{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:44Z","timestamp":1788872324703,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.vaccine.2012.02.036","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T15:47:12Z","timestamp":1330962432000},"page":"2811-2823","source":"Crossref","is-referenced-by-count":58,"title":["Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis"],"prefix":"10.1016","volume":"30","author":[{"given":"Michael J.","family":"Brennan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartholt","family":"Clagett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo A.","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewellys F.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2012.02.036_bib0005","unstructured":"World Health Organization. Global tuberculosis control: WHO report 2011. Geneva: WHO; 2011 October. 258 p. Available from: http:\/\/www.who.int\/tb\/publications\/global_report\/2011\/gtbr11_full.pdf."},{"issue":"6","key":"10.1016\/j.vaccine.2012.02.036_bib0010","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/ije\/22.6.1154","article-title":"Protective effect of BCG against tuberculosis meningitis and miliary tuberculosis: a meta-analysis","volume":"22","author":"Rodrigues","year":"1993","journal-title":"Int J Epidemiol"},{"issue":"9","key":"10.1016\/j.vaccine.2012.02.036_bib0015","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature","volume":"271","author":"Colditz","year":"1994","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.vaccine.2012.02.036_bib0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tube.2010.06.002","article-title":"The Achilles heel of BCG","volume":"90","author":"Orme","year":"2010","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.vaccine.2012.02.036_bib0025","unstructured":"Fine PE, Carneiro IA, Milstien JB, Clements CJ. Issues relating to the use of BCG in immunization programmes: a discussion document. Geneva: Department of Vaccines and Biologicals, World Health Organization; 1999 November. Publ. No.: 99.23. Ordering Code: WHO\/V&B\/99.23. Available from: http:\/\/www.who.int\/vaccines-documents\/DocsPDF99\/www9943.pdf."},{"issue":"9517","key":"10.1016\/j.vaccine.2012.02.036_bib0030","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(06)68507-3","article-title":"Effect of BCG vaccination on childhood tuberculosis meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness","volume":"367","author":"Trunz","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.vaccine.2012.02.036_bib0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-3083.2009.02352.x","article-title":"Neonatal BCG immunization followed by DNAhsp65 boosters: highly immunogenic but not protective against tuberculosis \u2013 a paradoxical effect of the vector?","volume":"71","author":"Pelizon","year":"2010","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2012.02.036_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.vaccine.2009.09.121","article-title":"Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs","volume":"28","author":"Dey","year":"2009","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2012.02.036_bib0045","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1128\/IAI.00685-08","article-title":"Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus Ankara expressing M. tuberculosis antigen 85A against murine tuberculosis","volume":"77","author":"Tchilian","year":"2009","journal-title":"Infect Immun"},{"issue":"6741","key":"10.1016\/j.vaccine.2012.02.036_bib0050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/22326","article-title":"Therapy of tuberculosis in mice by DNA vaccination","volume":"400","author":"Lowrie","year":"1999","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.vaccine.2012.02.036_bib0055","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1128\/IAI.73.8.5189-5193.2005","article-title":"Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA","volume":"73","author":"Taylor","year":"2005","journal-title":"Infect Immun"},{"issue":"48","key":"10.1016\/j.vaccine.2012.02.036_bib0060","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1016\/j.vaccine.2008.09.011","article-title":"The safety of post-exposure vaccination of mice infected with Mycobacterium tuberculosis","volume":"26","author":"Derrick","year":"2008","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2012.02.036_bib0065","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.coi.2009.05.017","article-title":"Tuberculosis vaccine research: the impact of immunology","volume":"21","author":"Barker","year":"2009","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.02.036_bib0070","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/IAI.70.2.672-678.2002","article-title":"Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis","volume":"70","author":"Brandt","year":"2002","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.vaccine.2012.02.036_bib0075","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1128\/IAI.71.11.6411-6419.2003","article-title":"Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination","volume":"71","author":"Buddle","year":"2003","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0080","first-page":"553","article-title":"Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis","volume":"94","author":"Palmer","year":"1966","journal-title":"Am Rev Respir Dis"},{"issue":"9493","key":"10.1016\/j.vaccine.2012.02.036_bib0085","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0140-6736(05)67145-0","article-title":"Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: the BCG-REVAC cluster-randomised trial","volume":"366","author":"Rodrigues","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.vaccine.2012.02.036_bib0090","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1128\/CVI.00006-10","article-title":"Highly persistent and effective