{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:17:05Z","timestamp":1780496225922,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009904","name":"CISA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009904","id-type":"DOI","asserted-by":"crossref"}]},{"name":"AHIP","award":["200-2002-00732"],"award-info":[{"award-number":["200-2002-00732"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.vaccine.2011.08.093","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T13:00:32Z","timestamp":1315314032000},"page":"8302-8308","source":"Crossref","is-referenced-by-count":51,"title":["Causality assessment of serious neurologic adverse events following 2009 H1N1 vaccination"],"prefix":"10.1016","volume":"29","author":[{"given":"S. Elizabeth","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Pahud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Vellozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Donofrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia L.","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Halsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger P.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin D.","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"LaRussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I.","family":"Tokars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"McGeeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie L.","family":"Aukes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Sejvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Slade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"April (7292)","key":"10.1016\/j.vaccine.2011.08.093_bib0005","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/4641112a","article-title":"Portrait of a year-old pandemic","volume":"464","author":"Butler","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0010","unstructured":"CDC. The 2009 H1N1 pandemic: summary highlights, April 2009\u20132010, a virus emerges. Available from: http:\/\/www.cdc.gov\/h1n1flu\/cdcresponse.htm#virus_emerges; 2010 [cited 24.11.10]."},{"issue":"November (51)","key":"10.1016\/j.vaccine.2011.08.093_bib0015","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1016\/j.vaccine.2010.09.104","article-title":"Resistance to vaccination: the attitudes and practices of primary healthcare workers confronting the H1N1 pandemic","volume":"28","author":"Hidiroglu","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0020","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1186\/1471-2458-10-596","article-title":"Healthcare workers as parents: attitudes toward vaccinating their children against pandemic influenza A\/H1N1","volume":"10","author":"Torun","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0025","unstructured":"US Department of Health and Human Services. National vaccine advisory committee report on 2009 H1N1 vaccine safety risk assessment. Available from: http:\/\/www.hhs.gov\/nvpo\/nvac\/reports\/vsrawg_repot_may2010.html [cited 13.01.11]."},{"key":"10.1016\/j.vaccine.2011.08.093_bib0030","unstructured":"CDC VAERS \u2013 Vaccine adverse event reporting system. Available from: http:\/\/vaers.hhs.gov\/index [cited 23.12.10]."},{"issue":"September (9)","key":"10.1016\/j.vaccine.2011.08.093_bib0035","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3928\/0090-4481-20040901-11","article-title":"The role of the vaccine adverse event reporting system (VAERS) in monitoring vaccine safety","volume":"33","author":"Iskander","year":"2004","journal-title":"Pediatr Ann"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0040","unstructured":"CDC. Vaccine safety \u2013 clinical immunization safety assessment (CISA) network. Available from: http:\/\/www.cdc.gov\/vaccinesafety\/Activities\/cisa.html; 2010 [cited 04.08.10]."},{"issue":"August (2)","key":"10.1016\/j.vaccine.2011.08.093_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/oxfordjournals.aje.a112795","article-title":"Guillain\u2013Barre syndrome following vaccination in the National Influenza Immunization Program, United States, 1976\u20131977","volume":"110","author":"Schonberger","year":"1979","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0050","unstructured":"The Brighton Collaboration. Available from: https:\/\/brightoncollaboration.org\/internet\/en\/index.html [cited 23.10.10]."},{"issue":"July (3)","key":"10.1016\/j.vaccine.2011.08.093_bib0055","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1053\/spid.2002.125864","article-title":"The science of evaluation of adverse events associated with vaccination","volume":"13","author":"Halsey","year":"2002","journal-title":"Semin Pediatr Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2011.08.093_bib0060","first-page":"178","article-title":"Monitoring signals for vaccine safety: the assessment of individual adverse event reports by an expert advisory committee. Advisory Committee on Causality Assessment","volume":"78","author":"Collet","year":"2000","journal-title":"Bull World Health Organ"},{"issue":"6\u20137","key":"10.1016\/j.vaccine.2011.08.093_bib0065","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/00365540701793709","article-title":"Acute neurological events associated with influenza vaccination: are the WHO criteria for assessing causality adequate?","volume":"40","author":"Kavadas","year":"2008","journal-title":"Scand J Infect Dis"},{"issue":"July (32)","key":"10.1016\/j.vaccine.2011.08.093_bib0070","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1016\/j.vaccine.2009.05.023","article-title":"Serious adverse events rarely reported after trivalent inactivated influenza vaccine (TIV) in children 6\u201323 months of age","volume":"27","author":"Rosenberg","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0075","unstructured":"FDA. Code of Federal regulations; postmarketing reporting of adverse drug experiences. Available from: http:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/CFRSearch.cfm?fr=314.80; 2010 [cited 24.11.10]."