{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:07:42Z","timestamp":1780625262393,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"29-30","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Biotechnology (DBT), New Delhi, India","award":["(BT\/PR3332\/AAQ\/01\/133\/2002)"],"award-info":[{"award-number":["(BT\/PR3332\/AAQ\/01\/133\/2002)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.vaccine.2011.04.088","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T15:10:40Z","timestamp":1305213040000},"page":"4720-4727","source":"Crossref","is-referenced-by-count":15,"title":["Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu\u2013Zn superoxide dismutase protein against Brucella abortus"],"prefix":"10.1016","volume":"29","author":[{"given":"Harisankar","family":"Singha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirul Islam","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakanta","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishat","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Owais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: an overview","volume":"3","author":"Corbel","year":"1997","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2011.04.088_bib0010","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.221575398","article-title":"The genome sequence of the facultative intracellular pathogen Brucella melitensis","volume":"99","author":"DelVecchio","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"20","key":"10.1016\/j.vaccine.2011.04.088_bib0015","doi-asserted-by":"crossref","first-page":"13148","DOI":"10.1073\/pnas.192319099","article-title":"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts","volume":"99","author":"Paulsen","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.088_bib0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","article-title":"Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum","volume":"198","author":"Celli","year":"2003","journal-title":"J Exp Med"},{"issue":"8","key":"10.1016\/j.vaccine.2011.04.088_bib0025","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/JB.187.8.2715-2726.2005","article-title":"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis","volume":"187","author":"Halling","year":"2005","journal-title":"J Bacteriol"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-1135(91)90091-S","article-title":"Biological properties of RB51; a stable rough strain of Brucella abortus","volume":"28","author":"Schurig","year":"1991","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2011.04.088_bib0035","first-page":"92","article-title":"Effect of reduced dosages of Brucella abortus strain 19 in cattle vaccinated as yearlings","volume":"83","author":"Deyoe","year":"1979","journal-title":"Proc Annu Meeting US Anim Health Assoc"},{"key":"10.1016\/j.vaccine.2011.04.088_bib0040","series-title":"Animal brucellosis","first-page":"284","author":"Nicoletti","year":"1990"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.088_bib0045","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2460\/ajvr.1990.51.04.518","article-title":"Differential reactivity of bovine lymphocytes to species of Brucella","volume":"51","author":"Smith","year":"1990","journal-title":"Am J Vet Res"},{"issue":"10","key":"10.1016\/j.vaccine.2011.04.088_bib0050","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0264-410X(96)00018-7","article-title":"Immunization of mice with recombinant L7\/L12 ribosomal protein confers protection against Brucella abortus infection","volume":"14","author":"Oliveira","year":"1996","journal-title":"Vaccine"},{"issue":"17\u201318","key":"10.1016\/j.vaccine.2011.04.088_bib0055","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0264-410X(97)00140-0","article-title":"Nucleic acid vaccination of Brucella abortus ribosomal L7\/L12 gene elicits immune response","volume":"15","author":"Kurar","year":"1997","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0060","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1128\/IAI.67.2.986-988.1999","article-title":"Vaccination with live Escherichia coli expressing Brucella abortus Cu\/Zn superoxide dismutase protects mice against virulent B. abortus","volume":"67","author":"Onate","year":"1999","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2011.04.088_bib0065","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/IAI.68.6.3286-3289.2000","article-title":"Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51","volume":"68","author":"Vemulapalli","year":"2000","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.vaccine.2011.04.088_bib0070","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1128\/IAI.71.9.4857-4861.2003","article-title":"A DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus induces protective immunity in BALB\/c mice","volume":"71","author":"Onate","year":"2003","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2011.04.088_bib0075","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1128\/IAI.73.6.3294-3300.2005","article-title":"An RNA vaccine based on recombinant Semliki Forest virus particles expressing the Cu\u2013Zn superoxide dismutase protein of Brucella abortus induces protective immunity in BALB\/c mice","volume":"73","author":"Onate","year":"2005","journal-title":"Infect Immun"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2011.04.088_bib0080","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.imbio.2005.09.004","article-title":"Evaluation of Brucella abortus DNA vaccine by expression of Cu\u2013Zn superoxide dismutase antigen fused to