{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:32:46Z","timestamp":1764401566723},"reference-count":44,"publisher":"Elsevier BV","issue":"29-30","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.vaccine.2011.04.070","type":"journal-article","created":{"date-parts":[[2011,5,8]],"date-time":"2011-05-08T14:18:58Z","timestamp":1304864338000},"page":"4829-4838","source":"Crossref","is-referenced-by-count":63,"title":["Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection"],"prefix":"10.1016","volume":"29","author":[{"given":"Emily Jane","family":"Bek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khairunnisa Mohamed","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patchara","family":"Phuektes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Choy","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenglun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Charles","family":"McMinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vaccine.2011.04.070_bib0005","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1086\/318454","article-title":"Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia","volume":"32","author":"McMinn","year":"2001","journal-title":"Clinical Infectious Diseases"},{"issue":"September (13)","key":"10.1016\/j.vaccine.2011.04.070_bib0010","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJM199909233411302","article-title":"Neurologic complications in children with enterovirus 71 infection","volume":"341","author":"Huang","year":"1999","journal-title":"New England Journal of Medicine"},{"issue":"9191","key":"10.1016\/j.vaccine.2011.04.070_bib0015","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0140-6736(99)04434-7","article-title":"Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease","volume":"354","author":"Chang","year":"1999","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.070_bib0020","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes","volume":"9","author":"Cardosa","year":"2003","journal-title":"Emerging Infectious Disease"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.070_bib0025","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","article-title":"An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China","volume":"44","author":"Zhang","year":"2009","journal-title":"Journal of Clinical Virology"},{"issue":"12","key":"10.1016\/j.vaccine.2011.04.070_bib0030","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998","volume":"73","author":"Brown","year":"1999","journal-title":"Journal of Virology"},{"issue":"10","key":"10.1016\/j.vaccine.2011.04.070_bib0035","first-page":"1350","article-title":"Enterovirus 71 isolated from a case of acute flaccid paralysis in India represents a new genotype","volume":"84","author":"Deshpande","year":"2003","journal-title":"Current Science"},{"issue":"September (11)","key":"10.1016\/j.vaccine.2011.04.070_bib0040","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1128\/JCM.00630-09","article-title":"Reemergence of enterovirus 71 in 2008 in Taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008","volume":"47","author":"Huang","year":"2009","journal-title":"Journal of Clinical Microbiology"},{"issue":"5","key":"10.1016\/j.vaccine.2011.04.070_bib0045","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1086\/511073","article-title":"Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study","volume":"44","author":"Ooi","year":"2007","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.070_bib0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jcv.2010.07.009","article-title":"Epidemiology of hand, foot, and mouth disease and genotype characterization of enterovirus 71 in Jiangsu, China","volume":"49","author":"Mao","year":"2010","journal-title":"Journal of Clinical Virology"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.070_bib0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.virol.2009.12.007","article-title":"Analysis of recombination and natural selection in human enterovirus 71","volume":"398","author":"Chen","year":"2010","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.vaccine.2011.04.070_bib0060","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00705-010-0722-0","article-title":"Emergence of enterovirus 71 \u201cdouble-recombinant\u201d strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71","volume":"155","author":"Yip","year":"2010","journal-title":"Archives of Virology"},{"issue":"5","key":"10.1016\/j.vaccine.2011.04.070_bib0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00001432-200310000-00002","article-title":"Infectious causes of acute flaccid paralysis","volume":"16","author":"Solomon","year":"2003","journal-title":"Current Opinion in Infectious Diseases"},{"issue":"August (16)","key":"10.1016\/j.vaccine.2011.04.070_bib0070","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia","volume":"75","author":"McMinn","year":"2001","journal-title":"Journal of Virology"},{"issue":"20","key":"10.1016\/j.vaccine.2011.04.070_bib0075","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1016\/j.vaccine.2010.03.003","article-title":"EV71: an emerging infectious disease vaccine target in the Far East?","volume":"28","author":"Xu","year":"2010","journal-title":"Vaccine"},{"issue":"29","key":"10.1016\/j.vaccine.2011.04.070_bib0215","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1016\/j.vaccine.2010.09.065","article-title":"Forecasting the economic value of an Enterovirus 71 (EV71) vaccine","volume":"28","author":"Lee","year":"2010","journal-title":"Vaccine"},{"issue":"15","key":"10.1016\/j.vaccine.2011.04.070_bib0085","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.vaccine.2008.01.058","article-title":"Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge","volume":"26","author":"Chung","year":"2008","journal-title":"Vaccine"},{"issue":"43","key":"10.1016\/j.vaccine.2011.04.070_bib0090","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1016\/j.vaccine.2010.08.052","article-title":"Enterovirus 71 virus-like particle vaccine: Improved production conditions for enhanced yield","volume":"28","author":"Chung","year":"2010","journal-title":"Vaccine"},{"issue":"15","key":"10.1016\/j.vaccine.2011.04.070_bib0095","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1016\/j.vaccine.2005.12.047","article-title":"Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71","volume":"24","author":"Chen","year":"2006","journal-title":"Vaccine"},{"issue":"5\u20136","key":"10.1016\/j.vaccine.2011.04.070_bib0100","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0264-410X(01)00385-1","article-title":"Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus","volume":"20","author":"Wu","year":"2001","journal-title":"Vaccine"},{"issue":"October (10)","key":"10.1016\/j.vaccine.2011.04.070_bib0105","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1128\/JCM.00479-09","article-title":"Monoclonal antibodies to VP1 recognize a broad range of enteroviruses","volume":"47","author":"Miao","year":"2009","journal-title":"Journal