{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:41:49Z","timestamp":1768351309794,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005850","name":"Region V \u201cGreat Lakes\u201d Regional Center of Excellence in Biodefense and Emerging Infectious Diseases Consortium","doi-asserted-by":"crossref","award":["NIH Award 1-U54-AI-057153"],"award-info":[{"award-number":["NIH Award 1-U54-AI-057153"]}],"id":[{"id":"10.13039\/100005850","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/NIAID Challenge Award","award":["U01-AI070559"],"award-info":[{"award-number":["U01-AI070559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.vaccine.2011.06.119","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T03:31:04Z","timestamp":1311391864000},"page":"6572-6583","source":"Crossref","is-referenced-by-count":61,"title":["Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines"],"prefix":"10.1016","volume":"29","author":[{"given":"Lauriane E.","family":"Quenee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Ciletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Elli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Hermanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Schneewind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2011.06.119_bib0005","first-page":"428","article-title":"La peste bubonique \u00e0 Hong-Kong","volume":"2","author":"Yersin","year":"1894","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0010","first-page":"625","article-title":"La propagation de la peste","volume":"12","author":"Simond","year":"1898","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis\u2014etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0020","doi-asserted-by":"crossref","first-page":"12800","DOI":"10.1073\/pnas.220225197","article-title":"Molecular identification by \u201csuicide PCR\u201d of Yersinia pestis as the agent of medieval black death","volume":"97","author":"Raoult","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/13623690208409635","article-title":"A short history of biological warfare","volume":"18","author":"Metcalfe","year":"2002","journal-title":"Med Confl Surviv"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0030","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1136\/bmj.1.1902.1461","article-title":"Remarks on the plague prophylactic fluid","volume":"1","author":"Haffkine","year":"1897","journal-title":"Br Med J"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0035","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4161\/hv.9866","article-title":"Plague vaccines and the molecular basis of immunity against Yersinia pestis","volume":"5","author":"Quenee","year":"2009","journal-title":"Hum Vaccin"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0040","first-page":"59","article-title":"Virulence of Pasteurella pestis and immunity to plague","volume":"37","author":"Burrows","year":"1963","journal-title":"Ergebn Mikrobiol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0045","first-page":"1045","article-title":"Mechanisms of long and short term immunity to plague","volume":"34","author":"Wake","year":"1978","journal-title":"Immunology"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0050","first-page":"653","article-title":"Effectiveness of live or killed plague vaccines in man","volume":"42","author":"Meyer","year":"1970","journal-title":"Bull WHO"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0055","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1093\/infdis\/129.Supplement_1.S37","article-title":"Plague immunization V. Indirect evidence for the efficacy of plague vaccine","volume":"129","author":"Cavanaugh","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0060","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1093\/infdis\/129.Supplement_1.S30","article-title":"Plague immunization IV. Clinical reactions and serological responses to inoculations of Haffkine and freeze-dried plague vaccine","volume":"129","author":"Meyer","year":"1974","journal-title":"J Infect Dis"},{"issue":"July (30)","key":"10.1016\/j.vaccine.2011.06.119_bib0065","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1016\/S0264-410X(01)00163-3","article-title":"Vaccination against bubonic and pneumonic plague","volume":"19","author":"Titball","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0070","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1111\/j.1365-2958.1992.tb01446.x","article-title":"Loss of the pigmentation phenotype in Yersinia pestis is due to the spontaneous deletion of 102kb of chromosomal DNA which is flanked by a repetitive element","volume":"6","author":"Fetherston","year":"1992","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0075","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1128\/JB.180.9.2321-2329.1998","article-title":"The 102-kilobase unstable region of Yersinia pestis comprises a high-pathogenicity island linked to a pigmentation segment which undergoes internal rearrangement","volume":"180","author":"Buchrieser","year":"1998","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0080","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1128\/JB.98.3.1404-1406.1969","article-title":"Mutation rate to non-pigmentation in Pasteurella pestis","volume":"98","author":"Brubaker","year":"1969","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0085","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.mi.09.100155.001345","article-title":"Plague","volume":"9","author":"Girard","year":"1955","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0090","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1093\/infdis\/129.Supplement_1.S85","article-title":"Live, attenuated Yersinia pestis vaccine: virulent in non-human primates, harmless to guinea pigs","volume":"129","author":"Meyer","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4049\/jimmunol.68.2.131","article-title":"Studies on immunization against plague I. The isolation and characterization of the soluble antigen of Pasteurella pestis","volume":"68","author":"Baker","year":"1952","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(03)00351-9","article-title":"Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation","volume":"113","author":"Zavialov","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0105","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1128\/IAI.70.3.1453-1460.2002","article-title":"Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis","volume":"70","author":"Du","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0110","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1128\/IAI.00612-06","article-title":"Effects of Psa and F1 on the adhesive and invasive interactions of Yersinia pestis with human respiratory tract epithelial cells","volume":"74","author":"Liu","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0115","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1128\/IAI.00105-08","article-title":"Yersinia pestis caf1 (F1) variants and the limits of plague vaccine protection","volume":"76","author":"Quenee","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0120","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2353\/ajpath.2009.071168","article-title":"Pneumonic plague pathogenesis and immunity in brown Norway rats","volume":"174","author":"Anderson","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0125","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1128\/IAI.01162-08","article-title":"Yersinia pestis IS1541 transposition provides for escape from plague immunity","volume":"77","author":"Cornelius","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0130","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1093\/clinids\/21.Supplement_2.S178","article-title":"Relationship between virulence and immunity as revealed in recent studies of the F1 capsule of Yersinia pestis","volume":"21","author":"Friedlander","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0135","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/177426b0","article-title":"An antigen determining virulence in Pasteurella pestis","volume":"177","author":"Burrows","year":"1956","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0140","first-page":"278","article-title":"The effect of loss of different virulence determinants on the virulence and immunogenicity of strains of Pasteurella pestis","volume":"39","author":"Burrows","year":"1958","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0145","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/IAI.54.2.428-434.1986","article-title":"A