{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:46:44Z","timestamp":1770785204653,"version":"3.50.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R21 AI076781"],"award-info":[{"award-number":["R21 AI076781"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R56 AI091731"],"award-info":[{"award-number":["R56 AI091731"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rochester General Hospital Kidd Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.vaccine.2012.06.016","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T17:17:09Z","timestamp":1340126229000},"page":"5382-5388","source":"Crossref","is-referenced-by-count":10,"title":["Antibody response to the central unglycosylated region of the respiratory syncytial virus attachment protein in mice"],"prefix":"10.1016","volume":"30","author":[{"given":"Yoshihiko","family":"Murata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seana C.","family":"Catherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.vaccine.2012.06.016_bib0005","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"Hall","year":"2009","journal-title":"N Engl J Med"},{"issue":"Pt 10","key":"10.1016\/j.vaccine.2012.06.016_bib0010","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1099\/0022-1317-78-10-2411","article-title":"Antigenic structure, evolution and immunobiology of human respiratory syncytial virus attachment (G) protein","volume":"78","author":"Melero","year":"1997","journal-title":"J Gen Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2012.06.016_bib0015","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1128\/JVI.01625-07","article-title":"Viral and host factors in human respiratory syncytial virus pathogenesis","volume":"82","author":"Collins","year":"2008","journal-title":"J Virol"},{"issue":"Pt 8","key":"10.1016\/j.vaccine.2012.06.016_bib0020","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1099\/0022-1317-68-8-2169","article-title":"Immunological differences between the envelope glycoproteins of two strains of human respiratory syncytial virus","volume":"68","author":"Walsh","year":"1987","journal-title":"J Gen Virol"},{"issue":"Pt 11","key":"10.1016\/j.vaccine.2012.06.016_bib0025","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1099\/0022-1317-70-11-2953","article-title":"Comparison of antigenic sites of subtype-specific respiratory syncytial virus attachment proteins","volume":"70","author":"Walsh","year":"1989","journal-title":"J Gen Virol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.06.016_bib0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1096-9071(199603)48:3<253::AID-JMV7>3.0.CO;2-7","article-title":"Analysis of the human serological immune response to a variable region of the attachment (G) protein of respiratory syncytial virus during primary infection","volume":"48","author":"Cane","year":"1996","journal-title":"J Med Virol"},{"issue":"4","key":"10.1016\/j.vaccine.2012.06.016_bib0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/(SICI)1096-9071(199704)51:4<297::AID-JMV7>3.0.CO;2-0","article-title":"Analysis of linear epitopes recognised by the primary human antibody response to a variable region of the attachment (G) protein of respiratory syncytial virus","volume":"51","author":"Cane","year":"1997","journal-title":"J Med Virol"},{"issue":"4","key":"10.1016\/j.vaccine.2012.06.016_bib0040","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<468::AID-JMV16>3.0.CO;2-E","article-title":"Evaluation of the antibody specificities of human convalescent-phase sera against the attachment (G) protein of human respiratory syncytial virus: influence of strain variation and carbohydrate side chains","volume":"60","author":"Palomo","year":"2000","journal-title":"J Med Virol"},{"issue":"8","key":"10.1016\/j.vaccine.2012.06.016_bib0045","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1128\/JVI.72.8.6922-6928.1998","article-title":"Antigenic structure of human respiratory syncytial virus fusion glycoprotein","volume":"72","author":"Lopez","year":"1998","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.06.016_bib0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0022-1759(96)00039-7","article-title":"Type-specific serologic diagnosis of respiratory syncytial virus infection, based on a synthetic peptide of the attachment protein G","volume":"193","author":"Langedijk","year":"1996","journal-title":"J Immunol Methods"},{"issue":"7","key":"10.1016\/j.vaccine.2012.06.016_bib0055","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1128\/JCM.35.7.1656-1660.1997","article-title":"A subtype-specific peptide-based enzyme immunoassay for detection of antibodies to the G protein of human respiratory syncytial virus is more sensitive than routine serological tests","volume":"35","author":"Langedijk","year":"1997","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.06.016_bib0060","first-page":"633","article-title":"Multiplex assay for detection of strain-specific antibodies against the two variable regions of the G protein of respiratory syncytial virus","volume":"9","author":"Jones","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"issue":"38","key":"10.1016\/j.vaccine.2012.06.016_bib0065","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1016\/j.vaccine.2010.07.011","article-title":"Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein","volume":"28","author":"Murata","year":"2010","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2012.06.016_bib0070","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/CVI.00432-09","article-title":"Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein","volume":"17","author":"Murata","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"Pt 