{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:45:41Z","timestamp":1758267941914},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.vaccine.2012.01.002","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T19:14:52Z","timestamp":1326222892000},"page":"2187-2196","source":"Crossref","is-referenced-by-count":9,"title":["Heparanase DNA vaccine delivered by electroporation induces humoral immunity and cytoimmunity in animal models"],"prefix":"10.1016","volume":"30","author":[{"given":"Jie","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouhuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunjuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haofei","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianfei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl.","key":"10.1016\/j.vaccine.2012.01.002_bib0005","first-page":"37","article-title":"Mammalian heparanase as mediator of tumor metastasis and angiogenesis","volume":"2","author":"Vlodavsky","year":"2000","journal-title":"Isr Med Assoc J"},{"issue":"3","key":"10.1016\/j.vaccine.2012.01.002_bib0010","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/A:1011375624902","article-title":"Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis","volume":"6","author":"Zcharia","year":"2001","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"15","key":"10.1016\/j.vaccine.2012.01.002_bib0015","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1158\/0008-5472.CAN-05-2363","article-title":"Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes","volume":"66","author":"Sommerfeldt","year":"2006","journal-title":"Cancer Res"},{"issue":"14","key":"10.1016\/j.vaccine.2012.01.002_bib0020","first-page":"3433","article-title":"Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity","volume":"59","author":"Parish","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.vaccine.2012.01.002_bib0025","unstructured":"http:\/\/clinicaltrials.gov\/ct2\/results?term=phosphomannopentaose+sulfate+and+PI88."},{"issue":"18","key":"10.1016\/j.vaccine.2012.01.002_bib0030","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1158\/1078-0432.CCR-05-2423","article-title":"A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors","volume":"12","author":"Basche","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.vaccine.2012.01.002_bib0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10637-007-9080-5","article-title":"A phase II study of the heparanase inhibitor PI-88 in patients with advanced melanoma","volume":"26","author":"Lewis","year":"2008","journal-title":"Invest New Drugs"},{"issue":"31","key":"10.1016\/j.vaccine.2012.01.002_bib0040","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.3748\/wjg.v11.i31.4916","article-title":"Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells","volume":"11","author":"Chen","year":"2005","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.vaccine.2012.01.002_bib0045","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4161\/cbt.6.4.3888","article-title":"Silencing of heparanase by siRNA inhibits tumor metastasis and angiogenesis of human breast cancer in vitro and in vivo","volume":"6","author":"Zhang","year":"2007","journal-title":"Cancer Biol Ther"},{"issue":"3","key":"10.1016\/j.vaccine.2012.01.002_bib0050","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/jb\/mvj061","article-title":"Novel heparanase-inhibiting antibody reduces neointima formation","volume":"139","author":"Myler","year":"2006","journal-title":"J Biochem"},{"issue":"4","key":"10.1016\/j.vaccine.2012.01.002_bib0055","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000107584","article-title":"Dendritic cells reconstituted with a human heparanase gene induce potent cytotoxic T-cell responses against gastric tumor cells in vitro","volume":"28","author":"Cai","year":"2007","journal-title":"Tumour Biol"},{"issue":"13","key":"10.1016\/j.vaccine.2012.01.002_bib0060","first-page":"97","article-title":"Cloning of human heparanse full-length cDNA from hepatoma","volume":"24","author":"Gan","year":"2008","journal-title":"Clin Med China"},{"issue":"5","key":"10.1016\/j.vaccine.2012.01.002_bib0065","first-page":"92","article-title":"Generation of mouse anti-human heparanase polyclonal antibody by genetic immunization","volume":"33","author":"Li","year":"2009","journal-title":"Bull Acad Mil Med Sci"},{"issue":"43","key":"10.1016\/j.vaccine.2012.01.002_bib0070","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1016\/j.vaccine.2008.07.093","article-title":"Electroporation-based DNA transfer enhances gene expression and immune responses to DNA vaccines in cattle","volume":"26","author":"van Drunen Littel-van den Hurk","year":"2008","journal-title":"Vaccine"},{"issue":"40","key":"10.1016\/j.vaccine.2012.01.002_bib0075","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1016\/j.vaccine.2009.07.005","article-title":"Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery","volume":"27","author":"Best","year":"2009","journal-title":"Vaccine"},{"issue":"36","key":"10.1016\/j.vaccine.2012.01.002_bib0080","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1016\/j.vaccine.2007.06.036","article-title":"Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation","volume":"25","author":"Doba\u00f1o","year":"2007","journal-title":"Vaccine"},{"issue":"Supplement","key":"10.1016\/j.vaccine.2012.01.002_bib0085","first-page":"207","article-title":"The treatment of tumors using electroporation of cell's membrane due to EM-pulses with antitumor drugs and the optimal of parameters EM-pulses","volume":"22","author":"Wang","year":"2006","journal-title":"J Microw"},{"key":"10.1016\/j.vaccine.2012.01.002_bib0090","first-page":"46","article-title":"Technology of gene pulse transfection and its application to the animal tumor therapy","volume":"4","author":"Gong","year":"2006","journal-title":"Life Sci Instrum"},{"issue":"9","key":"10.1016\/j.vaccine.2012.01.002_bib0095","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1593\/neo.08576","article-title":"HLA-A2-restricted cytotoxic T lymphocyte epitopes