IL-2","volume":"211","author":"Gonzalez-Smith","year":"2006","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.vaccine.2011.04.088_bib0085","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1128\/IAI.01151-08","article-title":"Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection","volume":"77","author":"Pasquevich","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.04.088_bib0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1574-695X.2010.00758.x","article-title":"Immunization of mice with recombinant S-adenosyl-l homocysteine hydrolase protein confers protection against Brucella melitensis infection","volume":"61","author":"Yang","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2011.04.088_bib0095","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/bi00454a010","article-title":"A protein isolated from Brucella abortus is a Cu\u2013Zn superoxide dismutase","volume":"29","author":"Beck","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.vaccine.2011.04.088_bib0100","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1128\/IAI.58.9.2935-2939.1990","article-title":"Cloning, expression and occurrence of the Brucella Cu\u2013Zn superoxide dismutase","volume":"58","author":"Bricker","year":"1990","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0105","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpharm.2008.04.036","article-title":"Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens","volume":"364","author":"Perrie","year":"2008","journal-title":"Int J Pharm"},{"issue":"5","key":"10.1016\/j.vaccine.2011.04.088_bib0110","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2460\/ajvr.1996.57.05.677","article-title":"Protection of BALB\/c mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitensis and Brucella suis biovar 4","volume":"57","author":"Winter","year":"1996","journal-title":"Am J Vet Res"},{"issue":"l 5","key":"10.1016\/j.vaccine.2011.04.088_bib0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.vaccine.2010.03.054","article-title":"Immunopotentiation of live brucellosis vaccine by adjuvants","volume":"28","author":"Denisov","year":"2010","journal-title":"Vaccine"},{"issue":"18","key":"10.1016\/j.vaccine.2011.04.088_bib0120","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1016\/j.vaccine.2007.01.066","article-title":"Liposomised recombinant ribosomal L7\/L12 protein protects BALB\/c mice against Brucella abortus 544 infection","volume":"25","author":"Mallick","year":"2007","journal-title":"Vaccine"},{"issue":"46","key":"10.1016\/j.vaccine.2011.04.088_bib0125","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1016\/j.vaccine.2007.09.008","article-title":"Escheriosome-mediated delivery of recombinant ribosomal L7\/L12 protein confers protection against murine brucellosis","volume":"25","author":"Mallick","year":"2007","journal-title":"Vaccine"},{"issue":"10\u201311","key":"10.1016\/j.vaccine.2011.04.088_bib0130","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.micinf.2008.05.007","article-title":"Escheriosomes entrapped DNA vaccine co-expressing Cu\u2013Zn superoxide dismutase and IL-18 confers protection against Brucella abortus","volume":"10","author":"Singha","year":"2008","journal-title":"Microbes Infect"},{"issue":"1","key":"10.1016\/j.vaccine.2011.04.088_bib0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/cimm.2001.1805","article-title":"Liposome mediated antigen delivery leads to induction of CD8+ T lymphocyte and antibody responses against the V3 loop region of HIV gp120","volume":"210","author":"Ahmad","year":"2001","journal-title":"Cell Immunol"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2011.04.088_bib0140","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0264-410X(00)00363-7","article-title":"Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection","volume":"19","author":"Dupre","year":"2001","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2011.04.088_bib0145","first-page":"143","article-title":"Designing immune responses with genetic immunization and immunostimulatory DNA sequences","volume":"35","author":"Thalhamer","year":"2001","journal-title":"Endocr Regul"},{"issue":"3","key":"10.1016\/j.vaccine.2011.04.088_bib0150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00109-001-0307-1","article-title":"Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens","volume":"80","author":"Biet","year":"2002","journal-title":"J Mol Med"},{"issue":"8","key":"10.1016\/j.vaccine.2011.04.088_bib0155","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1099\/0022-1317-51-8-661","volume":"51","author":"Rosinha","year":"2002","journal-title":"J Med Microbiol"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0602313","article-title":"Interleukin-18","volume":"73","author":"Gracie","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"Pt 3","key":"10.1016\/j.vaccine.2011.04.088_bib0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1099\/jmm.0.04998-0","article-title":"Enhancement of DNA vaccine potency against herpes simplex virus 1 by co-administration of an interleukin-18 expression plasmid as a genetic adjuvant","volume":"52","author":"Zhu","year":"2003","journal-title":"J Med Microbiol"},{"issue":"1","key":"10.1016\/j.vaccine.2011.04.088_bib0170","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1574-6968.2006.00253.x","article-title":"Brucella abortus d-alanyl-d-alanine carboxypeptidase contributes to its intracellular replication and resistance against nitric oxide","volume":"259","author":"Kikuchi","year":"2006","journal-title":"FEMS Microbiol Lett"},{"issue":"7","key":"10.1016\/j.vaccine.2011.04.088_bib0175","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.vaccine.2006.10.017","article-title":"Immune enhancing effects of recombinant bovine IL-18 on foot-and-mouth disease vaccination in mice model","volume":"25","author":"Shi","year":"2007","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2011.04.088_bib0180","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-3083.2003.01250.x","article-title":"Quantification of