{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:43:34Z","timestamp":1790480614475,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"41","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Ko 1579\/8-1"],"award-info":[{"award-number":["Ko 1579\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.vaccine.2011.05.069","type":"journal-article","created":{"date-parts":[[2011,6,18]],"date-time":"2011-06-18T16:47:45Z","timestamp":1308415665000},"page":"7125-7129","source":"Crossref","is-referenced-by-count":19,"title":["Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells"],"prefix":"10.1016","volume":"29","author":[{"given":"Timo","family":"Frensing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Heynisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Patzina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Kochs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Reichl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.vaccine.2011.05.069_bib0005","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1586\/erv.09.128","article-title":"Continuous cell lines as a production system for influenza vaccines","volume":"8","author":"Genzel","year":"2009","journal-title":"Expert Rev Vaccines"},{"issue":"December (4)","key":"10.1016\/j.vaccine.2011.05.069_bib0010","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jcv.2009.09.013","article-title":"Differential susceptibility of different cell lines to swine-origin influenza A H1N1 seasonal human influenza A H1N1 and avian influenza A H5N1 viruses","volume":"46","author":"Li","year":"2009","journal-title":"J Clin Virol"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2011.05.069_bib0015","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1586\/erv.09.31","article-title":"Trivalent MDCK cell culture-derived influenza vaccine Optaflu (Novartis Vaccines)","volume":"8","author":"Doroshenko","year":"2009","journal-title":"Expert Rev Vaccines"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.05.069_bib0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2005.09.024","article-title":"The interferon response circuit: induction and suppression by pathogenic viruses","volume":"344","author":"Haller","year":"2006","journal-title":"Virology"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.05.069_bib0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.micinf.2009.09.007","article-title":"Interplay between influenza A virus and the innate immune signaling","volume":"12","author":"Ehrhardt","year":"2010","journal-title":"Microbes Infect"},{"issue":"April (1)","key":"10.1016\/j.vaccine.2011.05.069_bib0030","first-page":"219","article-title":"Protective role of interferon-induced Mx GTPases against influenza viruses","volume":"28","author":"Haller","year":"2008","journal-title":"Rev Sci Tech"},{"issue":"January (4)","key":"10.1016\/j.vaccine.2011.05.069_bib0035","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1073\/pnas.0607038104","article-title":"IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses","volume":"104","author":"Lenschow","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2011.05.069_bib0040","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1128\/JVI.00105-08","article-title":"Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection","volume":"83","author":"Lai","year":"2009","journal-title":"J Virol"},{"issue":"August (4)","key":"10.1016\/j.vaccine.2011.05.069_bib0045","article-title":"Differential activation of host cell signalling pathways through infection with two variants of influenza A\/PR\/8\/34 (H1N1) in MDCK cells","author":"Heynisch","year":"2010","journal-title":"Vaccine"},{"issue":"July","key":"10.1016\/j.vaccine.2011.05.069_bib0050","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1099\/vir.0.020370-0","article-title":"High yields of influenza A virus in Madin\u2013Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state","volume":"91","author":"Seitz","year":"2010","journal-title":"J Gen Virol"},{"issue":"May (2)","key":"10.1016\/j.vaccine.2011.05.069_bib0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0042-6822(03)00119-3","article-title":"Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein","volume":"309","author":"Krug","year":"2003","journal-title":"Virology"},{"issue":"March (11)","key":"10.1016\/j.vaccine.2011.05.069_bib0060","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1074\/jbc.C109.095703","article-title":"Species Specificity of the NS1 Protein of Influenza B Virus NS1 Binds only human and non-human primate ubiquitin-like isg15 proteins","volume":"285","author":"Sridharan","year":"2010","journal-title":"J Biol Chem"},{"issue":"May (10)","key":"10.1016\/j.vaccine.2011.05.069_bib0065","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1128\/JVI.02395-09","article-title":"Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein","volume":"84","author":"Versteeg","year":"2010","journal-title":"J Virol"},{"issue":"June (17\u201318)","key":"10.1016\/j.vaccine.2011.05.069_bib0070","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.vaccine.2003.11.041","article-title":"Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture","volume":"22","author":"Genzel","year":"2004","journal-title":"Vaccine"},{"issue":"May (3)","key":"10.1016\/j.vaccine.2011.05.069_bib0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biologicals.2007.10.002","article-title":"Monitoring influenza virus content in vaccine production: precise assays for the quantitation of hemagglutination and neuraminidase activity","volume":"36","author":"Kalbfuss","year":"2008","journal-title":"Biologicals"},{"issue":"December (1\u20132)","key":"10.1016\/j.vaccine.2011.05.069_bib0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0014-5793(99)01598-7","article-title":"The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures","volume":"463","author":"Flohr","year":"1999","journal-title":"FEBS Lett"},{"issue":"July (14)","key":"10.1016\/j.vaccine.2011.05.069_bib0085","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1128\/JVI.00724-07","article-title":"Peptide-mediated interference with influenza A virus polymerase","volume":"81","author":"Ghanem","year":"2007","journal-title":"J Virol"},{"issue":"October (10)","key":"10.1016\/j.vaccine.2011.05.069_bib0090","article-title":"Identification of a PA-binding peptide with inhibitory activity against Influenza A and B virus replication","volume":"4.","author":"Wunderlich","year":"2009","journal-title":"Plos One"},{"issue":"April (7)","key":"10.1016\/j.vaccine.2011.05.069_bib0095","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1128\/JVI.01753-07","article-title":"Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase","volume":"82","author":"Dittmann","year":"2008","journal-title":"J Virol"},{"issue":"September (9)","key":"10.1016\/j.vaccine.2011.05.069_bib0100","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/jir.2009.0068","article-title":"Rhabdovirus evasion of the interferon system","volume":"29","author":"Rieder","year":"2009","journal-title":"J Interferon Cytokine Res"},{"issue":"8","key":"10.1016\/j.vaccine.2011.05.069_bib0105","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1348-0421.1980.tb02873.x","article-title":"Susceptibility of influenza viruses to interferon and to poly(I). Poly(C) determined by the plaque reduction method","volume":"24","author":"Machida","year":"1980","journal-title":"Microbiol Immunol"},{"issue":"October (4)","key":"10.1016\/j.vaccine.2011.05.069_bib0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF00775982","article-title":"Sensitivity of ortho- and paramyxovirus replication to human interferon alpha","volume":"10","author":"Strube","year":"1985","journal-title":"Mol Biol Rep"},{"issue":"September (9)","key":"10.1016\/j.vaccine.2011.05.069_bib0115","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nm757","article-title":"Lethal H5N1 influenza viruses escape host anti-viral cytokine responses","volume":"8","author":"Seo","year":"2002","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.vaccine.2011.05.069_bib0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1084\/jem.123.2.309","article-title":"The influence of cortisone on experimental viral infection. VII kinetics of interferon formation and its inhibition with hydrocortisone in relation to viral strain and virulence","volume":"123","author":"Smart","year":"1966","journal-title":"J Exp Med"},{"issue":"June (11)","key":"10.1016\/j.vaccine.2011.05.069_bib0125","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1128\/JVI.00272-10","article-title":"Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections","volume":"84","author":"Mordstein","year":"2010","journal-title":"J Virol"},{"issue":"September (1\u20132)","key":"10.1016\/j.vaccine.2011.05.069_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virusres.2008.04.028","article-title":"Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus","volume":"136","author":"Ueda","year":"2008","journal-title":"Virus Res"},{"issue":"April (16)","key":"10.1016\/j.vaccine.2011.05.069_bib0135","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1073\/pnas.0701849104","article-title":"Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene","volume":"104","author":"Grimm","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"November (21)","key":"10.1016\/j.vaccine.2011.05.069_bib0140","doi-asserted-by":"crossref","first-page":"10502","DOI":"10.1128\/JVI.00970-08","article-title":"Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells","volume":"82","author":"Murakami","year":"2008","journal-title":"J Virol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11008164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11008164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T19:22:15Z","timestamp":1712517735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11008164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":28,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0264410X11008164"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.05.069","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}