of Clinical Microbiology"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.070_bib0110","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbrc.2009.09.103","article-title":"Generation of neutralizing monoclonal antibodies against enterovirus 71 using synthetic peptides","volume":"390","author":"Li","year":"2009","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"46","key":"10.1016\/j.vaccine.2011.04.070_bib0220","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1016\/j.vaccine.2010.08.080","article-title":"Combined peptides of human enterovirus 71 protect against virus infection in mice","volume":"28","author":"Liu","year":"2010","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2011.04.070_bib0120","article-title":"DNA vaccine constructs against enterovirus 71 elicit immune response in mice","volume":"5","author":"Tung","year":"2007","journal-title":"Genetic Vaccines and Therapy"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.04.070_bib0125","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/JVI.00999-09","article-title":"Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease","volume":"84","author":"Ong","year":"2010","journal-title":"Journal of Virology"},{"key":"10.1016\/j.vaccine.2011.04.070_bib0130","series-title":"Sinovac developing vaccine for hand, foot and mouth disease","year":"2008"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2011.04.070_bib0135","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1099\/vir.0.83676-0","article-title":"The molecular basis of mouse adaptation by human enterovirus 71","volume":"89","author":"Chua","year":"2008","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.vaccine.2011.04.070_bib0140","first-page":"493","article-title":"A simple method of estimating fifty percent endpoint","volume":"27","author":"Reed","year":"1938","journal-title":"American Journal of Hygiene"},{"key":"10.1016\/j.vaccine.2011.04.070_bib0145","first-page":"556","article-title":"Ontogeny and development of extrathymic T cells in mouse liver","volume":"77","author":"Iiai","year":"1992","journal-title":"Immunology"},{"issue":"February (2)","key":"10.1016\/j.vaccine.2011.04.070_bib0150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1086\/315285","article-title":"Maternal antibody transfer in baboons and mice vaccinated with a Group B streptococcal polysaccharide conjugate","volume":"181","author":"Paoletti","year":"2000","journal-title":"Journal of Infectious Diseases"},{"issue":"September (17)","key":"10.1016\/j.vaccine.2011.04.070_bib0155","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.1128\/JVI.00236-07","article-title":"Retrograde axonal transport: a major transmission route of enterovirus 71 in mice","volume":"81","author":"Chen","year":"2007","journal-title":"Journal of Virology"},{"issue":"47","key":"10.1016\/j.vaccine.2011.04.070_bib0160","article-title":"The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments","volume":"7","author":"Jia","year":"2010","journal-title":"Virology Journal"},{"issue":"1","key":"10.1016\/j.vaccine.2011.04.070_bib0165","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/520149","article-title":"Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications","volume":"29","author":"Wang","year":"1999","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.070_bib0170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/1531-8249(199902)45:2<271::AID-ANA23>3.0.CO;2-Z","article-title":"Immunohistochemical detection of infected neurons as a rapid diagnosis of enterovirus 71 encephalomyelitis [2]","volume":"45","author":"Wong","year":"1999","journal-title":"Annals of Neurology"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.070_bib0175","first-page":"193","article-title":"First fatal case of enterovirus 71 infection in Hong Kong","volume":"7","author":"Ng","year":"2001","journal-title":"Hong Kong Medical Journal"},{"issue":"11","key":"10.1016\/j.vaccine.2011.04.070_bib0180","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.micinf.2007.06.002","article-title":"Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide","volume":"9","author":"Foo","year":"2007","journal-title":"Microbes and Infection"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.04.070_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JCM.40.1.10-15.2002","article-title":"Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000","volume":"40","author":"Wang","year":"2002","journal-title":"Journal of Clinical Microbiology"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.070_bib0190","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2217\/fvl.10.22","article-title":"Recent advances in research on human enterovirus 71","volume":"5","author":"Bek","year":"2010","journal-title":"Future Virology"},{"issue":"September (17)","key":"10.1016\/j.vaccine.2011.04.070_bib0195","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1128\/JVI.02856-06","article-title":"An attenuated strain of enterovirus 71 belonging to genotype A showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys","volume":"81","author":"Arita","year":"2007","journal-title":"Journal of Virology"},{"issue":"April (7)","key":"10.1016\/j.vaccine.2011.04.070_bib0200","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1128\/JVI.01019-09","article-title":"Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene","volume":"84","author":"Tee","year":"2010","journal-title":"Journal of Virology"},{"issue":"3","key":"10.1016\/j.vaccine.2011.04.070_bib0205","doi-asserted-by":"crossref","DOI":"10.3201\/eid0903.020285","article-title":"Enterovirus 71 outbreaks, Taiwan: occurrence and recognition","volume":"9","author":"Lin","year":"2003","journal-title":"Emerging Infectious Diseases"},{"issue":"8","key":"10.1016\/j.vaccine.2011.04.070_bib0210","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0264-410X(95)00211-I","article-title":"Inactivated poliovirus vaccine: past and present experience","volume":"14","author":"Murdin","year":"1996","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2011.04.070_bib0225","article-title":"The Triple A Approach to Ensuring Animal Welfare","volume":"10","author":"Davis","year":"1999","journal-title":"Animal Welfare Information Center Bulletin"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.070_bib0230","first-page":"28","article-title":"Guidelines for Assessing the Health and Condition of Mice","volume":"28","author":"Foltz","year":"1999","journal-title":"Lab Animal"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11006153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11006153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:17:49Z","timestamp":1592525869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11006153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":44,"journal-issue":{"issue":"29-30","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0264410X11006153"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.04.070","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}