cytokine gene expression using an economical real-time polymerase chain reaction method based on SYBR Green I","volume":"57","author":"Ramos-Payan","year":"2003","journal-title":"Scand J Immunol"},{"issue":"10","key":"10.1016\/j.vaccine.2011.04.088_bib0185","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1128\/IAI.69.10.6264-6270.2001","article-title":"Induction of immune response in BALB\/c mice with a DNA vaccine encoding bacterioferritin or P39 of Brucella spp","volume":"69","author":"Al-Mariri","year":"2001","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0190","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1099\/0022-1317-49-2-165","article-title":"Identification and partial characterisation of a new protective antigen of Brucella abortus","volume":"49","author":"Cespedes","year":"2000","journal-title":"J Med Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2011.04.088_bib0195","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1128\/IAI.70.5.2507-2511.2002","article-title":"A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB\/c mice","volume":"70","author":"Velikovsky","year":"2002","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.vaccine.2011.04.088_bib0200","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/IAI.73.10.6537-6546.2005","article-title":"A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response","volume":"73","author":"Cassataro","year":"2005","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0205","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11259-009-9337-x","article-title":"Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides","volume":"34","author":"Kaushik","year":"2010","journal-title":"Vet Res Commun"},{"issue":"10","key":"10.1016\/j.vaccine.2011.04.088_bib0210","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1128\/IAI.00331-06","article-title":"Comparison of protective efficacy of subcutaneous vs. intranasal immunization of mice with a Brucella melitensis lipopolysaccharide subunit vaccine","volume":"74","author":"Bhattacharjee","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.04.088_bib0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1479-0556-8-5","article-title":"Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensis challenge","volume":"8","author":"Commander","year":"2010","journal-title":"Genet Vaccines Ther"},{"issue":"10","key":"10.1016\/j.vaccine.2011.04.088_bib0220","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.2460\/ajvr.1992.53.10.1900","article-title":"Monophosphoryl lipid A-induced immune enhancement of Brucella abortus salt-extractable protein and lipopolysaccharide vaccines in BALB\/c mice","volume":"53","author":"Tabatabai","year":"1992","journal-title":"Am J Vet Res"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2011.04.088_bib0225","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0165-2427(98)00205-0","article-title":"Quantitative assessment by flow cytometry of T-lymphocytes producing antigen-specific gamma-interferon in Brucella immune cattle","volume":"66","author":"Weynants","year":"1998","journal-title":"Vet Immunol Immunopathol"},{"issue":"1","key":"10.1016\/j.vaccine.2011.04.088_bib0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1574-695X.2001.tb00536.x","article-title":"Immune control of Brucella abortus 2308 infections in BALB\/c mice","volume":"32","author":"Murphy","year":"2001","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2011.04.088_bib0235","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1128\/IAI.72.4.2081-2087.2004","article-title":"Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells","volume":"72","author":"Munoz-Montesino","year":"2004","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2011.04.088_bib0240","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.4049\/jimmunol.163.11.5871","article-title":"A distinct IL-18-induced pathway to fully activate NK T lymphocytes independently from TCR engagement","volume":"163","author":"Leite-De-Moraes","year":"1999","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.vaccine.2011.04.088_bib0245","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.4049\/jimmunol.162.9.5070","article-title":"IL-18 is a potent co inducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response","volume":"162","author":"Hoshino","year":"1999","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0250","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.4049\/jimmunol.164.2.1096","article-title":"Differential roles of IL-18 in allergic airway disease: induction of eotaxin by resident cell populations exacerbates eosinophil accumulation","volume":"164","author":"Campbell","year":"2000","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2011.04.088_bib0255","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.4049\/jimmunol.164.5.2701","article-title":"IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma","volume":"164","author":"Wild","year":"2000","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2011.04.088_bib0260","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/77811","article-title":"IL-18 induction of IgE: dependence on CD4+ T cells IL-4 and STAT6","volume":"1","author":"Yoshimoto","year":"2000","journal-title":"Nat Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11006438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11006438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T17:58:55Z","timestamp":1712426335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11006438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":52,"journal-issue":{"issue":"29-30","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0264410X11006438"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.04.088","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}