prime\/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant","volume":"17","author":"Kolibab","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0095","doi-asserted-by":"crossref","first-page":"e5139","DOI":"10.1371\/journal.pone.0005139","article-title":"CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination","volume":"4","author":"Elvang","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.vaccine.2012.02.036_bib0100","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.4049\/jimmunol.173.10.6357","article-title":"Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis","volume":"173","author":"Wang","year":"2004","journal-title":"J Immunol"},{"issue":"16","key":"10.1016\/j.vaccine.2012.02.036_bib0105","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1016\/j.vaccine.2005.12.066","article-title":"Priming but not boosting with plasmid DNA encoding mycolyl-transferase Ag85A from Mycobacterium tuberculosis increases the survival time of Mycobacterium bovis BCG vaccinated mice against low dose intravenous challenge with M. tuberculosis H37Rv","volume":"24","author":"Romano","year":"2006","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2012.02.036_bib0110","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.vaccine.2009.01.034","article-title":"Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Gu\u00e9rin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains","volume":"27","author":"Seki","year":"2009","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2012.02.036_bib0115","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1128\/CVI.05127-11","article-title":"Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells","volume":"18","author":"Ordway","year":"2011","journal-title":"Clin Vaccine Immunol"},{"issue":"8","key":"10.1016\/j.vaccine.2012.02.036_bib0120","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG \u2013 implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat Rev Microbiol"},{"issue":"9","key":"10.1016\/j.vaccine.2012.02.036_bib0125","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1172\/JCI24617","article-title":"Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis Calmette-Gu\u00e9rin mutants that secrete listeriolysin","volume":"115","author":"Grode","year":"2005","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.vaccine.2012.02.036_bib0130","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1128\/IAI.00517-06","article-title":"Intranasal boosting with an adenovirus-vectored vaccine markedly enhances protection by parenteral Mycobacterium bovis BCG immunization against pulmonary tuberculosis","volume":"74","author":"Santosuosso","year":"2006","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2012.02.036_bib0135","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1128\/IAI.00580-09","article-title":"Mycobacterium tuberculosis culture filtrate proteins plus CpG oligodeoxynucleotides confer protection to Mycobacterium bovis BCG-primed mice by inhibiting interleukin-4 secretion","volume":"77","author":"da Fonseca","year":"2009","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2012.02.036_bib0140","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.4049\/jimmunol.171.3.1602","article-title":"Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Gu\u00e9rin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara","volume":"171","author":"Goonetilleke","year":"2003","journal-title":"J Immunol"},{"issue":"August","key":"10.1016\/j.vaccine.2012.02.036_bib0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1479-0556-5-7","article-title":"Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming","volume":"5","author":"Gon\u00e7alves","year":"2007","journal-title":"Genet Vaccines Ther"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0150","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1128\/IAI.69.4.2714-2717.2001","article-title":"Boosting vaccine for tuberculosis","volume":"69","author":"Brooks","year":"2001","journal-title":"Infect Immun"},{"issue":"30","key":"10.1016\/j.vaccine.2012.02.036_bib0155","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1016\/j.vaccine.2009.04.027","article-title":"Neonatal vaccination with Mycobacterium bovis BCG: potential effects as a priming agent shown in a heterologous prime-boost immunization protocol","volume":"27","author":"Rahman","year":"2009","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2012.02.036_bib0160","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.4049\/jimmunol.177.9.6353","article-title":"Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Gu\u00e9rin immunity","volume":"177","author":"Dietrich","year":"2006","journal-title":"J Immunol"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2012.02.036_bib0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tube.2004.09.013","article-title":"Nasal boost with adjuvanted heat-killed BCG or arabinomannan\u2013protein conjugate improves primary BCG-induced protection in C57BL\/6 mice","volume":"85","author":"Haile","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"issue":"11","key":"10.1016\/j.vaccine.2012.02.036_bib0170","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1128\/IAI.72.11.6471-6479.2004","article-title":"Application of mycobacterial proteomics to vaccine design: improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis","volume":"72","author":"Mollenkopf","year":"2004","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2012.02.036_bib0175","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1128\/IAI.01290-06","article-title":"The combined CTA1-DD\/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis","volume":"75","author":"Andersen","year":"2007","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2012.02.036_bib0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nm.2285","article-title":"A multistage tuberculosis vaccine that confers efficient protection before and after exposure","volume":"17","author":"Aagaard","year":"2011","journal-title":"Nat