{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:15Z","timestamp":1788871575006,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 99&100-3112-B-016-002"],"award-info":[{"award-number":["NSC 99&100-3112-B-016-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["99&100-2321-B-002-026"],"award-info":[{"award-number":["99&100-2321-B-002-026"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"crossref","award":["NHRI-99&100A1-PDCO-0809111"],"award-info":[{"award-number":["NHRI-99&100A1-PDCO-0809111"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Economic Affairs","award":["99&100-EC-17-A-20-S1-028"],"award-info":[{"award-number":["99&100-EC-17-A-20-S1-028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.vaccine.2011.09.102","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T18:22:40Z","timestamp":1318962160000},"page":"5915-5922","source":"Crossref","is-referenced-by-count":29,"title":["Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome"],"prefix":"10.1016","volume":"31","author":[{"given":"Li-Chen","family":"Yen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Hsuan","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Teh","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Huei","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Mao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Kung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Len","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2011.09.102_bib0005","series-title":"Vaccines","first-page":"959","article-title":"Yellow fever vaccine","author":"Monath","year":"2008"},{"issue":"April (8)","key":"10.1016\/j.vaccine.2011.09.102_bib0010","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1086\/651271","article-title":"Japanese encephalitis: new options for active immunization","volume":"50","author":"Halstead","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.vaccine.2011.09.102_bib0015","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1371\/journal.pntd.0000437","article-title":"Japanese encephalitis \u2013 a pathological and clinical perspective","volume":"3","author":"Ghosh","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2011.09.102_bib0020","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2011.09.102_bib0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"February (2)","key":"10.1016\/j.vaccine.2011.09.102_bib0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2011.09.102_bib0035","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nbt.1542","article-title":"MicroRNA-mediated species-specific attenuation of influenza A virus","volume":"27","author":"Perez","year":"2009","journal-title":"Nat Biotechnol"},{"issue":"February (4)","key":"10.1016\/j.vaccine.2011.09.102_bib0145","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/JVI.02091-10","article-title":"Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype","volume":"85","author":"Heiss","year":"2011","journal-title":"J Virol"},{"issue":"September (3)","key":"10.1016\/j.vaccine.2011.09.102_bib0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chom.2008.08.003","article-title":"Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines","volume":"4","author":"Barnes","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"November (22)","key":"10.1016\/j.vaccine.2011.09.102_bib0045","doi-asserted-by":"crossref","first-page":"11009","DOI":"10.1128\/JVI.01608-08","article-title":"Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA","volume":"82","author":"Ylosmaki","year":"2008","journal-title":"J Virol"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2011.09.102_bib0050","doi-asserted-by":"crossref","first-page":"e1000440","DOI":"10.1371\/journal.ppat.1000440","article-title":"Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells","volume":"5","author":"Cawood","year":"2009","journal-title":"PLoS Pathog"},{"issue":"August (16)","key":"10.1016\/j.vaccine.2011.09.102_bib0055","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1158\/1078-0432.CCR-09-0051","article-title":"MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells","volume":"15","author":"Lee","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2011.09.102_bib0060","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/mt.2008.130","article-title":"A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication","volume":"16","author":"Edge","year":"2008","journal-title":"Mol Ther"},{"issue":"February (3)","key":"10.1016\/j.vaccine.2011.09.102_bib0065","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1128\/JVI.01788-09","article-title":"Attenuation of vesicular stomatitis virus encephalitis through microRNA targeting","volume":"84","author":"Kelly","year":"2010","journal-title":"J Virol"},{"issue":"November (11)","key":"10.1016\/j.vaccine.2011.09.102_bib0070","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/nm.1776","article-title":"Engineering microRNA responsiveness to decrease virus pathogenicity","volume":"14","author":"Kelly","year":"2008","journal-title":"Nat Med"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2011.09.102_bib0075","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nm1398","article-title":"Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer","volume":"12","author":"Brown","year":"2006","journal-title":"Nat Med"},{"issue":"December (12)","key":"10.1016\/j.vaccine.2011.09.102_bib0080","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/nbt1372","article-title":"Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state","volume":"25","author":"Brown","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"March (5)","key":"10.1016\/j.vaccine.2011.09.102_bib0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1101\/gad.1519207","article-title":"A functional study of miR-124 in the developing neural tube","volume":"21","author":"Cao","year":"2007","journal-title":"Genes Dev"},{"issue":"April (7)","key":"10.1016\/j.vaccine.2011.09.102_bib0090","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1101\/gad.1519107","article-title":"The microRNA miR-124 antagonizes the anti-neural REST\/SCP1 pathway during embryonic CNS development","volume":"21","author":"Visvanathan","year":"2007","journal-title":"Genes Dev"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2011.09.102_bib0095","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.69.1.258","article-title":"Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites)","volume":"69","author":"Amano","year":"1972","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"May (21)","key":"10.1016\/j.vaccine.2011.09.102_bib0100","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.vaccine.2009.03.007","article-title":"A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic ability","volume":"27","author":"Liang","year":"2009","journal-title":"Vaccine"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2011.09.102_bib0105","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1128\/JVI.71.8.5963-5971.1997","article-title":"Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells","volume":"71","author":"Liao","year":"1997","journal-title":"J Virol"},{"issue":"September (1)","key":"10.1016\/j.vaccine.2011.09.102_bib0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0168-1702(96)01343-3","article-title":"A highly attenuated strain of Japanese encephalitis virus induces a protective immune response in mice","volume":"44","author":"Lin","year":"1996","journal-title":"Virus Res"},{"issue":"September (1)","key":"10.1016\/j.vaccine.2011.09.102_bib0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/viro.1996.0457","article-title":"Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro","volume":"223","author":"Chen","year":"1996","journal-title":"Virology"},{"issue":"November (2)","key":"10.1016\/j.vaccine.2011.09.102_bib0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nmeth717","article-title":"Microarray-based, high-throughput gene expression profiling of microRNAs","volume":"1","author":"Nelson","year":"2004","journal-title":"Nat Methods"},{"issue":"3","key":"10.1016\/j.vaccine.2011.09.102_bib0125","doi-asserted-by":"crossref","first-page":"e1000820","DOI":"10.1371\/journal.ppat.1000820","article-title":"MicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interference","volume":"6","author":"Kelly","year":"2010","journal-title":"PLoS Pathog"},{"issue":"July (13)","key":"10.1016\/j.vaccine.2011.09.102_bib0130","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1128\/JVI.00117-08","article-title":"Cholesterol effectively blocks entry of flavivirus","volume":"82","author":"Lee","year":"2008","journal-title":"J Virol"},{"issue":"June (3)","key":"10.1016\/j.vaccine.2011.09.102_bib0135","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.bbrc.2010.04.080","article-title":"Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon","volume":"396","author":"Lee","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2011.09.102_bib0140","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nrg2628","article-title":"Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications","volume":"10","author":"Brown","year":"2009","journal-title":"Nat Rev Genet"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11015441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X11015441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T01:08:12Z","timestamp":1593133692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X11015441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":29,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0264410X11015441"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2011.09.102","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718194454.793528984","asserted-by":"object"}]},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}