{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:58:47Z","timestamp":1780981127475,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":351,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007729","name":"Dutch Ministry of Foreign Affairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007729","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006506","name":"Brazilian Ministry of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.vaccine.2012.11.034","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T12:42:27Z","timestamp":1366202547000},"page":"B227-B232","source":"Crossref","is-referenced-by-count":101,"special_numbering":"S2","title":["The Human Hookworm Vaccine"],"prefix":"10.1016","volume":"31","author":[{"given":"Peter J.","family":"Hotez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Diemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coreen","family":"Beaumier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Bethony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Bottazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Brooker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Roberto","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"da Silva Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marva","family":"Loblack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Medicis","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Correa","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip K.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2012.11.034_bib0005","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMra032492","article-title":"Hookworm infection","volume":"351","author":"Hotez","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0010","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/S0140-6736(09)60233-6","article-title":"Rescuing the bottom billion through control of neglected tropical diseases","volume":"373","author":"Hotez","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0015","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1371\/journal.pmed.0040277","article-title":"Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV\/AIDS, tuberculosis, and malaria","volume":"4","author":"Hotez","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0020","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1365-3156.2010.02542.x","article-title":"Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review","volume":"15","author":"Smith","year":"2010","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0025","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1371\/journal.pntd.0000291","article-title":"Hookworm-related anaemia among pregnant women: a systematic analysis","volume":"2","author":"Brooker","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1162\/qjec.121.1.73","article-title":"Disease and development: evidence from hookworm eradication in the American South","volume":"122","author":"Bleakley","year":"2007","journal-title":"Q J Econ"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1475-2875-5-99","article-title":"The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren","volume":"5","author":"Brooker","year":"2006","journal-title":"Malaria J"},{"issue":"6 Suppl.","key":"10.1016\/j.vaccine.2012.11.034_bib0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4269\/ajtmh.2007.77.88","article-title":"Epidemiology of plasmodium-helminth co-infection in Africa: population at risk, potential impact on anemia, and prospects for combining control","volume":"77","author":"Brooker","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0045","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nrmicro2438","article-title":"Developing vaccines to combat hookworm infection and intestinal schistosomiasis","volume":"8","author":"Hotez","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0050","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1377\/hlthaff.2011.0317","article-title":"A handful of \u2018antipoverty\u2019 vaccines exist for neglected diseases, but the world's poorest billion people need more","volume":"30","author":"Hotez","year":"2011","journal-title":"Health Aff (Millwood)"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0055","first-page":"1","article-title":"This wormy world","volume":"33","author":"Stoll","year":"1947","journal-title":"J Parasitol"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pep.2012.03.013","article-title":"Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen","volume":"83","author":"Goud","year":"2012","journal-title":"Protein Exp Purif"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0065","doi-asserted-by":"crossref","DOI":"10.4161\/hv.19726","article-title":"Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies","volume":"8","author":"Plieskatt","year":"2012","journal-title":"Hum Vaccine Immunother"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0070","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1086\/651953","article-title":"Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis","volume":"201","author":"Pearson","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0075","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1096\/fj.09-131433","article-title":"An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection","volume":"23","author":"Pearson","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0080","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4269\/ajtmh.2009.09-0237","article-title":"Immunologic profiles of persons recruited for a randomized, placebo-controlled clinical trial of hookworm infection","volume":"81","author":"Blount","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0085","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2222.2009.03433.x","article-title":"Experimental hookworm infection: a randomized placebo-controlled trial in asthma","volume":"40","author":"Feary","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0090","doi-asserted-by":"crossref","first-page":"e1002520","DOI":"10.1371\/journal.ppat.1002520","article-title":"Characterising the mucosal and systemic immune responses to experimental human hookworm infection","volume":"8","author":"Gaze","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.actatropica.2008.09.002","article-title":"The biotechnology-value chain: development of Sm14 as a schistosomiasis vaccine","volume":"108","author":"Tendler","year":"2008","journal-title":"Acta Trop"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0100","doi-asserted-by":"crossref","first-page":"e1704","DOI":"10.1371\/journal.pntd.0001704","article-title":"Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis","volume":"6","author":"Riveau","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0105","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1473-3099(06)70630-2","article-title":"Hookworm vaccines: past, present, and future","volume":"6","author":"Loukas","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-3024.2010.01224.x","article-title":"The immunobiology of human hookworm infections","volume":"32","author":"McSorley","year":"2010","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0115","doi-asserted-by":"crossref","first-page":"169076.e6","DOI":"10.1016\/j.jaci.2012.04.027","article-title":"Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths","volume":"130","author":"Diemert","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0120","doi-asserted-by":"crossref","first-page":"e1280","DOI":"10.1371\/journal.pntd.0001280","article-title":"Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses","volume":"5","author":"Geiger","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0125","doi-asserted-by":"crossref","first-page":"e24092","DOI":"10.1371\/journal.pone.0024092","article-title":"Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection","volume":"6","author":"McSorley","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0130","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/clpt.2009.16","article-title":"Mass drug administration and integrated control for the world's high prevalence neglected tropical diseases","volume":"85","author":"Hotez","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0135","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.1371\/journal.pmed.0020336","article-title":"\u201cRapid-impact interventions\u201d: how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor","volume":"2","author":"Molyneux","year":"2005","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0140","unstructured":"http:\/\/www.unitingtocombatntds.org\/downloads\/press\/ntd_event_london_declaration_on_ntds.pdf [accessed 09.06.12]."},{"issue":"Suppl. 4","key":"10.1016\/j.vaccine.2012.11.034_bib0145","doi-asserted-by":"crossref","first-page":"D104","DOI":"10.1016\/j.vaccine.2011.06.024","article-title":"Enlarging the \u201caudacious goal\u201d: elimination of the world's high prevalence neglected tropical diseases","volume":"29","author":"Hotez","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0150","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0155","first-page":"343","article-title":"Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar","volume":"81","author":"Albonico","year":"2003","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0160","doi-asserted-by":"crossref","first-page":"e1417","DOI":"10.1371\/journal.pntd.0001417","article-title":"Low efficacy of single dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR","volume":"6","author":"Soukhathammavong","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0165","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0035-9203(95)90101-9","article-title":"Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area","volume":"89","author":"Albonico","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0170","unstructured":"World Health Organization. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO Expert Committee 2002; WHO Technical Report Series 912."},{"key":"10.1016\/j.vaccine.2012.11.034_bib0175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(04)58004-1","article-title":"Human hookworm infection in the 21st century","volume":"58","author":"Brooker","year":"2004","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0180","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0035-9203(91)90241-P","article-title":"The impact of three-monthly age-targeted chemotherapy on Ascaris lumbricoides infection","volume":"85","author":"Thein-Hlaing","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0185","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.vaccine.2010.12.004","article-title":"The potential economic value of a hookworm vaccine","volume":"29","author":"Lee","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0190","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.1115538","article-title":"Health innovation networks to help developing countries address neglected diseases","volume":"309","author":"Morel","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2012.11.034_bib0195","unstructured":"http:\/\/www.dcvmn.com [accessed 17.06.12]."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12016271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12016271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:01:56Z","timestamp":1715227316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12016271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":39,"alternative-id":["S0264410X12016271"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.11.034","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}