{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:36:33Z","timestamp":1777426593350,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"50","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Global Health Research Initiative (GHRI)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.vaccine.2012.04.035","type":"journal-article","created":{"date-parts":[[2012,4,22]],"date-time":"2012-04-22T09:02:41Z","timestamp":1335085361000},"page":"7332-7341","source":"Crossref","is-referenced-by-count":19,"title":["Design and immunological properties of Helicobacter pylori glycoconjugates based on a truncated lipopolysaccharide lacking Lewis antigen and comprising an \u03b1-1,6-glucan chain"],"prefix":"10.1016","volume":"30","author":[{"given":"Eleonora","family":"Altman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Chandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Veloso-Pita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"KuoLee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangxue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"V\u00e9rez-Bencomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2012.04.035_bib0005","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CMR.10.4.720","article-title":"Helicobacter pylori","volume":"10","author":"Dunn","year":"1997","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0010","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1590\/S0036-36342004000600010","article-title":"Helicobacter pylori: focus on CagA and VacA major virulence factors","volume":"46","author":"Castillo-Rojas","year":"2004","journal-title":"Salud P\u00fablica de M\u00e9xico"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0015","first-page":"74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2002","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/CMR.00033-06","article-title":"Helicobacter pylori detection and antimicrobial susceptibility testing","volume":"20","author":"M\u00e9graud","year":"2007","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0025","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1586\/erv.09.62","article-title":"Development of vaccines against Helicobacter pylori","volume":"8","author":"Del Giudice","year":"2009","journal-title":"Expert Review of Vaccines"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrgastro.2011.1","article-title":"Vaccinating against Helicobacter pylori infection","volume":"8","author":"Czinn","year":"2011","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0065-2318(01)57016-X","article-title":"Helicobacter pylori: a wolf in sheep's clothing: the glycotype families of Helicobacter pylori lipopolysaccharides expressing histo-blood groups: structure, biosynthesis, and role in pathogenesis","volume":"57","author":"Monteiro","year":"2001","journal-title":"Advances in Carbohydrate Chemistry and Biochemistry"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0040","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.4049\/jimmunol.137.4.1181","article-title":"Vaccines consisting of periodate-cleaved oligosaccharides from the capsule of Haemophilus influenzae type b coupled to a protein carrier: structural and temporal requirements for priming in the human infant","volume":"137","author":"Anderson","year":"1986","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0045","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1128\/IAI.59.12.4450-4458.1991","article-title":"Preparation, characterization, and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 (Shiga's bacillus) bound to tetanus toxoid","volume":"59","author":"Chu","year":"1991","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0050","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.185.11.1929","article-title":"N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis","volume":"185","author":"Pon","year":"1997","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0055","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1128\/IAI.69.3.1351-1357.2001","article-title":"Safety and immunogenicity of improved Shigella O-specific polysaccharide\u2013protein conjugate vaccines in adults in Israel","volume":"69","author":"Passwell","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0060","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/01.inf.0000078156.03697.a5","article-title":"Safety and immunogenicity of Shigella sonnei-CRM9 and Shigella flexneri type 2a-rEPAsucc conjugate vaccines in one- to four-year old children","volume":"22","author":"Passwell","year":"2003","journal-title":"Pediatric Infectious Disease Journal"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0065","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1128\/IAI.64.10.4047-4053.1996","article-title":"Synthesis, characterization, and immunological properties of detoxified lipooligosaccharide from nontypable Haemophilus influenzae conjugated to proteins","volume":"64","author":"Gu","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0070","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0008-6215(02)00395-6","article-title":"Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their epitopes and results in conjugate vaccines having improved immunological properties","volume":"338","author":"Mieszala","year":"2003","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0075","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1016\/j.vaccine.2005.06.011","article-title":"Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits","volume":"23","author":"Cox","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0080","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1128\/IAI.01915-06","article-title":"Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis","volume":"75","author":"Yu","year":"2007","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0085","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1016\/j.vaccine.2011.03.102","article-title":"Mutant lipopolysaccharide-based conjugate vaccine demonstrates a broad-spectrum effectiveness against Moraxella catarrhalis","volume":"29","author":"Ren","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0090","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/S0264-410X(97)00102-3","article-title":"Immunobiological activities of chemically defined lipid A from Helicobacter pylori LPS in comparison with Porphyromonas gingivalis lipid A and Escherichia coli-type synthetic lipid A (compound 