{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T05:13:37Z","timestamp":1769318017714,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.vaccine.2011.03.087","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T15:40:04Z","timestamp":1302882004000},"page":"4142-4150","source":"Crossref","is-referenced-by-count":41,"title":["Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination"],"prefix":"10.1016","volume":"29","author":[{"given":"Zita","family":"Chovancova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Vlkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Litzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindrich","family":"Lokaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojtech","family":"Thon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2011.03.087_bib0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","article-title":"Common variable immunodeficiency disorders: division into distinct clinical phenotypes","volume":"112","author":"Chapel","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0020","doi-asserted-by":"crossref","first-page":"13451","DOI":"10.1073\/pnas.0901984106","article-title":"Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells","volume":"106","author":"Rakhmanov","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0285","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1025373601374","article-title":"Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects","volume":"23","author":"Piqueras","year":"2003","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0030","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1182\/blood.V99.5.1544","article-title":"Severe deficiency of switched memory B cells (CD27(+)IgM(\u2212)IgD(\u2212)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease","volume":"99","author":"Warnatz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0290","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.4049\/jimmunol.175.8.5498","article-title":"Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients","volume":"175","author":"Taubenheim","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0295","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2249.2005.02793.x","article-title":"Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method","volume":"140","author":"Ferry","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0045","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2249.2006.03274.x","article-title":"T and B lymphocyte subpopulations and activation\/differentiation markers in patients with selective IgA deficiency","volume":"147","author":"Litzman","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0300","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2249.1997.tb08314.x","article-title":"Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients","volume":"110","author":"Thon","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0055","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2249.1995.tb02281.x","article-title":"Defects in antigen-driven lymphocyte responses in common variable immunodeficiency (CVID) are due to a reduction in the number of antigen-specific CD4+ T cells","volume":"101","author":"Funauchi","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0305","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1182\/blood.V84.12.4234.bloodjournal84124234","article-title":"A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency","volume":"84","author":"Fischer","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0310","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.178.6.3932","article-title":"Unravelling the complexity of T cell abnormalities in common variable immunodeficiency","volume":"178","author":"Giovannetti","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0090-1229(90)90145-G","article-title":"Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2","volume":"56","author":"Bryant","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0075","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2141.1994.tb05068.x","article-title":"Impaired TCR signal transduction, but normal antigen presentation, in a patient with common variable immunodeficiency","volume":"88","author":"Fischer","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0315","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1073\/pnas.91.3.1099","article-title":"CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency","volume":"91","author":"Farrington","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0320","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2249.2009.03913.x","article-title":"Decrease in phenotypic regulatory T cells in subsets of patients with common variable immunodeficiency","volume":"156","author":"Horn","year":"2009","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2011.03.087_bib0325","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s10875-010-9424-3","article-title":"B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease","volume":"30","author":"Mouillot","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0330","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa051568","article-title":"An antibody-deficiency syndrome due to mutations in the CD19 gene","volume":"354","author":"van Zelm","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0335","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.clim.2004.07.002","article-title":"ICOS deficiency in patients with common variable immunodeficiency","volume":"113","author":"Salzer","year":"2004","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0340","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2011.03.087_bib0345","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI39748","article-title":"CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency","volume":"120","author":"van Zelm","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0350","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1073\/pnas.0700815104","article-title":"Role for Msh5 in the regulation of Ig class switch recombination","volume":"104","author":"Sekine","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0355","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI is mutant in common variable immunodeficiency and IgA deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0360","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0365","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10875-009-9317-5","article-title":"Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency","volume":"29","author":"Mohammadi","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.gde.2007.04.002","article-title":"Deconstructing common variable immunodeficiency by genetic analysis","volume":"17","author":"Schaffer","year":"2007","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0370","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0375","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.clim.2007.04.011","article-title":"Active vaccination in patients with common variable immunodeficiency (CVID)","volume":"124","author":"Goldacker","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0380","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/CVI.00489-07","article-title":"Serum bactericidal antibody responses to meningococcal polysaccharide vaccination as a basis for clinical classification of common variable immunodeficiency","volume":"15","author":"Rezaei","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0385","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/CVI.00389-09","article-title":"Serum bactericidal antibody response 1 year after meningococcal polysaccharide vaccination of patients with common variable