{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:17:31Z","timestamp":1789208251817,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":380,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.vaccine.2013.01.048","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T20:32:38Z","timestamp":1360355558000},"page":"1785-1792","source":"Crossref","is-referenced-by-count":60,"title":["Induction of immunogenicity by live attenuated Leishmania donovani centrin deleted parasites in dogs"],"prefix":"10.1016","volume":"31","author":[{"given":"Jacqueline Ara\u00fajo","family":"Fiuza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helton da Costa","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angamuthu","family":"Selvapandiyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas","family":"Gannavaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Delaqua","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Lacerda","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Castanheira","family":"Bartholomeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Correa-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira Lal","family":"Nakhasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Toshio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Desjeux","year":"2004","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"9","key":"10.1016\/j.vaccine.2013.01.048_bib0010","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/344312","article-title":"Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission","volume":"186","author":"Courtenay","year":"2002","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2013.01.048_bib0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0950268806006881","article-title":"Multilevel modelling of the incidence of visceral leishmaniasis in Teresina, Brazil","volume":"135","author":"Werneck","year":"2007","journal-title":"Epidemiol Infect"},{"issue":"12\u201313","key":"10.1016\/j.vaccine.2013.01.048_bib0020","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0020-7519(00)00136-3","article-title":"The leishmaniases as emerging and reemerging zoonoses","volume":"30","author":"Ashford","year":"2000","journal-title":"Int J Parasitol"},{"issue":"8","key":"10.1016\/j.vaccine.2013.01.048_bib0025","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.2460\/javma.2005.226.1316","article-title":"Autochthonous visceral leishmaniasis in dogs in North America","volume":"226","author":"Schantz","year":"2005","journal-title":"J Am Vet Med Assoc"},{"issue":"4","key":"10.1016\/j.vaccine.2013.01.048_bib0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.vetpar.2009.03.025","article-title":"Canine leishmaniosis in the United Kingdom: a zoonotic disease waiting for a vector?","volume":"163","author":"Shaw","year":"2009","journal-title":"Vet Parasitol"},{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0035","first-page":"417","article-title":"Leishmaniasis. Public health aspects and control","volume":"14","author":"DesjeuxF P.","year":"1996","journal-title":"Clin Dermatol"},{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0040","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4269\/ajtmh.2001.65.510","article-title":"Impact of canine control on the epidemiology of canine and human visceral leishmaniasis in Brazil","volume":"65","author":"Palatnik-de-Sousa","year":"2001","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.vaccine.2013.01.048_bib0045","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1086\/313697","article-title":"Natural history of Leishmania (Leishmania) chagasi infection in Northeastern Brazil: long-term follow-up","volume":"30","author":"Jeronimo","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.vaccine.2013.01.048_bib0050","first-page":"197","article-title":"Calazar na zona do Rio Doce \u2013 Minas Gerais. Resultados de medidas profilaticas","volume":"22","author":"Magalhaes","year":"1980","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"3","key":"10.1016\/j.vaccine.2013.01.048_bib0055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2915.2009.00815.x","article-title":"A long-lasting topical deltamethrin treatment to protect dogs against visceral leishmaniasis","volume":"23","author":"Courtenay","year":"2009","journal-title":"Med Vet Entomol"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2013.01.048_bib0060","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.ijpara.2005.07.001","article-title":"The current status of zoonotic leishmaniases and approaches to disease control","volume":"35","author":"Gramiccia","year":"2005","journal-title":"Int J Parasitol"},{"issue":"3","key":"10.1016\/j.vaccine.2013.01.048_bib0065","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4269\/ajtmh.1995.52.287","article-title":"Control of zoonotic visceral leishmaniasis: is it time to change strategies?","volume":"52","author":"Tesh","year":"1995","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"10.1016\/j.vaccine.2013.01.048_bib0070","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0304-4017(02)00115-2","article-title":"Chemotherapy of canine leishmaniosis","volume":"106","author":"Baneth","year":"2002","journal-title":"Vet Parasitol"},{"issue":"2","key":"10.1016\/j.vaccine.2013.01.048_bib0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4269\/ajtmh.1996.55.125","article-title":"The logic of visceral leishmaniasis control","volume":"55","author":"Dye","year":"1996","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"10.1016\/j.vaccine.2013.01.048_bib0080","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2174\/1566524043360212","article-title":"Progress in vaccine research and possible effector mechanisms in visceral leishmaniasis","volume":"4","author":"Ravindran","year":"2004","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.vaccine.2013.01.048_bib0085","first-page":"631460","article-title":"Immunity to visceral leishmaniasis using genetically defined