},{"issue":"October (10)","key":"10.1016\/j.vaccine.2011.08.093_bib0080","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(08)70215-1","article-title":"Clinical features, pathogenesis, and treatment of Guillain\u2013Barre syndrome","volume":"7","author":"van Doorn","year":"2008","journal-title":"Lancet Neurol"},{"issue":"March (6)","key":"10.1016\/j.vaccine.2011.08.093_bib0085","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1212\/WNL.56.6.758","article-title":"Preceding infections, immune factors, and outcome in Guillain\u2013Barre syndrome","volume":"56","author":"Hadden","year":"2001","journal-title":"Neurology"},{"issue":"November (20)","key":"10.1016\/j.vaccine.2011.08.093_bib0090","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1001\/jama.292.20.2478","article-title":"Guillain\u2013Barre syndrome following influenza vaccination","volume":"292","author":"Haber","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0095","series-title":"Vaccines","year":"2008"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.08.093_bib0100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.mehy.2009.07.014","article-title":"Revisiting the possibility of serious adverse events from the whole cell pertussis vaccine: were metabolically vulnerable children at risk?","volume":"74","author":"Wilson","year":"2010","journal-title":"Med Hypotheses"},{"issue":"September (13)","key":"10.1016\/j.vaccine.2011.08.093_bib0105","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMe0807372","article-title":"Identifying and addressing safety signals in clinical trials","volume":"359","author":"Fleming","year":"2008","journal-title":"N Engl J Med"},{"issue":"December (9707)","key":"10.1016\/j.vaccine.2011.08.093_bib0110","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(09)61877-8","article-title":"Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines","volume":"374","author":"Black","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1471-2458-11-329","article-title":"Estimating background rates of Guillain\u2013Barre Syndrome in Ontario in order to respond to safety concerns during pandemic H1N1\/09 immunization campaign","volume":"11","author":"Deeks","year":"2011","journal-title":"BMC Public Health"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.08.093_bib0120","first-page":"A12","article-title":"The prevalence of multiple sclerosis in 3 US communities","volume":"7","author":"Noonan","year":"2010","journal-title":"Prev Chronic Dis"},{"issue":"February (2)","key":"10.1016\/j.vaccine.2011.08.093_bib0125","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1212\/WNL.48.2.312","article-title":"A multicenter, randomized, double-blind, placebo-controlled trial of influenza immunization in multiple sclerosis","volume":"48","author":"Miller","year":"1997","journal-title":"Neurology"},{"issue":"December (12)","key":"10.1016\/j.vaccine.2011.08.093_bib0130","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/WNL.59.12.1837","article-title":"Immunization and MS: a summary of published evidence and recommendations","volume":"59","author":"Rutschmann","year":"2002","journal-title":"Neurology"},{"issue":"June (30)","key":"10.1016\/j.vaccine.2011.08.093_bib0135","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1016\/j.vaccine.2005.03.005","article-title":"Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines","volume":"23","author":"Schattner","year":"2005","journal-title":"Vaccine"},{"issue":"February (7)","key":"10.1016\/j.vaccine.2011.08.093_bib0140","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJMoa1008553","article-title":"Safety of influenza A (H1N1) vaccine in postmarketing surveillance in China","volume":"364","author":"Liang","year":"2011","journal-title":"N Engl J Med"},{"issue":"October (45)","key":"10.1016\/j.vaccine.2011.08.093_bib0145","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/j.vaccine.2010.09.021","article-title":"Adverse events following influenza A (H1N1) 2009 monovalent vaccines reported to the vaccine adverse event reporting system, United States, October 1, 2009\u2013January 31, 2010","volume":"28","author":"Vellozzi","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0150","doi-asserted-by":"crossref","first-page":"d3908","DOI":"10.1136\/bmj.d3908","article-title":"Guillain\u2013Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe","volume":"343","author":"Dieleman","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.vaccine.2011.08.093_bib0155","unstructured":"Institute of Medicine. Immunization safety review: influenza vaccines and neurological complications. Available from: http:\/\/www.iom.edu\/Reports\/2003\/Immunization-Safety-Review-Influenza-Vaccines-and-Neurological-Complications.aspx; 2003 [cited 07.07.11]"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11013636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11013636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T20:12:46Z","timestamp":1588795966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11013636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":31,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0264410X11013636"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.08.093","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}