (11)","key":"10.1016\/j.vaccine.2010.08.099_bib0185","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1128\/IAI.73.11.7304-7310.2005","article-title":"Cell-mediated protection against pulmonary Yersinia pestis infection","volume":"73","author":"Parent","year":"2005","journal-title":"Infect Immun"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2010.08.099_bib0190","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1128\/IAI.00559-09","article-title":"Absence of inflammation and pneumonia during infection with nonpigmented Yersinia pestis reveals a new role for the pgm locus in pathogenesis","volume":"78","author":"Lee-Lewis","year":"2010","journal-title":"Infect Immun"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2010.08.099_bib0195","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1128\/IAI.01236-09","article-title":"The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague","volume":"78","author":"Fetherston","year":"2010","journal-title":"Infect Immun"},{"issue":"September (36)","key":"10.1016\/j.vaccine.2010.08.099_bib0200","doi-asserted-by":"crossref","first-page":"12909","DOI":"10.1073\/pnas.0502849102","article-title":"Replication of Yersinia pestis in interferon gamma-activated macrophages requires ripA, a gene encoded in the pigmentation locus","volume":"102","author":"Pujol","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"December (49)","key":"10.1016\/j.vaccine.2010.08.099_bib0205","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1073\/pnas.0506840102","article-title":"Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity","volume":"102","author":"Lathem","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"January (5811)","key":"10.1016\/j.vaccine.2010.08.099_bib0210","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.1137195","article-title":"A plasminogen-activating protease specifically controls the development of primary pneumonic plague","volume":"315","author":"Lathem","year":"2007","journal-title":"Science"},{"issue":"February (2)","key":"10.1016\/j.vaccine.2010.08.099_bib0215","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/IAI.00403-06","article-title":"Delayed inflammatory response to primary pneumonic plague occurs in both outbred and inbred mice","volume":"75","author":"Bubeck","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.49.1.15","article-title":"Studies on plague immunity in experimental animals. II. Some factors of the immunity mechanism in bubonic plague","volume":"49","author":"Jawetz","year":"1944","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2010.08.099_bib0225","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4049\/jimmunol.64.3.139","article-title":"Immunity in plague: a critical consideration of some recent studies","volume":"64","author":"Meyer","year":"1950","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2010.08.099_bib0230","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/IAI.61.1.23-31.1993","article-title":"Association between virulence of Yersinia pestis and suppression of gamma interferon and tumor necrosis factor alpha","volume":"61","author":"Nakajima","year":"1993","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.vaccine.2010.08.099_bib0235","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/IAI.63.8.3021-3029.1995","article-title":"Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization","volume":"63","author":"Nakajima","year":"1995","journal-title":"Infect Immun"},{"issue":"November (11)","key":"10.1016\/j.vaccine.2010.08.099_bib0240","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1128\/IAI.73.11.7142-7150.2005","article-title":"Pathogenesis of Yersinia pestis infection in BALB\/c mice: effects on host macrophages and neutrophils","volume":"73","author":"Lukaszewski","year":"2005","journal-title":"Infect Immun"},{"issue":"October (4)","key":"10.1016\/j.vaccine.2010.08.099_bib0245","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.micpath.2004.06.009","article-title":"Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague","volume":"37","author":"Elvin","year":"2004","journal-title":"Microb Pathog"},{"issue":"February (2)","key":"10.1016\/j.vaccine.2010.08.099_bib0250","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat Rev Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X10012879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X10012879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T10:53:45Z","timestamp":1685789625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X10012879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0264410X10012879"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2010.08.099","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}