live-attenuated parasites","author":"Selvapandiyan","year":"2012","journal-title":"J Trop Med"},{"issue":"3","key":"10.1016\/j.vaccine.2013.01.048_bib0090","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.0900276","article-title":"Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis","volume":"183","author":"Selvapandiyan","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2013.01.048_bib0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00005-008-0010-9","article-title":"Live attenuated Leishmania vaccines: a potential strategic alternative","volume":"56","author":"Silvestre","year":"2008","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"3","key":"10.1016\/j.vaccine.2013.01.048_bib0100","first-page":"455","article-title":"Genetically modified live attenuated parasites as vaccines for leishmaniasis","volume":"123","author":"Selvapandiyan","year":"2006","journal-title":"Indian J Med Res"},{"issue":"24","key":"10.1016\/j.vaccine.2013.01.048_bib0105","doi-asserted-by":"crossref","first-page":"25703","DOI":"10.1074\/jbc.M402794200","article-title":"Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania","volume":"279","author":"Selvapandiyan","year":"2004","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.vaccine.2013.01.048_bib0110","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2249.2006.03206.x","article-title":"Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi","volume":"146","author":"Reis","year":"2006","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"10.1016\/j.vaccine.2013.01.048_bib0115","doi-asserted-by":"crossref","first-page":"e512","DOI":"10.1371\/journal.pntd.0000512","article-title":"Profile of central and effector memory T cells in the progression of chronic human chagas disease","volume":"3","author":"Fiuza","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2013.01.048_bib0120","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.rvsc.2007.09.008","article-title":"Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis","volume":"85","author":"Giunchetti","year":"2008","journal-title":"Res Vet Sci"},{"issue":"12\u201313","key":"10.1016\/j.vaccine.2013.01.048_bib0125","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.micinf.2007.08.004","article-title":"In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens","volume":"9","author":"Campi-Azevedo","year":"2007","journal-title":"Microbes Infect"},{"issue":"5\u20136","key":"10.1016\/j.vaccine.2013.01.048_bib0130","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1051\/vetres:2005033","article-title":"Immunogenicity in dogs of three recombinant antigens (TSA, LeIF and LmSTI1) potential vaccine candidates for canine visceral leishmaniasis","volume":"36","author":"Fujiwara","year":"2005","journal-title":"Vet Res"},{"issue":"39","key":"10.1016\/j.vaccine.2013.01.048_bib0135","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1016\/j.vaccine.2008.07.029","article-title":"Immunogenicity assay of the Leishmune vaccine against canine visceral leishmaniasis in Brazil","volume":"26","author":"Borja-Cabrera","year":"2008","journal-title":"Vaccine"},{"issue":"28","key":"10.1016\/j.vaccine.2013.01.048_bib0140","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1016\/j.vaccine.2005.02.009","article-title":"Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum","volume":"23","author":"Rafati","year":"2005","journal-title":"Vaccine"},{"issue":"19\u201320","key":"10.1016\/j.vaccine.2013.01.048_bib0145","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/S0264-410X(03)00032-X","article-title":"Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK","volume":"21","author":"Ramiro","year":"2003","journal-title":"Vaccine"},{"issue":"46","key":"10.1016\/j.vaccine.2013.01.048_bib0150","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1016\/j.vaccine.2007.08.023","article-title":"Vaccination with plasmid DNA encoding KMPII, TRYP, LACK and GP63 does not protect dogs against Leishmania infantum experimental challenge","volume":"25","author":"Rodriguez-Cortes","year":"2007","journal-title":"Vaccine"},{"issue":"46","key":"10.1016\/j.vaccine.2013.01.048_bib0155","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1016\/j.vaccine.2008.05.095","article-title":"Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein","volume":"26","author":"Fernandes","year":"2008","journal-title":"Vaccine"},{"issue":"44","key":"10.1016\/j.vaccine.2013.01.048_bib0160","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1016\/j.vaccine.2007.08.009","article-title":"Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs","volume":"25","author":"Giunchetti","year":"2007","journal-title":"Vaccine"},{"issue":"22","key":"10.1016\/j.vaccine.2013.01.048_bib0165","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.vaccine.2004.11.061","article-title":"Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes","volume":"23","author":"Lemesre","year":"2005","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0170","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.vaccine.2007.11.057","article-title":"A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs","volume":"26","author":"Giunchetti","year":"2008","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.vaccine.2013.01.048_bib0175","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.vaccine.2008.11.104","article-title":"T-cell-derived cytokines, nitric oxide production by peripheral blood monocytes and seric anti-Leishmania (Leishmania) chagasi IgG subclass patterns following immunization against canine visceral leishmaniasis using Leishvaccine and Leishmune","volume":"27","author":"Araujo","year":"2009","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2013.01.048_bib0180","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1586\/14760584.7.6.833","article-title":"FML vaccine against canine visceral leishmaniasis: from second-generation to synthetic vaccine","volume":"7","author":"Palatnik-de-Sousa","year":"2008","journal-title":"Expert