{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:59:54Z","timestamp":1790355594894,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.vaccine.2012.09.069","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T05:15:30Z","timestamp":1349673330000},"page":"7005-7012","source":"Crossref","is-referenced-by-count":12,"title":["The immunogenicity and safety of a single 0.5mL dose of virosomal subunit influenza vaccine administered to unprimed children aged \u22656 to &lt;36 months: Data from a randomized, Phase III study"],"prefix":"10.1016","volume":"30","author":[{"given":"Susanna","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Marchisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Montinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bianchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit Jan","family":"Weverling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Amendola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Fabiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pivetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Vincenzo","family":"Zuccotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.vaccine.2012.09.069_bib0005","first-page":"1059","article-title":"Influenza vaccination coverage among children aged 6 months\u201318 years \u2013 eight immunization information system sentinel sites, United States, 2008\u201309 influenza season","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR"},{"issue":"8","key":"10.1016\/j.vaccine.2012.09.069_bib0010","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1086\/507309","article-title":"Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5\u20138-year-old children","volume":"194","author":"Neuzil","year":"2006","journal-title":"J Infect Dis"},{"issue":"33","key":"10.1016\/j.vaccine.2012.09.069_bib0015","first-page":"1128","article-title":"Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2011","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR"},{"issue":"5","key":"10.1016\/j.vaccine.2012.09.069_bib0020","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1542\/peds.2006-1422","article-title":"Compliance with the recommendations for 2 doses of trivalent inactivated influenza vaccine in children less than 9 years of age receiving influenza vaccine for the first time: a Vaccine Safety Datalink study","volume":"118","author":"Jackson","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.vaccine.2012.09.069_bib0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1542\/peds.2005-0049","article-title":"Effectiveness of the 2003\u20132004 influenza vaccine among children 6 months to 8 years of age, with 1 vs 2 doses","volume":"116","author":"Ritzwoller","year":"2005","journal-title":"Pediatrics"},{"issue":"10 Suppl.","key":"10.1016\/j.vaccine.2012.09.069_bib0030","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1097\/01.inf.0000092188.48726.e4","article-title":"Socioeconomic impact of influenza on healthy children and their families","volume":"22","author":"Principi","year":"2003","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"10.1016\/j.vaccine.2012.09.069_bib0035","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJM200103223441204","article-title":"The Japanese experience with vaccinating schoolchildren against influenza","volume":"344","author":"Reichert","year":"2001","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.vaccine.2012.09.069_bib0040","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.vaccine.2004.09.025","article-title":"Herd immunity in adults against influenza-related illnesses with use of the trivalent-live attenuated influenza vaccine (CAIV-T) in children","volume":"23","author":"Piedra","year":"2005","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2012.09.069_bib0045","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1542\/peds.2004-2373","article-title":"A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children","volume":"115","author":"Englund","year":"2005","journal-title":"Pediatrics"},{"issue":"38","key":"10.1016\/j.vaccine.2012.09.069_bib0050","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1016\/j.vaccine.2010.07.041","article-title":"A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6\u201335 months","volume":"28","author":"Esposito","year":"2010","journal-title":"Vaccine"},{"issue":"33","key":"10.1016\/j.vaccine.2012.09.069_bib0055","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1016\/j.vaccine.2009.05.029","article-title":"Eleven years of Inflexal V \u2013 a virosomal adjuvanted influenza vaccine","volume":"27","author":"Herzog","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.09.069_bib0060","unstructured":"European Agency for the Evaluation of Medicinal Products (EMEA) \u2013 Committee for Proprietary Medicinal Products (CPMP). Note for guidance on harmonisation of requirements for influenza vaccines (CPMP\/BWP\/214\/96). London; 1997."},{"key":"10.1016\/j.vaccine.2012.09.069_bib0065","series-title":"WHO manual on animal influenza diagnosis and surveillance","author":"World Health Organization","year":"2002"},{"key":"10.1016\/j.vaccine.2012.09.069_bib0070","unstructured":"Centers for Disease Control and Prevention. The Flu Season. Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD); 2011 [accessed 29.03.12]."},{"issue":"Suppl. 4","key":"10.1016\/j.vaccine.2012.09.069_bib0075","doi-asserted-by":"crossref","first-page":"D45","DOI":"10.1016\/j.vaccine.2010.08.028","article-title":"The need for quadrivalent vaccine against seasonal influenza","volume":"28","author":"Belshe","year":"2010","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2012.09.069_bib0080","doi-asserted-by":"crossref","DOI":"10.4161\/hv.8.1.18278","article-title":"Influenza vaccination coverage rate in children: reasons for a failure and how to go forward","volume":"8","author":"Olivier","year":"2012","journal-title":"Hum Vaccin Immunother"},{"issue":"31","key":"10.1016\/j.vaccine.2012.09.069_bib0085","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1016\/j.vaccine.2010.05.036","article-title":"High costs of influenza: direct medical costs of influenza disease in young children","volume":"28","author":"Fairbrother","year":"2010","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2012.09.069_bib0090","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.vaccine.2006.09.042","article-title":"Influenza