506)","volume":"15","author":"Ogawa","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0095","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1128\/IAI.64.11.4598-4605.1996","article-title":"Expression of the human cell surface glycoconjugates Lewis X and Lewis Y by Helicobacter pylori isolates is related to cagA status","volume":"64","author":"Wirth","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0100","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1128\/IAI.64.6.2031-2040.1996","article-title":"Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity","volume":"64","author":"Appelmelk","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0105","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/j.carres.2011.06.036","article-title":"Lipopolysaccharide structures of Helicobacter pylori wild-type strain 26695 and 26695 HP0826::Kan mutant devoid of the O-chain polysaccharide component","volume":"346","author":"Altman","year":"2011","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0110","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1111\/j.1742-4658.2011.08270.x","article-title":"A re-investigation of the lipopolysaccharide structure of Helicobacter pylori strain Sydney (SS1)","volume":"278","author":"Altman","year":"2011","journal-title":"FEBS Journal"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0115","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/j.vaccine.2011.02.063","article-title":"Synthesis and immunogenicity of a Helicobacter pylori lipopolysaccharide-based conjugate","volume":"29","author":"Monteiro","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0120","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1046\/j.1365-2958.2000.01784.x","article-title":"Functional genomics of Helicobacter pylori: identification of a \u03b2-1,4 galactosyltransferase and generation of mutants with altered lipopolysaccharide","volume":"35","author":"Logan","year":"2000","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0125","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1523-5378.2011.00860.x","article-title":"Characterization and functional activity of murine monoclonal antibodies specific for \u03b11,6-glucan chain of Helicobacter pylori lipopolysaccharide","volume":"16","author":"Harrison","year":"2011","journal-title":"Helicobacter"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0130","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1128\/IAI.69.7.4382-4389.2001","article-title":"Type I Helicobacter pylori lipopolysaccharide stimulates Toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells","author":"Kawahara","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0135","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/glycob\/cwi057","article-title":"Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori","volume":"15","author":"Logan","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0140","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/JB.187.15.5156-5165.2005","article-title":"Identification of a d-glycero-d-manno-heptosyltransferase gene from Helicobacter pylori","volume":"187","author":"Hiratsuka","year":"2005","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0145","first-page":"83","article-title":"Bacterial polysaccharides. Extraction with phenol\u2013water and further applications of the procedure","volume":"5","author":"Westphal","year":"1965","journal-title":"Methods in Carbohydrate Chemistry"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0150","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/glycob\/cwg106","article-title":"Occurrence of a nontypable Helicobacter pylori strain lacking Lewis blood group O antigens and DD-heptoglycan: evidence for the role of the core alpha1,6-glucan in colonization","volume":"13","author":"Altman","year":"2003","journal-title":"Glycobiology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0155","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1128\/jb.173.6.1862-1866.1991","article-title":"Structure, serological specificity, and synthesis of artificial glycoconjugates representing the genus-specific lipopolysaccharide epitope of Chlamidia spp","volume":"173","author":"Holst","year":"1991","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0160","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1023\/A:1006903524007","article-title":"Conjugation of 5-azido-3-oxapentyl glycosides with thiolated proteins through the use of thiophilic derivatives","volume":"15","author":"Fern\u00e1ndez-Santana","year":"1998","journal-title":"Glycoconjugate Journal"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0165","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0170","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0175","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1099\/jmm.0.47783-0","article-title":"Analysis of Helicobacter pylori isolates from Chile: occurrence of a selective type 1 Lewis b antigen expression in lipopolysaccharide","volume":"57","author":"Altman","year":"2008","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0180","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1574-695X.2008.00416.x","article-title":"Effect of the HP0159 mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori","volume":"58","author":"Altman","year":"2008","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0185","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1440-1746.2001.02459.x","article-title":"Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10","volume":"16","author":"Chen","year":"2001","journal-title":"Gastroenterologia y Hepatologia"},{"key":"10.1016\/j.vaccine.2012.04.035_bib0190","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1128\/IAI.72.7.3925-3931.2004","article-title":"Helicobacter pylori with a truncated lipopolysaccharide O chain fails to induce gastritis in SCID mice injected with splenocytes from wild-type C57BL\/6J mice","volume":"72","author":"Eaton","year":"2004","journal-title":"Infection and Immunity"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1200566X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1200566X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T05:55:50Z","timestamp":1687413350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X1200566X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":38,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0264410X1200566X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.04.035","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}