Rev Vaccines"},{"issue":"4","key":"10.1016\/j.vaccine.2013.01.048_bib0185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4314\/eamj.v82i4.9280","article-title":"Vaccinations with live-attenuated Leishmania major promastigotes and challenge infection with L major in BALB\/c mice","volume":"82","author":"Onyalo","year":"2005","journal-title":"East Afr Med J"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2013.01.048_bib0190","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0165-2478(98)00132-1","article-title":"T-cell response in human leishmaniasis","volume":"65","author":"Kharazmi","year":"1999","journal-title":"Immunol Lett"},{"issue":"4","key":"10.1016\/j.vaccine.2013.01.048_bib0195","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0952-7915(93)90033-O","article-title":"T-cell and cytokine responses in leishmaniasis","volume":"5","author":"Reed","year":"1993","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0200","first-page":"441","article-title":"Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes","volume":"30","author":"Lasri","year":"1999","journal-title":"Vet Res"},{"issue":"1-2","key":"10.1016\/j.vaccine.2013.01.048_bib0205","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vetimm.2011.02.007","article-title":"Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis","volume":"141","author":"Araujo","year":"2011","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2013.01.048_bib0210","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fimmu.2012.00005","article-title":"CD8(+) T cells in leishmania infections: friends or foes?","volume":"3","author":"Stager","year":"2012","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2013.01.048_bib0215","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/eji.1830220211","article-title":"Altered course of visceral leishmaniasis in mice expressing transgenic I-E molecules","volume":"22","author":"Kaye","year":"1992","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2013.01.048_bib0220","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/IAI.74.1.773-776.2006","article-title":"Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen","volume":"74","author":"Polley","year":"2006","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0225","doi-asserted-by":"crossref","first-page":"e1000431","DOI":"10.1371\/journal.ppat.1000431","article-title":"B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections","volume":"5","author":"Joshi","year":"2009","journal-title":"PLoS Pathog"},{"issue":"8","key":"10.1016\/j.vaccine.2013.01.048_bib0230","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/eji.200839017","article-title":"Complete protection against experimental visceral leishmaniasis with complete soluble antigen from attenuated Leishmania donovani promastigotes involves Th1-immunity and down-regulation of IL-10","volume":"39","author":"Bhaumik","year":"2009","journal-title":"Eur J Immunol"},{"issue":"12","key":"10.1016\/j.vaccine.2013.01.048_bib0235","doi-asserted-by":"crossref","first-page":"e1429","DOI":"10.1371\/journal.pntd.0001429","article-title":"Potentiating effects of MPL on DSPC bearing cationic liposomes promote recombinant GP63 vaccine efficacy: high immunogenicity and protection","volume":"5","author":"Mazumder","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"11","key":"10.1016\/j.vaccine.2013.01.048_bib0240","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.4049\/jimmunol.161.11.6171","article-title":"LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile","volume":"161","author":"Skeiky","year":"1998","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.vaccine.2013.01.048_bib0245","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/intimm\/5.9.1119","article-title":"Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent","volume":"5","author":"Macatonia","year":"1993","journal-title":"Int Immunol"},{"issue":"21","key":"10.1016\/j.vaccine.2013.01.048_bib0250","doi-asserted-by":"crossref","first-page":"10188","DOI":"10.1073\/pnas.90.21.10188","article-title":"Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming","volume":"90","author":"Seder","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.vaccine.2013.01.048_bib0255","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pt.2005.03.006","article-title":"Second-generation vaccines against leishmaniasis","volume":"21","author":"Coler","year":"2005","journal-title":"Trends Parasitol"},{"issue":"1","key":"10.1016\/j.vaccine.2013.01.048_bib0260","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2005.01.009","article-title":"T helper (h)1\/Th2 and Leishmania: paradox rather than paradigm","volume":"99","author":"Alexander","year":"2005","journal-title":"Immunol Lett"},{"issue":"Suppl.","key":"10.1016\/j.vaccine.2013.01.048_bib0265","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1017\/S0031182006001831","article-title":"Leishmania vaccines: progress and problems","volume":"133","author":"Kedzierski","year":"2006","journal-title":"Parasitology"},{"issue":"11","key":"10.1016\/j.vaccine.2013.01.048_bib0270","doi-asserted-by":"crossref","first-page":"e49780","DOI":"10.1371\/journal.pone.0049780","article-title":"Performance of LBSap vaccine after intradermal challenge with L. infantum and saliva of Lu. longipalpis: immunogenicity and parasitological evaluation","volume":"7","author":"Roatt","year":"2012","journal-title":"PLoS ONE"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X13001266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X13001266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T06:18:22Z","timestamp":1688019502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X13001266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":54,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0264410X13001266"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.01.048","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}