{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:23:56Z","timestamp":1761675836074},"reference-count":24,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.vaccine.2011.02.074","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T06:48:48Z","timestamp":1299566928000},"page":"3596-3599","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacology and toxicology of an oral tablet whole cells inactivated cholera vaccine in Sprague Dawley rats"],"prefix":"10.1016","volume":"29","author":[{"given":"Yulie\u00e9","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Francisco","family":"Infante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Sifontes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiyana","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"A\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonsire","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Luis","family":"Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Cedr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reynaldo","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa L.","family":"Sol\u00eds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Talavera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2011.02.074_bib0005","unstructured":"Word Health Organization. WHO. Weekly Epidemiological Record, No. 31; 4 August 2006."},{"issue":"6","key":"10.1016\/j.vaccine.2011.02.074_bib0010","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3855\/jidc.410","article-title":"Is cholera disease associated with poverty?","volume":"3","author":"Talavera","year":"2009","journal-title":"J Infect Dev Ctries"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0015","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/j.vaccine.2004.12.029","article-title":"Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries","volume":"23","author":"Walter","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0020","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.vaccine.2006.09.049","article-title":"Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults","volume":"25","author":"Anha","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0025","unstructured":"Word Health Organization. Nonclinical evaluation. Available from: http:\/\/www.who.int\/biologicals\/areas\/vaccines\/nonclinical_evaluation\/en\/index.html."},{"key":"10.1016\/j.vaccine.2011.02.074_bib0030","unstructured":"Word Health Organization. Guidelines for the production and control of inactivated oral cholera vaccines. WHO Technical Report, Series No. 924; 2004."},{"key":"10.1016\/j.vaccine.2011.02.074_bib0035","unstructured":"Proceedings of the workshop on non-clinical safety evaluation of preventive vaccines: recent advances and regulatory considerations, vol. I, Monday, December 2, 2002, Arlington, Virginia. Miller Reporting Co., Inc., 735 8th Street, S.E. Washington, DC 20003-2802, (202) 546\u20136666."},{"issue":"7","key":"10.1016\/j.vaccine.2011.02.074_bib0040","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.arcmed.2009.09.003","article-title":"Toxicity study per repeated dose of the V. cholerae attenuated vaccine in Sprague Dawley rats","volume":"40","author":"Sifontes","year":"2009","journal-title":"Arch Med Res"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0045","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1016\/j.vaccine.2005.12.064","article-title":"Formulation in tablets of a cholera whole cells inactivated vaccine candidate","volume":"24","author":"Talavera","year":"2006","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2011.02.074_bib0050","first-page":"56","article-title":"Estandarizaci\u00f3n del ensayo Vibriocida modificado para la determinaci\u00f3n de anticuerpos contra Vibrio cholerae","volume":"51","author":"Cedr\u00e9","year":"1999","journal-title":"Rev Cubana Med Trop"},{"issue":"2","key":"10.1016\/j.vaccine.2011.02.074_bib0055","first-page":"11","article-title":"Toxicity study per single dose of vax-SPIRAL vaccine in Sprague Dawley rats","volume":"13","author":"Infante","year":"2004","journal-title":"Vacci Monitor"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0060","first-page":"175","article-title":"Laboratory rats","volume":"vol. 2","author":"Canadian Council on Animal Care and Use","year":"1993"},{"issue":"2","key":"10.1016\/j.vaccine.2011.02.074_bib0065","first-page":"111","article-title":"Determination of toxicity in reiterative dose of the arsenical","volume":"17","author":"P\u00e9rez","year":"2001","journal-title":"Oncol Cuban Mag"},{"issue":"2","key":"10.1016\/j.vaccine.2011.02.074_bib0070","first-page":"155","article-title":"Localization of Vibrio Cholerae 01 in the intestinal tissue","volume":"11","author":"Sincharoen Kul","year":"1993","journal-title":"Asia Pac J Allergy Immunol"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0075","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1440-1797.2005.00494.x","article-title":"Propylthiouracil attenuates acetaminophen-induced renal damage in the rat","volume":"10","author":"Abraham","year":"2005","journal-title":"Nephrology"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0080","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cca.2005.07.032","article-title":"Effect of squalene on cyclophosphamide-induced toxicity","volume":"364","author":"Senthilkumar","year":"2006","journal-title":"Clin Chem Acta"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0085","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1248\/bpb.28.1304","article-title":"Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug","volume":"28","author":"Tasduq","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0090","series-title":"Laboratory animal medicine management","article-title":"Biology and medicine of rats","author":"Pritchett","year":"2004"},{"issue":"3","key":"10.1016\/j.vaccine.2011.02.074_bib0095","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1248\/bpb.28.556","article-title":"Pharmacokinetic behavior of Micafungin in rats with carbon tetrachloride-induced acute hepatic failure","volume":"28","author":"Kkunishi","year":"2005","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"10.1016\/j.vaccine.2011.02.074_bib0100","first-page":"110","article-title":"Regional variation in the histological appearance of the small and large intestine of the rat following acute and chronic administration of Melo's Conguer Mixtare","volume":"18","author":"Didia","year":"1999","journal-title":"West Afr J Med"},{"issue":"1","key":"10.1016\/j.vaccine.2011.02.074_bib0105","first-page":"1","article-title":"Immunogenicity assay and local toxicity of Neisseria meningitidis cochlear Sprague Dawley rats","volume":"18","author":"Infante","year":"2009","journal-title":"Vacci Monitor"},{"issue":"2","key":"10.1016\/j.vaccine.2011.02.074_bib0110","first-page":"41","article-title":"Non toxicity for a single dose study and local tolerance of the vaccine against Neisseria meningitides serogruop A and C using Sprague Dawley rats","volume":"18","author":"Fari\u00f1as","year":"2009","journal-title":"Vacci Monitor"},{"issue":"2","key":"10.1016\/j.vaccine.2011.02.074_bib0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1128\/JCM.24.2.203-209.1986","article-title":"Breast milk and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease","volume":"24","author":"Jertborn","year":"1986","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2011.02.074_bib0120","first-page":"308","article-title":"Protection against cholera in breast-fed children by antibodies in breast milk","author":"Glass","year":"1983","journal-title":"N Engl J Med"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11003094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11003094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T05:41:57Z","timestamp":1592372517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11003094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0264410X11003094"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.02.074","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}