{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:12:05Z","timestamp":1789873925171,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":410,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Wellcome Trust, Animal Health in the Developing World","award":["075818"],"award-info":[{"award-number":["075818"]}]},{"name":"the Australian National Health and Medical Research Council","award":["350279"],"award-info":[{"award-number":["350279"]}]},{"name":"the Australian National Health and Medical Research Council","award":["400109"],"award-info":[{"award-number":["400109"]}]},{"name":"the Australian National Health and Medical Research Council","award":["628320"],"award-info":[{"award-number":["628320"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.vaccine.2012.04.019","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T10:54:11Z","timestamp":1334832851000},"page":"3824-3828","source":"Crossref","is-referenced-by-count":38,"title":["Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens"],"prefix":"10.1016","volume":"30","author":[{"given":"Charles G.","family":"Gauci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar M.","family":"Jayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando E.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lackenby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall W.","family":"Lightowlers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2012.04.019_bib0005","series-title":"Taenia solium cysticercosis: from basic to clinical science.","first-page":"63","article-title":"Taenia solium cysticercosis: an overview of global distribution and transmission","author":"Schantz","year":"2002"},{"issue":"10","key":"10.1016\/j.vaccine.2012.04.019_bib0010","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.ijpara.2010.05.001","article-title":"Eradication of Taenia solium cysticercosis: a role for vaccination of pigs","volume":"40","author":"Lightowlers","year":"2010","journal-title":"International Journal for Parasitology"},{"issue":"5","key":"10.1016\/j.vaccine.2012.04.019_bib0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/156802608783790839","article-title":"Vaccines against cysticercosis","volume":"8","author":"Sciutto","year":"2008","journal-title":"Current Topics in Medicinal Chemistry"},{"issue":"9","key":"10.1016\/j.vaccine.2012.04.019_bib0020","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1128\/IAI.72.9.5292-5297.2004","article-title":"Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens","volume":"72","author":"Flisser","year":"2004","journal-title":"Infection and Immunity"},{"issue":"6","key":"10.1016\/j.vaccine.2012.04.019_bib0025","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4269\/ajtmh.2005.72.837","article-title":"Vaccination of pigs to control human neurocysticercosis","volume":"72","author":"Gonzalez","year":"2005","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"5","key":"10.1016\/j.vaccine.2012.04.019_bib0030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ijpara.2010.01.006","article-title":"Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon","volume":"40","author":"Assana","year":"2010","journal-title":"International Journal for Parasitology"},{"issue":"2","key":"10.1016\/j.vaccine.2012.04.019_bib0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0166-6851(00)00364-9","article-title":"Alternative splicing and sequence diversity of transcripts from the oncosphere stage of Taenia solium with homology to the 45W antigen of Taenia ovis","volume":"112","author":"Gauci","year":"2001","journal-title":"Molecular and Biochemical Parasitology"},{"issue":"2","key":"10.1016\/j.vaccine.2012.04.019_bib0040","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0166-6851(03)00005-7","article-title":"Molecular cloning of genes encoding oncosphere proteins reveals conservation of modular protein structure in cestode antigens","volume":"127","author":"Gauci","year":"2003","journal-title":"Molecular and Biochemical Parasitology"},{"issue":"2","key":"10.1016\/j.vaccine.2012.04.019_bib0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0020-7519(95)00097-6","article-title":"Identification and cDNA cloning of two novel low molecular weight host- protective antigens from Taenia ovis oncospheres","volume":"26","author":"Harrison","year":"1996","journal-title":"International Journal for Parasitology"},{"issue":"4","key":"10.1016\/j.vaccine.2012.04.019_bib0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.exppara.2006.01.006","article-title":"Taenia solium and Taenia ovis: stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres","volume":"113","author":"Gauci","year":"2006","journal-title":"Experimental Parasitology"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2012.04.019_bib0055","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1365-3024.2010.01230.x","article-title":"Variation in the cellular localization of host-protective oncospheral antigens in Taenia saginata and Taenia solium","volume":"32","author":"Jabbar","year":"2010","journal-title":"Parasite Immunology"},{"issue":"10","key":"10.1016\/j.vaccine.2012.04.019_bib0060","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pt.2004.07.010","article-title":"Drug resistance in veterinary helminths","volume":"20","author":"Wolstenholme","year":"2004","journal-title":"Trends in Parasitology"},{"issue":"1","key":"10.1016\/j.vaccine.2012.04.019_bib0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molbiopara.2005.10.014","article-title":"Conservation of the vaccine antigen gene, TSOL18, among genetically variant isolates of Taenia solium","volume":"146","author":"Gauci","year":"2006","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.vaccine.2012.04.019_bib0070","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12033-010-9368-0","article-title":"Strategies for optimal expression of vaccine antigens from Taeniid cestode parasites in Escherichia coli","volume":"48","author":"Gauci","year":"2011","journal-title":"Molecular