from human heparanase as novel targets for broad-spectrum tumor immunotherapy","volume":"10","author":"Chen","year":"2008","journal-title":"Neoplasia"},{"issue":"6","key":"10.1016\/j.vaccine.2012.01.002_bib0100","first-page":"2609","article-title":"Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice","volume":"61","author":"Kr\u00f6ger","year":"2001","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.vaccine.2012.01.002_bib0105","first-page":"21","article-title":"Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen","volume":"56","author":"Lin","year":"1996","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.vaccine.2012.01.002_bib0110","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/mt.2009.32","article-title":"Adoptive transfer of human papillomavirus E7-specific CTL enhances tumor chemoresponse through the perforin\/granzyme-mediated pathway","volume":"17","author":"Sin","year":"2009","journal-title":"Mol Ther"},{"issue":"3","key":"10.1016\/j.vaccine.2012.01.002_bib0115","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10529-012-1099-9","article-title":"Expression of human heparanase in Pichia yeast expression system","volume":"18","author":"Liu","year":"2007","journal-title":"Lett Biotechnol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.01.002_bib0120","first-page":"220","article-title":"A serological investigation of four infectious diseases of cattle","volume":"23","author":"Chen","year":"2004","journal-title":"J Mountain Agric Biol"},{"issue":"8","key":"10.1016\/j.vaccine.2012.01.002_bib0125","first-page":"595","article-title":"Purification of rat and rabbit anti-Trichinella spiral IgG antibody from serum using caprylic acid-Ammonium sulfate (CA-AS)","volume":"3","author":"Liu","year":"2008","journal-title":"J Pathogen Biol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.01.002_bib0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ijc.21188","article-title":"Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA","volume":"117","author":"Mennuni","year":"2005","journal-title":"Int J Cancer"},{"issue":"5","key":"10.1016\/j.vaccine.2012.01.002_bib0135","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1158\/0008-5472.CAN-07-5965","article-title":"H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo","volume":"68","author":"Tang","year":"2008","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.vaccine.2012.01.002_bib0190","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jcb.22005","article-title":"Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis","volume":"106","author":"Roy","year":"2009","journal-title":"J Cell Biochem"},{"issue":"11","key":"10.1016\/j.vaccine.2012.01.002_bib0145","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s00262-008-0497-2","article-title":"Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer","volume":"57","author":"Williams","year":"2008","journal-title":"Cancer Immunol Immunother"},{"issue":"17","key":"10.1016\/j.vaccine.2012.01.002_bib0150","doi-asserted-by":"crossref","first-page":"8779","DOI":"10.1158\/0008-5472.CAN-06-1382","article-title":"Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis","volume":"66","author":"Zhao","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.vaccine.2012.01.002_bib0155","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00262-008-0465-x","article-title":"Optimized DNA vaccines to specifically induce therapeutic CD8T cell responses against autochthonous breast tumors","volume":"57","author":"Cho","year":"2008","journal-title":"Cancer Immunol Immunother"},{"issue":"21","key":"10.1016\/j.vaccine.2012.01.002_bib0160","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1016\/j.vaccine.2005.08.027","article-title":"Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center","volume":"24","author":"Bergman","year":"2006","journal-title":"Vaccine"},{"issue":"January\u2013February (1)","key":"10.1016\/j.vaccine.2012.01.002_bib0165","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1939-1676.2010.0627.x","article-title":"Xenogeneic murine tyrosinase DNA vaccine for malignant melanoma of the digit of dogs","volume":"25","author":"Manley","year":"2011","journal-title":"J Vet Intern Med"},{"issue":"1","key":"10.1016\/j.vaccine.2012.01.002_bib0170","first-page":"10","article-title":"Effects of anti-heparanase antibody on the growth and invasion of HCCLM6 human hepatocellular carcinoma cells","volume":"31","author":"Han","year":"2009","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"issue":"14","key":"10.1016\/j.vaccine.2012.01.002_bib0175","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1096\/fj.07-8866com","article-title":"Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing","volume":"21","author":"Gingis-Velitski","year":"2007","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.vaccine.2012.01.002_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjp.0707182","article-title":"Heparanase: a target for drug discovery in cancer and inflammation","volume":"151","author":"McKenzie","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2012.01.002_bib0185","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.drudis.2011.02.015","article-title":"Heparanase: a universal immunotherapeutic target in human cancers","volume":"16","author":"Zhang","year":"2011","journal-title":"Drug Discov Today"},{"issue":"3","key":"10.1016\/j.vaccine.2012.01.002_bib0140","first-page":"467","article-title":"Application of gene introduction in vivo by electroporation in preclinical and clinical trials","volume":"21","author":"Luan","year":"2009","journal-title":"Chin Bull Life Sci"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12000035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12000035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T09:10:46Z","timestamp":1561194646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12000035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0264410X12000035"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.01.002","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}