3","key":"10.1016\/j.vaccine.2012.06.016_bib0075","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1099\/0022-1317-66-3-409","article-title":"Purification and characterization of the respiratory syncytial virus fusion protein","volume":"66","author":"Walsh","year":"1985","journal-title":"J Gen Virol"},{"issue":"6","key":"10.1016\/j.vaccine.2012.06.016_bib0080","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/infdis\/155.6.1198","article-title":"Immunization with glycoprotein subunits of respiratory syncytial virus to protect cotton rats against viral infection","volume":"155","author":"Walsh","year":"1987","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2012.06.016_bib0085","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb2606s46","article-title":"Methods for monitoring dynamics of pulmonary RSV replication by viral culture and by real-time reverse transcription-PCR in vivo: detection of abortive viral replication","author":"Boukhvalova","year":"2010","journal-title":"Curr Protoc Cell Biol"},{"issue":"24","key":"10.1016\/j.vaccine.2012.06.016_bib0090","doi-asserted-by":"crossref","first-page":"13710","DOI":"10.1128\/JVI.01351-07","article-title":"Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats","volume":"81","author":"Mok","year":"2007","journal-title":"J Virol"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2012.06.016_bib0095","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-4347(99)00442-9","article-title":"Purification of respiratory syncytial virus F and G proteins","volume":"737","author":"Roder","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"1","key":"10.1016\/j.vaccine.2012.06.016_bib0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1128\/JVI.47.1.171-177.1983","article-title":"Monoclonal antibodies to respiratory syncytial virus proteins: identification of the fusion protein","volume":"47","author":"Walsh","year":"1983","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.06.016_bib0105","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/JVI.01755-09","article-title":"Vaccination to induce antibodies blocking the CX3C\u2013CX3CR1 interaction of respiratory syncytial virus G protein reduces pulmonary inflammation and virus replication in mice","volume":"84","author":"Zhang","year":"2010","journal-title":"J Virol"},{"issue":"9","key":"10.1016\/j.vaccine.2012.06.016_bib0110","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1128\/JVI.73.9.7099-7107.1999","article-title":"Respiratory syncytial virus G and\/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB\/c mice","volume":"73","author":"Tripp","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2012.06.016_bib0115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1743-422X-6-81","article-title":"Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres","volume":"6","author":"Murata","year":"2009","journal-title":"Virol J"},{"issue":"9","key":"10.1016\/j.vaccine.2012.06.016_bib0120","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm918","article-title":"A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measles","volume":"9","author":"Polack","year":"2003","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.vaccine.2012.06.016_bib0125","doi-asserted-by":"crossref","first-page":"e34331","DOI":"10.1371\/journal.pone.0034331","article-title":"The respiratory syncytial virus g protein conserved domain induces a persistent and protective antibody response in rodents","volume":"7","author":"Nguyen","year":"2012","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.vaccine.2012.06.016_bib0130","doi-asserted-by":"crossref","first-page":"10710","DOI":"10.1128\/JVI.00986-09","article-title":"Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans","volume":"83","author":"Kwilas","year":"2009","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.06.016_bib0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/viro.1996.0379","article-title":"Host cell effect upon glycosylation and antigenicity of human respiratory syncytial virus G glycoprotein","volume":"221","author":"Garcia-Beato","year":"1996","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.vaccine.2012.06.016_bib0140","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nm.1894","article-title":"Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease","volume":"15","author":"Delgado","year":"2009","journal-title":"Nat Med"},{"issue":"45","key":"10.1016\/j.vaccine.2012.06.016_bib0145","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1016\/j.vaccine.2009.06.090","article-title":"Antibody quantity versus quality after influenza vaccination","volume":"27","author":"Feng","year":"2009","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.vaccine.2012.06.016_bib0150","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1086\/591460","article-title":"Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus","volume":"198","author":"Shinoff","year":"2008","journal-title":"J Infect Dis"},{"issue":"Pt 2","key":"10.1016\/j.vaccine.2012.06.016_bib0155","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1099\/0022-1317-69-2-293","article-title":"The purification of four respiratory syncytial virus proteins and their evaluation as protective agents against experimental infection in BALB\/c mice","volume":"69","author":"Routledge","year":"1988","journal-title":"J Gen Virol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.06.016_bib0160","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1128\/JVI.01709-09","article-title":"Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB\/c mice, with no evidence of