Med"},{"issue":"53","key":"10.1016\/j.vaccine.2012.02.036_bib0185","doi-asserted-by":"crossref","first-page":"53ra74","DOI":"10.1126\/scitranslmed.3001094","article-title":"A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis","volume":"2","author":"Bertholet","year":"2010","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.vaccine.2012.02.036_bib0190","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1128\/IAI.73.6.3814-3816.2005","article-title":"Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs","volume":"73","author":"Williams","year":"2005","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2012.02.036_bib0195","doi-asserted-by":"crossref","first-page":"e5856","DOI":"10.1371\/journal.pone.0005856","article-title":"Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis","volume":"4","author":"Xing","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0200","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.vaccine.2009.10.114","article-title":"Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen","volume":"28","author":"Skeiky","year":"2009","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2012.02.036_bib0205","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1128\/IAI.73.8.4676-4683.2005","article-title":"Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein","volume":"73","author":"Horwitz","year":"2005","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2012.02.036_bib0210","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1208\/s12248-010-9193-1","article-title":"Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity","volume":"12","author":"Lu","year":"2010","journal-title":"AAPS J"},{"issue":"7","key":"10.1016\/j.vaccine.2012.02.036_bib0215","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1073\/pnas.0712077106","article-title":"Defined tuberculosis vaccine, Mtb72F\/AS02A, evidence of protection in cynomolgus monkeys","volume":"106","author":"Reed","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0220","doi-asserted-by":"crossref","first-page":"e5264","DOI":"10.1371\/journal.pone.0005264","article-title":"MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques","volume":"4","author":"Verreck","year":"2009","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.vaccine.2012.02.036_bib0225","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1016\/j.vaccine.2007.01.014","article-title":"Evaluation of a novel vaccine (HVJ-liposome\/HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB","volume":"25","author":"Okada","year":"2007","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2012.02.036_bib0230","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1128\/IAI.00287-09","article-title":"Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis","volume":"77","author":"Vordermeier","year":"2009","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2012.02.036_bib0235","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vaccine.2008.10.034","article-title":"Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-gamma producing T-cells","volume":"27","author":"Badell","year":"2009","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2012.02.036_bib0240","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1128\/IAI.72.11.6622-6632.2004","article-title":"The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs","volume":"72","author":"Brandt","year":"2004","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0245","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1128\/IAI.74.4.2128-2137.2006","article-title":"An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis","volume":"74","author":"Majlessi","year":"2006","journal-title":"Infect Immun"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2012.02.036_bib0250","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tube.2004.09.009","article-title":"Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis","volume":"85","author":"Williams","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"issue":"12","key":"10.1016\/j.vaccine.2012.02.036_bib0255","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1128\/IAI.72.12.6945-6950.2004","article-title":"A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice","volume":"72","author":"Ferraz","year":"2004","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2012.02.036_bib0260","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.vaccine.2005.07.115","article-title":"Protective efficacy induced by Mycobacterium bovis bacilli Calmette-Gu\u00e9rin can be augmented in an antigen independent manner by use of non-coding plasmid DNA","volume":"24","author":"Hogarth","year":"2006","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2012.02.036_bib0265","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/dna.2006.25.438","article-title":"A combined DNA vaccine-prime, BCG-boost strategy results in better protection against Mycobacterium bovis challenge","volume":"25","author":"Cai","year":"2006","journal-title":"DNA Cell Biol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.02.036_bib0270","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/IAI.69.2.681-686.2001","article-title":"Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis","volume":"69","author":"McShane","year":"2001","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2012.02.036_bib0275","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1046\/j.1365-2567.2003.01589.x","article-title":"A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis","volume":"108","author":"Skinner","year":"2003","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.vaccine.2012.02.036_bib0280","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1128\/IAI.71.9.4901-4907.2003","article-title":"A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis","volume":"71","author":"Skinner","year":"2003","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12002198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12002198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T09:56:55Z","timestamp":1543139815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12002198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":56,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0264410X12002198"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.02.036","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}