{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:54:09Z","timestamp":1775904849717,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Human Frontier Science Program"},{"name":"Ministry of Health, Labour, and Welfare, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.vaccine.2011.06.073","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T19:49:36Z","timestamp":1311277776000},"page":"6252-6258","source":"Crossref","is-referenced-by-count":21,"title":["Effect of rice-expressed amyloid \u03b2 in the Tg2576 Alzheimer's disease transgenic mouse model"],"prefix":"10.1016","volume":"29","author":[{"given":"Jun","family":"Nojima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Ishiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2011.06.073_bib0005","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/archneur.62.2.192","article-title":"Defining molecular targets to prevent Alzheimer disease","volume":"62","author":"Selkoe","year":"2005","journal-title":"Arch Neurol"},{"issue":"5054","key":"10.1016\/j.vaccine.2011.06.073_bib0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.vaccine.2011.06.073_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abbi.1993.1112","article-title":"Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease","volume":"301","author":"Miller","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"22","key":"10.1016\/j.vaccine.2011.06.073_bib0020","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1073\/pnas.90.22.10836","article-title":"beta-Amyloid-(1\u201342) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease","volume":"90","author":"Roher","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"issue":"18","key":"10.1016\/j.vaccine.2011.06.073_bib0025","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/bi00069a001","article-title":"The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease","volume":"32","author":"Jarrett","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.vaccine.2011.06.073_bib0030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1749-6632.2000.tb06943.x","article-title":"Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice","volume":"920","author":"Lemere","year":"2000","journal-title":"Ann NY Acad Sci"},{"issue":"6740","key":"10.1016\/j.vaccine.2011.06.073_bib0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.vaccine.2011.06.073_bib0040","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1002\/jnr.22503","article-title":"Efficient four-drug cocktail therapy targeting amyloid-\u03b2 peptide for Alzheimer's disease","volume":"88","author":"Asai","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.vaccine.2011.06.073_bib0045","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/78682","article-title":"Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease","volume":"6","author":"Bard","year":"2001","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.vaccine.2011.06.073_bib0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1212\/01.WNL.0000073623.84147.A8","article-title":"Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization","volume":"61","author":"Orgogozo","year":"2003","journal-title":"Neurology"},{"issue":"9634","key":"10.1016\/j.vaccine.2011.06.073_bib0055","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","article-title":"Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial","volume":"372","author":"Holmes","year":"2008","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.vaccine.2011.06.073_bib0060","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/adt.2004.2.383","article-title":"Expression of amyloid-beta 1\u201340 and 1\u201342 peptides in Capsicum annum var. angulosum for oral immunization","volume":"2","author":"Szab\u00f3","year":"2004","journal-title":"Assay Drug Dev Technol"},{"issue":"4","key":"10.1016\/j.vaccine.2011.06.073_bib0065","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbrc.2010.07.120","article-title":"Reduction of amyloid beta-peptide accumulation in Tg2576 transgenic mice by oral vaccination","volume":"399","author":"Ishii-Katsuno","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.vaccine.2011.06.073_bib0070","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1271\/bbb.100861","article-title":"Production of anti-amyloid \u03b2 antibodies in mice fed rice expressing amyloid \u03b2","volume":"75","author":"Nojima","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"issue":"3","key":"10.1016\/j.vaccine.2011.06.073_bib0075","doi-asserted-by":"crossref","first-page":"301","DOI":"10.7150\/ijbs.7.301","article-title":"Transgenic rice expressing amyloid \u03b2-peptide for oral immunization","volume":"7","author":"Yoshida","year":"2011","journal-title":"Int J Biol Sci"},{"issue":"12","key":"10.1016\/j.vaccine.2011.06.073_bib0080","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/archneur.61.12.1859","article-title":"Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease","volume":"61","author":"Qu","year":"2004","journal-title":"Arch Neurol"},{"issue":"5","key":"10.1016\/j.vaccine.2011.06.073_bib0085","doi-asserted-by":"crossref","first-page":"e2124","DOI":"10.1371\/journal.pone.0002124","article-title":"Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine\u2014a novel immunotherapeutic strategy","volume":"3","author":"Movsesyan","year":"2008","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.vaccine.2011.06.073_bib0090","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1096\/fj.06-7685com","article-title":"Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model","volume":"21","author":"Mouri","year":"2007","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.vaccine.2011.06.073_bib0095","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jgm.993","article-title":"Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1\u20136 upregulates IL-10 expression and reduces amyloid load in a Mo\/Hu APPswe PS1dE9 mouse model of Alzheimer's disease","volume":"9","author":"Kim","year":"2007","journal-title":"J Gene Med"},{"issue":"2","key":"10.1016\/j.vaccine.2011.06.073_bib0100","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/gt.2009.140","article-title":"DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice","volume":"17","author":"Davtyan","year":"2010","journal-title":"Gene Ther"},{"issue":"15","key":"10.1016\/j.vaccine.2011.06.073_bib0105","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1073\/pnas.151261398","article-title":"Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease","volume":"98","author":"DeMattos","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"27","key":"10.1016\/j.vaccine.2011.06.073_bib0110","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1523\/JNEUROSCI.1090-04.2004","article-title":"Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition","volume":"24","author":"Wilcock","year":"2004","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.vaccine.2011.06.073_bib0115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuron.2010.10.020","article-title":"Transsynaptic progression of amyloid-\u03b2-induced neuronal dysfunction within the entorhinal-hippocampal network","volume":"68","author":"Harris","year":"2010","journal-title":"Neuron"},{"issue":"23","key":"10.1016\/j.vaccine.2011.06.073_bib0120","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1016\/j.lfs.2005.10.014","article-title":"Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats","volume":"78","author":"Kopniczky","year":"2006","journal-title":"Life Sci"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11009479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11009479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T07:57:26Z","timestamp":1543651046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11009479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":24,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0264410X11009479"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.06.073","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}