low-Ca2+ response operon encodes the V antigen of Yersinia pestis","volume":"54","author":"Perry","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0150","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1118476","article-title":"The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles","volume":"310","author":"Mueller","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0155","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1046\/j.1365-2958.1999.01408.x","article-title":"The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation","volume":"32","author":"Petterson","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0160","doi-asserted-by":"crossref","first-page":"36869","DOI":"10.1074\/jbc.M002467200","article-title":"LcrV a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cells","volume":"275","author":"Lee","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0165","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1128\/JB.183.15.4588-4598.2001","article-title":"On the role of LcrG and LcrV during the type III targeting of effector Yops by Yersinia enterocolitica","volume":"183","author":"DeBord","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0170","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.1114580","article-title":"Plague bacteria target immune cells during infection","volume":"309","author":"Marketon","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0175","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.71.7.3673-3681.2003","article-title":"Interleukin-10 and the inhibition of innate immunity to yersiniae: roles of Yops and LcrV (V antigen)","author":"Brubaker","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0180","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/IAI.63.8.3021-3029.1995","article-title":"Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization","volume":"63","author":"Nakajima","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0185","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.chom.2008.09.004","article-title":"TLR6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis","volume":"4","author":"DePaolo","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0190","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","article-title":"Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine","volume":"16","author":"Heath","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1574-695X.1995.tb00196.x","article-title":"A new improved sub-unit vaccine for plague: the basis of protection","volume":"12","author":"Williamson","year":"1995","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0200","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1016\/j.vaccine.2011.04.084","article-title":"Recombinant (F1+V) vaccine protects cynomolgus macaques against pneumonic plague","volume":"29","author":"Williamson","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0205","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1021\/bp050098r","article-title":"Design and testing for a non-tagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plage","volume":"21","author":"Powell","year":"2005","journal-title":"Biotechnol Prog"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.micpath.2010.10.002","article-title":"Cynomolgus macaque model for pneumonic plague","volume":"50","author":"Warren","year":"2011","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0215","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1016\/j.vaccine.2009.01.050","article-title":"A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague","volume":"27","author":"Chichester","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0220","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pep.2010.10.011","article-title":"Purification and characterization of a recombinant Yersinia pestis V-F1 \u201creversed\u201d fusion protein for use as a new subunit vaccine against plague","volume":"76","author":"Goodin","year":"2011","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0225","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1128\/IAI.73.8.5152-5159.2005","article-title":"LcrV plague vaccine with altered immunomodulatory properties","volume":"73","author":"Overheim","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0230","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1128\/IAI.01860-05","article-title":"Immunogenicity and protective immunity against bubonic and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV","volume":"74","author":"DeBord","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0235","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.ajpath.2010.12.028","article-title":"Pneumonic plague in guinea pigs and its prevention by subunit vaccines","volume":"178","author":"Quenee","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0240","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1128\/IAI.00699-08","article-title":"V10 subunit vaccine protects cynomolgus macaques from lethal pneumonic plague","volume":"76","author":"Cornelius","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0245","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.vaccine.2009.11.076","article-title":"Amino acid residues 196-225 of LcrV represent a plague protective epitope","volume":"28","author":"Quenee","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0250","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4269\/ajtmh.1994.51.109","article-title":"Cat-transmitted fatal pneumonic plague in a person who traveled from Colorado to Arizona","volume":"51","author":"Doll","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0255","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/35097083","article-title":"Genome sequence of Yersinia pestis, the causative agent of plague","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0260","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1099\/00222615-45-6-440","article-title":"Virulence of pPst+ and pPst\u2212 strains of Yersinia pestis for guinea-pigs","volume":"45","author":"Samoilova","year":"1996","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0265","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/IAI.01296-09","article-title":"Milestones in progression of primary pneumonic plague in cynomolgus macaques","volume":"78","author":"Koster","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0270","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1600-0684.2010.00443.x","article-title":"Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation","volume":"40","author":"Layton","year":"2011","journal-title":"J Med Primatol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0275","doi-asserted-by":"crossref","first-page":"e959","DOI":"10.1371\/journal.pntd.0000959","article-title":"Levofloxacin cures experimental pneumonic plague in African Green monkeys","volume":"5","author":"Layton","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0280","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2249.1999.00859.x","article-title":"An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model","volume":"116","author":"Williamson","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0285","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1128\/IAI.62.10.4192-4201.1994","article-title":"Passive immunity to yersiniae mediated by anti-recombinant V antigen and Protein A-V antigen fusion peptide","volume":"62","author":"Motin","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0290","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0002-9440(10)62360-7","article-title":"Kinetics of disease progression and host response in a rat model of bubonic plague","volume":"166","author":"Sebbane","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.vaccine.2011.06.119_bib0295","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1016\/j.vaccine.2009.09.061","article-title":"N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection","volume":"27","author":"Hill","year":"2009","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1101022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1101022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T08:07:52Z","timestamp":1686211672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X1101022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":59,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0264410X1101022X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.06.119","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}