{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T05:49:39Z","timestamp":1776577779650,"version":"3.51.2"},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.vaccine.2012.12.049","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T16:16:00Z","timestamp":1357143360000},"page":"1012-1018","source":"Crossref","is-referenced-by-count":23,"title":["Cell recruitment and antigen trafficking in afferent lymph after injection of antigen and poly(I:C) containing liposomes, in aqueous or oil-based formulations"],"prefix":"10.1016","volume":"31","author":[{"given":"Michael","family":"de Veer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Neeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Burke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Pleasance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Nathanielsz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Elhay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Meeusen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vaccine.2012.12.049_bib0005","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.coi.2012.03.008","article-title":"Adjuvants for human vaccines","volume":"24","author":"Alving","year":"2012","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2012.12.049_bib0010","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.immuni.2010.10.002","article-title":"Vaccine adjuvants: putting innate immunity to work","volume":"33","author":"Coffman","year":"2010","journal-title":"Immunity"},{"issue":"September (64)","key":"10.1016\/j.vaccine.2012.12.049_bib0015","first-page":"195","article-title":"New developments in vaccine research\u2014unveiling the secret of vaccine adjuvants","volume":"12","author":"de Veer","year":"2011","journal-title":"Discov Med"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2012.12.049_bib0020","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ni.2039","article-title":"Immunological mechanisms of vaccination","volume":"131","author":"Pulendran","year":"2011","journal-title":"Nat Immunol"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2012.12.049_bib0025","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1517\/17425240903018863","article-title":"Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators","volume":"6","author":"Nordly","year":"2009","journal-title":"Expert Opin Drug Deliv"},{"issue":"November (11)","key":"10.1016\/j.vaccine.2012.12.049_bib0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"13","key":"10.1016\/j.vaccine.2012.12.049_bib0035","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.vaccine.2012.01.070","article-title":"Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens","volume":"30","author":"Watson","year":"2012","journal-title":"Vaccine"},{"issue":"156","key":"10.1016\/j.vaccine.2012.12.049_bib0040","first-page":"1479","article-title":"First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients","volume":"10","author":"Berinstein","year":"2012","journal-title":"J Transl Med"},{"issue":"44","key":"10.1016\/j.vaccine.2012.12.049_bib0045","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1016\/j.vaccine.2010.08.084","article-title":"Efficacy of a single dose hepatitis B depot vaccine","volume":"28","author":"MacDonald","year":"2010","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2012.12.049_bib0050","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/CJI.0b013e3181c1f1e9","article-title":"A novel breast\/ovarian cancer peptide vaccine platform that promotes specific type-1 but not Treg\/Tr1-type responses","volume":"33","author":"Karkada","year":"2010","journal-title":"J Immunother"},{"issue":"40","key":"10.1016\/j.vaccine.2012.12.049_bib0055","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1016\/j.vaccine.2010.07.056","article-title":"The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant","volume":"28","author":"de Veer","year":"2010","journal-title":"Vaccine"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2012.12.049_bib0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.0141-9838.2001.00432.x","article-title":"Mechanisms of immunity to Haemonchus contortus infection in sheep","volume":"24","author":"Balic","year":"2002","journal-title":"Parasite Immunol"},{"issue":"6","key":"10.1016\/j.vaccine.2012.12.049_bib0065","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.4049\/jimmunol.1000824","article-title":"Existence of CD8alpha-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species","volume":"185","author":"Contreras","year":"2010","journal-title":"J Immunol"},{"issue":"June (3)","key":"10.1016\/j.vaccine.2012.12.049_bib0070","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/smim.2000.0253","article-title":"Localization dose and time of antigens determine immune reactivity","volume":"12","author":"Zinkernagel","year":"2000","journal-title":"Semin Immunol"},{"key":"10.1016\/j.vaccine.2012.12.049_bib0075","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/icb.2011.53","article-title":"Modulation of soluble and particulate antigen transport in afferent lymph by monophosphoryl lipid A","volume":"90","author":"de Veer","year":"2011","journal-title":"Immunol