{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:38:39Z","timestamp":1794019119199,"version":"4.8.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"German Federal Agency for Agriculture and Food (BLE)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.vaccine.2011.04.116","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T18:02:24Z","timestamp":1306087344000},"page":"6352-6357","source":"Crossref","is-referenced-by-count":37,"title":["A DNA vaccine encoding the E protein of West Nile Virus is protective and can be boosted by recombinant domain DIII"],"prefix":"10.1016","volume":"29","author":[{"given":"Anne","family":"Schneeweiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Chabierski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Salomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Delaroque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiya","family":"Al-Robaiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Grunwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"B\u00fcrki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe G.","family":"Liebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ulbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2011.04.116_bib0005","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3201\/eid1108.050289b","article-title":"Virology, pathology, and clinical manifestations of West Nile virus disease","volume":"11","author":"Hayes","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0010","first-page":"29","article-title":"Epidemiology of west Nile in Europe and in the Mediterranean basin","volume":"4","author":"Calistri","year":"2010","journal-title":"Open Virol J"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1051\/vetres\/2010039","article-title":"West Nile virus and its emergence in the United States of America","volume":"41","author":"Murray","year":"2010","journal-title":"Vet Res"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0020","doi-asserted-by":"crossref","DOI":"10.2807\/ese.13.45.19030-en","article-title":"West Nile virus infections in Hungary. August\u2013September 2008","volume":"13","author":"Krisztalovics","year":"2008","journal-title":"Euro Surveill"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0025","doi-asserted-by":"crossref","DOI":"10.2807\/ese.14.44.19384-en","article-title":"Genome sequence analysis of the first human West Nile virus isolated in Italy in 2009","volume":"14","author":"Barzon","year":"2009","journal-title":"Euro Surveill"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2011.04.116_bib0030","article-title":"Outbreak of West Nile virus infection in humans, Romania, July to October 2010","volume":"16","author":"Sirbu","year":"2011","journal-title":"Euro Surveill"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0035","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.2741\/3432","article-title":"The host immunologic response to West Nile encephalitis virus","volume":"14","author":"Diamond","year":"2009","journal-title":"Front Biosci"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0040","doi-asserted-by":"crossref","unstructured":"Ulbert S, West Nile Virus\u2014the complex biology of an emerging pathogen. Intervirology, in press.","DOI":"10.1159\/000328320"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0045","first-page":"221","article-title":"Equine vaccine for West Nile virus","volume":"114","author":"Ng","year":"2003","journal-title":"Dev Biol (Basel)"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0050","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.vetimm.2008.02.002","article-title":"A West Nile virus (WNV) recombinant canarypox virus vaccine elicits WNV-specific neutralizing antibodies and cell-mediated immune responses in the horse","volume":"123","author":"El Garch","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0055","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1086\/523650","article-title":"A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial","volume":"196","author":"Martin","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vaccine.2007.10.055","article-title":"Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus","volume":"26","author":"Martina","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0065","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1128\/CVI.00119-09","article-title":"Immunogenicity and protective efficacy of a recombinant subunit West Nile virus vaccine in rhesus monkeys","volume":"16","author":"Lieberman","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0070","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nrg2432","article-title":"DNA vaccines: ready for prime time?","volume":"9","author":"Kutzler","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0075","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1128\/JVI.75.9.4040-4047.2001","article-title":"West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays","volume":"75","author":"Davis","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.virol.2004.11.022","volume":"332","author":"Anwar","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0085","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.micinf.2007.05.013","article-title":"Co-immunization with West Nile DNA and inactivated vaccines provides synergistic increases in their immunogenicities in mice","volume":"9","author":"Ishikawa","year":"2007","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0090","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0264-410X(01)00515-1","article-title":"Immune response to synthetic peptides of dengue prM protein","volume":"20","author":"V\u00e1zquez","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0095","doi-asserted-by":"crossref","first-page":"13097","DOI":"10.1128\/JVI.76.24.13097-13100.2002","article-title":"Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein","volume":"76","author":"Beasley","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0100","doi-asserted-by":"crossref","first-page":"11828","DOI":"10.1128\/JVI.00643-07","article-title":"Induction of epitope-specific neutralizing antibodies against West Nile virus","volume":"81","author":"Oliphant","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0105","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.4049\/jimmunol.163.12.6756","article-title":"A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms","volume":"163","author":"Aberle","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0110","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0264-410X(01)00492-3","article-title":"Protective efficacy of a plasmid DNA encoding Japanese encephalitis virus envelope protein fused to tissue plasminogen activator signal sequences: studies in a murine intracerebral virus challenge model","volume":"20","author":"Ashok","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1743-422X-7-95","article-title":"Enhancement of anti-DIII antibodies by the C3d derivative P28 results in lower viral titers and augments protection in mice","volume":"7","author":"Dunn","year":"2010","journal-title":"Virol J"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0120","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.178.5.2699","article-title":"Immunization of flavivirus West Nile recombinant envelope domain III protein induced specific immune response and protection against West Nile virus infection","volume":"178","author":"Chu","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00029330-200703020-00012","article-title":"Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer","volume":"120","author":"Li","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0130","first-page":"493","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Hygiene"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0135","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nature03956","article-title":"Structural basis of West Nile virus neutralization by a therapeutic antibody","volume":"437","author":"Nybakken","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0140","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.4049\/jimmunol.181.2.1563","article-title":"The memory T cell response to West Nile virus in symptomatic humans following natural infection is not influenced by age and is dominated by a restricted set of CD8+ T cell epitopes","volume":"181","author":"Parsons","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0145","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1016\/j.vaccine.2005.08.017","article-title":"Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation","volume":"24","author":"Otten","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0150","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1128\/JVI.74.9.4244-4252.2000","article-title":"A single intramuscular injection of recombinant plasmid DNA induces protective immunity and prevents Japanese encephalitis in mice","volume":"74","author":"Chang","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0155","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1016\/j.vaccine.2009.01.137","article-title":"Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII","volume":"27","author":"Ramanathan","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.04.116_bib0160","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.coi.2009.05.016","article-title":"Heterologous prime-boost vaccination","volume":"21","author":"Lu","year":"2009","journal-title":"Curr Opin Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11006827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11006827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T23:33:58Z","timestamp":1686094438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11006827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":32,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0264410X11006827"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.04.116","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}