immunodeficiency","volume":"17","author":"Rezaei","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0390","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1016\/j.vaccine.2010.07.027","article-title":"Vaccination against tick-borne encephalitis virus tests specific IgG production ability in patients under immunoglobulin substitution therapy","volume":"28","author":"Seidel","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0165","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0022-1759(83)90308-3","article-title":"A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells","volume":"65","author":"Czerkinsky","year":"1983","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0170","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0090-1229(80)90146-4","article-title":"Endogenous cortisol: a regulator of the number of lymphocytes in peripheral blood","volume":"17","author":"Thomson","year":"1980","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0175","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/bmj.286.6372.1171","article-title":"Diurnal variation of lymphocyte subsets identified by monoclonal antibodies","volume":"286","author":"Bertouch","year":"1983","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0180","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.4049\/jimmunol.122.6.2498","article-title":"Characterization of a circulating subpopulation of spontaneous antitetanus toxoid antibody producing B cells following in vivo booster immunization","volume":"122","author":"Stevens","year":"1979","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0185","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI111341","article-title":"Antibody synthesis by bone marrow cells in vitro following primary and booster tetanus toxoid immunization in humans","volume":"73","author":"Kodo","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0190","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF00915075","article-title":"Human IgA antibody and immunoglobulin production after in vivo tetanus toxoid immunization: size and surface membrane phenotype analysis","volume":"2","author":"Thiele","year":"1982","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0195","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/clim.2001.5052","article-title":"Long-term low-dose IL-2 enhances immune function in common variable immunodeficiency","volume":"100","author":"Cunningham-Rundles","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0200","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1172\/JCI106756","article-title":"Immunologic responses to bacteriophage phi-X 174 in immunodeficiency diseases","volume":"50","author":"Ochs","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0205","first-page":"231","article-title":"Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease","volume":"7","author":"Rezaei","year":"2008","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0210","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.clim.2006.05.003","article-title":"Memory switched B cell percentage and not serum immunoglobulin concentration is associated with clinical complications in children and adults with specific antibody deficiency and common variable immunodeficiency","volume":"120","author":"Alachkar","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0215","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1182\/blood.V89.4.1288","article-title":"Evidence for a large compartment of IgM-expressing memory B cells in humans","volume":"89","author":"Klein","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0220","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1521-6616(03)00092-5","article-title":"Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM","volume":"108","author":"Shi","year":"2003","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0225","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/eji.200939531","article-title":"Memory B cells: effectors of long-lived immune responses","volume":"39","author":"Tangye","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0395","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","article-title":"Human blood IgM \u201cmemory\u201d B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire","volume":"104","author":"Weller","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0235","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.clim.2008.02.013","article-title":"Memory B cells in common variable immunodeficiency: clinical associations and sex differences","volume":"128","author":"Sanchez-Ramon","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0240","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cyto.b.20432","article-title":"Flowcytometric phenotyping of common variable immunodeficiency","volume":"74","author":"Warnatz","year":"2008","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.0105-2896.2004.0109.x","article-title":"Peripheral development of B cells in mouse and man","volume":"197","author":"Carsetti","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0250","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/eji.200839129","article-title":"Clonal dissection of the human memory B-cell repertoire following infection and vaccination","volume":"39","author":"Pinna","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0255","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1007\/PL00000761","article-title":"Peripheral B cell survival","volume":"57","author":"Agenes","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0400","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.clim.2005.11.011","article-title":"CD8+HLA\u2212DR+ T lymphocytes are increased in common variable immunodeficiency patients with impaired memory B-cell differentiation","volume":"119","author":"Viallard","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0265","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clim.2005.03.019","article-title":"Immune competence and switched memory B cells in common variable immunodeficiency","volume":"116","author":"Ko","year":"2005","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0405","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/eji.1830260136","article-title":"Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency","volume":"26","author":"Fischer","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0410","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1182\/blood-2009-02-207423","article-title":"Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency","volume":"114","author":"Borte","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0280","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI116701","article-title":"Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin","volume":"92","author":"Nonoyama","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0415","doi-asserted-by":"crossref","first-page":"800","DOI":"10.4049\/jimmunol.180.2.800","article-title":"CpG drives human transitional B cells to terminal differentiation and production of natural antibodies","volume":"180","author":"Capolunghi","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.03.087_bib0420","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jaut.2010.09.006","article-title":"Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies","volume":"36","author":"Bayry","year":"2011","journal-title":"J Autoimmun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11004695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11004695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T10:00:51Z","timestamp":1686045651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11004695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":58,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0264410X11004695"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.03.087","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}