biotechnology"},{"key":"10.1016\/j.vaccine.2012.04.019_bib0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","article-title":"Single-step purification of polypeptides expressed in Escherichia coli as fusion proteins with glutathione S-transferase","volume":"67","author":"Smith","year":"1988","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.vaccine.2012.04.019_bib0080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0378-1119(88)90004-2","article-title":"Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein","volume":"67","author":"di Guan","year":"1988","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.vaccine.2012.04.019_bib0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-3024.2006.00820.x","article-title":"Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A","volume":"28","author":"Kyngdon","year":"2006","journal-title":"Parasite Immunology"},{"issue":"6","key":"10.1016\/j.vaccine.2012.04.019_bib0090","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-3024.2009.01197.x","article-title":"Antibody responses to the host-protective Taenia solium oncosphere protein TSOL18 in pigs are directed against conformational epitopes","volume":"32","author":"Assana","year":"2010","journal-title":"Parasite Immunology"},{"issue":"3","key":"10.1016\/j.vaccine.2012.04.019_bib0095","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/expr.1996.0121","article-title":"Taenia saginata: vaccination against cysticercosis in cattle with recombinant oncosphere antigens","volume":"84","author":"Lightowlers","year":"1996","journal-title":"Experimental Parasitology"},{"issue":"5","key":"10.1016\/j.vaccine.2012.04.019_bib0100","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0020-7519(98)00034-4","article-title":"A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18kDa antigens","volume":"28","author":"Gauci","year":"1998","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vaccine.2012.04.019_bib0105","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0065-308X(08)60277-8","article-title":"Hydatidosis\/cysticercosis: immune mechanisms and immunization against infection","volume":"21","author":"Rickard","year":"1982","journal-title":"Advances in Parasitology"},{"issue":"9","key":"10.1016\/j.vaccine.2012.04.019_bib0110","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/omi.2010.0127","article-title":"Designing the next generation of vaccines for global public health","volume":"15","author":"Bagnoli","year":"2011","journal-title":"OMICS"},{"issue":"9","key":"10.1016\/j.vaccine.2012.04.019_bib0115","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1089\/omi.2010.0150","article-title":"Vaccinomics for the major blood feeding helminths of humans","volume":"15","author":"Loukas","year":"2011","journal-title":"OMICS"},{"issue":"9","key":"10.1016\/j.vaccine.2012.04.019_bib0120","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1172\/JCI38330","article-title":"Vaccinology in the genome era","volume":"119","author":"Rinaudo","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/j.vaccine.2012.04.019_bib0125","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00436-010-2045-1","article-title":"Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates","volume":"108","author":"Farias","year":"2011","journal-title":"Parasitology Research"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2012.04.019_bib0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.drudis.2009.01.011","article-title":"Schistosomes--proteomics studies for potential novel vaccines and drug targets","volume":"14","author":"DeMarco","year":"2009","journal-title":"Drug Discovery Today"},{"issue":"5 Suppl. 1","key":"10.1016\/j.vaccine.2012.04.019_bib0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/S0074-02762004000900008","article-title":"From genomes to vaccines via the proteome","volume":"99","author":"Wilson","year":"2004","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"issue":"7","key":"10.1016\/j.vaccine.2012.04.019_bib0140","doi-asserted-by":"crossref","first-page":"271","DOI":"10.6026\/97320630006271","article-title":"Immunoinformatics prediction of linear epitopes from Taenia solium TSOL18","volume":"6","author":"Zimic","year":"2011","journal-title":"Bioinformation"},{"issue":"11","key":"10.1016\/j.vaccine.2012.04.019_bib0145","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0020-7519(03)00174-7","article-title":"Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites","volume":"33","author":"Lightowlers","year":"2003","journal-title":"International Journal for Parasitology"},{"issue":"10","key":"10.1016\/j.vaccine.2012.04.019_bib0150","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1365-3024.1996.d01-20.x","article-title":"Host-protective fragments and antibody binding epitopes of the Taenia ovis 45W recombinant antigen","volume":"18","author":"Lightowlers","year":"1996","journal-title":"Parasite Immunology"},{"issue":"11","key":"10.1016\/j.vaccine.2012.04.019_bib0155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-3024.1998.00176.x","article-title":"Epitope specificities and antibody responses to the EG95 hydatid vaccine","volume":"20","author":"Woollard","year":"1998","journal-title":"Parasite Immunology"},{"issue":"5","key":"10.1016\/j.vaccine.2012.04.019_bib0160","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0264-410X(96)00229-0","article-title":"Urea\/DTT solubilization of a recombinant Taenia ovis antigen, 45W, expressed as a GST fusion protein results in enhanced protective immune response to the 45W moiety","volume":"15","author":"Rothel","year":"1997","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12005415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12005415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T09:35:19Z","timestamp":1713864919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12005415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":32,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0264410X12005415"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.04.019","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}