vaccination: the paediatric perspective","volume":"25","author":"Ramet","year":"2007","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2012.09.069_bib0095","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1542\/peds.112.4.821","article-title":"Potential burden of universal influenza vaccination of young children on visits to primary care practices","volume":"112","author":"Szilagyi","year":"2003","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.vaccine.2012.09.069_bib0100","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1001\/archpedi.158.9.867","article-title":"The feasibility of universal influenza vaccination for infants and toddlers","volume":"158","author":"Humiston","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"44","key":"10.1016\/j.vaccine.2012.09.069_bib0105","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.44.19700-en","article-title":"Differences in national influenza vaccination policies across the European Union, Norway and Iceland 2008\u20132009","volume":"15","author":"Mereckiene","year":"2010","journal-title":"Euro Surveill"},{"key":"10.1016\/j.vaccine.2012.09.069_bib0110","article-title":"Council recommendation of 22 December 2009 on seasonal influenza vaccination (text with EEA relevance) (2009\/1019\/EU)","author":"Council of the European Union","year":"2009","journal-title":"Off J Eur Union"},{"key":"10.1016\/j.vaccine.2012.09.069_bib0115","first-page":"ACS-5","article-title":"Statement on seasonal influenza for 2011\u20132012","volume":"37","author":"Public Health Agency of Canada","year":"2001","journal-title":"Can Commun Dis Rep"},{"issue":"1","key":"10.1016\/j.vaccine.2012.09.069_bib0120","doi-asserted-by":"crossref","DOI":"10.4161\/hv.8.1.17957","article-title":"Recommendations for the use of influenza vaccine in pediatrics","volume":"8","author":"Esposito","year":"2012","journal-title":"Hum Vaccin Immunother"},{"issue":"38","key":"10.1016\/j.vaccine.2012.09.069_bib0125","first-page":"1063","article-title":"Influenza vaccination coverage among children aged 6\u201323 months \u2013 United States, 2007\u201308 influenza season","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2012.09.069_bib0130","unstructured":"Centers for Disease Control and Prevention. March flu vaccination coverage. Available at: http:\/\/www.cdc.gov\/flu\/professionals\/vaccination\/nfs-survey-march2012.htm [accessed 28.08.12]."},{"key":"10.1016\/j.vaccine.2012.09.069_bib0135","unstructured":"Vaccine European New Integrated collaboration Effort II Consortium. Final report: seasonal influenza vaccination survey in EU\/EAA, influenza season 2009\u201310; 2011. Available at: http:\/\/venice.cineca.org\/Final_Seasonal_Influenza_Vaccination_Survey_2010.pdf [accessed 28.08.12]."},{"issue":"6","key":"10.1016\/j.vaccine.2012.09.069_bib0140","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jinf.2009.04.001","article-title":"Vaccination coverage rates in eleven European countries during two consecutive influenza seasons","volume":"58","author":"Blank","year":"2009","journal-title":"J Infect"},{"issue":"2","key":"10.1016\/j.vaccine.2012.09.069_bib0145","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1542\/peds.2004-1519","article-title":"Adverse events after inactivated influenza vaccination among children less than 2 years of age: analysis of reports from the vaccine adverse event reporting system, 1990\u20132003","volume":"115","author":"McMahon","year":"2005","journal-title":"Pediatrics"},{"issue":"8","key":"10.1016\/j.vaccine.2012.09.069_bib0150","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.vaccine.2008.12.008","article-title":"Safe vaccination of children with a virosomal adjuvanted influenza vaccine","volume":"27","author":"Kunzi","year":"2009","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2012.09.069_bib0155","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.vaccine.2011.12.042","article-title":"Febrile seizures after 2010\u20132011 influenza vaccine in young children, United States: a vaccine safety signal from the vaccine adverse event reporting system","volume":"30","author":"Leroy","year":"2012","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2012.09.069_bib0160","doi-asserted-by":"crossref","first-page":"751","DOI":"10.2165\/00044011-200222110-00004","article-title":"Ten years of experience with the trivalent split-influenza vaccine, Fluarix","volume":"22","author":"Hehme","year":"2002","journal-title":"Clin Drug Invest"},{"issue":"16","key":"10.1016\/j.vaccine.2012.09.069_bib0165","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1016\/j.vaccine.2011.02.012","article-title":"Fever following administration of two inactivated influenza vaccines \u2013 a survey of parents of New Zealand infants and children 5 years of age and under","volume":"29","author":"Petousis-Harris","year":"2011","journal-title":"Vaccine"},{"issue":"32","key":"10.1016\/j.vaccine.2012.09.069_bib0170","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1016\/j.vaccine.2011.05.054","article-title":"Trivalent influenza vaccine and febrile adverse events in Australia, 2010: clinical features and potential mechanisms","volume":"29","author":"Blyth","year":"2011","journal-title":"Vaccine"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2012.09.069_bib0175","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1071\/NB11024","article-title":"NSW annual report describing adverse events following immunisation, 2010","volume":"22","author":"Mahajan","year":"2011","journal-title":"NSW Public Health Bull"},{"key":"10.1016\/j.vaccine.2012.09.069_bib0180","unstructured":"US Food and Drug Administration. Fluarix \u2013 influenza virus vaccine. Review of pre-licensure safety data. US Food and Drug Administration; 2012 [accessed 29.03.12]."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12014016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12014016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T13:25:34Z","timestamp":1562246734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12014016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":36,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0264410X12014016"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.09.069","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}