immunopathology","volume":"84","author":"Murawski","year":"2010","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.vaccine.2012.06.016_bib0165","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0264-410X(89)90278-8","article-title":"Immunization of cotton rats with the fusion (F) and large (G) glycoproteins of respiratory syncytial virus (RSV) protects against RSV challenge without potentiating RSV disease","volume":"7","author":"Murphy","year":"1989","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2012.06.016_bib0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/infdis\/164.1.15","article-title":"Group-specific serum antibody responses in children with primary and recurrent respiratory syncytial virus infections","volume":"164","author":"Muelenaer","year":"1991","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2012.06.016_bib0175","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/infdis\/157.4.640","article-title":"Strain-specific serum antibody responses in infants undergoing primary infection with respiratory syncytial virus","volume":"157","author":"Hendry","year":"1988","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2012.06.016_bib0180","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1086\/340823","article-title":"Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats","volume":"185","author":"Blanco","year":"2002","journal-title":"J Infect Dis"},{"issue":"18","key":"10.1016\/j.vaccine.2012.06.016_bib0185","doi-asserted-by":"crossref","first-page":"9584","DOI":"10.1128\/JVI.00302-10","article-title":"Gene expression differences in lungs of mice during secondary immune responses to respiratory syncytial virus infection","volume":"84","author":"Schuurhof","year":"2010","journal-title":"J Virol"},{"issue":"4","key":"10.1016\/j.vaccine.2012.06.016_bib0190","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1128\/JVI.72.4.2871-2880.1998","article-title":"Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge","volume":"72","author":"Johnson","year":"1998","journal-title":"J Virol"},{"issue":"10","key":"10.1016\/j.vaccine.2012.06.016_bib0195","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1128\/JVI.73.10.8485-8495.1999","article-title":"Secreted respiratory syncytial virus G glycoprotein induces interleukin-5 (IL-5). IL-13, and eosinophilia by an IL-4-independent mechanism","volume":"73","author":"Johnson","year":"1999","journal-title":"J Virol"},{"issue":"24","key":"10.1016\/j.vaccine.2012.06.016_bib0200","doi-asserted-by":"crossref","first-page":"12191","DOI":"10.1128\/JVI.01604-08","article-title":"The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes","volume":"82","author":"Bukreyev","year":"2008","journal-title":"J Virol"},{"issue":"7","key":"10.1016\/j.vaccine.2012.06.016_bib0205","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1128\/JVI.62.7.2228-2233.1988","article-title":"Further characterization of the soluble form of the G glycoprotein of respiratory syncytial virus","volume":"62","author":"Hendricks","year":"1988","journal-title":"J Virol"},{"issue":"42","key":"10.1016\/j.vaccine.2012.06.016_bib0210","doi-asserted-by":"crossref","first-page":"38988","DOI":"10.1074\/jbc.M106288200","article-title":"Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein","volume":"276","author":"Gorman","year":"2001","journal-title":"J Biol Chem"},{"issue":"18","key":"10.1016\/j.vaccine.2012.06.016_bib0215","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1128\/JVI.77.18.9831-9844.2003","article-title":"Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C\u2013CX3CR1 interaction and expression of substance P","volume":"77","author":"Haynes","year":"2003","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.06.016_bib0220","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.4049\/jimmunol.176.3.1600","article-title":"Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+T cell responses","volume":"176","author":"Harcourt","year":"2006","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.06.016_bib0225","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2217\/fmb.09.1","article-title":"The host response and molecular pathogenesis associated with respiratory syncytial virus infection","volume":"4","author":"Oshansky","year":"2009","journal-title":"Future Microbiol"},{"issue":"18","key":"10.1016\/j.vaccine.2012.06.016_bib0230","doi-asserted-by":"crossref","first-page":"9632","DOI":"10.1128\/JVI.00451-10","article-title":"Prophylactic treatment with a G glycoprotein monoclonal antibody reduces pulmonary inflammation in respiratory syncytial virus (RSV)-challenged naive and formalin-inactivated RSV-immunized BALB\/c mice","volume":"84","author":"Radu","year":"2010","journal-title":"J Virol"},{"issue":"7","key":"10.1016\/j.vaccine.2012.06.016_bib0235","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1128\/JVI.78.7.3524-3532.2004","article-title":"The soluble form of human respiratory syncytial virus attachment protein differs from the membrane-bound form in its oligomeric state but is still capable of binding to cell surface proteoglycans","volume":"78","author":"Escribano-Romero","year":"2004","journal-title":"J Virol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12008572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12008572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T16:43:38Z","timestamp":1594313018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12008572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":47,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0264410X12008572"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.06.016","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}