Cell Biol"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2012.12.049_bib0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1189\/jlb.0809549","article-title":"When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system","volume":"87","author":"Silva","year":"2010","journal-title":"J Leukoc Biol"},{"issue":"2","key":"10.1016\/j.vaccine.2012.12.049_bib0085","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/sj.icb.7100125","article-title":"Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling","volume":"86","author":"Wilson","year":"2008","journal-title":"Immunol Cell Biol"},{"issue":"3","key":"10.1016\/j.vaccine.2012.12.049_bib0090","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jconrel.2012.03.016","article-title":"A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog","volume":"160","author":"Christensen","year":"2012","journal-title":"J Control Release"},{"issue":"12","key":"10.1016\/j.vaccine.2012.12.049_bib0095","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1084\/jem.20081430","article-title":"Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes","volume":"205","author":"Jakubzick","year":"2008","journal-title":"J Exp Med"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2012.12.049_bib0100","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/eji.201040498","article-title":"From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets","volume":"40","author":"Guilliams","year":"2010","journal-title":"Eur J Immunol"},{"issue":"December (12)","key":"10.1016\/j.vaccine.2012.12.049_bib0105","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/ni.1822","article-title":"Dendritic cell subsets in primary and secondary T cell responses at body surfaces","volume":"10","author":"Heath","year":"2009","journal-title":"Nat Immunol"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2012.12.049_bib0110","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0264-410X(01)00332-2","article-title":"Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX","volume":"20","author":"Windon","year":"2001","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2012.12.049_bib0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1365-2567.1999.00681.x","article-title":"Local immune responses in afferent and efferent lymph","volume":"96","author":"Haig","year":"1999","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.vaccine.2012.12.049_bib0150","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2010.03.027","article-title":"Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response","volume":"145","author":"Henriksen-Lacey","year":"2010","journal-title":"J Control Release"},{"issue":"3","key":"10.1016\/j.vaccine.2012.12.049_bib0155","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jconrel.2012.03.016","article-title":"A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog","volume":"160","author":"Christensen","year":"2012","journal-title":"J Control Release"},{"issue":"October (5)","key":"10.1016\/j.vaccine.2012.12.049_bib0120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.0818-9641.2004.01282.x","article-title":"Liposome-stabilized oil-in-water emulsions as adjuvants: increased emulsion stability promotes induction of cytotoxic T lymphocytes against an HIV envelope antigen","volume":"82","author":"Richards","year":"2004","journal-title":"Immunol Cell Biol"},{"issue":"38","key":"10.1016\/j.vaccine.2012.12.049_bib0125","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1016\/j.vaccine.2010.07.025","article-title":"A liposome-based platform, VacciMax, and its modified water-free platform DepoVax enhance efficacy of in vivo nucleic acid delivery","volume":"28","author":"Karkada","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2012.12.049_bib0130","series-title":"Long acting animal health drug products, fundamentals and applications","article-title":"Veterinary vaccines","author":"Elhay","year":"2012"},{"issue":"February (1)","key":"10.1016\/j.vaccine.2012.12.049_bib0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.smim.2007.12.004","article-title":"Ectopic lymphoid tissues and local immunity","volume":"20","author":"Carragher","year":"2008","journal-title":"Semin Immunol"},{"issue":"October (10)","key":"10.1016\/j.vaccine.2012.12.049_bib0140","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1128\/CVI.00143-07","article-title":"Improved efficacy of a licensed acellular pertussis vaccine, reformulated in an adjuvant emulsion of liposomes in oil, in a murine model","volume":"14","author":"Mansour","year":"2007","journal-title":"Clin Vaccine Immunol"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2012.12.049_bib0145","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12018361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X12018361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T16:59:17Z","timestamp":1562518757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X12018361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0264410X12018361"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2012.12.049","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}